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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RABGEF1
Full Name:
Rab5 GDP/GTP exchange factor
Alias:
Rabaptin-5-associated exchange factor for Rab5; RABEX5; Rabex-5; RAP1
Type:
Guanine nucleotide exchange protein
Mass (Da):
79371
Number AA:
708
UniProt ID:
Q9UJ41
International Prot ID:
IPI00418213
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005769
GO:0055037
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006897
GO:0019941
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
V
V
V
T
G
R
E
P
D
S
R
Site 2
S11
V
T
G
R
E
P
D
S
R
R
Q
D
G
A
M
Site 3
S19
R
R
Q
D
G
A
M
S
S
S
D
A
E
D
D
Site 4
S20
R
Q
D
G
A
M
S
S
S
D
A
E
D
D
F
Site 5
S21
Q
D
G
A
M
S
S
S
D
A
E
D
D
F
L
Site 6
T32
D
D
F
L
E
P
A
T
P
T
A
T
Q
A
G
Site 7
T61
P
A
L
R
G
P
P
T
Q
G
A
C
S
S
C
Site 8
S67
P
T
Q
G
A
C
S
S
C
V
Q
R
G
P
V
Site 9
T90
A
A
G
E
H
A
A
T
E
G
R
E
G
A
P
Site 10
S98
E
G
R
E
G
A
P
S
V
S
G
T
H
A
L
Site 11
T102
G
A
P
S
V
S
G
T
H
A
L
L
Q
R
P
Site 12
S140
V
V
S
R
K
K
M
S
L
K
S
E
R
R
G
Site 13
S143
R
K
K
M
S
L
K
S
E
R
R
G
I
H
V
Site 14
S153
R
G
I
H
V
D
Q
S
D
L
L
C
K
K
G
Site 15
Y164
C
K
K
G
C
G
Y
Y
G
N
P
A
W
Q
G
Site 16
Y181
S
K
C
W
R
E
E
Y
H
K
A
R
Q
K
Q
Site 17
S249
E
E
E
E
A
F
A
S
S
Q
S
S
Q
G
A
Site 18
S250
E
E
E
A
F
A
S
S
Q
S
S
Q
G
A
Q
Site 19
S253
A
F
A
S
S
Q
S
S
Q
G
A
Q
S
L
T
Site 20
S258
Q
S
S
Q
G
A
Q
S
L
T
F
S
K
F
E
Site 21
T260
S
Q
G
A
Q
S
L
T
F
S
K
F
E
E
K
Site 22
S262
G
A
Q
S
L
T
F
S
K
F
E
E
K
K
T
Site 23
T269
S
K
F
E
E
K
K
T
N
E
K
T
R
K
V
Site 24
T277
N
E
K
T
R
K
V
T
T
V
K
K
F
F
S
Site 25
S284
T
T
V
K
K
F
F
S
A
S
S
R
V
G
S
Site 26
S286
V
K
K
F
F
S
A
S
S
R
V
G
S
K
K
Site 27
S287
K
K
F
F
S
A
S
S
R
V
G
S
K
K
E
Site 28
S291
S
A
S
S
R
V
G
S
K
K
E
I
Q
E
A
Site 29
S302
I
Q
E
A
K
A
P
S
P
S
I
N
R
Q
T
Site 30
S304
E
A
K
A
P
S
P
S
I
N
R
Q
T
S
I
Site 31
T309
S
P
S
I
N
R
Q
T
S
I
E
T
D
R
V
Site 32
S310
P
S
I
N
R
Q
T
S
I
E
T
D
R
V
S
Site 33
T313
N
R
Q
T
S
I
E
T
D
R
V
S
K
E
F
Site 34
S317
S
I
E
T
D
R
V
S
K
E
F
I
E
F
L
Site 35
T326
E
F
I
E
F
L
K
T
F
H
K
T
G
Q
E
Site 36
Y347
L
F
L
E
G
M
H
Y
K
R
D
L
S
I
E
Site 37
S352
M
H
Y
K
R
D
L
S
I
E
E
Q
S
E
C
Site 38
S357
D
L
S
I
E
E
Q
S
E
C
A
Q
D
F
Y
Site 39
Y364
S
E
C
A
Q
D
F
Y
H
N
V
A
E
R
M
Site 40
T373
N
V
A
E
R
M
Q
T
R
G
K
E
R
R
F
Site 41
S399
T
S
G
D
P
P
A
S
A
S
Q
S
A
G
N
Site 42
S401
G
D
P
P
A
S
A
S
Q
S
A
G
N
T
G
Site 43
S403
P
P
A
S
A
S
Q
S
A
G
N
T
G
V
E
Site 44
T407
A
S
Q
S
A
G
N
T
G
V
E
P
P
H
P
Site 45
Y431
I
M
D
Q
I
E
K
Y
I
M
T
R
L
Y
K
Site 46
Y437
K
Y
I
M
T
R
L
Y
K
Y
V
F
C
P
E
Site 47
S497
T
D
I
I
E
M
D
S
K
R
V
P
R
D
K
Site 48
S528
I
T
K
N
E
P
A
S
A
D
D
F
L
P
T
Site 49
S550
G
N
P
P
R
L
Q
S
N
I
Q
Y
I
T
R
Site 50
Y554
R
L
Q
S
N
I
Q
Y
I
T
R
F
C
N
P
Site 51
S562
I
T
R
F
C
N
P
S
R
L
M
T
G
E
D
Site 52
T566
C
N
P
S
R
L
M
T
G
E
D
G
Y
Y
F
Site 53
Y572
M
T
G
E
D
G
Y
Y
F
T
N
L
C
C
A
Site 54
S590
I
E
K
L
D
A
Q
S
L
N
L
S
Q
E
D
Site 55
S594
D
A
Q
S
L
N
L
S
Q
E
D
F
D
R
Y
Site 56
Y601
S
Q
E
D
F
D
R
Y
M
S
G
Q
T
S
P
Site 57
S603
E
D
F
D
R
Y
M
S
G
Q
T
S
P
R
K
Site 58
T606
D
R
Y
M
S
G
Q
T
S
P
R
K
Q
E
A
Site 59
S607
R
Y
M
S
G
Q
T
S
P
R
K
Q
E
A
E
Site 60
S617
K
Q
E
A
E
S
W
S
P
D
A
C
L
G
V
Site 61
S635
Y
K
N
L
D
L
L
S
Q
L
N
E
R
Q
E
Site 62
T659
E
K
D
L
I
D
W
T
D
G
I
A
R
E
V
Site 63
Y673
V
Q
D
I
V
E
K
Y
P
L
E
I
K
P
P
Site 64
S689
Q
P
L
A
A
I
D
S
E
N
V
E
N
D
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation