KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
HACL1
Full Name:
2-hydroxyacyl-CoA lyase 1
Alias:
2-HPCL; 2-hydroxyphytanol-CoA lyase; 2-hydroxyphytanoyl-CoA lyase; HPCL; HPCL2; PHYH2; Phytanoyl-CoA 2-hydroxylase 2; Phytanoyl-CoA hydroxylase 2
Type:
Lyase; EC 4.1.-.-
Mass (Da):
63710
Number AA:
578
UniProt ID:
Q9UJ83
International Prot ID:
IPI00296535
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005777
Uniprot
OncoNet
Molecular Function:
GO:0016830
GO:0042802
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0001561
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
P
D
S
N
F
A
E
R
S
E
Site 2
S10
D
S
N
F
A
E
R
S
E
E
Q
V
S
G
A
Site 3
Y54
A
Q
Q
L
G
I
K
Y
I
G
M
R
N
E
Q
Site 4
Y65
R
N
E
Q
A
A
C
Y
A
A
S
A
I
G
Y
Site 5
S111
P
L
L
V
I
G
G
S
S
E
R
N
Q
E
T
Site 6
S112
L
L
V
I
G
G
S
S
E
R
N
Q
E
T
M
Site 7
Y134
Q
V
E
A
C
R
L
Y
T
K
F
S
A
R
P
Site 8
T135
V
E
A
C
R
L
Y
T
K
F
S
A
R
P
S
Site 9
S138
C
R
L
Y
T
K
F
S
A
R
P
S
S
I
E
Site 10
S142
T
K
F
S
A
R
P
S
S
I
E
A
I
P
F
Site 11
S158
I
E
K
A
V
R
S
S
I
Y
G
R
P
G
A
Site 12
Y160
K
A
V
R
S
S
I
Y
G
R
P
G
A
C
Y
Site 13
Y167
Y
G
R
P
G
A
C
Y
V
D
I
P
A
D
F
Site 14
Y186
V
N
V
N
S
I
K
Y
M
E
R
C
M
S
P
Site 15
S192
K
Y
M
E
R
C
M
S
P
P
I
S
M
A
E
Site 16
Y240
I
K
K
L
V
E
Q
Y
K
L
P
F
L
P
T
Site 17
T247
Y
K
L
P
F
L
P
T
P
M
G
K
G
V
V
Site 18
Y260
V
V
P
D
N
H
P
Y
C
V
G
A
A
R
S
Site 19
Y295
H
F
G
L
P
P
R
Y
Q
P
D
V
K
F
I
Site 20
T339
L
L
E
E
L
D
K
T
P
W
Q
Y
P
P
E
Site 21
T352
P
E
S
K
W
W
K
T
L
R
E
K
M
K
S
Site 22
S359
T
L
R
E
K
M
K
S
N
E
A
A
S
K
E
Site 23
S372
K
E
L
A
S
K
K
S
L
P
M
N
Y
Y
T
Site 24
Y377
K
K
S
L
P
M
N
Y
Y
T
V
F
Y
H
V
Site 25
Y378
K
S
L
P
M
N
Y
Y
T
V
F
Y
H
V
Q
Site 26
Y382
M
N
Y
Y
T
V
F
Y
H
V
Q
E
Q
L
P
Site 27
S396
P
R
D
C
F
V
V
S
E
G
A
N
T
M
D
Site 28
Y412
G
R
T
V
L
Q
N
Y
L
P
R
H
R
L
D
Site 29
T422
R
H
R
L
D
A
G
T
F
G
T
M
G
V
G
Site 30
T425
L
D
A
G
T
F
G
T
M
G
V
G
L
G
F
Site 31
T523
S
H
Y
E
Q
V
M
T
A
F
G
G
K
G
Y
Site 32
Y530
T
A
F
G
G
K
G
Y
F
V
Q
T
P
E
E
Site 33
T534
G
K
G
Y
F
V
Q
T
P
E
E
L
Q
K
S
Site 34
S541
T
P
E
E
L
Q
K
S
L
R
Q
S
L
A
D
Site 35
S545
L
Q
K
S
L
R
Q
S
L
A
D
T
T
K
P
Site 36
T549
L
R
Q
S
L
A
D
T
T
K
P
S
L
I
N
Site 37
T550
R
Q
S
L
A
D
T
T
K
P
S
L
I
N
I
Site 38
S553
L
A
D
T
T
K
P
S
L
I
N
I
M
I
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation