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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HOOK1
Full Name:
Protein Hook homologue 1
Alias:
HK1; Hook 1
Type:
Microtubule, Cytoplasm, Cytoskeleton protein
Mass (Da):
84648
Number AA:
728
UniProt ID:
Q9UJC3
International Prot ID:
IPI00026305
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0070695
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
GO:0045022
GO:0007032
GO:0008333
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
L
Q
T
F
N
T
A
S
P
C
Q
D
V
K
Q
Site 2
Y89
L
Q
G
I
M
S
Y
Y
H
E
F
L
G
Q
Q
Site 3
S112
L
N
Q
I
T
E
C
S
D
P
V
E
L
G
R
Site 4
T143
E
H
I
Q
N
I
M
T
L
E
E
S
V
Q
H
Site 5
S161
T
A
I
Q
E
L
M
S
K
E
I
L
S
S
P
Site 6
S166
L
M
S
K
E
I
L
S
S
P
P
N
D
A
V
Site 7
S167
M
S
K
E
I
L
S
S
P
P
N
D
A
V
G
Site 8
S217
T
L
Q
D
E
K
N
S
L
V
S
E
N
E
M
Site 9
S235
K
L
D
Q
L
D
G
S
F
D
D
P
N
T
V
Site 10
T241
G
S
F
D
D
P
N
T
V
V
A
K
K
Y
F
Site 11
Y247
N
T
V
V
A
K
K
Y
F
H
A
Q
L
Q
L
Site 12
Y271
L
E
A
A
K
D
D
Y
R
V
H
C
E
E
L
Site 13
T293
Q
H
R
N
D
E
L
T
S
L
A
E
E
T
R
Site 14
T312
E
I
D
V
L
R
A
T
S
D
K
A
N
K
L
Site 15
S313
I
D
V
L
R
A
T
S
D
K
A
N
K
L
E
Site 16
T322
K
A
N
K
L
E
S
T
V
E
I
Y
R
Q
K
Site 17
T342
D
L
R
K
Q
V
K
T
L
Q
E
T
N
M
M
Site 18
Y350
L
Q
E
T
N
M
M
Y
M
H
N
T
V
S
L
Site 19
T354
N
M
M
Y
M
H
N
T
V
S
L
E
E
E
L
Site 20
S356
M
Y
M
H
N
T
V
S
L
E
E
E
L
K
K
Site 21
T373
A
A
R
T
Q
L
E
T
Y
K
R
Q
V
Q
D
Site 22
Y374
A
R
T
Q
L
E
T
Y
K
R
Q
V
Q
D
L
Site 23
S386
Q
D
L
H
V
K
L
S
S
E
S
K
R
A
D
Site 24
S389
H
V
K
L
S
S
E
S
K
R
A
D
T
L
A
Site 25
T394
S
E
S
K
R
A
D
T
L
A
F
E
M
K
R
Site 26
T422
R
L
I
E
Q
R
D
T
L
K
E
T
N
E
E
Site 27
S433
T
N
E
E
L
R
C
S
Q
V
Q
Q
D
H
L
Site 28
S446
H
L
N
Q
T
D
A
S
A
T
K
S
Y
E
N
Site 29
S450
T
D
A
S
A
T
K
S
Y
E
N
L
A
A
E
Site 30
S484
L
R
L
Q
Q
E
G
S
E
N
E
R
I
E
E
Site 31
S513
L
E
T
E
Q
R
L
S
K
E
R
I
R
E
L
Site 32
S530
Q
I
E
D
L
Q
K
S
L
Q
E
Q
G
S
K
Site 33
S536
K
S
L
Q
E
Q
G
S
K
S
E
G
E
S
S
Site 34
S538
L
Q
E
Q
G
S
K
S
E
G
E
S
S
S
K
Site 35
S542
G
S
K
S
E
G
E
S
S
S
K
L
K
Q
K
Site 36
S543
S
K
S
E
G
E
S
S
S
K
L
K
Q
K
L
Site 37
T619
K
A
R
N
V
I
K
T
L
D
P
K
L
N
P
Site 38
S628
D
P
K
L
N
P
A
S
A
E
I
M
L
L
R
Site 39
S650
R
R
I
E
I
L
E
S
E
C
K
V
A
K
F
Site 40
Y660
K
V
A
K
F
R
D
Y
E
E
K
L
I
V
S
Site 41
S673
V
S
A
W
Y
N
K
S
L
A
F
Q
K
L
G
Site 42
S683
F
Q
K
L
G
M
E
S
R
L
V
S
G
G
G
Site 43
S687
G
M
E
S
R
L
V
S
G
G
G
A
C
S
D
Site 44
T695
G
G
G
A
C
S
D
T
G
A
C
T
P
A
R
Site 45
T699
C
S
D
T
G
A
C
T
P
A
R
S
F
L
A
Site 46
S703
G
A
C
T
P
A
R
S
F
L
A
Q
Q
R
H
Site 47
T712
L
A
Q
Q
R
H
I
T
N
T
R
R
N
L
S
Site 48
T714
Q
Q
R
H
I
T
N
T
R
R
N
L
S
V
K
Site 49
S719
T
N
T
R
R
N
L
S
V
K
V
P
A
T
T
Site 50
S727
V
K
V
P
A
T
T
S
D
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation