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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL21
Full Name:
Alias:
Type:
Mass (Da):
66617
Number AA:
597
UniProt ID:
Q9UJP4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
S
D
P
A
H
A
L
S
L
L
R
G
L
S
Q
Site 2
S26
L
S
L
L
R
G
L
S
Q
L
R
A
E
R
K
Site 3
T38
E
R
K
F
L
D
V
T
L
E
A
A
G
G
R
Site 4
S72
F
A
G
Q
L
R
E
S
R
A
E
R
V
R
L
Site 5
Y184
P
L
A
R
L
L
R
Y
L
R
D
D
G
L
C
Site 6
Y199
V
P
K
E
E
A
A
Y
Q
L
A
L
R
W
V
Site 7
Y265
R
D
F
Q
A
A
R
Y
D
R
H
D
R
G
P
Site 8
S281
P
R
M
R
P
R
P
S
T
G
L
A
E
I
L
Site 9
T282
R
M
R
P
R
P
S
T
G
L
A
E
I
L
V
Site 10
Y307
E
L
V
T
V
D
C
Y
N
P
Q
T
G
Q
W
Site 11
Y316
P
Q
T
G
Q
W
R
Y
L
A
E
F
P
D
H
Site 12
S329
D
H
L
G
G
G
Y
S
I
V
A
L
G
N
D
Site 13
T340
L
G
N
D
I
Y
V
T
G
G
S
D
G
S
R
Site 14
S346
V
T
G
G
S
D
G
S
R
L
Y
D
C
V
W
Site 15
Y349
G
S
D
G
S
R
L
Y
D
C
V
W
R
Y
N
Site 16
Y374
P
M
L
K
A
R
E
Y
H
S
S
S
V
L
D
Site 17
S376
L
K
A
R
E
Y
H
S
S
S
V
L
D
G
L
Site 18
S377
K
A
R
E
Y
H
S
S
S
V
L
D
G
L
L
Site 19
S378
A
R
E
Y
H
S
S
S
V
L
D
G
L
L
Y
Site 20
S391
L
Y
V
V
A
A
D
S
T
E
R
Y
D
H
T
Site 21
T392
Y
V
V
A
A
D
S
T
E
R
Y
D
H
T
T
Site 22
Y395
A
A
D
S
T
E
R
Y
D
H
T
T
D
S
W
Site 23
T398
S
T
E
R
Y
D
H
T
T
D
S
W
E
A
L
Site 24
T399
T
E
R
Y
D
H
T
T
D
S
W
E
A
L
Q
Site 25
Y410
E
A
L
Q
P
M
T
Y
P
M
D
N
C
S
T
Site 26
S449
D
P
D
T
D
L
W
S
L
V
D
C
G
Q
L
Site 27
S460
C
G
Q
L
P
P
W
S
F
A
P
K
T
A
T
Site 28
Y485
D
S
A
E
V
D
V
Y
N
P
T
R
N
E
W
Site 29
S517
L
G
G
K
L
Y
V
S
G
G
Y
D
N
T
F
Site 30
T523
V
S
G
G
Y
D
N
T
F
E
L
S
D
V
V
Site 31
S527
Y
D
N
T
F
E
L
S
D
V
V
E
A
Y
D
Site 32
T537
V
E
A
Y
D
P
E
T
R
A
W
S
V
V
G
Site 33
S541
D
P
E
T
R
A
W
S
V
V
G
R
L
P
E
Site 34
T550
V
G
R
L
P
E
P
T
F
W
H
G
S
V
S
Site 35
T566
F
R
Q
F
M
P
Q
T
F
S
G
G
R
G
F
Site 36
S568
Q
F
M
P
Q
T
F
S
G
G
R
G
F
E
L
Site 37
S577
G
R
G
F
E
L
D
S
G
S
D
D
M
D
P
Site 38
S579
G
F
E
L
D
S
G
S
D
D
M
D
P
G
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation