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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LEF1
Full Name:
Lymphoid enhancer-binding factor 1
Alias:
Type:
Transcription protein
Mass (Da):
44201
Number AA:
399
UniProt ID:
Q9UJU2
International Prot ID:
IPI00007156
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0008301
GO:0005515
GO:0043565
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0001837
GO:0060021
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
G
D
P
E
L
C
A
T
D
E
M
I
P
F
K
Site 2
S42
E
K
I
F
A
E
I
S
H
P
E
E
E
G
D
Site 3
S55
G
D
L
A
D
I
K
S
S
L
V
N
E
S
E
Site 4
S56
D
L
A
D
I
K
S
S
L
V
N
E
S
E
I
Site 5
S61
K
S
S
L
V
N
E
S
E
I
I
P
A
S
N
Site 6
S67
E
S
E
I
I
P
A
S
N
G
H
E
V
A
R
Site 7
S79
V
A
R
Q
A
Q
T
S
Q
E
P
Y
H
D
K
Site 8
Y83
A
Q
T
S
Q
E
P
Y
H
D
K
A
R
E
H
Site 9
Y102
K
H
P
D
G
G
L
Y
N
K
G
P
S
Y
S
Site 10
S107
G
L
Y
N
K
G
P
S
Y
S
S
Y
S
G
Y
Site 11
Y108
L
Y
N
K
G
P
S
Y
S
S
Y
S
G
Y
I
Site 12
S109
Y
N
K
G
P
S
Y
S
S
Y
S
G
Y
I
M
Site 13
S110
N
K
G
P
S
Y
S
S
Y
S
G
Y
I
M
M
Site 14
Y111
K
G
P
S
Y
S
S
Y
S
G
Y
I
M
M
P
Site 15
S112
G
P
S
Y
S
S
Y
S
G
Y
I
M
M
P
N
Site 16
Y114
S
Y
S
S
Y
S
G
Y
I
M
M
P
N
M
N
Site 17
Y125
P
N
M
N
N
D
P
Y
M
S
N
G
S
L
S
Site 18
S127
M
N
N
D
P
Y
M
S
N
G
S
L
S
P
P
Site 19
S130
D
P
Y
M
S
N
G
S
L
S
P
P
I
P
R
Site 20
S132
Y
M
S
N
G
S
L
S
P
P
I
P
R
T
S
Site 21
T138
L
S
P
P
I
P
R
T
S
N
K
V
P
V
V
Site 22
S139
S
P
P
I
P
R
T
S
N
K
V
P
V
V
Q
Site 23
T155
S
H
A
V
H
P
L
T
P
L
I
T
Y
S
D
Site 24
T159
H
P
L
T
P
L
I
T
Y
S
D
E
H
F
S
Site 25
Y160
P
L
T
P
L
I
T
Y
S
D
E
H
F
S
P
Site 26
S161
L
T
P
L
I
T
Y
S
D
E
H
F
S
P
G
Site 27
S166
T
Y
S
D
E
H
F
S
P
G
S
H
P
S
H
Site 28
S169
D
E
H
F
S
P
G
S
H
P
S
H
I
P
S
Site 29
S172
F
S
P
G
S
H
P
S
H
I
P
S
D
V
N
Site 30
S176
S
H
P
S
H
I
P
S
D
V
N
S
K
Q
G
Site 31
S180
H
I
P
S
D
V
N
S
K
Q
G
M
S
R
H
Site 32
T195
P
P
A
P
D
I
P
T
F
Y
P
L
S
P
G
Site 33
Y197
A
P
D
I
P
T
F
Y
P
L
S
P
G
G
V
Site 34
S200
I
P
T
F
Y
P
L
S
P
G
G
V
G
Q
I
Site 35
T208
P
G
G
V
G
Q
I
T
P
P
L
G
W
Q
G
Site 36
Y219
G
W
Q
G
Q
P
V
Y
P
I
T
G
G
F
R
Site 37
T222
G
Q
P
V
Y
P
I
T
G
G
F
R
Q
P
Y
Site 38
Y229
T
G
G
F
R
Q
P
Y
P
S
S
L
S
V
D
Site 39
S231
G
F
R
Q
P
Y
P
S
S
L
S
V
D
T
S
Site 40
S232
F
R
Q
P
Y
P
S
S
L
S
V
D
T
S
M
Site 41
S234
Q
P
Y
P
S
S
L
S
V
D
T
S
M
S
R
Site 42
T237
P
S
S
L
S
V
D
T
S
M
S
R
F
S
H
Site 43
S238
S
S
L
S
V
D
T
S
M
S
R
F
S
H
H
Site 44
S240
L
S
V
D
T
S
M
S
R
F
S
H
H
M
I
Site 45
S243
D
T
S
M
S
R
F
S
H
H
M
I
P
G
P
Site 46
T255
P
G
P
P
G
P
H
T
T
G
I
P
H
P
A
Site 47
T256
G
P
P
G
P
H
T
T
G
I
P
H
P
A
I
Site 48
T265
I
P
H
P
A
I
V
T
P
Q
V
K
Q
E
H
Site 49
T275
V
K
Q
E
H
P
H
T
D
S
D
L
M
H
V
Site 50
S277
Q
E
H
P
H
T
D
S
D
L
M
H
V
K
P
Site 51
Y309
P
L
N
A
F
M
L
Y
M
K
E
M
R
A
N
Site 52
S341
G
R
R
W
H
A
L
S
R
E
E
Q
A
K
Y
Site 53
Y348
S
R
E
E
Q
A
K
Y
Y
E
L
A
R
K
E
Site 54
Y349
R
E
E
Q
A
K
Y
Y
E
L
A
R
K
E
R
Site 55
Y363
R
Q
L
H
M
Q
L
Y
P
G
W
S
A
R
D
Site 56
Y372
G
W
S
A
R
D
N
Y
G
K
K
K
K
R
K
Site 57
S386
K
R
E
K
L
Q
E
S
A
S
G
T
G
P
R
Site 58
S388
E
K
L
Q
E
S
A
S
G
T
G
P
R
M
T
Site 59
T390
L
Q
E
S
A
S
G
T
G
P
R
M
T
A
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation