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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX41
Full Name:
Probable ATP-dependent RNA helicase DDX41
Alias:
ABS; abstrakt; DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; DEAD-box protein 41; DEAD-box protein abstrakt homolog; MGC8828
Type:
RNA binding protein; EC 3.6.1.-; Helicase
Mass (Da):
69838
Number AA:
622
UniProt ID:
Q9UJV9
International Prot ID:
IPI00007208
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005681
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006915
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
P
E
R
K
R
A
R
T
D
E
V
P
A
G
G
Site 2
S21
D
E
V
P
A
G
G
S
R
S
E
A
E
D
E
Site 3
S23
V
P
A
G
G
S
R
S
E
A
E
D
E
D
D
Site 4
Y33
E
D
E
D
D
E
D
Y
V
P
Y
V
P
L
R
Site 5
Y36
D
D
E
D
Y
V
P
Y
V
P
L
R
Q
R
R
Site 6
S66
A
E
E
E
Q
Q
D
S
G
S
E
P
R
G
D
Site 7
S68
E
E
Q
Q
D
S
G
S
E
P
R
G
D
E
D
Site 8
S83
D
I
P
L
G
P
Q
S
N
V
S
L
L
D
Q
Site 9
S86
L
G
P
Q
S
N
V
S
L
L
D
Q
H
Q
H
Site 10
S104
K
A
E
A
R
K
E
S
A
K
E
K
Q
L
K
Site 11
S119
E
E
E
K
I
L
E
S
V
A
E
G
R
A
L
Site 12
Y138
E
M
A
K
G
I
T
Y
D
D
P
I
K
T
S
Site 13
T144
T
Y
D
D
P
I
K
T
S
W
T
P
P
R
Y
Site 14
T147
D
P
I
K
T
S
W
T
P
P
R
Y
V
L
S
Site 15
Y151
T
S
W
T
P
P
R
Y
V
L
S
M
S
E
E
Site 16
S154
T
P
P
R
Y
V
L
S
M
S
E
E
R
H
E
Site 17
S156
P
R
Y
V
L
S
M
S
E
E
R
H
E
R
V
Site 18
Y167
H
E
R
V
R
K
K
Y
H
I
L
V
E
G
D
Site 19
S182
G
I
P
P
P
I
K
S
F
K
E
M
K
F
P
Site 20
T205
K
K
G
I
H
H
P
T
P
I
Q
I
Q
G
I
Site 21
S253
Q
E
K
R
L
P
F
S
K
R
E
G
P
Y
G
Site 22
S266
Y
G
L
I
I
C
P
S
R
E
L
A
R
Q
T
Site 23
T273
S
R
E
L
A
R
Q
T
H
G
I
L
E
Y
Y
Site 24
Y279
Q
T
H
G
I
L
E
Y
Y
C
R
L
L
Q
E
Site 25
Y280
T
H
G
I
L
E
Y
Y
C
R
L
L
Q
E
D
Site 26
S288
C
R
L
L
Q
E
D
S
S
P
L
L
R
C
A
Site 27
S289
R
L
L
Q
E
D
S
S
P
L
L
R
C
A
L
Site 28
T360
G
F
E
G
D
I
R
T
I
F
S
Y
F
K
G
Site 29
Y364
D
I
R
T
I
F
S
Y
F
K
G
Q
R
Q
T
Site 30
T371
Y
F
K
G
Q
R
Q
T
L
L
F
S
A
T
M
Site 31
T377
Q
T
L
L
F
S
A
T
M
P
K
K
I
Q
N
Site 32
S388
K
I
Q
N
F
A
K
S
A
L
V
K
P
V
T
Site 33
T395
S
A
L
V
K
P
V
T
I
N
V
G
R
A
G
Site 34
Y414
D
V
I
Q
E
V
E
Y
V
K
E
E
A
K
M
Site 35
Y423
K
E
E
A
K
M
V
Y
L
L
E
C
L
Q
K
Site 36
Y507
A
I
Q
H
V
I
N
Y
D
M
P
E
E
I
E
Site 37
Y516
M
P
E
E
I
E
N
Y
V
H
R
I
G
R
T
Site 38
T533
S
G
N
T
G
I
A
T
T
F
I
N
K
A
C
Site 39
T593
G
G
L
G
H
R
I
T
D
C
P
K
L
E
A
Site 40
T603
P
K
L
E
A
M
Q
T
K
Q
V
S
N
I
G
Site 41
S607
A
M
Q
T
K
Q
V
S
N
I
G
R
K
D
Y
Site 42
Y614
S
N
I
G
R
K
D
Y
L
A
H
S
S
M
D
Site 43
S619
K
D
Y
L
A
H
S
S
M
D
F
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation