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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DNMT3L
Full Name:
DNA (cytosine-5)-methyltransferase 3-like
Alias:
Cytosine-5-methyltransferase 3-like; Cytosine-5-methyltransferase 3-like protein; DNA (cytosine-5-)-methyltransferase 3-like; DNM3L; MGC1090
Type:
Transcription, coactivator/corepressor; Amino Acid Metabolism - cysteine and methionine
Mass (Da):
43670
Number AA:
387
UniProt ID:
Q9UJW3
International Prot ID:
IPI00002935
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0008047
GO:0019899
GO:0016564
PhosphoSite+
KinaseNET
Biological Process:
GO:0006306
GO:0006349
GO:0007283
Phosida
TranscriptoNet
STRING
Kinexus Products
DNA (cytosine-5)-methyltransferase 3-like pan-specific antibody AB-NN242-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN242-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
L
V
G
S
S
E
L
S
S
S
V
S
P
G
T
Site 2
S27
V
G
S
S
E
L
S
S
S
V
S
P
G
T
G
Site 3
S28
G
S
S
E
L
S
S
S
V
S
P
G
T
G
R
Site 4
S30
S
E
L
S
S
S
V
S
P
G
T
G
R
D
L
Site 5
T33
S
S
S
V
S
P
G
T
G
R
D
L
I
A
Y
Site 6
Y40
T
G
R
D
L
I
A
Y
E
V
K
A
N
Q
R
Site 7
T63
C
G
S
L
Q
V
H
T
Q
H
P
L
F
E
G
Site 8
Y87
F
L
D
A
L
F
L
Y
D
D
D
G
Y
Q
S
Site 9
Y92
F
L
Y
D
D
D
G
Y
Q
S
Y
C
S
I
C
Site 10
Y95
D
D
D
G
Y
Q
S
Y
C
S
I
C
C
S
G
Site 11
T130
D
S
L
V
G
P
G
T
S
G
K
V
H
A
M
Site 12
S149
C
Y
L
C
L
P
S
S
R
S
G
L
L
Q
R
Site 13
S151
L
C
L
P
S
S
R
S
G
L
L
Q
R
R
R
Site 14
S162
Q
R
R
R
K
W
R
S
Q
L
K
A
F
Y
D
Site 15
Y168
R
S
Q
L
K
A
F
Y
D
R
E
S
E
N
P
Site 16
S172
K
A
F
Y
D
R
E
S
E
N
P
L
E
M
F
Site 17
T181
N
P
L
E
M
F
E
T
V
P
V
W
R
R
Q
Site 18
S194
R
Q
P
V
R
V
L
S
L
F
E
D
I
K
K
Site 19
T204
E
D
I
K
K
E
L
T
S
L
G
F
L
E
S
Site 20
S205
D
I
K
K
E
L
T
S
L
G
F
L
E
S
G
Site 21
S211
T
S
L
G
F
L
E
S
G
S
D
P
G
Q
L
Site 22
S213
L
G
F
L
E
S
G
S
D
P
G
Q
L
K
H
Site 23
T225
L
K
H
V
V
D
V
T
D
T
V
R
K
D
V
Site 24
T227
H
V
V
D
V
T
D
T
V
R
K
D
V
E
E
Site 25
Y242
W
G
P
F
D
L
V
Y
G
A
T
P
P
L
G
Site 26
T251
A
T
P
P
L
G
H
T
C
D
R
P
P
S
W
Site 27
Y259
C
D
R
P
P
S
W
Y
L
F
Q
F
H
R
L
Site 28
Y269
Q
F
H
R
L
L
Q
Y
A
R
P
K
P
G
S
Site 29
S276
Y
A
R
P
K
P
G
S
P
R
P
F
F
W
M
Site 30
S325
Q
N
A
V
R
V
W
S
N
I
P
A
I
R
S
Site 31
S332
S
N
I
P
A
I
R
S
S
R
H
W
A
L
V
Site 32
S333
N
I
P
A
I
R
S
S
R
H
W
A
L
V
S
Site 33
S340
S
R
H
W
A
L
V
S
E
E
E
L
S
L
L
Site 34
S345
L
V
S
E
E
E
L
S
L
L
A
Q
N
K
Q
Site 35
Y375
C
F
L
P
L
R
E
Y
F
K
Y
F
S
T
E
Site 36
Y378
P
L
R
E
Y
F
K
Y
F
S
T
E
L
T
S
Site 37
S380
R
E
Y
F
K
Y
F
S
T
E
L
T
S
S
L
Site 38
T381
E
Y
F
K
Y
F
S
T
E
L
T
S
S
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation