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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Cdc23
Full Name:
Cell division cycle protein 23 homolog
Alias:
Anaphase promoting complex subunit 8; APC8; CC23; Cell division cycle 23; Cyclosome subunit 8
Type:
Cell cycle regulation
Mass (Da):
68834
Number AA:
597
UniProt ID:
Q9UJX2
International Prot ID:
IPI00005822
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005680
GO:0005829
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0000080
GO:0031145
GO:0051301
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
A
P
V
L
S
I
N
S
D
F
S
D
L
R
E
Site 2
S27
L
S
I
N
S
D
F
S
D
L
R
E
I
K
K
Site 3
T43
L
L
L
I
A
G
L
T
R
E
R
G
L
L
H
Site 4
S51
R
E
R
G
L
L
H
S
S
K
W
S
A
E
L
Site 5
Y87
D
A
Q
D
M
D
A
Y
T
L
A
K
A
Y
F
Site 6
T88
A
Q
D
M
D
A
Y
T
L
A
K
A
Y
F
D
Site 7
Y93
A
Y
T
L
A
K
A
Y
F
D
V
K
E
Y
D
Site 8
Y99
A
Y
F
D
V
K
E
Y
D
R
A
A
H
F
L
Site 9
Y115
G
C
N
S
K
K
A
Y
F
L
Y
M
Y
S
R
Site 10
Y118
S
K
K
A
Y
F
L
Y
M
Y
S
R
Y
L
S
Site 11
Y120
K
A
Y
F
L
Y
M
Y
S
R
Y
L
S
G
E
Site 12
S121
A
Y
F
L
Y
M
Y
S
R
Y
L
S
G
E
K
Site 13
Y123
F
L
Y
M
Y
S
R
Y
L
S
G
E
K
K
K
Site 14
S125
Y
M
Y
S
R
Y
L
S
G
E
K
K
K
D
D
Site 15
T134
E
K
K
K
D
D
E
T
V
D
S
L
G
P
L
Site 16
S137
K
D
D
E
T
V
D
S
L
G
P
L
E
K
G
Site 17
S159
R
E
L
R
V
E
L
S
K
K
H
Q
A
R
E
Site 18
S223
K
E
M
L
K
F
L
S
L
P
D
T
W
M
K
Site 19
Y251
I
E
E
A
L
Q
K
Y
Q
N
L
I
D
V
G
Site 20
Y273
V
S
Q
I
A
V
A
Y
H
N
I
R
D
I
D
Site 21
S284
R
D
I
D
K
A
L
S
I
F
N
E
L
R
K
Site 22
Y295
E
L
R
K
Q
D
P
Y
R
I
E
N
M
D
T
Site 23
T302
Y
R
I
E
N
M
D
T
F
S
N
L
L
Y
V
Site 24
S304
I
E
N
M
D
T
F
S
N
L
L
Y
V
R
S
Site 25
Y308
D
T
F
S
N
L
L
Y
V
R
S
M
K
S
E
Site 26
S311
S
N
L
L
Y
V
R
S
M
K
S
E
L
S
Y
Site 27
S314
L
Y
V
R
S
M
K
S
E
L
S
Y
L
A
H
Site 28
S317
R
S
M
K
S
E
L
S
Y
L
A
H
N
L
C
Site 29
Y318
S
M
K
S
E
L
S
Y
L
A
H
N
L
C
E
Site 30
Y329
N
L
C
E
I
D
K
Y
R
V
E
T
C
C
V
Site 31
Y340
T
C
C
V
I
G
N
Y
Y
S
L
R
S
Q
H
Site 32
Y341
C
C
V
I
G
N
Y
Y
S
L
R
S
Q
H
E
Site 33
S345
G
N
Y
Y
S
L
R
S
Q
H
E
K
A
A
L
Site 34
Y353
Q
H
E
K
A
A
L
Y
F
Q
R
A
L
K
L
Site 35
T381
E
Y
M
E
M
K
N
T
S
A
A
I
Q
A
Y
Site 36
Y399
I
E
V
N
K
R
D
Y
R
A
W
Y
G
L
G
Site 37
Y403
K
R
D
Y
R
A
W
Y
G
L
G
Q
T
Y
E
Site 38
Y417
E
I
L
K
M
P
F
Y
C
L
Y
Y
Y
R
R
Site 39
Y422
P
F
Y
C
L
Y
Y
Y
R
R
A
H
Q
L
R
Site 40
S433
H
Q
L
R
P
N
D
S
R
M
L
V
A
L
G
Site 41
Y456
L
V
E
A
K
K
C
Y
W
R
A
Y
A
V
G
Site 42
Y460
K
K
C
Y
W
R
A
Y
A
V
G
D
V
E
K
Site 43
S483
L
H
E
Q
L
T
E
S
E
Q
A
A
Q
C
Y
Site 44
Y515
E
E
S
T
A
F
R
Y
L
A
Q
Y
Y
F
K
Site 45
Y519
A
F
R
Y
L
A
Q
Y
Y
F
K
C
K
L
W
Site 46
Y520
F
R
Y
L
A
Q
Y
Y
F
K
C
K
L
W
D
Site 47
S530
C
K
L
W
D
E
A
S
T
C
A
Q
K
C
C
Site 48
T542
K
C
C
A
F
N
D
T
R
E
E
G
K
A
L
Site 49
T562
Q
L
R
N
Q
G
E
T
P
T
T
E
V
P
A
Site 50
T564
R
N
Q
G
E
T
P
T
T
E
V
P
A
P
F
Site 51
T565
N
Q
G
E
T
P
T
T
E
V
P
A
P
F
F
Site 52
S576
A
P
F
F
L
P
A
S
L
S
A
N
N
T
P
Site 53
S578
F
F
L
P
A
S
L
S
A
N
N
T
P
T
R
Site 54
T582
A
S
L
S
A
N
N
T
P
T
R
R
V
S
P
Site 55
T584
L
S
A
N
N
T
P
T
R
R
V
S
P
L
N
Site 56
S588
V
S
P
L
N
L
S
S
V
T
P
_
_
_
_
Site 57
S593
R
V
S
P
L
N
L
S
S
V
T
P
_
_
_
Site 58
S594
V
S
P
L
N
L
S
S
V
T
P
_
_
_
_
Site 59
T596
P
L
N
L
S
S
V
T
P
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation