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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
APC2
Full Name:
Anaphase-promoting complex subunit 2
Alias:
ANAPC2; Anaphase promoting complex subunit 2; ANC2; Cyclosome subunit 2; KIAA1406
Type:
Ubiquitin conjugating protein
Mass (Da):
93828
Number AA:
822
UniProt ID:
Q9UJX6
International Prot ID:
IPI00002549
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005680
GO:0031461
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0031625
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0031145
GO:0051301
GO:0008054
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
V
V
V
A
E
G
D
S
D
S
R
P
G
Q
E
Site 2
S14
V
A
E
G
D
S
D
S
R
P
G
Q
E
L
L
Site 3
T44
L
G
L
V
S
S
R
T
S
G
A
V
P
P
K
Site 4
S45
G
L
V
S
S
R
T
S
G
A
V
P
P
K
E
Site 5
S88
N
D
L
Q
A
N
I
S
P
E
F
W
N
A
I
Site 6
S101
A
I
S
Q
C
E
N
S
A
D
E
P
Q
C
L
Site 7
Y125
L
E
S
R
L
D
P
Y
L
R
S
L
E
L
L
Site 8
S128
R
L
D
P
Y
L
R
S
L
E
L
L
E
K
W
Site 9
S164
L
R
G
V
L
F
F
S
T
P
R
T
F
Q
E
Site 10
T165
R
G
V
L
F
F
S
T
P
R
T
F
Q
E
M
Site 11
T168
L
F
F
S
T
P
R
T
F
Q
E
M
I
Q
R
Site 12
Y184
Y
G
C
F
L
R
V
Y
M
Q
S
K
R
K
G
Site 13
S187
F
L
R
V
Y
M
Q
S
K
R
K
G
E
G
G
Site 14
Y207
E
G
E
L
D
S
R
Y
A
R
R
R
Y
Y
R
Site 15
Y212
S
R
Y
A
R
R
R
Y
Y
R
L
L
Q
S
P
Site 16
Y213
R
Y
A
R
R
R
Y
Y
R
L
L
Q
S
P
L
Site 17
S218
R
Y
Y
R
L
L
Q
S
P
L
C
A
G
C
S
Site 18
S244
L
E
Q
F
H
Q
L
S
Q
V
L
H
R
L
S
Site 19
Y281
E
D
R
C
R
G
E
Y
E
R
S
F
L
R
E
Site 20
S284
C
R
G
E
Y
E
R
S
F
L
R
E
F
H
K
Site 21
S314
D
G
P
A
R
P
A
S
P
E
A
G
N
T
L
Site 22
T320
A
S
P
E
A
G
N
T
L
R
R
W
R
C
H
Site 23
Y333
C
H
V
Q
R
F
F
Y
R
I
Y
A
S
L
R
Site 24
Y336
Q
R
F
F
Y
R
I
Y
A
S
L
R
I
E
E
Site 25
S346
L
R
I
E
E
L
F
S
I
V
R
D
F
P
D
Site 26
S354
I
V
R
D
F
P
D
S
R
P
A
I
E
D
L
Site 27
Y363
P
A
I
E
D
L
K
Y
C
L
E
R
T
D
Q
Site 28
S377
Q
R
Q
Q
L
L
V
S
L
K
A
A
L
E
T
Site 29
T393
L
L
H
P
G
V
N
T
C
D
I
I
T
L
Y
Site 30
Y427
A
C
E
P
I
R
R
Y
L
R
T
R
E
D
T
Site 31
T430
P
I
R
R
Y
L
R
T
R
E
D
T
V
R
Q
Site 32
T434
Y
L
R
T
R
E
D
T
V
R
Q
I
V
A
G
Site 33
T443
R
Q
I
V
A
G
L
T
G
D
S
D
G
T
G
Site 34
S446
V
A
G
L
T
G
D
S
D
G
T
G
D
L
A
Site 35
S457
G
D
L
A
V
E
L
S
K
T
D
P
A
S
L
Site 36
T459
L
A
V
E
L
S
K
T
D
P
A
S
L
E
T
Site 37
S463
L
S
K
T
D
P
A
S
L
E
T
G
Q
D
S
Site 38
S470
S
L
E
T
G
Q
D
S
E
D
D
S
G
E
P
Site 39
S474
G
Q
D
S
E
D
D
S
G
E
P
E
D
W
V
Site 40
S492
V
D
A
D
P
G
K
S
S
S
K
R
R
S
S
Site 41
S493
D
A
D
P
G
K
S
S
S
K
R
R
S
S
D
Site 42
S494
A
D
P
G
K
S
S
S
K
R
R
S
S
D
I
Site 43
S498
K
S
S
S
K
R
R
S
S
D
I
I
S
L
L
Site 44
S499
S
S
S
K
R
R
S
S
D
I
I
S
L
L
V
Site 45
S507
D
I
I
S
L
L
V
S
I
Y
G
S
K
D
L
Site 46
Y509
I
S
L
L
V
S
I
Y
G
S
K
D
L
F
I
Site 47
S511
L
L
V
S
I
Y
G
S
K
D
L
F
I
N
E
Site 48
Y519
K
D
L
F
I
N
E
Y
R
S
L
L
A
D
R
Site 49
S532
D
R
L
L
H
Q
F
S
F
S
P
E
R
E
I
Site 50
S534
L
L
H
Q
F
S
F
S
P
E
R
E
I
R
N
Site 51
S567
M
L
K
D
M
A
D
S
R
R
I
N
A
N
I
Site 52
Y626
L
E
A
Y
C
K
K
Y
E
Q
L
K
A
M
R
Site 53
T634
E
Q
L
K
A
M
R
T
L
S
W
K
H
T
L
Site 54
S636
L
K
A
M
R
T
L
S
W
K
H
T
L
G
L
Site 55
T640
R
T
L
S
W
K
H
T
L
G
L
V
T
M
D
Site 56
T677
F
Q
D
Q
A
S
W
T
L
E
E
L
S
K
A
Site 57
S697
A
L
L
R
R
R
M
S
V
W
L
Q
Q
G
V
Site 58
T712
L
R
E
E
P
P
G
T
F
S
V
I
E
E
E
Site 59
S714
E
E
P
P
G
T
F
S
V
I
E
E
E
R
P
Site 60
S732
D
N
M
V
L
I
D
S
D
D
E
S
D
S
G
Site 61
S736
L
I
D
S
D
D
E
S
D
S
G
M
A
S
Q
Site 62
S738
D
S
D
D
E
S
D
S
G
M
A
S
Q
A
D
Site 63
S742
E
S
D
S
G
M
A
S
Q
A
D
Q
K
E
E
Site 64
S769
L
T
N
L
E
S
L
S
L
D
R
I
Y
N
M
Site 65
Y798
D
L
Q
E
L
Q
G
Y
L
Q
K
K
V
R
D
Site 66
Y810
V
R
D
Q
Q
L
V
Y
S
A
G
V
Y
R
L
Site 67
S811
R
D
Q
Q
L
V
Y
S
A
G
V
Y
R
L
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation