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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GDF2
Full Name:
Growth/differentiation factor 2
Alias:
BMP9; BMP-9; Growth differentiation factor 2
Type:
Mass (Da):
47320
Number AA:
429
UniProt ID:
Q9UK05
International Prot ID:
IPI00007015
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0005125
GO:0008083
PhosphoSite+
KinaseNET
Biological Process:
GO:0030509
GO:0032924
GO:0040007
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
L
Q
G
K
P
L
Q
S
W
G
R
G
S
A
G
Site 2
S32
L
Q
S
W
G
R
G
S
A
G
G
N
A
H
S
Site 3
S39
S
A
G
G
N
A
H
S
P
L
G
V
P
G
G
Site 4
S69
V
K
V
D
F
L
R
S
L
N
L
S
G
V
P
Site 5
S73
F
L
R
S
L
N
L
S
G
V
P
S
Q
D
K
Site 6
S77
L
N
L
S
G
V
P
S
Q
D
K
T
R
V
E
Site 7
T81
G
V
P
S
Q
D
K
T
R
V
E
P
P
Q
Y
Site 8
Y88
T
R
V
E
P
P
Q
Y
M
I
D
L
Y
N
R
Site 9
Y93
P
Q
Y
M
I
D
L
Y
N
R
Y
T
S
D
K
Site 10
Y96
M
I
D
L
Y
N
R
Y
T
S
D
K
S
T
T
Site 11
T97
I
D
L
Y
N
R
Y
T
S
D
K
S
T
T
P
Site 12
S98
D
L
Y
N
R
Y
T
S
D
K
S
T
T
P
A
Site 13
S101
N
R
Y
T
S
D
K
S
T
T
P
A
S
N
I
Site 14
T102
R
Y
T
S
D
K
S
T
T
P
A
S
N
I
V
Site 15
T103
Y
T
S
D
K
S
T
T
P
A
S
N
I
V
R
Site 16
S106
D
K
S
T
T
P
A
S
N
I
V
R
S
F
S
Site 17
S111
P
A
S
N
I
V
R
S
F
S
M
E
D
A
I
Site 18
T123
D
A
I
S
I
T
A
T
E
D
F
P
F
Q
K
Site 19
T146
I
P
R
H
E
Q
I
T
R
A
E
L
R
L
Y
Site 20
Y153
T
R
A
E
L
R
L
Y
V
S
C
Q
N
H
V
Site 21
S155
A
E
L
R
L
Y
V
S
C
Q
N
H
V
D
P
Site 22
S163
C
Q
N
H
V
D
P
S
H
D
L
K
G
S
V
Site 23
T179
I
Y
D
V
L
D
G
T
D
A
W
D
S
A
T
Site 24
S184
D
G
T
D
A
W
D
S
A
T
E
T
K
T
F
Site 25
T188
A
W
D
S
A
T
E
T
K
T
F
L
V
S
Q
Site 26
T190
D
S
A
T
E
T
K
T
F
L
V
S
Q
D
I
Site 27
S194
E
T
K
T
F
L
V
S
Q
D
I
Q
D
E
G
Site 28
T204
I
Q
D
E
G
W
E
T
L
E
V
S
S
A
V
Site 29
S208
G
W
E
T
L
E
V
S
S
A
V
K
R
W
V
Site 30
S217
A
V
K
R
W
V
R
S
D
S
T
K
S
K
N
Site 31
S219
K
R
W
V
R
S
D
S
T
K
S
K
N
K
L
Site 32
T229
S
K
N
K
L
E
V
T
V
E
S
H
R
K
G
Site 33
S232
K
L
E
V
T
V
E
S
H
R
K
G
C
D
T
Site 34
T239
S
H
R
K
G
C
D
T
L
D
I
S
V
P
P
Site 35
S243
G
C
D
T
L
D
I
S
V
P
P
G
S
R
N
Site 36
S262
V
V
F
S
N
D
H
S
S
G
T
K
E
T
R
Site 37
S263
V
F
S
N
D
H
S
S
G
T
K
E
T
R
L
Site 38
S277
L
E
L
R
E
M
I
S
H
E
Q
E
S
V
L
Site 39
S282
M
I
S
H
E
Q
E
S
V
L
K
K
L
S
K
Site 40
S288
E
S
V
L
K
K
L
S
K
D
G
S
T
E
A
Site 41
S292
K
K
L
S
K
D
G
S
T
E
A
G
E
S
S
Site 42
T293
K
L
S
K
D
G
S
T
E
A
G
E
S
S
H
Site 43
S298
G
S
T
E
A
G
E
S
S
H
E
E
D
T
D
Site 44
S299
S
T
E
A
G
E
S
S
H
E
E
D
T
D
G
Site 45
S312
D
G
H
V
A
A
G
S
T
L
A
R
R
K
R
Site 46
S320
T
L
A
R
R
K
R
S
A
G
A
G
S
H
C
Site 47
S325
K
R
S
A
G
A
G
S
H
C
Q
K
T
S
L
Site 48
T330
A
G
S
H
C
Q
K
T
S
L
R
V
N
F
E
Site 49
S331
G
S
H
C
Q
K
T
S
L
R
V
N
F
E
D
Site 50
Y354
A
P
K
E
Y
E
A
Y
E
C
K
G
G
C
F
Site 51
S402
P
T
K
L
S
P
I
S
V
L
Y
K
D
D
M
Site 52
Y416
M
G
V
P
T
L
K
Y
H
Y
E
G
M
S
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation