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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RSK4
Full Name:
90 kDa ribosomal protein S6 kinase 6
Alias:
EC 2.7.1.37; EC 2.7.11.1; KS6A6; P90-RSK 6; Pp90RSK4; Ribosomal protein S6 kinase alpha 6; Ribosomal protein S6 kinase, 90kDa, polypeptide 6; Ribosomal S6 kinase 4; RPS6KA6; RSK-4; S6K-alpha 6
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); EC 2.7.1.37;
AGC
group; RSK family; RSK subfamily
Mass (Da):
83872
Number AA:
745
UniProt ID:
Q9UK32
International Prot ID:
IPI00007123
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007417
GO:0006468
GO:0007243
Phosida
TranscriptoNet
STRING
Kinexus Products
Ribosomal S6 protein-serine kinase 4 / Ribosomal protein S6 kinase alpha-6 (L678-R696, human) peptide - Powder PE-01BFF85T#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BFF85T
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
D
R
E
M
E
V
F
S
G
G
G
A
S
S
G
Site 2
S25
F
S
G
G
G
A
S
S
G
E
V
N
G
L
K
Site 3
S45
M
E
E
G
E
A
D
S
C
H
D
E
G
V
V
Site 4
T58
V
V
K
E
I
P
I
T
H
H
V
K
E
G
Y
Site 5
S83
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
Site 6
T94
V
F
L
V
R
K
K
T
G
P
D
A
G
Q
L
Site 7
Y102
G
P
D
A
G
Q
L
Y
A
M
K
V
L
K
K
Site 8
T120
K
V
R
D
R
V
R
T
K
M
E
R
D
I
L
Site 9
Y140
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
Site 10
S165
G
D
V
F
T
R
L
S
K
E
V
L
F
T
E
Site 11
T171
L
S
K
E
V
L
F
T
E
E
D
V
K
F
Y
Site 12
T215
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
Site 13
S220
K
L
T
D
F
G
L
S
K
E
S
V
D
Q
E
Site 14
Y231
V
D
Q
E
K
K
A
Y
S
F
C
G
T
V
E
Site 15
S232
D
Q
E
K
K
A
Y
S
F
C
G
T
V
E
Y
Site 16
T236
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
Site 17
Y239
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
Site 18
S251
V
V
N
R
R
G
H
S
Q
S
A
D
W
W
S
Site 19
T281
Q
G
K
D
R
N
E
T
M
N
M
I
L
K
A
Site 20
S318
N
P
A
N
R
L
G
S
E
G
V
E
E
I
K
Site 21
Y339
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
Site 22
S351
Q
P
P
F
K
P
A
S
G
K
P
D
D
T
F
Site 23
T357
A
S
G
K
P
D
D
T
F
C
F
D
P
E
F
Site 24
T368
D
P
E
F
T
A
K
T
P
K
D
S
P
G
L
Site 25
S372
T
A
K
T
P
K
D
S
P
G
L
P
A
S
A
Site 26
S378
D
S
P
G
L
P
A
S
A
N
A
H
Q
L
F
Site 27
S389
H
Q
L
F
K
G
F
S
F
V
A
T
S
I
A
Site 28
T393
K
G
F
S
F
V
A
T
S
I
A
E
E
Y
K
Site 29
S394
G
F
S
F
V
A
T
S
I
A
E
E
Y
K
I
Site 30
S436
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
Site 31
Y437
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
Site 32
S460
A
V
K
I
I
D
K
S
K
R
D
P
S
E
E
Site 33
S465
D
K
S
K
R
D
P
S
E
E
I
E
I
L
M
Site 34
Y474
E
I
E
I
L
M
R
Y
G
Q
H
P
N
I
I
Site 35
Y494
F
D
D
G
R
Y
V
Y
L
V
T
D
L
M
K
Site 36
S516
I
L
K
Q
K
C
F
S
E
R
E
A
S
D
I
Site 37
S521
C
F
S
E
R
E
A
S
D
I
L
Y
V
I
S
Site 38
Y525
R
E
A
S
D
I
L
Y
V
I
S
K
T
V
D
Site 39
S547
V
H
R
D
L
K
P
S
N
I
L
Y
M
D
E
Site 40
Y551
L
K
P
S
N
I
L
Y
M
D
E
S
A
S
A
Site 41
S555
N
I
L
Y
M
D
E
S
A
S
A
D
S
I
R
Site 42
S560
D
E
S
A
S
A
D
S
I
R
I
C
D
F
G
Site 43
T581
G
E
N
G
L
L
L
T
P
C
Y
T
A
N
F
Site 44
Y599
E
V
L
M
Q
Q
G
Y
D
A
A
C
D
I
W
Site 45
T620
Y
T
M
L
A
G
Y
T
P
F
A
N
G
P
N
Site 46
T629
F
A
N
G
P
N
D
T
P
E
E
I
L
L
R
Site 47
S643
R
I
G
N
G
K
F
S
L
S
G
G
N
W
D
Site 48
S645
G
N
G
K
F
S
L
S
G
G
N
W
D
N
I
Site 49
S653
G
G
N
W
D
N
I
S
D
G
A
K
D
L
L
Site 50
S661
D
G
A
K
D
L
L
S
H
M
L
H
M
D
P
Site 51
T673
M
D
P
H
Q
R
Y
T
A
E
Q
I
L
K
H
Site 52
S700
Q
P
K
R
N
D
V
S
H
V
V
K
G
A
M
Site 53
Y711
K
G
A
M
V
A
T
Y
S
A
L
T
H
K
T
Site 54
T718
Y
S
A
L
T
H
K
T
F
Q
P
V
L
E
P
Site 55
S730
L
E
P
V
A
A
S
S
L
A
Q
R
R
S
M
Site 56
S736
S
S
L
A
Q
R
R
S
M
K
K
R
T
S
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation