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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DBR1
Full Name:
Lariat debranching enzyme
Alias:
debranching enzyme 1; debranching enzyme homolog 1 (S. cerevisiae)
Type:
RNA processing; EC 3.1.-.-; Hydrolase
Mass (Da):
61555
Number AA:
544
UniProt ID:
Q9UK59
International Prot ID:
IPI00305545
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008419
GO:0046872
PhosphoSite+
KinaseNET
Biological Process:
GO:0000375
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
H
G
E
L
D
K
I
Y
E
T
L
A
L
A
E
Site 2
Y65
Y
R
H
M
Q
T
F
Y
R
Y
Y
S
G
E
K
Site 3
Y68
M
Q
T
F
Y
R
Y
Y
S
G
E
K
K
A
P
Site 4
S69
Q
T
F
Y
R
Y
Y
S
G
E
K
K
A
P
V
Site 5
T78
E
K
K
A
P
V
L
T
L
F
I
G
G
N
H
Site 6
S129
G
I
S
G
I
F
K
S
H
D
Y
R
K
G
H
Site 7
Y132
G
I
F
K
S
H
D
Y
R
K
G
H
F
E
C
Site 8
Y142
G
H
F
E
C
P
P
Y
N
S
S
T
I
R
S
Site 9
S144
F
E
C
P
P
Y
N
S
S
T
I
R
S
I
Y
Site 10
S145
E
C
P
P
Y
N
S
S
T
I
R
S
I
Y
H
Site 11
T146
C
P
P
Y
N
S
S
T
I
R
S
I
Y
H
V
Site 12
Y151
S
S
T
I
R
S
I
Y
H
V
R
N
I
E
V
Site 13
Y159
H
V
R
N
I
E
V
Y
K
L
K
Q
L
K
Q
Site 14
Y181
H
D
W
P
R
S
I
Y
H
Y
G
N
K
K
Q
Site 15
Y183
W
P
R
S
I
Y
H
Y
G
N
K
K
Q
L
L
Site 16
T192
N
K
K
Q
L
L
K
T
K
S
F
F
R
Q
E
Site 17
S194
K
Q
L
L
K
T
K
S
F
F
R
Q
E
V
E
Site 18
S207
V
E
N
N
T
L
G
S
P
A
A
S
E
L
L
Site 19
S211
T
L
G
S
P
A
A
S
E
L
L
E
H
L
K
Site 20
T220
L
L
E
H
L
K
P
T
Y
W
F
S
A
H
L
Site 21
Y221
L
E
H
L
K
P
T
Y
W
F
S
A
H
L
H
Site 22
T249
K
G
Q
T
A
R
A
T
K
F
L
A
L
D
K
Site 23
S274
L
E
I
E
H
D
P
S
A
P
D
Y
L
E
Y
Site 24
Y278
H
D
P
S
A
P
D
Y
L
E
Y
D
I
E
W
Site 25
Y281
S
A
P
D
Y
L
E
Y
D
I
E
W
L
T
I
Site 26
T287
E
Y
D
I
E
W
L
T
I
L
R
A
T
D
D
Site 27
Y317
G
L
H
A
R
W
D
Y
S
A
T
E
E
G
M
Site 28
S318
L
H
A
R
W
D
Y
S
A
T
E
E
G
M
K
Site 29
Y348
F
S
V
T
A
A
C
Y
D
P
S
K
P
Q
T
Site 30
T355
Y
D
P
S
K
P
Q
T
Q
M
Q
L
I
H
R
Site 31
T367
I
H
R
I
N
P
Q
T
T
E
F
C
A
Q
L
Site 32
S404
E
E
Q
D
D
V
E
S
N
D
S
G
E
D
Q
Site 33
S407
D
D
V
E
S
N
D
S
G
E
D
Q
S
E
Y
Site 34
S412
N
D
S
G
E
D
Q
S
E
Y
N
T
D
T
S
Site 35
Y414
S
G
E
D
Q
S
E
Y
N
T
D
T
S
A
L
Site 36
T416
E
D
Q
S
E
Y
N
T
D
T
S
A
L
S
S
Site 37
T418
Q
S
E
Y
N
T
D
T
S
A
L
S
S
I
N
Site 38
S419
S
E
Y
N
T
D
T
S
A
L
S
S
I
N
P
Site 39
S423
T
D
T
S
A
L
S
S
I
N
P
D
E
I
M
Site 40
S439
D
E
E
E
D
E
D
S
I
V
S
A
H
S
G
Site 41
S445
D
S
I
V
S
A
H
S
G
M
N
T
P
S
V
Site 42
T449
S
A
H
S
G
M
N
T
P
S
V
E
P
S
D
Site 43
S451
H
S
G
M
N
T
P
S
V
E
P
S
D
Q
A
Site 44
S455
N
T
P
S
V
E
P
S
D
Q
A
S
E
F
S
Site 45
S459
V
E
P
S
D
Q
A
S
E
F
S
A
S
F
S
Site 46
S462
S
D
Q
A
S
E
F
S
A
S
F
S
D
V
R
Site 47
S464
Q
A
S
E
F
S
A
S
F
S
D
V
R
I
L
Site 48
S466
S
E
F
S
A
S
F
S
D
V
R
I
L
P
G
Site 49
S474
D
V
R
I
L
P
G
S
M
I
V
S
S
D
D
Site 50
S478
L
P
G
S
M
I
V
S
S
D
D
T
V
D
S
Site 51
S479
P
G
S
M
I
V
S
S
D
D
T
V
D
S
T
Site 52
T482
M
I
V
S
S
D
D
T
V
D
S
T
I
D
R
Site 53
S485
S
S
D
D
T
V
D
S
T
I
D
R
E
G
K
Site 54
T486
S
D
D
T
V
D
S
T
I
D
R
E
G
K
P
Site 55
T496
R
E
G
K
P
G
G
T
V
E
S
G
N
G
E
Site 56
T506
S
G
N
G
E
D
L
T
K
V
P
L
K
R
L
Site 57
S514
K
V
P
L
K
R
L
S
D
E
H
E
P
E
Q
Site 58
Y533
K
R
R
N
Q
A
I
Y
A
A
V
D
D
D
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation