PhosphoNET

           
Protein Info 
   
Short Name:  USP21
Full Name:  Ubiquitin carboxyl-terminal hydrolase 21
Alias:  Deubiquitinating enzyme 21; Ubiquitin specific peptidase 21; Ubiquitin thioesterase 21; Ubiquitin-specific-processing protease 21; USP16; USP23
Type:  EC 3.1.2.15; Protease; Ubiquitin conjugating system
Mass (Da):  62637
Number AA:  565
UniProt ID:  Q9UK80
International Prot ID:  IPI00007262
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005634     Uniprot OncoNet
Molecular Function:  GO:0019784  GO:0003713  GO:0004221 PhosphoSite+ KinaseNET
Biological Process:  GO:0016578  GO:0045893  GO:0006350 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S25NIQPRVGSKLPFAPR
Site 2S35PFAPRARSKERRNPA
Site 3S43KERRNPASGPNPMLR
Site 4T73LELGRGRTSGPRPRG
Site 5S74ELGRGRTSGPRPRGP
Site 6S93HGVPLPGSPPPTVAL
Site 7T106ALPLPSRTNLARSKS
Site 8S111SRTNLARSKSVSSGD
Site 9S113TNLARSKSVSSGDLR
Site 10S115LARSKSVSSGDLRPM
Site 11S116ARSKSVSSGDLRPMG
Site 12S140GELGAALSRLALRPE
Site 13T150ALRPEPPTLRRSTSL
Site 14S154EPPTLRRSTSLRRLG
Site 15T155PPTLRRSTSLRRLGG
Site 16S156PTLRRSTSLRRLGGF
Site 17T168GGFPGPPTLFSIRTE
Site 18S171PGPPTLFSIRTEPPA
Site 19T174PTLFSIRTEPPASHG
Site 20S179IRTEPPASHGSFHMI
Site 21S182EPPASHGSFHMISAR
Site 22S187HGSFHMISARSSEPF
Site 23S190FHMISARSSEPFYSD
Site 24S191HMISARSSEPFYSDD
Site 25Y195ARSSEPFYSDDKMAH
Site 26S196RSSEPFYSDDKMAHH
Site 27T204DDKMAHHTLLLGSGH
Site 28S231NAVLQCLSSTRPLRD
Site 29S274GALWHPDSCEAVNPT
Site 30Y290FRAVFQKYVPSFSGY
Site 31S293VFQKYVPSFSGYSQQ
Site 32Y297YVPSFSGYSQQDAQE
Site 33S335LANGPVPSPPRRGGA
Site 34S350LLEEPELSDDDRANL
Site 35Y362ANLMWKRYLEREDSK
Site 36S368RYLEREDSKIVDLFV
Site 37S431TKEEELESENAPVCD
Site 38T444CDRCRQKTRSTKKLT
Site 39S446RCRQKTRSTKKLTVQ
Site 40T447CRQKTRSTKKLTVQR
Site 41T451TRSTKKLTVQRFPRI
Site 42S467VLHLNRFSASRGSIK
Site 43S472RFSASRGSIKKSSVG
Site 44S476SRGSIKKSSVGVDFP
Site 45S477RGSIKKSSVGVDFPL
Site 46S488DFPLQRLSLGDFASD
Site 47S494LSLGDFASDKAGSPV
Site 48S499FASDKAGSPVYQLYA
Site 49Y502DKAGSPVYQLYALCN
Site 50Y505GSPVYQLYALCNHSG
Site 51S535GWHVYNDSRVSPVSE
Site 52S538VYNDSRVSPVSENQV
Site 53S541DSRVSPVSENQVASS
Site 54S548SENQVASSEGYVLFY
Site 55Y555SEGYVLFYQLMQEPP
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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