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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CPSF3
Full Name:
Cleavage and polyadenylation specificity factor subunit 3
Alias:
Cleavage and polyadenylation specificity factor, 73 kDa; CPSF; CPSF 73 kDa; CPSF73; CPSF-73; EC 3.1.27.-
Type:
RNA binding protein, Ribonuclease, RNA processing
Mass (Da):
77486
Number AA:
684
UniProt ID:
Q9UKF6
International Prot ID:
IPI00007818
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
GO:0005654
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0004519
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006379
GO:0006378
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
A
I
P
A
E
E
S
D
Q
L
L
I
R
P
Site 2
T87
L
P
W
F
L
Q
K
T
S
F
K
G
R
T
F
Site 3
T93
K
T
S
F
K
G
R
T
F
M
T
H
A
T
K
Site 4
S108
A
I
Y
R
W
L
L
S
D
Y
V
K
V
S
N
Site 5
Y110
Y
R
W
L
L
S
D
Y
V
K
V
S
N
I
S
Site 6
S114
L
S
D
Y
V
K
V
S
N
I
S
A
D
D
M
Site 7
Y123
I
S
A
D
D
M
L
Y
T
E
T
D
L
E
E
Site 8
T177
A
G
V
K
L
L
Y
T
G
D
F
S
R
Q
E
Site 9
Y256
L
L
L
I
L
D
E
Y
W
Q
N
H
P
E
L
Site 10
Y269
E
L
H
D
I
P
I
Y
Y
A
S
S
L
A
K
Site 11
Y270
L
H
D
I
P
I
Y
Y
A
S
S
L
A
K
K
Site 12
Y285
C
M
A
V
Y
Q
T
Y
V
N
A
M
N
D
K
Site 13
S334
A
S
P
G
M
M
Q
S
G
L
S
R
E
L
F
Site 14
S337
G
M
M
Q
S
G
L
S
R
E
L
F
E
S
W
Site 15
S343
L
S
R
E
L
F
E
S
W
C
T
D
K
R
N
Site 16
T376
S
E
P
E
E
I
T
T
M
S
G
Q
K
L
P
Site 17
S378
P
E
E
I
T
T
M
S
G
Q
K
L
P
L
K
Site 18
S387
Q
K
L
P
L
K
M
S
V
D
Y
I
S
F
S
Site 19
Y390
P
L
K
M
S
V
D
Y
I
S
F
S
A
H
T
Site 20
S392
K
M
S
V
D
Y
I
S
F
S
A
H
T
D
Y
Site 21
Y399
S
F
S
A
H
T
D
Y
Q
Q
T
S
E
F
I
Site 22
Y435
K
A
A
L
I
R
E
Y
E
D
N
D
E
V
H
Site 23
T451
E
V
H
N
P
R
N
T
E
A
V
T
L
N
F
Site 24
S482
P
E
Q
G
Q
R
V
S
G
I
L
V
K
R
N
Site 25
Y492
L
V
K
R
N
F
N
Y
H
I
L
S
P
C
D
Site 26
Y503
S
P
C
D
L
S
N
Y
T
D
L
A
M
S
T
Site 27
T504
P
C
D
L
S
N
Y
T
D
L
A
M
S
T
V
Site 28
Y519
K
Q
T
Q
A
I
P
Y
T
G
P
F
N
L
L
Site 29
Y576
A
N
P
S
N
D
M
Y
A
D
T
V
T
T
V
Site 30
S602
K
G
A
V
Q
K
V
S
K
K
L
E
M
H
V
Site 31
Y610
K
K
L
E
M
H
V
Y
S
K
R
L
E
I
M
Site 32
S611
K
L
E
M
H
V
Y
S
K
R
L
E
I
M
L
Site 33
S636
V
K
D
D
S
I
L
S
V
T
V
D
G
K
T
Site 34
T638
D
D
S
I
L
S
V
T
V
D
G
K
T
A
N
Site 35
T643
S
V
T
V
D
G
K
T
A
N
L
N
L
E
T
Site 36
T652
N
L
N
L
E
T
R
T
V
E
C
E
E
G
S
Site 37
S659
T
V
E
C
E
E
G
S
E
D
D
E
S
L
R
Site 38
S664
E
G
S
E
D
D
E
S
L
R
E
M
V
E
L
Site 39
Y677
E
L
A
A
Q
R
L
Y
E
A
L
T
P
V
H
Site 40
T681
Q
R
L
Y
E
A
L
T
P
V
H
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation