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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GPATCH8
Full Name:
G patch domain-containing protein 8
Alias:
Type:
DNA repair
Mass (Da):
164197
Number AA:
1502
UniProt ID:
Q9UKJ3
International Prot ID:
IPI00457284
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y22
Q
G
N
H
F
D
Q
Y
E
E
G
H
L
E
I
Site 2
S40
S
L
D
K
P
I
E
S
D
N
I
G
H
R
L
Site 3
S62
L
G
Q
G
L
G
K
S
L
Q
G
R
T
D
P
Site 4
Y90
R
M
E
M
E
L
D
Y
A
E
D
A
T
E
R
Site 5
T95
L
D
Y
A
E
D
A
T
E
R
R
R
V
L
E
Site 6
T108
L
E
V
E
K
E
D
T
E
E
L
R
Q
K
Y
Site 7
Y115
T
E
E
L
R
Q
K
Y
K
D
Y
V
D
K
E
Site 8
Y118
L
R
Q
K
Y
K
D
Y
V
D
K
E
K
A
I
Site 9
Y137
E
D
L
R
A
N
F
Y
C
E
L
C
D
K
Q
Site 10
Y145
C
E
L
C
D
K
Q
Y
Q
K
H
Q
E
F
D
Site 11
S179
R
E
F
A
R
N
V
S
S
R
S
R
K
D
E
Site 12
S180
E
F
A
R
N
V
S
S
R
S
R
K
D
E
K
Site 13
S212
Q
A
E
C
A
P
G
S
G
P
M
F
K
P
T
Site 14
T220
G
P
M
F
K
P
T
T
V
A
V
D
E
E
G
Site 15
S235
G
E
D
D
K
D
E
S
A
T
N
S
G
T
G
Site 16
S239
K
D
E
S
A
T
N
S
G
T
G
A
T
A
S
Site 17
S254
C
G
L
G
S
E
F
S
T
D
K
G
G
P
F
Site 18
T255
G
L
G
S
E
F
S
T
D
K
G
G
P
F
T
Site 19
T293
G
I
K
N
N
L
G
T
P
L
Q
K
L
G
V
Site 20
S314
K
A
P
V
K
L
E
S
I
A
S
V
F
K
D
Site 21
S317
V
K
L
E
S
I
A
S
V
F
K
D
H
A
E
Site 22
T332
E
G
T
S
E
D
G
T
K
P
D
E
K
S
S
Site 23
S338
G
T
K
P
D
E
K
S
S
D
Q
G
L
Q
K
Site 24
S349
G
L
Q
K
V
G
D
S
D
G
S
S
N
L
D
Site 25
S353
V
G
D
S
D
G
S
S
N
L
D
G
K
K
E
Site 26
S369
E
D
P
Q
D
G
G
S
L
A
S
T
L
S
K
Site 27
S372
Q
D
G
G
S
L
A
S
T
L
S
K
L
K
R
Site 28
T373
D
G
G
S
L
A
S
T
L
S
K
L
K
R
M
Site 29
S375
G
S
L
A
S
T
L
S
K
L
K
R
M
K
R
Site 30
Y393
A
G
A
T
E
P
E
Y
Y
H
Y
I
P
P
A
Site 31
Y394
G
A
T
E
P
E
Y
Y
H
Y
I
P
P
A
H
Site 32
Y396
T
E
P
E
Y
Y
H
Y
I
P
P
A
H
C
K
Site 33
S417
F
L
L
F
M
R
A
S
E
Q
M
D
G
D
N
Site 34
T425
E
Q
M
D
G
D
N
T
T
H
P
K
N
A
P
Site 35
S434
H
P
K
N
A
P
E
S
K
K
G
S
S
P
K
Site 36
S438
A
P
E
S
K
K
G
S
S
P
K
P
K
S
C
Site 37
S439
P
E
S
K
K
G
S
S
P
K
P
K
S
C
I
Site 38
S444
G
S
S
P
K
P
K
S
C
I
K
A
A
A
S
Site 39
S451
S
C
I
K
A
A
A
S
Q
G
A
E
K
T
V
Site 40
T457
A
S
Q
G
A
E
K
T
V
S
E
V
S
E
Q
Site 41
S459
Q
G
A
E
K
T
V
S
E
V
S
E
Q
P
K
Site 42
S469
S
E
Q
P
K
E
T
S
M
T
E
P
S
E
P
Site 43
T471
Q
P
K
E
T
S
M
T
E
P
S
E
P
G
S
Site 44
S474
E
T
S
M
T
E
P
S
E
P
G
S
K
A
E
Site 45
S478
T
E
P
S
E
P
G
S
K
A
E
A
K
K
A
Site 46
S491
K
A
L
G
G
D
V
S
D
Q
S
L
E
S
H
Site 47
S494
G
G
D
V
S
D
Q
S
L
E
S
H
S
Q
K
Site 48
S497
V
S
D
Q
S
L
E
S
H
S
Q
K
V
S
E
Site 49
S499
D
Q
S
L
E
S
H
S
Q
K
V
S
E
T
Q
Site 50
S503
E
S
H
S
Q
K
V
S
E
T
Q
M
C
E
S
Site 51
T505
H
S
Q
K
V
S
E
T
Q
M
C
E
S
N
S
Site 52
S510
S
E
T
Q
M
C
E
S
N
S
S
K
E
T
S
Site 53
S512
T
Q
M
C
E
S
N
S
S
K
E
T
S
L
A
Site 54
S513
Q
M
C
E
S
N
S
S
K
E
T
S
L
A
T
Site 55
T516
E
S
N
S
S
K
E
T
S
L
A
T
P
A
G
Site 56
S517
S
N
S
S
K
E
T
S
L
A
T
P
A
G
K
Site 57
T520
S
K
E
T
S
L
A
T
P
A
G
K
E
S
Q
Site 58
S526
A
T
P
A
G
K
E
S
Q
E
G
P
K
H
P
Site 59
S546
P
V
L
S
K
D
E
S
T
A
L
Q
W
P
S
Site 60
S564
I
F
T
K
A
E
P
S
I
S
Y
S
C
N
P
Site 61
S566
T
K
A
E
P
S
I
S
Y
S
C
N
P
L
Y
Site 62
S568
A
E
P
S
I
S
Y
S
C
N
P
L
Y
F
D
Site 63
Y573
S
Y
S
C
N
P
L
Y
F
D
F
K
L
S
R
Site 64
S597
E
K
P
K
D
I
G
S
S
S
K
D
H
L
Q
Site 65
S599
P
K
D
I
G
S
S
S
K
D
H
L
Q
G
L
Site 66
S614
D
P
G
E
P
N
K
S
K
E
V
G
G
E
K
Site 67
S625
G
G
E
K
I
V
R
S
S
G
G
R
M
D
A
Site 68
S626
G
E
K
I
V
R
S
S
G
G
R
M
D
A
P
Site 69
S635
G
R
M
D
A
P
A
S
G
S
A
C
S
G
L
Site 70
S637
M
D
A
P
A
S
G
S
A
C
S
G
L
N
K
Site 71
S650
N
K
Q
E
P
G
G
S
H
G
S
E
T
E
D
Site 72
S653
E
P
G
G
S
H
G
S
E
T
E
D
T
G
R
Site 73
T655
G
G
S
H
G
S
E
T
E
D
T
G
R
S
L
Site 74
T658
H
G
S
E
T
E
D
T
G
R
S
L
P
S
K
Site 75
S661
E
T
E
D
T
G
R
S
L
P
S
K
K
E
R
Site 76
S672
K
K
E
R
S
G
K
S
H
R
H
K
K
K
K
Site 77
S684
K
K
K
K
H
K
K
S
S
K
H
K
R
K
H
Site 78
S685
K
K
K
H
K
K
S
S
K
H
K
R
K
H
K
Site 79
T695
K
R
K
H
K
A
D
T
E
E
K
S
S
K
A
Site 80
S699
K
A
D
T
E
E
K
S
S
K
A
E
S
G
E
Site 81
S700
A
D
T
E
E
K
S
S
K
A
E
S
G
E
K
Site 82
S704
E
K
S
S
K
A
E
S
G
E
K
S
K
K
R
Site 83
S708
K
A
E
S
G
E
K
S
K
K
R
K
K
R
K
Site 84
S721
R
K
R
K
K
N
K
S
S
A
P
A
D
S
E
Site 85
S727
K
S
S
A
P
A
D
S
E
R
G
P
K
P
E
Site 86
S738
P
K
P
E
P
P
G
S
G
S
P
A
P
P
R
Site 87
S740
P
E
P
P
G
S
G
S
P
A
P
P
R
R
R
Site 88
S754
R
R
R
A
Q
D
D
S
Q
R
R
S
L
P
A
Site 89
S758
Q
D
D
S
Q
R
R
S
L
P
A
E
E
G
S
Site 90
S766
L
P
A
E
E
G
S
S
G
K
K
D
E
G
G
Site 91
S778
E
G
G
G
G
S
S
S
Q
D
H
G
G
R
K
Site 92
S793
H
K
G
E
L
P
P
S
S
C
Q
R
R
A
G
Site 93
S794
K
G
E
L
P
P
S
S
C
Q
R
R
A
G
T
Site 94
T801
S
C
Q
R
R
A
G
T
K
R
S
S
R
S
S
Site 95
S804
R
R
A
G
T
K
R
S
S
R
S
S
H
R
S
Site 96
S805
R
A
G
T
K
R
S
S
R
S
S
H
R
S
Q
Site 97
S807
G
T
K
R
S
S
R
S
S
H
R
S
Q
P
S
Site 98
S808
T
K
R
S
S
R
S
S
H
R
S
Q
P
S
S
Site 99
S811
S
S
R
S
S
H
R
S
Q
P
S
S
G
D
E
Site 100
S814
S
S
H
R
S
Q
P
S
S
G
D
E
D
S
D
Site 101
S815
S
H
R
S
Q
P
S
S
G
D
E
D
S
D
D
Site 102
S820
P
S
S
G
D
E
D
S
D
D
A
S
S
H
R
Site 103
S824
D
E
D
S
D
D
A
S
S
H
R
L
H
Q
K
Site 104
S825
E
D
S
D
D
A
S
S
H
R
L
H
Q
K
S
Site 105
S832
S
H
R
L
H
Q
K
S
P
S
Q
Y
S
E
E
Site 106
S834
R
L
H
Q
K
S
P
S
Q
Y
S
E
E
E
E
Site 107
S845
E
E
E
E
E
E
D
S
G
S
E
H
S
R
S
Site 108
S847
E
E
E
E
D
S
G
S
E
H
S
R
S
R
S
Site 109
S850
E
D
S
G
S
E
H
S
R
S
R
S
R
S
G
Site 110
S852
S
G
S
E
H
S
R
S
R
S
R
S
G
R
R
Site 111
S854
S
E
H
S
R
S
R
S
R
S
G
R
R
H
S
Site 112
S856
H
S
R
S
R
S
R
S
G
R
R
H
S
S
H
Site 113
S861
S
R
S
G
R
R
H
S
S
H
R
S
S
R
R
Site 114
S862
R
S
G
R
R
H
S
S
H
R
S
S
R
R
S
Site 115
S865
R
R
H
S
S
H
R
S
S
R
R
S
Y
S
S
Site 116
S866
R
H
S
S
H
R
S
S
R
R
S
Y
S
S
S
Site 117
S869
S
H
R
S
S
R
R
S
Y
S
S
S
S
D
A
Site 118
Y870
H
R
S
S
R
R
S
Y
S
S
S
S
D
A
S
Site 119
S871
R
S
S
R
R
S
Y
S
S
S
S
D
A
S
S
Site 120
S872
S
S
R
R
S
Y
S
S
S
S
D
A
S
S
D
Site 121
S873
S
R
R
S
Y
S
S
S
S
D
A
S
S
D
Q
Site 122
S874
R
R
S
Y
S
S
S
S
D
A
S
S
D
Q
S
Site 123
S877
Y
S
S
S
S
D
A
S
S
D
Q
S
C
Y
S
Site 124
S878
S
S
S
S
D
A
S
S
D
Q
S
C
Y
S
R
Site 125
S881
S
D
A
S
S
D
Q
S
C
Y
S
R
Q
R
S
Site 126
Y883
A
S
S
D
Q
S
C
Y
S
R
Q
R
S
Y
S
Site 127
S884
S
S
D
Q
S
C
Y
S
R
Q
R
S
Y
S
D
Site 128
S888
S
C
Y
S
R
Q
R
S
Y
S
D
D
S
Y
S
Site 129
Y889
C
Y
S
R
Q
R
S
Y
S
D
D
S
Y
S
D
Site 130
S890
Y
S
R
Q
R
S
Y
S
D
D
S
Y
S
D
Y
Site 131
S893
Q
R
S
Y
S
D
D
S
Y
S
D
Y
S
D
R
Site 132
Y894
R
S
Y
S
D
D
S
Y
S
D
Y
S
D
R
S
Site 133
S895
S
Y
S
D
D
S
Y
S
D
Y
S
D
R
S
R
Site 134
Y897
S
D
D
S
Y
S
D
Y
S
D
R
S
R
R
H
Site 135
S898
D
D
S
Y
S
D
Y
S
D
R
S
R
R
H
S
Site 136
S901
Y
S
D
Y
S
D
R
S
R
R
H
S
K
R
S
Site 137
S905
S
D
R
S
R
R
H
S
K
R
S
H
D
S
D
Site 138
S908
S
R
R
H
S
K
R
S
H
D
S
D
D
S
D
Site 139
S911
H
S
K
R
S
H
D
S
D
D
S
D
Y
A
S
Site 140
S914
R
S
H
D
S
D
D
S
D
Y
A
S
S
K
H
Site 141
Y916
H
D
S
D
D
S
D
Y
A
S
S
K
H
R
S
Site 142
S918
S
D
D
S
D
Y
A
S
S
K
H
R
S
K
R
Site 143
S919
D
D
S
D
Y
A
S
S
K
H
R
S
K
R
H
Site 144
S923
Y
A
S
S
K
H
R
S
K
R
H
K
Y
S
S
Site 145
Y928
H
R
S
K
R
H
K
Y
S
S
S
D
D
D
Y
Site 146
S929
R
S
K
R
H
K
Y
S
S
S
D
D
D
Y
S
Site 147
S930
S
K
R
H
K
Y
S
S
S
D
D
D
Y
S
L
Site 148
S931
K
R
H
K
Y
S
S
S
D
D
D
Y
S
L
S
Site 149
Y935
Y
S
S
S
D
D
D
Y
S
L
S
C
S
Q
S
Site 150
S936
S
S
S
D
D
D
Y
S
L
S
C
S
Q
S
R
Site 151
S938
S
D
D
D
Y
S
L
S
C
S
Q
S
R
S
R
Site 152
S940
D
D
Y
S
L
S
C
S
Q
S
R
S
R
S
R
Site 153
S942
Y
S
L
S
C
S
Q
S
R
S
R
S
R
S
H
Site 154
S944
L
S
C
S
Q
S
R
S
R
S
R
S
H
T
R
Site 155
S946
C
S
Q
S
R
S
R
S
R
S
H
T
R
E
R
Site 156
S948
Q
S
R
S
R
S
R
S
H
T
R
E
R
S
R
Site 157
T950
R
S
R
S
R
S
H
T
R
E
R
S
R
S
R
Site 158
S954
R
S
H
T
R
E
R
S
R
S
R
G
R
S
R
Site 159
S956
H
T
R
E
R
S
R
S
R
G
R
S
R
S
S
Site 160
S960
R
S
R
S
R
G
R
S
R
S
S
S
C
S
R
Site 161
S962
R
S
R
G
R
S
R
S
S
S
C
S
R
S
R
Site 162
S963
S
R
G
R
S
R
S
S
S
C
S
R
S
R
S
Site 163
S964
R
G
R
S
R
S
S
S
C
S
R
S
R
S
K
Site 164
S966
R
S
R
S
S
S
C
S
R
S
R
S
K
R
R
Site 165
S968
R
S
S
S
C
S
R
S
R
S
K
R
R
S
R
Site 166
S970
S
S
C
S
R
S
R
S
K
R
R
S
R
S
T
Site 167
S974
R
S
R
S
K
R
R
S
R
S
T
T
A
H
S
Site 168
S976
R
S
K
R
R
S
R
S
T
T
A
H
S
W
Q
Site 169
T977
S
K
R
R
S
R
S
T
T
A
H
S
W
Q
R
Site 170
T978
K
R
R
S
R
S
T
T
A
H
S
W
Q
R
S
Site 171
S981
S
R
S
T
T
A
H
S
W
Q
R
S
R
S
Y
Site 172
S985
T
A
H
S
W
Q
R
S
R
S
Y
S
R
D
R
Site 173
S987
H
S
W
Q
R
S
R
S
Y
S
R
D
R
S
R
Site 174
Y988
S
W
Q
R
S
R
S
Y
S
R
D
R
S
R
S
Site 175
S989
W
Q
R
S
R
S
Y
S
R
D
R
S
R
S
T
Site 176
S993
R
S
Y
S
R
D
R
S
R
S
T
R
S
P
S
Site 177
S995
Y
S
R
D
R
S
R
S
T
R
S
P
S
Q
R
Site 178
T996
S
R
D
R
S
R
S
T
R
S
P
S
Q
R
S
Site 179
S998
D
R
S
R
S
T
R
S
P
S
Q
R
S
G
S
Site 180
S1000
S
R
S
T
R
S
P
S
Q
R
S
G
S
R
K
Site 181
S1003
T
R
S
P
S
Q
R
S
G
S
R
K
R
S
W
Site 182
S1005
S
P
S
Q
R
S
G
S
R
K
R
S
W
G
H
Site 183
S1009
R
S
G
S
R
K
R
S
W
G
H
E
S
P
E
Site 184
S1014
K
R
S
W
G
H
E
S
P
E
E
R
H
S
G
Site 185
S1020
E
S
P
E
E
R
H
S
G
R
R
D
F
I
R
Site 186
S1028
G
R
R
D
F
I
R
S
K
I
Y
R
S
Q
S
Site 187
Y1031
D
F
I
R
S
K
I
Y
R
S
Q
S
P
H
Y
Site 188
S1033
I
R
S
K
I
Y
R
S
Q
S
P
H
Y
F
R
Site 189
S1035
S
K
I
Y
R
S
Q
S
P
H
Y
F
R
S
G
Site 190
Y1038
Y
R
S
Q
S
P
H
Y
F
R
S
G
R
G
E
Site 191
S1041
Q
S
P
H
Y
F
R
S
G
R
G
E
G
P
G
Site 192
S1058
D
D
G
R
G
D
D
S
K
A
T
G
P
P
S
Site 193
T1061
R
G
D
D
S
K
A
T
G
P
P
S
Q
N
S
Site 194
S1065
S
K
A
T
G
P
P
S
Q
N
S
N
I
G
T
Site 195
S1068
T
G
P
P
S
Q
N
S
N
I
G
T
G
R
G
Site 196
T1072
S
Q
N
S
N
I
G
T
G
R
G
S
E
G
D
Site 197
S1076
N
I
G
T
G
R
G
S
E
G
D
C
S
P
E
Site 198
S1081
R
G
S
E
G
D
C
S
P
E
D
K
N
S
V
Site 199
S1087
C
S
P
E
D
K
N
S
V
T
A
K
L
L
L
Site 200
S1099
L
L
L
E
K
I
Q
S
R
K
V
E
R
K
P
Site 201
S1107
R
K
V
E
R
K
P
S
V
S
E
E
V
Q
A
Site 202
S1109
V
E
R
K
P
S
V
S
E
E
V
Q
A
T
P
Site 203
T1115
V
S
E
E
V
Q
A
T
P
N
K
A
G
P
K
Site 204
Y1130
L
K
D
P
P
Q
G
Y
F
G
P
K
L
P
P
Site 205
S1138
F
G
P
K
L
P
P
S
L
G
N
K
P
V
L
Site 206
T1154
L
I
G
K
L
P
A
T
R
K
P
N
K
K
C
Site 207
S1175
R
G
E
E
Q
E
Q
S
E
T
E
E
G
P
P
Site 208
T1177
E
E
Q
E
Q
S
E
T
E
E
G
P
P
G
S
Site 209
S1184
T
E
E
G
P
P
G
S
S
D
A
L
F
G
H
Site 210
S1185
E
E
G
P
P
G
S
S
D
A
L
F
G
H
Q
Site 211
S1195
L
F
G
H
Q
F
P
S
E
E
T
T
G
P
L
Site 212
T1199
Q
F
P
S
E
E
T
T
G
P
L
L
D
P
P
Site 213
S1210
L
D
P
P
P
E
E
S
K
S
G
E
A
T
A
Site 214
S1212
P
P
P
E
E
S
K
S
G
E
A
T
A
D
H
Site 215
T1216
E
S
K
S
G
E
A
T
A
D
H
P
V
A
P
Site 216
T1226
H
P
V
A
P
L
G
T
P
A
H
S
D
C
Y
Site 217
S1230
P
L
G
T
P
A
H
S
D
C
Y
P
G
D
P
Site 218
Y1233
T
P
A
H
S
D
C
Y
P
G
D
P
T
I
S
Site 219
S1240
Y
P
G
D
P
T
I
S
H
N
Y
L
P
D
P
Site 220
Y1243
D
P
T
I
S
H
N
Y
L
P
D
P
S
D
G
Site 221
S1248
H
N
Y
L
P
D
P
S
D
G
D
T
L
E
S
Site 222
T1252
P
D
P
S
D
G
D
T
L
E
S
L
D
S
S
Site 223
S1255
S
D
G
D
T
L
E
S
L
D
S
S
S
Q
P
Site 224
S1258
D
T
L
E
S
L
D
S
S
S
Q
P
G
P
V
Site 225
S1259
T
L
E
S
L
D
S
S
S
Q
P
G
P
V
E
Site 226
S1260
L
E
S
L
D
S
S
S
Q
P
G
P
V
E
S
Site 227
S1268
Q
P
G
P
V
E
S
S
L
L
P
I
A
P
D
Site 228
S1281
P
D
L
E
H
F
P
S
Y
A
P
P
S
G
D
Site 229
Y1282
D
L
E
H
F
P
S
Y
A
P
P
S
G
D
P
Site 230
S1286
F
P
S
Y
A
P
P
S
G
D
P
S
I
E
S
Site 231
S1290
A
P
P
S
G
D
P
S
I
E
S
T
D
G
A
Site 232
T1294
G
D
P
S
I
E
S
T
D
G
A
E
D
A
S
Site 233
S1301
T
D
G
A
E
D
A
S
L
A
P
L
E
S
Q
Site 234
T1311
P
L
E
S
Q
P
I
T
F
T
P
E
E
M
E
Site 235
T1313
E
S
Q
P
I
T
F
T
P
E
E
M
E
K
Y
Site 236
Y1320
T
P
E
E
M
E
K
Y
S
K
L
Q
Q
A
A
Site 237
T1414
H
I
P
Q
P
H
L
T
P
I
S
L
S
H
L
Site 238
S1417
Q
P
H
L
T
P
I
S
L
S
H
L
T
H
S
Site 239
S1424
S
L
S
H
L
T
H
S
I
I
P
G
H
P
A
Site 240
S1490
P
L
L
H
P
I
F
S
G
Q
D
L
Q
H
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation