KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PARP4
Full Name:
Poly [ADP-ribose] polymerase 4
Alias:
193-kDa vault protein; ADP- ribose; ADP-ribosyltransferase (NAD+; ADPRTL1; H5 proline-rich; I-alpha-I-related; P193; PARP- related/IalphaI-related H5/proline-rich; PARP-4; PARPL; PARP-related; PH5P; Poly (ADP-ribose) polymerase family, member 4; Poly (ADP-ribose) polymerase)-like 1; Poly(ADP-ribose) synthetase; Poly(ADP-ribosyl)transferase-like 1; Polymerase; Vault poly; Vault poly(ADP-ribose) polymerase; Vault protein, 193-kDa; VAULT3; Von Willebrand factor A domain containing 5C; VPARP; VWA5C
Type:
Transferase; EC 2.4.2.30
Mass (Da):
192589
Number AA:
1724
UniProt ID:
Q9UKK3
International Prot ID:
IPI00296909
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0030529
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003950
GO:0019899
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0008219
GO:0006954
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
I
F
C
L
K
V
K
Y
L
P
Q
Q
Q
K
K
Site 2
T28
Q
Q
K
K
K
L
Q
T
D
I
K
E
N
G
G
Site 3
S38
K
E
N
G
G
K
F
S
F
S
L
N
P
Q
C
Site 4
S40
N
G
G
K
F
S
F
S
L
N
P
Q
C
T
H
Site 5
S57
L
D
N
A
D
V
L
S
Q
Y
Q
L
N
S
I
Site 6
Y59
N
A
D
V
L
S
Q
Y
Q
L
N
S
I
Q
K
Site 7
S80
N
P
D
F
I
W
K
S
I
R
E
K
R
L
L
Site 8
Y92
R
L
L
D
V
K
N
Y
D
P
Y
K
P
L
D
Site 9
Y95
D
V
K
N
Y
D
P
Y
K
P
L
D
I
T
P
Site 10
T101
P
Y
K
P
L
D
I
T
P
P
P
D
Q
K
A
Site 11
S110
P
P
D
Q
K
A
S
S
S
E
V
K
T
E
G
Site 12
S111
P
D
Q
K
A
S
S
S
E
V
K
T
E
G
L
Site 13
T115
A
S
S
S
E
V
K
T
E
G
L
C
P
D
S
Site 14
S122
T
E
G
L
C
P
D
S
A
T
E
E
E
D
T
Site 15
T129
S
A
T
E
E
E
D
T
V
E
L
T
E
F
G
Site 16
Y154
Q
D
F
E
V
A
K
Y
N
T
L
E
K
V
G
Site 17
S176
V
V
V
E
L
Q
C
S
R
D
S
R
D
C
P
Site 18
S179
E
L
Q
C
S
R
D
S
R
D
C
P
F
L
I
Site 19
T198
L
L
D
D
G
M
E
T
R
R
Q
F
A
I
K
Site 20
T207
R
Q
F
A
I
K
K
T
S
E
D
A
S
E
Y
Site 21
S208
Q
F
A
I
K
K
T
S
E
D
A
S
E
Y
F
Site 22
S212
K
K
T
S
E
D
A
S
E
Y
F
E
N
Y
I
Site 23
Y214
T
S
E
D
A
S
E
Y
F
E
N
Y
I
E
E
Site 24
T234
F
L
L
R
E
H
F
T
P
E
A
T
Q
L
A
Site 25
S256
L
L
E
E
V
M
N
S
S
T
L
S
Q
E
V
Site 26
T258
E
E
V
M
N
S
S
T
L
S
Q
E
V
S
D
Site 27
S290
L
K
P
V
N
R
I
S
L
N
D
V
S
K
A
Site 28
T322
E
Q
L
Q
K
M
M
T
E
F
Y
R
L
I
P
Site 29
T362
D
M
V
N
V
C
E
T
N
L
S
K
P
N
P
Site 30
S365
N
V
C
E
T
N
L
S
K
P
N
P
P
S
L
Site 31
S371
L
S
K
P
N
P
P
S
L
A
K
Y
R
A
L
Site 32
Y375
N
P
P
S
L
A
K
Y
R
A
L
R
C
K
I
Site 33
S405
E
V
L
Q
N
H
H
S
K
S
P
V
D
V
L
Site 34
S407
L
Q
N
H
H
S
K
S
P
V
D
V
L
Q
I
Site 35
T424
V
G
R
V
N
E
T
T
E
F
L
S
K
L
G
Site 36
T467
E
D
R
G
V
Q
R
T
D
V
G
N
L
G
S
Site 37
S474
T
D
V
G
N
L
G
S
G
I
Y
F
S
D
S
Site 38
Y477
G
N
L
G
S
G
I
Y
F
S
D
S
L
S
T
Site 39
S481
S
G
I
Y
F
S
D
S
L
S
T
S
I
K
Y
Site 40
S483
I
Y
F
S
D
S
L
S
T
S
I
K
Y
S
H
Site 41
S485
F
S
D
S
L
S
T
S
I
K
Y
S
H
P
G
Site 42
Y488
S
L
S
T
S
I
K
Y
S
H
P
G
E
T
D
Site 43
S489
L
S
T
S
I
K
Y
S
H
P
G
E
T
D
G
Site 44
T497
H
P
G
E
T
D
G
T
R
L
L
L
I
C
D
Site 45
S519
D
L
H
E
K
D
F
S
L
T
E
A
P
P
G
Site 46
T521
H
E
K
D
F
S
L
T
E
A
P
P
G
Y
D
Site 47
Y527
L
T
E
A
P
P
G
Y
D
S
V
H
G
V
S
Site 48
S529
E
A
P
P
G
Y
D
S
V
H
G
V
S
Q
T
Site 49
S534
Y
D
S
V
H
G
V
S
Q
T
A
S
V
T
T
Site 50
T536
S
V
H
G
V
S
Q
T
A
S
V
T
T
D
F
Site 51
S538
H
G
V
S
Q
T
A
S
V
T
T
D
F
E
D
Site 52
Y551
E
D
D
E
F
V
V
Y
K
T
N
Q
V
K
M
Site 53
Y560
T
N
Q
V
K
M
K
Y
I
I
K
F
S
M
P
Site 54
S577
Q
I
K
D
F
H
P
S
D
H
T
E
L
E
E
Site 55
Y585
D
H
T
E
L
E
E
Y
R
P
E
F
S
N
F
Site 56
Y598
N
F
S
K
V
E
D
Y
Q
L
P
D
A
K
T
Site 57
T605
Y
Q
L
P
D
A
K
T
S
S
S
T
K
A
G
Site 58
S607
L
P
D
A
K
T
S
S
S
T
K
A
G
L
Q
Site 59
S608
P
D
A
K
T
S
S
S
T
K
A
G
L
Q
D
Site 60
T644
A
Q
V
I
V
F
Q
T
Y
T
N
K
S
H
V
Site 61
Y645
Q
V
I
V
F
Q
T
Y
T
N
K
S
H
V
P
Site 62
S649
F
Q
T
Y
T
N
K
S
H
V
P
I
E
A
K
Site 63
Y657
H
V
P
I
E
A
K
Y
I
F
P
L
D
D
K
Site 64
S707
G
H
G
A
Y
L
M
S
Q
D
A
P
D
V
F
Site 65
T768
L
N
E
N
L
Q
D
T
V
E
K
I
C
I
K
Site 66
S782
K
E
I
G
T
K
Q
S
F
S
L
T
M
S
I
Site 67
T786
T
K
Q
S
F
S
L
T
M
S
I
E
M
P
Y
Site 68
T818
D
C
K
A
V
I
S
T
M
E
G
S
S
L
D
Site 69
S823
I
S
T
M
E
G
S
S
L
D
S
S
G
F
S
Site 70
S826
M
E
G
S
S
L
D
S
S
G
F
S
L
H
I
Site 71
S827
E
G
S
S
L
D
S
S
G
F
S
L
H
I
G
Site 72
S830
S
L
D
S
S
G
F
S
L
H
I
G
L
S
A
Site 73
T891
S
S
S
M
E
G
V
T
F
L
Q
A
K
Q
I
Site 74
Y921
I
I
Q
F
G
T
G
Y
K
E
L
F
S
Y
P
Site 75
Y927
G
Y
K
E
L
F
S
Y
P
K
H
I
T
S
N
Site 76
S933
S
Y
P
K
H
I
T
S
N
T
A
A
A
E
F
Site 77
T945
A
E
F
I
M
S
A
T
P
T
M
G
N
T
D
Site 78
T956
G
N
T
D
F
W
K
T
L
R
Y
L
S
L
L
Site 79
Y959
D
F
W
K
T
L
R
Y
L
S
L
L
Y
P
A
Site 80
S961
W
K
T
L
R
Y
L
S
L
L
Y
P
A
R
G
Site 81
Y964
L
R
Y
L
S
L
L
Y
P
A
R
G
S
R
N
Site 82
S976
S
R
N
I
L
L
V
S
D
G
H
L
Q
D
E
Site 83
S984
D
G
H
L
Q
D
E
S
L
T
L
Q
L
V
K
Site 84
T997
V
K
R
S
R
P
H
T
R
L
F
A
C
G
I
Site 85
Y1026
C
G
A
G
V
F
E
Y
F
N
A
K
S
K
H
Site 86
S1034
F
N
A
K
S
K
H
S
W
R
K
Q
I
E
D
Site 87
T1044
K
Q
I
E
D
Q
M
T
R
L
C
S
P
S
C
Site 88
S1048
D
Q
M
T
R
L
C
S
P
S
C
H
S
V
S
Site 89
S1050
M
T
R
L
C
S
P
S
C
H
S
V
S
V
K
Site 90
S1055
S
P
S
C
H
S
V
S
V
K
W
Q
Q
L
N
Site 91
Y1087
R
N
D
R
L
L
V
Y
G
F
I
P
H
C
T
Site 92
T1119
S
T
T
E
L
Q
K
T
T
G
T
M
I
H
K
Site 93
T1120
T
T
E
L
Q
K
T
T
G
T
M
I
H
K
L
Site 94
Y1136
A
R
A
L
I
R
D
Y
E
D
G
I
L
H
E
Site 95
S1157
M
K
K
Q
T
L
K
S
L
I
I
K
L
S
K
Site 96
S1167
I
K
L
S
K
E
N
S
L
I
T
Q
F
T
S
Site 97
T1173
N
S
L
I
T
Q
F
T
S
F
V
A
V
E
K
Site 98
S1174
S
L
I
T
Q
F
T
S
F
V
A
V
E
K
R
Site 99
S1186
E
K
R
D
E
N
E
S
P
F
P
D
I
P
K
Site 100
Y1208
E
D
V
D
F
L
P
Y
M
S
W
Q
G
E
P
Site 101
S1223
Q
E
A
V
R
N
Q
S
L
L
A
S
S
E
W
Site 102
S1227
R
N
Q
S
L
L
A
S
S
E
W
P
E
L
R
Site 103
S1228
N
Q
S
L
L
A
S
S
E
W
P
E
L
R
L
Site 104
S1236
E
W
P
E
L
R
L
S
K
R
K
H
R
K
I
Site 105
S1246
K
H
R
K
I
P
F
S
K
R
K
M
E
L
S
Site 106
S1253
S
K
R
K
M
E
L
S
Q
P
E
V
S
E
D
Site 107
S1288
V
E
K
L
L
D
L
S
W
T
E
S
C
K
P
Site 108
T1290
K
L
L
D
L
S
W
T
E
S
C
K
P
T
A
Site 109
S1292
L
D
L
S
W
T
E
S
C
K
P
T
A
T
E
Site 110
T1296
W
T
E
S
C
K
P
T
A
T
E
P
L
F
K
Site 111
S1306
E
P
L
F
K
K
V
S
P
W
E
T
S
T
S
Site 112
T1310
K
K
V
S
P
W
E
T
S
T
S
S
F
F
P
Site 113
S1311
K
V
S
P
W
E
T
S
T
S
S
F
F
P
I
Site 114
S1313
S
P
W
E
T
S
T
S
S
F
F
P
I
L
A
Site 115
S1314
P
W
E
T
S
T
S
S
F
F
P
I
L
A
P
Site 116
T1328
P
A
V
G
S
Y
L
T
P
T
T
R
A
H
S
Site 117
T1330
V
G
S
Y
L
T
P
T
T
R
A
H
S
P
A
Site 118
T1331
G
S
Y
L
T
P
T
T
R
A
H
S
P
A
S
Site 119
S1335
T
P
T
T
R
A
H
S
P
A
S
L
S
F
A
Site 120
S1338
T
R
A
H
S
P
A
S
L
S
F
A
S
Y
R
Site 121
S1340
A
H
S
P
A
S
L
S
F
A
S
Y
R
Q
V
Site 122
S1349
A
S
Y
R
Q
V
A
S
F
G
S
A
A
P
P
Site 123
S1362
P
P
R
Q
F
D
A
S
Q
F
S
Q
G
P
V
Site 124
S1365
Q
F
D
A
S
Q
F
S
Q
G
P
V
P
G
T
Site 125
T1372
S
Q
G
P
V
P
G
T
C
A
D
W
I
P
Q
Site 126
S1382
D
W
I
P
Q
S
A
S
C
P
T
G
P
P
Q
Site 127
S1393
G
P
P
Q
N
P
P
S
A
P
Y
C
G
I
V
Site 128
S1408
F
S
G
S
S
L
S
S
A
Q
S
A
P
L
Q
Site 129
S1411
S
S
L
S
S
A
Q
S
A
P
L
Q
H
P
G
Site 130
T1421
L
Q
H
P
G
G
F
T
T
R
P
S
A
G
T
Site 131
S1425
G
G
F
T
T
R
P
S
A
G
T
F
P
E
L
Site 132
T1428
T
T
R
P
S
A
G
T
F
P
E
L
D
S
P
Site 133
S1434
G
T
F
P
E
L
D
S
P
Q
L
H
F
S
L
Site 134
S1440
D
S
P
Q
L
H
F
S
L
P
T
D
P
D
P
Site 135
S1453
D
P
I
R
G
F
G
S
Y
H
P
S
A
Y
S
Site 136
Y1454
P
I
R
G
F
G
S
Y
H
P
S
A
Y
S
P
Site 137
Y1459
G
S
Y
H
P
S
A
Y
S
P
F
H
F
Q
P
Site 138
S1460
S
Y
H
P
S
A
Y
S
P
F
H
F
Q
P
S
Site 139
S1467
S
P
F
H
F
Q
P
S
A
A
S
L
T
A
N
Site 140
S1470
H
F
Q
P
S
A
A
S
L
T
A
N
L
R
L
Site 141
S1489
A
L
P
E
A
L
C
S
Q
S
R
T
T
P
V
Site 142
T1493
A
L
C
S
Q
S
R
T
T
P
V
D
L
C
L
Site 143
T1494
L
C
S
Q
S
R
T
T
P
V
D
L
C
L
L
Site 144
S1504
D
L
C
L
L
E
E
S
V
G
S
L
E
G
S
Site 145
S1507
L
L
E
E
S
V
G
S
L
E
G
S
R
C
P
Site 146
S1521
P
V
F
A
F
Q
S
S
D
T
E
S
D
E
L
Site 147
T1523
F
A
F
Q
S
S
D
T
E
S
D
E
L
S
E
Site 148
S1525
F
Q
S
S
D
T
E
S
D
E
L
S
E
V
L
Site 149
S1529
D
T
E
S
D
E
L
S
E
V
L
Q
D
S
C
Site 150
T1544
F
L
Q
I
K
C
D
T
K
D
D
S
I
P
C
Site 151
S1548
K
C
D
T
K
D
D
S
I
P
C
F
L
E
V
Site 152
T1574
W
Q
D
A
V
P
W
T
E
L
L
S
L
Q
T
Site 153
S1605
L
N
T
N
G
L
H
S
F
L
K
Q
K
G
I
Site 154
S1614
L
K
Q
K
G
I
Q
S
L
G
V
K
G
R
E
Site 155
T1629
C
L
L
D
L
I
A
T
M
L
V
L
Q
F
I
Site 156
S1649
K
E
G
I
V
F
K
S
L
M
K
M
D
D
P
Site 157
T1679
A
S
E
W
V
R
R
T
E
G
Q
Y
P
S
I
Site 158
Y1683
V
R
R
T
E
G
Q
Y
P
S
I
C
P
R
L
Site 159
S1685
R
T
E
G
Q
Y
P
S
I
C
P
R
L
E
L
Site 160
S1698
E
L
G
N
D
W
D
S
A
T
K
Q
L
L
G
Site 161
T1700
G
N
D
W
D
S
A
T
K
Q
L
L
G
L
Q
Site 162
S1713
L
Q
P
I
S
T
V
S
P
L
H
R
V
L
H
Site 163
Y1721
P
L
H
R
V
L
H
Y
S
Q
G
_
_
_
_
Site 164
S1722
L
H
R
V
L
H
Y
S
Q
G
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation