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Updated November 2019
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Protein Info
Short Name:
ADAMTS7
Full Name:
A disintegrin and metalloproteinase with thrombospondin motifs 7
Alias:
Type:
Mass (Da):
184095
Number AA:
1686
UniProt ID:
Q9UKP4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
P
G
G
P
S
P
R
S
P
A
P
L
Site 2
S9
P
G
G
P
S
P
R
S
P
A
P
L
L
R
P
Site 3
T37
G
P
A
P
G
R
A
T
E
G
R
A
A
L
D
Site 4
S59
D
A
G
G
S
F
L
S
Y
E
L
W
P
R
A
Site 5
S73
A
L
R
K
R
D
V
S
V
R
R
D
A
P
A
Site 6
Y82
R
R
D
A
P
A
F
Y
E
L
Q
Y
R
G
R
Site 7
Y86
P
A
F
Y
E
L
Q
Y
R
G
R
E
L
R
F
Site 8
T96
R
E
L
R
F
N
L
T
A
N
Q
H
L
L
A
Site 9
S108
L
L
A
P
G
F
V
S
E
T
R
R
R
G
G
Site 10
T110
A
P
G
F
V
S
E
T
R
R
R
G
G
L
G
Site 11
T125
R
A
H
I
R
A
H
T
P
A
C
H
L
L
G
Site 12
S159
L
K
G
V
F
Q
L
S
N
E
D
Y
F
I
E
Site 13
Y163
F
Q
L
S
N
E
D
Y
F
I
E
P
L
D
S
Site 14
S170
Y
F
I
E
P
L
D
S
A
P
A
R
P
G
H
Site 15
Y184
H
A
Q
P
H
V
V
Y
K
R
Q
A
P
E
R
Site 16
S198
R
L
A
Q
R
G
D
S
S
A
P
S
T
C
G
Site 17
S199
L
A
Q
R
G
D
S
S
A
P
S
T
C
G
V
Site 18
S202
R
G
D
S
S
A
P
S
T
C
G
V
Q
V
Y
Site 19
T203
G
D
S
S
A
P
S
T
C
G
V
Q
V
Y
P
Site 20
Y209
S
T
C
G
V
Q
V
Y
P
E
L
E
S
R
R
Site 21
S214
Q
V
Y
P
E
L
E
S
R
R
E
R
W
E
Q
Site 22
S237
L
R
R
L
H
Q
R
S
V
S
K
E
K
W
V
Site 23
S239
R
L
H
Q
R
S
V
S
K
E
K
W
V
E
T
Site 24
S373
C
Q
P
H
R
S
C
S
I
N
E
D
T
G
L
Site 25
S393
V
A
H
E
L
G
H
S
F
G
I
Q
H
D
G
Site 26
S401
F
G
I
Q
H
D
G
S
G
N
D
C
E
P
V
Site 27
S416
G
K
R
P
F
I
M
S
P
Q
L
L
Y
D
A
Site 28
T427
L
Y
D
A
A
P
L
T
W
S
R
C
S
R
Q
Site 29
Y435
W
S
R
C
S
R
Q
Y
I
T
R
F
L
D
R
Site 30
Y468
S
V
P
P
G
V
L
Y
D
V
S
H
Q
C
R
Site 31
Y478
S
H
Q
C
R
L
Q
Y
G
A
Y
S
A
F
C
Site 32
T514
L
D
A
A
V
D
G
T
R
C
G
E
N
K
W
Site 33
T566
Q
S
A
E
R
Q
C
T
Q
P
T
P
K
Y
K
Site 34
T569
E
R
Q
C
T
Q
P
T
P
K
Y
K
G
R
Y
Site 35
Y572
C
T
Q
P
T
P
K
Y
K
G
R
Y
C
V
G
Site 36
S598
A
C
P
A
G
R
P
S
F
R
H
V
Q
C
S
Site 37
Y612
S
H
F
D
A
M
L
Y
K
G
Q
L
H
T
W
Site 38
Y639
H
C
R
P
A
N
E
Y
F
A
E
K
L
R
D
Site 39
T652
R
D
A
V
V
D
G
T
P
C
Y
Q
V
R
A
Site 40
Y655
V
V
D
G
T
P
C
Y
Q
V
R
A
S
R
D
Site 41
T699
G
N
G
S
T
C
H
T
V
S
G
T
F
E
E
Site 42
S701
G
S
T
C
H
T
V
S
G
T
F
E
E
A
E
Site 43
T703
T
C
H
T
V
S
G
T
F
E
E
A
E
G
L
Site 44
S741
A
N
F
L
A
L
R
S
E
D
P
E
K
Y
F
Site 45
Y747
R
S
E
D
P
E
K
Y
F
L
N
G
G
W
T
Site 46
Y761
T
I
Q
W
N
G
D
Y
Q
V
A
G
T
T
F
Site 47
T769
Q
V
A
G
T
T
F
T
Y
A
R
R
G
N
W
Site 48
Y770
V
A
G
T
T
F
T
Y
A
R
R
G
N
W
E
Site 49
T780
R
G
N
W
E
N
L
T
S
P
G
P
T
K
E
Site 50
S781
G
N
W
E
N
L
T
S
P
G
P
T
K
E
P
Site 51
T785
N
L
T
S
P
G
P
T
K
E
P
V
W
I
Q
Site 52
S798
I
Q
L
L
F
Q
E
S
N
P
G
V
H
Y
E
Site 53
Y806
N
P
G
V
H
Y
E
Y
T
I
H
R
E
A
G
Site 54
T807
P
G
V
H
Y
E
Y
T
I
H
R
E
A
G
G
Site 55
S875
D
D
Q
Q
R
K
C
S
E
Q
P
C
P
A
R
Site 56
S892
A
G
E
W
Q
L
C
S
S
S
C
G
P
G
G
Site 57
S893
G
E
W
Q
L
C
S
S
S
C
G
P
G
G
L
Site 58
S894
E
W
Q
L
C
S
S
S
C
G
P
G
G
L
S
Site 59
T932
E
H
L
P
R
P
P
T
E
T
P
C
N
R
H
Site 60
T934
L
P
R
P
P
T
E
T
P
C
N
R
H
V
P
Site 61
T962
S
V
T
C
G
E
G
T
Q
R
R
N
V
L
C
Site 62
T970
Q
R
R
N
V
L
C
T
N
D
T
G
V
P
C
Site 63
T973
N
V
L
C
T
N
D
T
G
V
P
C
D
E
A
Site 64
S985
D
E
A
Q
Q
P
A
S
E
V
T
C
S
L
P
Site 65
T1000
L
C
R
W
P
L
G
T
L
G
P
E
G
S
G
Site 66
S1006
G
T
L
G
P
E
G
S
G
S
G
S
S
S
H
Site 67
S1008
L
G
P
E
G
S
G
S
G
S
S
S
H
E
L
Site 68
S1010
P
E
G
S
G
S
G
S
S
S
H
E
L
F
N
Site 69
S1012
G
S
G
S
G
S
S
S
H
E
L
F
N
E
A
Site 70
S1031
H
H
L
A
P
R
P
S
P
A
S
S
P
K
P
Site 71
S1034
A
P
R
P
S
P
A
S
S
P
K
P
G
T
M
Site 72
S1035
P
R
P
S
P
A
S
S
P
K
P
G
T
M
G
Site 73
Y1064
P
V
F
V
D
D
F
Y
Y
D
Y
N
F
I
N
Site 74
Y1067
V
D
D
F
Y
Y
D
Y
N
F
I
N
F
H
E
Site 75
S1077
I
N
F
H
E
D
L
S
Y
G
P
S
E
E
P
Site 76
Y1078
N
F
H
E
D
L
S
Y
G
P
S
E
E
P
D
Site 77
S1081
E
D
L
S
Y
G
P
S
E
E
P
D
L
D
L
Site 78
T1091
P
D
L
D
L
A
G
T
G
D
R
T
P
P
P
Site 79
T1095
L
A
G
T
G
D
R
T
P
P
P
H
S
H
P
Site 80
S1100
D
R
T
P
P
P
H
S
H
P
A
A
P
S
T
Site 81
S1106
H
S
H
P
A
A
P
S
T
G
S
P
V
P
A
Site 82
T1107
S
H
P
A
A
P
S
T
G
S
P
V
P
A
T
Site 83
S1109
P
A
A
P
S
T
G
S
P
V
P
A
T
E
P
Site 84
T1114
T
G
S
P
V
P
A
T
E
P
P
A
A
K
E
Site 85
S1129
E
G
V
L
G
P
W
S
P
S
P
W
P
S
Q
Site 86
S1131
V
L
G
P
W
S
P
S
P
W
P
S
Q
A
G
Site 87
S1135
W
S
P
S
P
W
P
S
Q
A
G
R
S
P
P
Site 88
S1140
W
P
S
Q
A
G
R
S
P
P
P
P
S
E
Q
Site 89
S1145
G
R
S
P
P
P
P
S
E
Q
T
P
G
N
P
Site 90
T1148
P
P
P
P
S
E
Q
T
P
G
N
P
L
I
N
Site 91
T1162
N
F
L
P
E
E
D
T
P
I
G
A
P
D
L
Site 92
S1173
A
P
D
L
G
L
P
S
L
S
W
P
R
V
S
Site 93
S1175
D
L
G
L
P
S
L
S
W
P
R
V
S
T
D
Site 94
S1180
S
L
S
W
P
R
V
S
T
D
G
L
Q
T
P
Site 95
T1181
L
S
W
P
R
V
S
T
D
G
L
Q
T
P
A
Site 96
T1186
V
S
T
D
G
L
Q
T
P
A
T
P
E
S
Q
Site 97
T1189
D
G
L
Q
T
P
A
T
P
E
S
Q
N
D
F
Site 98
S1192
Q
T
P
A
T
P
E
S
Q
N
D
F
P
V
G
Site 99
S1202
D
F
P
V
G
K
D
S
Q
S
Q
L
P
P
P
Site 100
S1204
P
V
G
K
D
S
Q
S
Q
L
P
P
P
W
R
Site 101
T1214
P
P
P
W
R
D
R
T
N
E
V
F
K
D
D
Site 102
S1237
P
H
L
P
P
R
P
S
S
T
L
P
P
L
S
Site 103
S1238
H
L
P
P
R
P
S
S
T
L
P
P
L
S
P
Site 104
T1239
L
P
P
R
P
S
S
T
L
P
P
L
S
P
V
Site 105
S1244
S
S
T
L
P
P
L
S
P
V
G
S
T
H
S
Site 106
S1248
P
P
L
S
P
V
G
S
T
H
S
S
P
S
P
Site 107
T1249
P
L
S
P
V
G
S
T
H
S
S
P
S
P
D
Site 108
S1251
S
P
V
G
S
T
H
S
S
P
S
P
D
V
A
Site 109
S1252
P
V
G
S
T
H
S
S
P
S
P
D
V
A
E
Site 110
S1254
G
S
T
H
S
S
P
S
P
D
V
A
E
L
W
Site 111
S1308
P
E
M
K
V
R
D
S
S
L
E
P
G
T
P
Site 112
S1309
E
M
K
V
R
D
S
S
L
E
P
G
T
P
S
Site 113
T1314
D
S
S
L
E
P
G
T
P
S
F
P
T
P
G
Site 114
S1316
S
L
E
P
G
T
P
S
F
P
T
P
G
P
G
Site 115
T1319
P
G
T
P
S
F
P
T
P
G
P
G
S
W
D
Site 116
S1324
F
P
T
P
G
P
G
S
W
D
L
Q
T
V
A
Site 117
S1362
G
P
K
G
Q
P
E
S
L
S
P
E
V
P
L
Site 118
S1364
K
G
Q
P
E
S
L
S
P
E
V
P
L
S
S
Site 119
S1370
L
S
P
E
V
P
L
S
S
R
L
L
S
T
P
Site 120
S1371
S
P
E
V
P
L
S
S
R
L
L
S
T
P
A
Site 121
S1375
P
L
S
S
R
L
L
S
T
P
A
W
D
S
P
Site 122
T1376
L
S
S
R
L
L
S
T
P
A
W
D
S
P
A
Site 123
S1381
L
S
T
P
A
W
D
S
P
A
N
S
H
R
V
Site 124
S1385
A
W
D
S
P
A
N
S
H
R
V
P
E
T
Q
Site 125
T1391
N
S
H
R
V
P
E
T
Q
P
L
A
P
S
L
Site 126
S1397
E
T
Q
P
L
A
P
S
L
A
E
A
G
P
P
Site 127
S1439
V
W
R
P
V
R
C
S
S
G
R
D
E
D
C
Site 128
S1440
W
R
P
V
R
C
S
S
G
R
D
E
D
C
A
Site 129
S1475
S
G
N
W
S
K
C
S
R
S
C
G
G
G
S
Site 130
S1477
N
W
S
K
C
S
R
S
C
G
G
G
S
S
V
Site 131
S1482
S
R
S
C
G
G
G
S
S
V
R
D
V
Q
C
Site 132
S1483
R
S
C
G
G
G
S
S
V
R
D
V
Q
C
V
Site 133
T1492
R
D
V
Q
C
V
D
T
R
D
L
R
P
L
R
Site 134
S1533
T
S
S
W
R
E
C
S
E
A
C
G
G
G
E
Site 135
T1546
G
E
Q
Q
R
L
V
T
C
P
E
P
G
L
C
Site 136
T1561
E
E
A
L
R
P
N
T
T
R
P
C
N
T
H
Site 137
S1608
T
G
L
P
E
E
D
S
D
Q
C
G
H
E
A
Site 138
S1619
G
H
E
A
W
P
E
S
S
R
P
C
G
T
E
Site 139
S1642
R
C
E
R
D
R
L
S
F
G
F
C
E
T
L
Site 140
S1667
I
R
T
Q
C
C
R
S
C
S
P
P
S
H
G
Site 141
S1669
T
Q
C
C
R
S
C
S
P
P
S
H
G
A
P
Site 142
S1672
C
R
S
C
S
P
P
S
H
G
A
P
S
R
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
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2019 Kinexus Bioinformatics Corporation