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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAMTS6
Full Name:
A disintegrin and metalloproteinase with thrombospondin motifs 6
Alias:
ADAM metallopeptidase with thrombospondin type 1 motif, 6; ADAM-TS 6; ADAM-TS6; ADAMTS-6; ATS6; EC 3.4.24.-
Type:
Mass (Da):
97107
Number AA:
860
UniProt ID:
Q9UKP5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
L
S
L
I
M
A
S
S
E
F
H
S
D
H
R
Site 2
S23
M
A
S
S
E
F
H
S
D
H
R
L
S
Y
S
Site 3
S28
F
H
S
D
H
R
L
S
Y
S
S
Q
E
E
F
Site 4
Y29
H
S
D
H
R
L
S
Y
S
S
Q
E
E
F
L
Site 5
S31
D
H
R
L
S
Y
S
S
Q
E
E
F
L
T
Y
Site 6
T37
S
S
Q
E
E
F
L
T
Y
L
E
H
Y
Q
L
Site 7
Y38
S
Q
E
E
F
L
T
Y
L
E
H
Y
Q
L
T
Site 8
Y42
F
L
T
Y
L
E
H
Y
Q
L
T
I
P
I
R
Site 9
T45
Y
L
E
H
Y
Q
L
T
I
P
I
R
V
D
Q
Site 10
S58
D
Q
N
G
A
F
L
S
F
T
V
K
N
D
K
Site 11
T60
N
G
A
F
L
S
F
T
V
K
N
D
K
H
S
Site 12
S67
T
V
K
N
D
K
H
S
R
R
R
R
S
M
D
Site 13
S72
K
H
S
R
R
R
R
S
M
D
P
I
D
P
Q
Site 14
S90
S
K
L
F
F
K
L
S
A
Y
G
K
H
F
H
Site 15
T101
K
H
F
H
L
N
L
T
L
N
T
D
F
V
S
Site 16
T104
H
L
N
L
T
L
N
T
D
F
V
S
K
H
F
Site 17
Y115
S
K
H
F
T
V
E
Y
W
G
K
D
G
P
Q
Site 18
Y133
D
F
L
D
N
C
H
Y
T
G
Y
L
Q
D
Q
Site 19
Y136
D
N
C
H
Y
T
G
Y
L
Q
D
Q
R
S
T
Site 20
S142
G
Y
L
Q
D
Q
R
S
T
T
K
V
A
L
S
Site 21
T143
Y
L
Q
D
Q
R
S
T
T
K
V
A
L
S
N
Site 22
T144
L
Q
D
Q
R
S
T
T
K
V
A
L
S
N
C
Site 23
Y165
I
A
T
E
D
E
E
Y
F
I
E
P
L
K
N
Site 24
T173
F
I
E
P
L
K
N
T
T
E
D
S
K
H
F
Site 25
S177
L
K
N
T
T
E
D
S
K
H
F
S
Y
E
N
Site 26
S181
T
E
D
S
K
H
F
S
Y
E
N
G
H
P
H
Site 27
Y182
E
D
S
K
H
F
S
Y
E
N
G
H
P
H
V
Site 28
Y191
N
G
H
P
H
V
I
Y
K
K
S
A
L
Q
Q
Site 29
S194
P
H
V
I
Y
K
K
S
A
L
Q
Q
R
H
L
Site 30
Y202
A
L
Q
Q
R
H
L
Y
D
H
S
H
C
G
V
Site 31
T224
K
P
W
W
L
N
D
T
S
T
V
S
Y
S
L
Site 32
T226
W
W
L
N
D
T
S
T
V
S
Y
S
L
P
I
Site 33
S228
L
N
D
T
S
T
V
S
Y
S
L
P
I
N
N
Site 34
Y229
N
D
T
S
T
V
S
Y
S
L
P
I
N
N
T
Site 35
S230
D
T
S
T
V
S
Y
S
L
P
I
N
N
T
H
Site 36
S245
I
H
H
R
Q
K
R
S
V
S
I
E
R
F
V
Site 37
S247
H
R
Q
K
R
S
V
S
I
E
R
F
V
E
T
Site 38
Y286
M
N
I
V
A
K
L
Y
R
D
S
S
L
G
N
Site 39
S289
V
A
K
L
Y
R
D
S
S
L
G
N
V
V
N
Site 40
S290
A
K
L
Y
R
D
S
S
L
G
N
V
V
N
I
Site 41
S324
H
A
D
K
S
L
D
S
F
C
K
W
Q
K
S
Site 42
S334
K
W
Q
K
S
I
L
S
H
Q
S
D
G
N
T
Site 43
T341
S
H
Q
S
D
G
N
T
I
P
E
N
G
I
A
Site 44
S388
C
E
P
E
R
S
C
S
I
N
E
D
I
G
L
Site 45
S397
N
E
D
I
G
L
G
S
A
F
T
I
A
H
E
Site 46
T439
A
A
H
I
T
A
N
T
N
P
F
S
W
S
A
Site 47
S443
T
A
N
T
N
P
F
S
W
S
A
C
S
R
D
Site 48
Y451
W
S
A
C
S
R
D
Y
I
T
S
F
L
D
S
Site 49
T453
A
C
S
R
D
Y
I
T
S
F
L
D
S
G
R
Site 50
S454
C
S
R
D
Y
I
T
S
F
L
D
S
G
R
G
Site 51
S458
Y
I
T
S
F
L
D
S
G
R
G
T
C
L
D
Site 52
T462
F
L
D
S
G
R
G
T
C
L
D
N
E
P
P
Site 53
Y475
P
P
K
R
D
F
L
Y
P
A
V
A
P
G
Q
Site 54
Y484
A
V
A
P
G
Q
V
Y
D
A
D
E
Q
C
R
Site 55
Y494
D
E
Q
C
R
F
Q
Y
G
A
T
S
R
Q
C
Site 56
Y503
A
T
S
R
Q
C
K
Y
G
E
V
C
R
E
L
Site 57
T521
S
K
S
N
R
C
V
T
N
S
I
P
A
A
E
Site 58
S523
S
N
R
C
V
T
N
S
I
P
A
A
E
G
T
Site 59
T573
L
W
G
E
C
S
R
T
C
G
G
G
V
S
S
Site 60
S579
R
T
C
G
G
G
V
S
S
S
L
R
H
C
D
Site 61
S580
T
C
G
G
G
V
S
S
S
L
R
H
C
D
S
Site 62
S581
C
G
G
G
V
S
S
S
L
R
H
C
D
S
P
Site 63
S587
S
S
L
R
H
C
D
S
P
A
P
S
G
G
G
Site 64
S591
H
C
D
S
P
A
P
S
G
G
G
K
Y
C
L
Site 65
Y596
A
P
S
G
G
G
K
Y
C
L
G
E
R
K
R
Site 66
Y604
C
L
G
E
R
K
R
Y
R
S
C
N
T
D
P
Site 67
S606
G
E
R
K
R
Y
R
S
C
N
T
D
P
C
P
Site 68
Y636
N
M
P
F
R
G
K
Y
Y
N
W
K
P
Y
T
Site 69
Y662
L
A
E
G
Y
N
F
Y
T
E
R
A
P
A
V
Site 70
S699
G
C
D
N
I
L
G
S
D
A
R
E
D
R
C
Site 71
S714
R
V
C
G
G
D
G
S
T
C
D
A
I
E
G
Site 72
S726
I
E
G
F
F
N
D
S
L
P
R
G
G
Y
M
Site 73
Y732
D
S
L
P
R
G
G
Y
M
E
V
V
Q
I
P
Site 74
S742
V
V
Q
I
P
R
G
S
V
H
I
E
V
R
E
Site 75
S753
E
V
R
E
V
A
M
S
K
N
Y
I
A
L
K
Site 76
Y766
L
K
S
E
G
D
D
Y
Y
I
N
G
A
W
T
Site 77
Y767
K
S
E
G
D
D
Y
Y
I
N
G
A
W
T
I
Site 78
Y789
V
A
G
T
A
F
H
Y
K
R
P
T
D
E
P
Site 79
T793
A
F
H
Y
K
R
P
T
D
E
P
E
S
L
E
Site 80
S798
R
P
T
D
E
P
E
S
L
E
A
L
G
P
T
Site 81
T831
Y
K
F
N
V
P
I
T
R
T
G
S
G
D
N
Site 82
S835
V
P
I
T
R
T
G
S
G
D
N
E
V
G
F
Site 83
T855
P
W
S
E
C
S
A
T
C
A
G
G
V
Q
R
Site 84
Y880
N
S
I
V
Q
N
N
Y
C
D
P
D
S
K
P
Site 85
S885
N
N
Y
C
D
P
D
S
K
P
P
E
N
Q
R
Site 86
S933
C
I
R
K
I
G
P
S
E
E
E
T
L
D
Y
Site 87
T937
I
G
P
S
E
E
E
T
L
D
Y
S
G
C
L
Site 88
Y940
S
E
E
E
T
L
D
Y
S
G
C
L
T
H
R
Site 89
S941
E
E
E
T
L
D
Y
S
G
C
L
T
H
R
P
Site 90
T945
L
D
Y
S
G
C
L
T
H
R
P
V
E
K
E
Site 91
T972
A
L
D
W
S
E
C
T
P
K
C
G
P
G
F
Site 92
S988
H
R
I
V
L
C
K
S
S
D
L
S
K
T
F
Site 93
S992
L
C
K
S
S
D
L
S
K
T
F
P
A
A
Q
Site 94
T994
K
S
S
D
L
S
K
T
F
P
A
A
Q
C
P
Site 95
S1013
P
P
V
R
I
R
C
S
L
G
R
C
P
P
P
Site 96
T1042
G
L
G
Q
Q
M
R
T
V
Q
C
L
S
Y
T
Site 97
S1047
M
R
T
V
Q
C
L
S
Y
T
G
Q
A
S
S
Site 98
Y1048
R
T
V
Q
C
L
S
Y
T
G
Q
A
S
S
D
Site 99
S1054
S
Y
T
G
Q
A
S
S
D
C
L
E
T
V
R
Site 100
T1059
A
S
S
D
C
L
E
T
V
R
P
P
S
M
Q
Site 101
S1064
L
E
T
V
R
P
P
S
M
Q
Q
C
E
S
K
Site 102
S1070
P
S
M
Q
Q
C
E
S
K
C
D
S
T
P
I
Site 103
S1074
Q
C
E
S
K
C
D
S
T
P
I
S
N
T
E
Site 104
T1075
C
E
S
K
C
D
S
T
P
I
S
N
T
E
E
Site 105
S1078
K
C
D
S
T
P
I
S
N
T
E
E
C
K
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation