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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PACSIN3
Full Name:
Protein kinase C and casein kinase substrate in neurons protein 3
Alias:
Endophilin I; PACN3; Protein kinase C and casein kinase substrate in neurons 3; SDPIII; SH3 domain-containing protein 6511; Syndapin III
Type:
Vesicle protein; Adaptor/scaffold
Mass (Da):
48487
Number AA:
424
UniProt ID:
Q9UKS6
International Prot ID:
IPI00783170
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0008092
GO:0019899
GO:0008092
PhosphoSite+
KinaseNET
Biological Process:
GO:0006897
GO:0045806
GO:0051044
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
G
G
E
A
L
G
G
S
F
W
E
A
G
N
Y
Site 2
Y22
S
F
W
E
A
G
N
Y
R
R
T
V
Q
R
V
Site 3
T25
E
A
G
N
Y
R
R
T
V
Q
R
V
E
D
G
Site 4
S41
R
L
C
G
D
L
V
S
C
F
Q
E
R
A
R
Site 5
Y53
R
A
R
I
E
K
A
Y
A
Q
Q
L
A
D
W
Site 6
T67
W
A
R
K
W
R
G
T
V
E
K
G
P
Q
Y
Site 7
Y74
T
V
E
K
G
P
Q
Y
G
T
L
E
K
A
W
Site 8
T76
E
K
G
P
Q
Y
G
T
L
E
K
A
W
H
A
Site 9
S107
E
K
L
Q
G
Q
D
S
E
R
V
R
A
W
Q
Site 10
S129
V
L
G
G
F
R
E
S
R
A
A
E
D
G
F
Site 11
S153
R
L
K
E
V
E
A
S
K
K
S
Y
H
A
A
Site 12
T166
A
A
R
K
D
E
K
T
A
Q
T
R
E
S
H
Site 13
S172
K
T
A
Q
T
R
E
S
H
A
K
A
D
S
A
Site 14
S178
E
S
H
A
K
A
D
S
A
V
S
Q
E
Q
L
Site 15
S181
A
K
A
D
S
A
V
S
Q
E
Q
L
R
K
L
Site 16
T202
C
A
K
E
A
E
K
T
K
A
Q
Y
E
Q
T
Site 17
Y216
T
L
A
E
L
H
R
Y
T
P
R
Y
M
E
D
Site 18
T217
L
A
E
L
H
R
Y
T
P
R
Y
M
E
D
M
Site 19
Y220
L
H
R
Y
T
P
R
Y
M
E
D
M
E
Q
A
Site 20
S256
L
H
Q
H
L
D
L
S
S
S
E
K
F
H
E
Site 21
S257
H
Q
H
L
D
L
S
S
S
E
K
F
H
E
L
Site 22
S258
Q
H
L
D
L
S
S
S
E
K
F
H
E
L
H
Site 23
S276
H
Q
G
I
E
A
A
S
D
E
E
D
L
R
W
Site 24
S303
W
P
Q
F
E
E
W
S
L
D
T
Q
R
T
I
Site 25
T306
F
E
E
W
S
L
D
T
Q
R
T
I
S
R
K
Site 26
T309
W
S
L
D
T
Q
R
T
I
S
R
K
E
K
G
Site 27
S311
L
D
T
Q
R
T
I
S
R
K
E
K
G
G
R
Site 28
S319
R
K
E
K
G
G
R
S
P
D
E
V
T
L
T
Site 29
T324
G
R
S
P
D
E
V
T
L
T
S
I
V
P
T
Site 30
T326
S
P
D
E
V
T
L
T
S
I
V
P
T
R
D
Site 31
S327
P
D
E
V
T
L
T
S
I
V
P
T
R
D
G
Site 32
T335
I
V
P
T
R
D
G
T
A
P
P
P
Q
S
P
Site 33
S341
G
T
A
P
P
P
Q
S
P
G
S
P
G
T
G
Site 34
S344
P
P
P
Q
S
P
G
S
P
G
T
G
Q
D
E
Site 35
T347
Q
S
P
G
S
P
G
T
G
Q
D
E
E
W
S
Site 36
S354
T
G
Q
D
E
E
W
S
D
E
E
S
P
R
K
Site 37
S358
E
E
W
S
D
E
E
S
P
R
K
A
A
T
G
Site 38
Y372
G
V
R
V
R
A
L
Y
D
Y
A
G
Q
E
A
Site 39
Y374
R
V
R
A
L
Y
D
Y
A
G
Q
E
A
D
E
Site 40
S383
G
Q
E
A
D
E
L
S
F
R
A
G
E
E
L
Site 41
S394
G
E
E
L
L
K
M
S
E
E
D
E
Q
G
W
Site 42
Y414
Q
S
G
R
I
G
L
Y
P
A
N
Y
V
E
C
Site 43
Y418
I
G
L
Y
P
A
N
Y
V
E
C
V
G
A
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation