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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IKZF2
Full Name:
Ikaros family zinc finger protein 2
Alias:
HELI; HELIOS; Zinc finger protein Helios; ZNFN1A2
Type:
Transcription factor
Mass (Da):
59574
Number AA:
526
UniProt ID:
Q9UKS7
International Prot ID:
IPI00007757
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
E
T
E
A
I
D
G
Y
I
T
C
D
N
E
L
Site 2
S17
I
T
C
D
N
E
L
S
P
E
R
E
H
S
N
Site 3
S23
L
S
P
E
R
E
H
S
N
M
A
I
D
L
T
Site 4
T30
S
N
M
A
I
D
L
T
S
S
T
P
N
G
Q
Site 5
S31
N
M
A
I
D
L
T
S
S
T
P
N
G
Q
H
Site 6
S32
M
A
I
D
L
T
S
S
T
P
N
G
Q
H
A
Site 7
T33
A
I
D
L
T
S
S
T
P
N
G
Q
H
A
S
Site 8
S40
T
P
N
G
Q
H
A
S
P
S
H
M
T
S
T
Site 9
S42
N
G
Q
H
A
S
P
S
H
M
T
S
T
N
S
Site 10
S46
A
S
P
S
H
M
T
S
T
N
S
V
K
L
E
Site 11
T47
S
P
S
H
M
T
S
T
N
S
V
K
L
E
M
Site 12
S49
S
H
M
T
S
T
N
S
V
K
L
E
M
Q
S
Site 13
S56
S
V
K
L
E
M
Q
S
D
E
E
C
D
R
K
Site 14
S66
E
C
D
R
K
P
L
S
R
E
D
E
I
R
G
Site 15
S78
I
R
G
H
D
E
G
S
S
L
E
E
P
L
I
Site 16
S79
R
G
H
D
E
G
S
S
L
E
E
P
L
I
E
Site 17
T135
M
V
H
K
R
S
H
T
G
E
R
P
F
H
C
Site 18
Y175
F
K
C
P
F
C
S
Y
A
C
R
R
R
D
A
Site 19
T184
C
R
R
R
D
A
L
T
G
H
L
R
T
H
S
Site 20
S191
T
G
H
L
R
T
H
S
V
G
K
P
H
K
C
Site 21
Y200
G
K
P
H
K
C
N
Y
C
G
R
S
Y
K
Q
Site 22
Y205
C
N
Y
C
G
R
S
Y
K
Q
R
S
S
L
E
Site 23
S210
R
S
Y
K
Q
R
S
S
L
E
E
H
K
E
R
Site 24
Y221
H
K
E
R
C
H
N
Y
L
Q
N
V
S
M
E
Site 25
S235
E
A
A
G
Q
V
M
S
H
H
V
P
P
M
E
Site 26
S256
P
I
M
D
N
N
I
S
L
V
P
F
E
R
P
Site 27
S278
G
N
M
G
K
R
K
S
S
T
P
Q
K
F
V
Site 28
S279
N
M
G
K
R
K
S
S
T
P
Q
K
F
V
G
Site 29
T280
M
G
K
R
K
S
S
T
P
Q
K
F
V
G
E
Site 30
S293
G
E
K
L
M
R
F
S
Y
P
D
I
H
F
D
Site 31
Y294
E
K
L
M
R
F
S
Y
P
D
I
H
F
D
M
Site 32
S342
P
L
M
Q
H
P
P
S
T
I
A
E
V
A
P
Site 33
Y355
A
P
V
I
S
S
A
Y
S
Q
V
Y
H
P
N
Site 34
S356
P
V
I
S
S
A
Y
S
Q
V
Y
H
P
N
R
Site 35
Y359
S
S
A
Y
S
Q
V
Y
H
P
N
R
I
E
R
Site 36
S369
N
R
I
E
R
P
I
S
R
E
T
A
D
S
H
Site 37
T372
E
R
P
I
S
R
E
T
A
D
S
H
E
N
N
Site 38
S375
I
S
R
E
T
A
D
S
H
E
N
N
M
D
G
Site 39
S385
N
N
M
D
G
P
I
S
L
I
R
P
K
S
R
Site 40
S391
I
S
L
I
R
P
K
S
R
P
Q
E
R
E
A
Site 41
S399
R
P
Q
E
R
E
A
S
P
S
N
S
C
L
D
Site 42
S401
Q
E
R
E
A
S
P
S
N
S
C
L
D
S
T
Site 43
S403
R
E
A
S
P
S
N
S
C
L
D
S
T
D
S
Site 44
S407
P
S
N
S
C
L
D
S
T
D
S
E
S
S
H
Site 45
T408
S
N
S
C
L
D
S
T
D
S
E
S
S
H
D
Site 46
S410
S
C
L
D
S
T
D
S
E
S
S
H
D
D
H
Site 47
S412
L
D
S
T
D
S
E
S
S
H
D
D
H
Q
S
Site 48
S413
D
S
T
D
S
E
S
S
H
D
D
H
Q
S
Y
Site 49
S419
S
S
H
D
D
H
Q
S
Y
Q
G
H
P
A
L
Site 50
S433
L
N
P
K
R
K
Q
S
P
A
Y
M
K
E
D
Site 51
T447
D
V
K
A
L
D
T
T
K
A
P
K
G
S
L
Site 52
Y458
K
G
S
L
K
D
I
Y
K
V
F
N
G
E
G
Site 53
T487
F
L
D
H
V
M
Y
T
I
H
M
G
C
H
G
Site 54
Y512
G
Y
R
S
Q
D
R
Y
E
F
S
S
H
I
V
Site 55
S516
Q
D
R
Y
E
F
S
S
H
I
V
R
G
E
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation