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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HDAC9
Full Name:
Histone deacetylase 9
Alias:
EC 3.5.1.98; HD7; HD7B; HD9; HDAC7B; HDRP; Histone deacetylase-related protein; KIAA0744; MEF2-interacting transcription repressor MITR; MITR
Type:
Histone deacetylase complex, Cytoplasm protein
Mass (Da):
111297
Number AA:
1011
UniProt ID:
Q9UKV0
International Prot ID:
IPI00232519
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0000118
GO:0035097
Uniprot
OncoNet
Molecular Function:
GO:0004407
GO:0042826
GO:0016566
PhosphoSite+
KinaseNET
Biological Process:
GO:0030183
GO:0032869
GO:0007507
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
H
S
M
I
S
S
V
D
V
K
S
E
V
Site 2
S22
P
V
G
L
E
P
I
S
P
L
D
L
R
T
D
Site 3
T28
I
S
P
L
D
L
R
T
D
L
R
M
M
M
P
Site 4
T141
R
E
R
A
V
A
S
T
E
V
K
Q
K
L
Q
Site 5
S153
K
L
Q
E
F
L
L
S
K
S
A
T
K
D
T
Site 6
S155
Q
E
F
L
L
S
K
S
A
T
K
D
T
P
T
Site 7
T157
F
L
L
S
K
S
A
T
K
D
T
P
T
N
G
Site 8
T160
S
K
S
A
T
K
D
T
P
T
N
G
K
N
H
Site 9
T162
S
A
T
K
D
T
P
T
N
G
K
N
H
S
V
Site 10
S168
P
T
N
G
K
N
H
S
V
S
R
H
P
K
L
Site 11
S170
N
G
K
N
H
S
V
S
R
H
P
K
L
W
Y
Site 12
Y177
S
R
H
P
K
L
W
Y
T
A
A
H
H
T
S
Site 13
S184
Y
T
A
A
H
H
T
S
L
D
Q
S
S
P
P
Site 14
S188
H
H
T
S
L
D
Q
S
S
P
P
L
S
G
T
Site 15
S189
H
T
S
L
D
Q
S
S
P
P
L
S
G
T
S
Site 16
S193
D
Q
S
S
P
P
L
S
G
T
S
P
S
Y
K
Site 17
T195
S
S
P
P
L
S
G
T
S
P
S
Y
K
Y
T
Site 18
S196
S
P
P
L
S
G
T
S
P
S
Y
K
Y
T
L
Site 19
S198
P
L
S
G
T
S
P
S
Y
K
Y
T
L
P
G
Site 20
Y199
L
S
G
T
S
P
S
Y
K
Y
T
L
P
G
A
Site 21
Y201
G
T
S
P
S
Y
K
Y
T
L
P
G
A
Q
D
Site 22
T202
T
S
P
S
Y
K
Y
T
L
P
G
A
Q
D
A
Site 23
T218
D
D
F
P
L
R
K
T
A
S
E
P
N
L
K
Site 24
S220
F
P
L
R
K
T
A
S
E
P
N
L
K
V
R
Site 25
S239
Q
K
V
A
E
R
R
S
S
P
L
L
R
R
K
Site 26
S240
K
V
A
E
R
R
S
S
P
L
L
R
R
K
D
Site 27
S253
K
D
G
N
V
V
T
S
F
K
K
R
M
F
E
Site 28
T262
K
K
R
M
F
E
V
T
E
S
S
V
S
S
S
Site 29
S264
R
M
F
E
V
T
E
S
S
V
S
S
S
S
P
Site 30
S265
M
F
E
V
T
E
S
S
V
S
S
S
S
P
G
Site 31
S267
E
V
T
E
S
S
V
S
S
S
S
P
G
S
G
Site 32
S268
V
T
E
S
S
V
S
S
S
S
P
G
S
G
P
Site 33
S269
T
E
S
S
V
S
S
S
S
P
G
S
G
P
S
Site 34
S270
E
S
S
V
S
S
S
S
P
G
S
G
P
S
S
Site 35
S273
V
S
S
S
S
P
G
S
G
P
S
S
P
N
N
Site 36
S276
S
S
P
G
S
G
P
S
S
P
N
N
G
P
T
Site 37
S277
S
P
G
S
G
P
S
S
P
N
N
G
P
T
G
Site 38
S285
P
N
N
G
P
T
G
S
V
T
E
N
E
T
S
Site 39
T287
N
G
P
T
G
S
V
T
E
N
E
T
S
V
L
Site 40
S292
S
V
T
E
N
E
T
S
V
L
P
P
T
P
H
Site 41
T297
E
T
S
V
L
P
P
T
P
H
A
E
Q
M
V
Site 42
S305
P
H
A
E
Q
M
V
S
Q
Q
R
I
L
I
H
Site 43
S320
E
D
S
M
N
L
L
S
L
Y
T
S
P
S
L
Site 44
Y322
S
M
N
L
L
S
L
Y
T
S
P
S
L
P
N
Site 45
S339
L
G
L
P
A
V
P
S
Q
L
N
A
S
N
S
Site 46
S344
V
P
S
Q
L
N
A
S
N
S
L
K
E
K
Q
Site 47
S346
S
Q
L
N
A
S
N
S
L
K
E
K
Q
K
C
Site 48
S371
L
P
G
Q
Y
G
G
S
I
P
A
S
S
S
H
Site 49
S375
Y
G
G
S
I
P
A
S
S
S
H
P
H
V
T
Site 50
S376
G
G
S
I
P
A
S
S
S
H
P
H
V
T
L
Site 51
S377
G
S
I
P
A
S
S
S
H
P
H
V
T
L
E
Site 52
T382
S
S
S
H
P
H
V
T
L
E
G
K
P
P
N
Site 53
S390
L
E
G
K
P
P
N
S
S
H
Q
A
L
L
Q
Site 54
S422
G
V
P
L
H
P
Q
S
P
L
A
T
K
E
R
Site 55
T426
H
P
Q
S
P
L
A
T
K
E
R
I
S
P
G
Site 56
S431
L
A
T
K
E
R
I
S
P
G
I
R
G
T
H
Site 57
T437
I
S
P
G
I
R
G
T
H
K
L
P
R
H
R
Site 58
T449
R
H
R
P
L
N
R
T
Q
S
A
P
L
P
Q
Site 59
S451
R
P
L
N
R
T
Q
S
A
P
L
P
Q
S
T
Site 60
S489
I
H
M
N
K
L
L
S
K
S
I
E
Q
L
K
Site 61
S491
M
N
K
L
L
S
K
S
I
E
Q
L
K
Q
P
Site 62
S500
E
Q
L
K
Q
P
G
S
H
L
E
E
A
E
E
Site 63
S522
M
Q
E
D
R
A
P
S
S
G
N
S
T
R
S
Site 64
S523
Q
E
D
R
A
P
S
S
G
N
S
T
R
S
D
Site 65
S526
R
A
P
S
S
G
N
S
T
R
S
D
S
S
A
Site 66
T527
A
P
S
S
G
N
S
T
R
S
D
S
S
A
C
Site 67
S529
S
S
G
N
S
T
R
S
D
S
S
A
C
V
D
Site 68
S531
G
N
S
T
R
S
D
S
S
A
C
V
D
D
T
Site 69
S532
N
S
T
R
S
D
S
S
A
C
V
D
D
T
L
Site 70
S554
V
K
E
E
P
V
D
S
D
E
D
A
Q
I
Q
Site 71
T580
Q
Q
P
F
L
E
P
T
H
T
R
A
L
S
V
Site 72
T582
P
F
L
E
P
T
H
T
R
A
L
S
V
R
Q
Site 73
S586
P
T
H
T
R
A
L
S
V
R
Q
A
P
L
A
Site 74
S607
L
E
K
H
R
L
V
S
R
T
H
S
S
P
A
Site 75
T609
K
H
R
L
V
S
R
T
H
S
S
P
A
A
S
Site 76
S611
R
L
V
S
R
T
H
S
S
P
A
A
S
V
L
Site 77
S612
L
V
S
R
T
H
S
S
P
A
A
S
V
L
P
Site 78
S616
T
H
S
S
P
A
A
S
V
L
P
H
P
A
M
Site 79
S631
D
R
P
L
Q
P
G
S
A
T
G
I
A
Y
D
Site 80
S663
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
Site 81
S686
R
I
Q
G
R
K
A
S
L
E
E
I
Q
L
V
Site 82
S695
E
E
I
Q
L
V
H
S
E
H
H
S
L
L
Y
Site 83
S699
L
V
H
S
E
H
H
S
L
L
Y
G
T
N
P
Site 84
Y702
S
E
H
H
S
L
L
Y
G
T
N
P
L
D
G
Site 85
S722
R
I
L
L
G
D
D
S
Q
K
F
F
S
S
L
Site 86
S727
D
D
S
Q
K
F
F
S
S
L
P
C
G
G
L
Site 87
S728
D
S
Q
K
F
F
S
S
L
P
C
G
G
L
G
Site 88
S738
C
G
G
L
G
V
D
S
D
T
I
W
N
E
L
Site 89
T740
G
L
G
V
D
S
D
T
I
W
N
E
L
H
S
Site 90
S767
E
L
A
S
K
V
A
S
G
E
L
K
N
G
F
Site 91
Y832
N
G
T
Q
Q
A
F
Y
A
D
P
S
I
L
Y
Site 92
Y839
Y
A
D
P
S
I
L
Y
I
S
L
H
R
Y
D
Site 93
S841
D
P
S
I
L
Y
I
S
L
H
R
Y
D
E
G
Site 94
Y845
L
Y
I
S
L
H
R
Y
D
E
G
N
F
F
P
Site 95
S854
E
G
N
F
F
P
G
S
G
A
P
N
E
V
G
Site 96
Y887
P
P
M
G
D
V
E
Y
L
E
A
F
R
T
I
Site 97
T893
E
Y
L
E
A
F
R
T
I
V
K
P
V
A
K
Site 98
T920
F
D
A
L
E
G
H
T
P
P
L
G
G
Y
K
Site 99
T959
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
Site 100
S988
A
E
D
I
L
H
Q
S
P
N
M
N
A
V
I
Site 101
S1005
Q
K
I
I
E
I
Q
S
M
S
L
K
F
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation