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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYH2
Full Name:
Myosin-2
Alias:
MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2; Myosin heavy chain 2; Myosin heavy chain 2a; Myosin heavy chain IIa; Myosin heavy chain, skeletal muscle, adult 2; Myosin, heavy chain 2, skeletal muscle, adult
Type:
Motor protein
Mass (Da):
223044
Number AA:
1941
UniProt ID:
Q9UKX2
International Prot ID:
IPI00007856
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005925
GO:0005859
GO:0032982
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003779
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0030049
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
D
S
E
L
A
V
Site 2
S3
_
_
_
_
_
M
S
S
D
S
E
L
A
V
F
Site 3
S20
A
A
P
F
L
R
K
S
E
R
E
R
I
E
A
Site 4
T36
N
R
P
F
D
A
K
T
S
V
F
V
A
E
P
Site 5
S46
F
V
A
E
P
K
E
S
F
V
K
G
T
I
Q
Site 6
T61
S
R
E
G
G
K
V
T
V
K
T
E
G
G
A
Site 7
T64
G
G
K
V
T
V
K
T
E
G
G
A
T
L
T
Site 8
T69
V
K
T
E
G
G
A
T
L
T
V
K
D
D
Q
Site 9
T71
T
E
G
G
A
T
L
T
V
K
D
D
Q
V
F
Site 10
Y85
F
P
M
N
P
P
K
Y
D
K
I
E
D
M
A
Site 11
Y104
L
H
E
P
A
V
L
Y
N
L
K
E
R
Y
A
Site 12
Y135
P
Y
K
W
L
P
V
Y
K
P
E
V
V
T
A
Site 13
S157
E
A
P
P
H
I
F
S
I
S
D
N
A
Y
Q
Site 14
Y163
F
S
I
S
D
N
A
Y
Q
F
M
L
T
D
R
Site 15
T168
N
A
Y
Q
F
M
L
T
D
R
E
N
Q
S
I
Site 16
T178
E
N
Q
S
I
L
I
T
G
E
S
G
A
G
K
Site 17
T186
G
E
S
G
A
G
K
T
V
N
T
K
R
V
I
Site 18
T189
G
A
G
K
T
V
N
T
K
R
V
I
Q
Y
F
Site 19
T218
T
S
G
K
I
Q
G
T
L
E
D
Q
I
I
S
Site 20
T238
E
A
F
G
N
A
K
T
V
R
N
D
N
S
S
Site 21
S244
K
T
V
R
N
D
N
S
S
R
F
G
K
F
I
Site 22
S245
T
V
R
N
D
N
S
S
R
F
G
K
F
I
R
Site 23
S263
G
T
T
G
K
L
A
S
A
D
I
E
T
Y
L
Site 24
Y269
A
S
A
D
I
E
T
Y
L
L
E
K
S
R
V
Site 25
S274
E
T
Y
L
L
E
K
S
R
V
V
F
Q
L
K
Site 26
Y286
Q
L
K
A
E
R
S
Y
H
I
F
Y
Q
I
T
Site 27
Y290
E
R
S
Y
H
I
F
Y
Q
I
T
S
N
K
K
Site 28
Y311
L
L
I
T
T
N
P
Y
D
Y
P
F
V
S
Q
Site 29
Y313
I
T
T
N
P
Y
D
Y
P
F
V
S
Q
G
E
Site 30
S317
P
Y
D
Y
P
F
V
S
Q
G
E
I
S
V
A
Site 31
S322
F
V
S
Q
G
E
I
S
V
A
S
I
D
D
Q
Site 32
S325
Q
G
E
I
S
V
A
S
I
D
D
Q
E
E
L
Site 33
T335
D
Q
E
E
L
M
A
T
D
S
A
I
D
I
L
Site 34
T381
E
Q
A
E
P
D
G
T
E
V
A
D
K
A
A
Site 35
Y389
E
V
A
D
K
A
A
Y
L
Q
S
L
N
S
A
Site 36
S392
D
K
A
A
Y
L
Q
S
L
N
S
A
D
L
L
Site 37
Y404
D
L
L
K
A
L
C
Y
P
R
V
K
V
G
N
Site 38
Y413
R
V
K
V
G
N
E
Y
V
T
K
G
Q
T
V
Site 39
T415
K
V
G
N
E
Y
V
T
K
G
Q
T
V
E
Q
Site 40
T452
R
I
N
Q
Q
L
D
T
K
Q
P
R
Q
Y
F
Site 41
Y458
D
T
K
Q
P
R
Q
Y
F
I
G
V
L
D
I
Site 42
T484
E
Q
L
C
I
N
F
T
N
E
K
L
Q
Q
F
Site 43
Y504
F
V
L
E
Q
E
E
Y
K
K
E
G
I
E
W
Site 44
S535
E
K
P
M
G
I
F
S
I
L
E
E
E
C
M
Site 45
S550
F
P
K
A
T
D
T
S
F
K
N
K
L
Y
D
Site 46
Y556
T
S
F
K
N
K
L
Y
D
Q
H
L
G
K
S
Site 47
Y591
H
Y
A
G
V
V
D
Y
N
I
T
G
W
L
E
Site 48
T607
N
K
D
P
L
N
E
T
V
V
G
L
Y
Q
K
Site 49
Y612
N
E
T
V
V
G
L
Y
Q
K
S
A
M
K
T
Site 50
T619
Y
Q
K
S
A
M
K
T
L
A
Q
L
F
S
G
Site 51
S625
K
T
L
A
Q
L
F
S
G
A
Q
T
A
E
G
Site 52
T629
Q
L
F
S
G
A
Q
T
A
E
G
E
G
A
G
Site 53
S648
K
G
G
K
K
K
G
S
S
F
Q
T
V
S
A
Site 54
S649
G
G
K
K
K
G
S
S
F
Q
T
V
S
A
L
Site 55
T652
K
K
G
S
S
F
Q
T
V
S
A
L
F
R
E
Site 56
T666
E
N
L
N
K
L
M
T
N
L
R
S
T
H
P
Site 57
T671
L
M
T
N
L
R
S
T
H
P
H
F
V
R
C
Site 58
T686
I
I
P
N
E
T
K
T
P
G
A
M
E
H
E
Site 59
Y721
G
F
P
S
R
I
L
Y
A
D
F
K
Q
R
Y
Site 60
S744
P
E
G
Q
F
I
D
S
K
K
A
S
E
K
L
Site 61
S748
F
I
D
S
K
K
A
S
E
K
L
L
A
S
I
Site 62
T760
A
S
I
D
I
D
H
T
Q
Y
K
F
G
H
T
Site 63
Y807
G
F
L
A
R
V
E
Y
Q
R
M
V
E
R
R
Site 64
Y822
E
A
I
F
C
I
Q
Y
N
I
R
S
F
M
N
Site 65
S848
K
I
K
P
L
L
K
S
A
E
T
E
K
E
M
Site 66
S872
I
K
D
E
L
A
K
S
E
A
K
R
K
E
L
Site 67
T885
E
L
E
E
K
M
V
T
L
L
K
E
K
N
D
Site 68
S954
R
K
L
E
D
E
C
S
E
L
K
K
D
I
D
Site 69
T966
D
I
D
D
L
E
L
T
L
A
K
V
E
K
E
Site 70
T977
V
E
K
E
K
H
A
T
E
N
K
V
K
N
L
Site 71
T994
E
M
A
G
L
D
E
T
I
A
K
L
T
K
E
Site 72
S1043
Q
V
D
D
L
E
G
S
L
E
Q
E
K
K
L
Site 73
S1094
K
K
K
E
F
E
I
S
N
L
Q
S
K
I
E
Site 74
S1098
F
E
I
S
N
L
Q
S
K
I
E
D
E
Q
A
Site 75
S1134
E
I
E
A
E
R
A
S
R
A
K
A
E
K
Q
Site 76
S1143
A
K
A
E
K
Q
R
S
D
L
S
R
E
L
E
Site 77
S1146
E
K
Q
R
S
D
L
S
R
E
L
E
E
I
S
Site 78
S1153
S
R
E
L
E
E
I
S
E
R
L
E
E
A
G
Site 79
T1197
Q
H
E
A
T
A
A
T
L
R
K
K
H
A
D
Site 80
S1205
L
R
K
K
H
A
D
S
V
A
E
L
G
E
Q
Site 81
S1228
Q
K
L
E
K
E
K
S
E
M
K
M
E
I
D
Site 82
S1239
M
E
I
D
D
L
A
S
N
V
E
T
V
S
K
Site 83
T1243
D
L
A
S
N
V
E
T
V
S
K
A
K
G
N
Site 84
T1257
N
L
E
K
M
C
R
T
L
E
D
Q
L
S
E
Site 85
S1263
R
T
L
E
D
Q
L
S
E
L
K
S
K
E
E
Site 86
S1267
D
Q
L
S
E
L
K
S
K
E
E
E
Q
Q
R
Site 87
T1280
Q
R
L
I
N
D
L
T
A
Q
R
G
R
L
Q
Site 88
T1288
A
Q
R
G
R
L
Q
T
E
S
G
E
F
S
R
Site 89
S1290
R
G
R
L
Q
T
E
S
G
E
F
S
R
Q
L
Site 90
S1294
Q
T
E
S
G
E
F
S
R
Q
L
D
E
K
E
Site 91
S1305
D
E
K
E
A
L
V
S
Q
L
S
R
G
K
Q
Site 92
S1341
A
L
A
H
A
L
Q
S
S
R
H
D
C
D
L
Site 93
Y1353
C
D
L
L
R
E
Q
Y
E
E
E
Q
E
S
K
Site 94
S1359
Q
Y
E
E
E
Q
E
S
K
A
E
L
Q
R
A
Site 95
S1368
A
E
L
Q
R
A
L
S
K
A
N
T
E
V
A
Site 96
T1372
R
A
L
S
K
A
N
T
E
V
A
Q
W
R
T
Site 97
T1379
T
E
V
A
Q
W
R
T
K
Y
E
T
D
A
I
Site 98
Y1381
V
A
Q
W
R
T
K
Y
E
T
D
A
I
Q
R
Site 99
T1383
Q
W
R
T
K
Y
E
T
D
A
I
Q
R
T
E
Site 100
T1389
E
T
D
A
I
Q
R
T
E
E
L
E
E
A
K
Site 101
S1419
A
V
N
A
K
C
A
S
L
E
K
T
K
Q
R
Site 102
T1423
K
C
A
S
L
E
K
T
K
Q
R
L
Q
N
E
Site 103
S1476
T
H
A
E
L
E
A
S
Q
K
E
A
R
S
L
Site 104
S1482
A
S
Q
K
E
A
R
S
L
G
T
E
L
F
K
Site 105
Y1494
L
F
K
I
K
N
A
Y
E
E
S
L
D
Q
L
Site 106
T1503
E
S
L
D
Q
L
E
T
L
K
R
E
N
K
N
Site 107
S1516
K
N
L
Q
Q
E
I
S
D
L
T
E
Q
I
A
Site 108
T1519
Q
Q
E
I
S
D
L
T
E
Q
I
A
E
G
G
Site 109
S1556
A
L
E
E
A
E
A
S
L
E
H
E
E
G
K
Site 110
S1576
L
E
L
N
Q
V
K
S
E
V
D
R
K
I
A
Site 111
S1605
R
I
V
E
S
M
Q
S
T
L
D
A
E
I
R
Site 112
T1606
I
V
E
S
M
Q
S
T
L
D
A
E
I
R
S
Site 113
Y1649
A
A
E
A
L
R
N
Y
R
N
T
Q
G
I
L
Site 114
T1652
A
L
R
N
Y
R
N
T
Q
G
I
L
K
D
T
Site 115
S1669
H
L
D
D
A
L
R
S
Q
E
D
L
K
E
Q
Site 116
T1697
E
I
E
E
L
R
A
T
L
E
Q
T
E
R
S
Site 117
T1701
L
R
A
T
L
E
Q
T
E
R
S
R
K
I
A
Site 118
S1716
E
Q
E
L
L
D
A
S
E
R
V
Q
L
L
H
Site 119
T1724
E
R
V
Q
L
L
H
T
Q
N
T
S
L
I
N
Site 120
T1727
Q
L
L
H
T
Q
N
T
S
L
I
N
T
K
K
Site 121
S1728
L
L
H
T
Q
N
T
S
L
I
N
T
K
K
K
Site 122
T1738
N
T
K
K
K
L
E
T
D
I
S
Q
M
Q
G
Site 123
S1741
K
K
L
E
T
D
I
S
Q
M
Q
G
E
M
E
Site 124
S1782
L
K
K
E
Q
D
T
S
A
H
L
E
R
M
K
Site 125
T1857
E
R
R
V
K
E
L
T
Y
Q
T
E
E
D
R
Site 126
Y1858
R
R
V
K
E
L
T
Y
Q
T
E
E
D
R
K
Site 127
S1883
K
L
Q
A
K
V
K
S
Y
K
R
Q
A
E
E
Site 128
T1897
E
A
E
E
Q
S
N
T
N
L
A
K
F
R
K
Site 129
S1921
E
R
A
D
I
A
E
S
Q
V
N
K
L
R
V
Site 130
S1930
V
N
K
L
R
V
K
S
R
E
V
H
T
K
V
Site 131
T1935
V
K
S
R
E
V
H
T
K
V
I
S
E
E
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation