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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
INTS6
Full Name:
Integrator complex subunit 6
Alias:
DBI-1; DDX26; DDX26A; DEAD box protein; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26; DICE1; HDB; INT6; Integrator complex subunit 6: Protein deleted in cancer 1: Protein DDX26: DBI-1: Integrator complex subunit 6, isoform CRAa: Putative uncharacterized protein INTS6; Notchl2; RNA helicase HDB
Type:
Tumor suppressor
Mass (Da):
100390
Number AA:
887
UniProt ID:
Q9UL03
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0032039
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004888
PhosphoSite+
KinaseNET
Biological Process:
GO:0016180
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
F
L
I
D
T
S
A
S
M
N
Q
R
S
H
L
Site 2
T22
N
Q
R
S
H
L
G
T
T
Y
L
D
T
A
K
Site 3
Y24
R
S
H
L
G
T
T
Y
L
D
T
A
K
G
A
Site 4
T27
L
G
T
T
Y
L
D
T
A
K
G
A
V
E
T
Site 5
T34
T
A
K
G
A
V
E
T
F
M
K
L
R
A
R
Site 6
S45
L
R
A
R
D
P
A
S
R
G
D
R
Y
M
L
Site 7
Y50
P
A
S
R
G
D
R
Y
M
L
V
T
F
E
E
Site 8
T54
G
D
R
Y
M
L
V
T
F
E
E
P
P
Y
A
Site 9
Y60
V
T
F
E
E
P
P
Y
A
I
K
A
G
W
K
Site 10
T87
L
Q
A
E
G
L
T
T
L
G
Q
S
L
R
T
Site 11
T106
L
N
L
N
R
L
V
T
G
I
D
N
Y
G
Q
Site 12
Y111
L
V
T
G
I
D
N
Y
G
Q
G
R
N
P
F
Site 13
T136
T
D
G
S
K
L
T
T
T
S
G
V
Q
D
E
Site 14
S150
E
L
H
L
P
L
N
S
P
L
P
G
S
E
L
Site 15
S155
L
N
S
P
L
P
G
S
E
L
T
K
E
P
F
Site 16
S180
L
R
L
P
G
T
M
S
V
E
S
E
Q
L
T
Site 17
S183
P
G
T
M
S
V
E
S
E
Q
L
T
G
V
P
Site 18
T187
S
V
E
S
E
Q
L
T
G
V
P
L
D
D
S
Site 19
S207
C
E
V
T
G
G
R
S
Y
S
V
C
S
P
R
Site 20
Y208
E
V
T
G
G
R
S
Y
S
V
C
S
P
R
M
Site 21
S209
V
T
G
G
R
S
Y
S
V
C
S
P
R
M
L
Site 22
S212
G
R
S
Y
S
V
C
S
P
R
M
L
N
Q
C
Site 23
S243
E
K
A
G
P
D
P
S
P
V
E
D
G
Q
P
Site 24
S253
E
D
G
Q
P
D
I
S
R
P
F
G
S
Q
P
Site 25
Y269
H
S
C
H
K
L
I
Y
V
R
P
N
P
K
T
Site 26
T276
Y
V
R
P
N
P
K
T
G
V
P
I
G
H
W
Site 27
S295
S
F
W
P
D
Q
N
S
P
T
L
P
P
R
T
Site 28
T297
W
P
D
Q
N
S
P
T
L
P
P
R
T
S
H
Site 29
T302
S
P
T
L
P
P
R
T
S
H
P
V
V
K
F
Site 30
S303
P
T
L
P
P
R
T
S
H
P
V
V
K
F
S
Site 31
Y327
D
K
L
P
F
D
K
Y
E
L
E
P
S
P
L
Site 32
S332
D
K
Y
E
L
E
P
S
P
L
T
Q
F
I
L
Site 33
T335
E
L
E
P
S
P
L
T
Q
F
I
L
E
R
K
Site 34
T346
L
E
R
K
S
P
Q
T
C
W
Q
V
Y
V
S
Site 35
Y351
P
Q
T
C
W
Q
V
Y
V
S
N
S
A
K
Y
Site 36
S359
V
S
N
S
A
K
Y
S
E
L
G
H
P
F
G
Site 37
S411
P
T
L
K
W
R
Q
S
F
E
S
Y
L
K
T
Site 38
S414
K
W
R
Q
S
F
E
S
Y
L
K
T
M
P
P
Site 39
Y415
W
R
Q
S
F
E
S
Y
L
K
T
M
P
P
Y
Site 40
T418
S
F
E
S
Y
L
K
T
M
P
P
Y
Y
L
G
Site 41
Y422
Y
L
K
T
M
P
P
Y
Y
L
G
P
L
K
K
Site 42
Y423
L
K
T
M
P
P
Y
Y
L
G
P
L
K
K
A
Site 43
S443
A
P
N
L
I
A
D
S
M
E
Y
G
L
S
Y
Site 44
S449
D
S
M
E
Y
G
L
S
Y
S
V
I
S
Y
L
Site 45
Y450
S
M
E
Y
G
L
S
Y
S
V
I
S
Y
L
K
Site 46
S451
M
E
Y
G
L
S
Y
S
V
I
S
Y
L
K
K
Site 47
S454
G
L
S
Y
S
V
I
S
Y
L
K
K
L
S
Q
Site 48
Y455
L
S
Y
S
V
I
S
Y
L
K
K
L
S
Q
Q
Site 49
S460
I
S
Y
L
K
K
L
S
Q
Q
A
K
I
E
S
Site 50
S467
S
Q
Q
A
K
I
E
S
D
R
V
I
G
S
V
Site 51
S473
E
S
D
R
V
I
G
S
V
G
K
K
V
V
Q
Site 52
S488
E
T
G
I
K
V
R
S
R
S
H
G
L
S
M
Site 53
S490
G
I
K
V
R
S
R
S
H
G
L
S
M
A
Y
Site 54
S494
R
S
R
S
H
G
L
S
M
A
Y
R
K
D
F
Site 55
Y497
S
H
G
L
S
M
A
Y
R
K
D
F
Q
Q
L
Site 56
S509
Q
Q
L
L
Q
G
I
S
E
D
V
P
H
R
L
Site 57
T540
N
K
D
L
K
P
Q
T
F
R
N
A
Y
D
I
Site 58
Y545
P
Q
T
F
R
N
A
Y
D
I
P
R
R
N
L
Site 59
T557
R
N
L
L
D
H
L
T
R
M
R
S
N
L
L
Site 60
S561
D
H
L
T
R
M
R
S
N
L
L
K
S
T
R
Site 61
S566
M
R
S
N
L
L
K
S
T
R
R
F
L
K
G
Site 62
Y590
P
I
A
Q
M
G
N
Y
Q
E
Y
L
K
Q
V
Site 63
Y593
Q
M
G
N
Y
Q
E
Y
L
K
Q
V
P
S
P
Site 64
S599
E
Y
L
K
Q
V
P
S
P
L
R
E
L
D
P
Site 65
T614
D
Q
P
R
R
L
H
T
F
G
N
P
F
K
L
Site 66
S661
P
K
R
R
R
C
M
S
P
L
L
R
G
R
Q
Site 67
T687
K
G
P
P
A
P
T
T
Q
A
Q
P
D
L
I
Site 68
T705
P
L
H
K
I
S
E
T
T
N
D
S
I
I
H
Site 69
T728
D
Q
L
S
S
D
I
T
P
N
A
M
D
T
E
Site 70
T734
I
T
P
N
A
M
D
T
E
F
S
A
S
S
P
Site 71
S737
N
A
M
D
T
E
F
S
A
S
S
P
A
S
L
Site 72
S739
M
D
T
E
F
S
A
S
S
P
A
S
L
L
E
Site 73
S740
D
T
E
F
S
A
S
S
P
A
S
L
L
E
R
Site 74
S743
F
S
A
S
S
P
A
S
L
L
E
R
P
T
N
Site 75
T749
A
S
L
L
E
R
P
T
N
H
M
E
A
L
G
Site 76
T766
H
L
G
T
N
D
L
T
V
G
G
F
L
E
N
Site 77
S791
A
E
E
N
I
P
A
S
S
L
N
K
G
K
K
Site 78
S804
K
K
L
M
H
C
R
S
H
E
E
V
N
T
E
Site 79
T810
R
S
H
E
E
V
N
T
E
L
K
A
Q
I
M
Site 80
Y827
I
R
K
P
G
R
K
Y
E
R
I
F
T
L
L
Site 81
T832
R
K
Y
E
R
I
F
T
L
L
K
H
V
Q
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation