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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Hcn2
Full Name:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Alias:
BCNG2; BCNG-2; Brain cyclic nucleotide gated channel 2; Brain cyclic nucleotide-gated channel 2; HAC-1; Hyperpolarization activated cyclic nucleotide-gated potassium channel 2
Type:
Channel, cation
Mass (Da):
96950
Number AA:
889
UniProt ID:
Q9UL51
International Prot ID:
IPI00218946
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0030552
GO:0030955
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007267
GO:0006936
GO:0006813
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
G
G
G
R
P
G
E
S
P
G
A
T
P
A
P
Site 2
T17
P
G
E
S
P
G
A
T
P
A
P
G
P
P
P
Site 3
S77
G
P
R
G
R
L
R
S
R
D
S
S
C
G
R
Site 4
S80
G
R
L
R
S
R
D
S
S
C
G
R
P
G
T
Site 5
S81
R
L
R
S
R
D
S
S
C
G
R
P
G
T
P
Site 6
T87
S
S
C
G
R
P
G
T
P
G
A
A
S
T
A
Site 7
S92
P
G
T
P
G
A
A
S
T
A
K
G
S
P
N
Site 8
T93
G
T
P
G
A
A
S
T
A
K
G
S
P
N
G
Site 9
S97
A
A
S
T
A
K
G
S
P
N
G
E
C
G
R
Site 10
S110
G
R
G
E
P
Q
C
S
P
A
G
P
E
G
P
Site 11
S124
P
A
R
G
P
K
V
S
F
S
C
R
G
A
A
Site 12
S126
R
G
P
K
V
S
F
S
C
R
G
A
A
S
G
Site 13
S132
F
S
C
R
G
A
A
S
G
P
A
P
G
P
G
Site 14
S146
G
P
A
E
E
A
G
S
E
E
A
G
P
A
G
Site 15
S158
P
A
G
E
P
R
G
S
Q
A
S
F
M
Q
R
Site 16
S161
E
P
R
G
S
Q
A
S
F
M
Q
R
Q
F
G
Site 17
S179
Q
P
G
V
N
K
F
S
L
R
M
F
G
S
Q
Site 18
S185
F
S
L
R
M
F
G
S
Q
K
A
V
E
R
E
Site 19
S198
R
E
Q
E
R
V
K
S
A
G
A
W
I
I
H
Site 20
Y213
P
Y
S
D
F
R
F
Y
W
D
F
T
M
L
L
Site 21
Y286
P
E
K
I
K
K
K
Y
L
R
T
W
F
V
V
Site 22
S314
I
V
E
K
G
I
D
S
E
V
Y
K
T
A
R
Site 23
Y317
K
G
I
D
S
E
V
Y
K
T
A
R
A
L
R
Site 24
Y430
S
H
M
L
C
I
G
Y
G
R
Q
A
P
E
S
Site 25
S437
Y
G
R
Q
A
P
E
S
M
T
D
I
W
L
T
Site 26
S468
H
A
T
A
L
I
Q
S
L
D
S
S
R
R
Q
Site 27
S471
A
L
I
Q
S
L
D
S
S
R
R
Q
Y
Q
E
Site 28
S472
L
I
Q
S
L
D
S
S
R
R
Q
Y
Q
E
K
Site 29
Y476
L
D
S
S
R
R
Q
Y
Q
E
K
Y
K
Q
V
Site 30
Y480
R
R
Q
Y
Q
E
K
Y
K
Q
V
E
Q
Y
M
Site 31
S488
K
Q
V
E
Q
Y
M
S
F
H
K
L
P
A
D
Site 32
Y503
F
R
Q
K
I
H
D
Y
Y
E
H
R
Y
Q
G
Site 33
Y504
R
Q
K
I
H
D
Y
Y
E
H
R
Y
Q
G
K
Site 34
S517
G
K
M
F
D
E
D
S
I
L
G
E
L
N
G
Site 35
Y570
E
V
F
Q
P
G
D
Y
I
I
R
E
G
T
I
Site 36
T576
D
Y
I
I
R
E
G
T
I
G
K
K
M
Y
F
Site 37
Y582
G
T
I
G
K
K
M
Y
F
I
Q
H
G
V
V
Site 38
S602
G
N
K
E
M
K
L
S
D
G
S
Y
F
G
E
Site 39
T614
F
G
E
I
C
L
L
T
R
G
R
R
T
A
S
Site 40
T619
L
L
T
R
G
R
R
T
A
S
V
R
A
D
T
Site 41
S621
T
R
G
R
R
T
A
S
V
R
A
D
T
Y
C
Site 42
T626
T
A
S
V
R
A
D
T
Y
C
R
L
Y
S
L
Site 43
Y627
A
S
V
R
A
D
T
Y
C
R
L
Y
S
L
S
Site 44
Y631
A
D
T
Y
C
R
L
Y
S
L
S
V
D
N
F
Site 45
S632
D
T
Y
C
R
L
Y
S
L
S
V
D
N
F
N
Site 46
S634
Y
C
R
L
Y
S
L
S
V
D
N
F
N
E
V
Site 47
Y645
F
N
E
V
L
E
E
Y
P
M
M
R
R
A
F
Site 48
T654
M
M
R
R
A
F
E
T
V
A
I
D
R
L
D
Site 49
S668
D
R
I
G
K
K
N
S
I
L
L
H
K
V
Q
Site 50
Y697
I
I
Q
E
I
V
K
Y
D
R
E
M
V
Q
Q
Site 51
S754
V
G
P
L
A
L
G
S
P
R
L
V
R
R
P
Site 52
S771
G
P
A
P
A
A
A
S
P
G
P
P
P
P
A
Site 53
S779
P
G
P
P
P
P
A
S
P
P
G
A
P
A
S
Site 54
S786
S
P
P
G
A
P
A
S
P
R
A
P
R
T
S
Site 55
T792
A
S
P
R
A
P
R
T
S
P
Y
G
G
L
P
Site 56
S793
S
P
R
A
P
R
T
S
P
Y
G
G
L
P
A
Site 57
Y795
R
A
P
R
T
S
P
Y
G
G
L
P
A
A
P
Site 58
S814
A
L
P
A
R
R
L
S
R
A
S
R
P
L
S
Site 59
S817
A
R
R
L
S
R
A
S
R
P
L
S
A
S
Q
Site 60
S821
S
R
A
S
R
P
L
S
A
S
Q
P
S
L
P
Site 61
S823
A
S
R
P
L
S
A
S
Q
P
S
L
P
H
G
Site 62
S826
P
L
S
A
S
Q
P
S
L
P
H
G
A
P
G
Site 63
S837
G
A
P
G
P
A
A
S
T
R
P
A
S
S
S
Site 64
T838
A
P
G
P
A
A
S
T
R
P
A
S
S
S
T
Site 65
S842
A
A
S
T
R
P
A
S
S
S
T
P
R
L
G
Site 66
S843
A
S
T
R
P
A
S
S
S
T
P
R
L
G
P
Site 67
S844
S
T
R
P
A
S
S
S
T
P
R
L
G
P
T
Site 68
T845
T
R
P
A
S
S
S
T
P
R
L
G
P
T
P
Site 69
T851
S
T
P
R
L
G
P
T
P
A
A
R
A
A
A
Site 70
S860
A
A
R
A
A
A
P
S
P
D
R
R
D
S
A
Site 71
S866
P
S
P
D
R
R
D
S
A
S
P
G
A
A
G
Site 72
S868
P
D
R
R
D
S
A
S
P
G
A
A
G
G
L
Site 73
S880
G
G
L
D
P
Q
D
S
A
R
S
R
L
S
S
Site 74
S883
D
P
Q
D
S
A
R
S
R
L
S
S
N
L
_
Site 75
S886
D
S
A
R
S
R
L
S
S
N
L
_
_
_
_
Site 76
S887
S
A
R
S
R
L
S
S
N
L
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation