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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TAO2
Full Name:
Thousand and one amino acid protein 2
Alias:
EC 2.7.11.1; KIAA0881; MAP3K17; Prostate-derived STE20-like kinase 1; PSK; PSK1; PSK-1; Serine/threonine-protein kinase TAO2; TAO kinase 2; TAO1; TAOK2
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1;
STE
group; STE20 family; TAO subfamily
Mass (Da):
138251
Number AA:
1235
UniProt ID:
Q9UL54
International Prot ID:
IPI00465168
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016023
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0000186
GO:0006915
Phosida
TranscriptoNet
STRING
Kinexus Products
TAOSubtide - TAOK2 (PSK) protein kinase substrate peptide - Powder PE-01BJN95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BJN95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
P
A
G
G
R
A
G
S
L
K
D
P
D
V
A
Site 2
S29
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
Site 3
Y43
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
Site 4
S51
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
Site 5
S60
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
Site 6
Y61
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
Site 7
S62
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
Site 8
T88
Q
K
L
R
H
P
N
T
I
Q
Y
R
G
C
Y
Site 9
Y95
T
I
Q
Y
R
G
C
Y
L
R
E
H
T
A
W
Site 10
Y107
T
A
W
L
V
M
E
Y
C
L
G
S
A
S
D
Site 11
S113
E
Y
C
L
G
S
A
S
D
L
L
E
V
H
K
Site 12
S181
S
I
M
A
P
A
N
S
F
V
G
T
P
Y
W
Site 13
T185
P
A
N
S
F
V
G
T
P
Y
W
M
A
P
E
Site 14
S242
Y
H
I
A
Q
N
E
S
P
V
L
Q
S
G
H
Site 15
S247
N
E
S
P
V
L
Q
S
G
H
W
S
E
Y
F
Site 16
Y253
Q
S
G
H
W
S
E
Y
F
R
N
F
V
D
S
Site 17
T271
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
Site 18
S272
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
Site 19
Y309
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
Site 20
Y338
E
E
E
E
A
E
P
Y
M
H
R
A
G
T
L
Site 21
T344
P
Y
M
H
R
A
G
T
L
T
S
L
E
S
S
Site 22
T346
M
H
R
A
G
T
L
T
S
L
E
S
S
H
S
Site 23
S347
H
R
A
G
T
L
T
S
L
E
S
S
H
S
V
Site 24
S350
G
T
L
T
S
L
E
S
S
H
S
V
P
S
M
Site 25
S351
T
L
T
S
L
E
S
S
H
S
V
P
S
M
S
Site 26
S353
T
S
L
E
S
S
H
S
V
P
S
M
S
I
S
Site 27
S356
E
S
S
H
S
V
P
S
M
S
I
S
A
S
S
Site 28
S358
S
H
S
V
P
S
M
S
I
S
A
S
S
Q
S
Site 29
S360
S
V
P
S
M
S
I
S
A
S
S
Q
S
S
S
Site 30
S362
P
S
M
S
I
S
A
S
S
Q
S
S
S
V
N
Site 31
S363
S
M
S
I
S
A
S
S
Q
S
S
S
V
N
S
Site 32
S365
S
I
S
A
S
S
Q
S
S
S
V
N
S
L
A
Site 33
S366
I
S
A
S
S
Q
S
S
S
V
N
S
L
A
D
Site 34
S367
S
A
S
S
Q
S
S
S
V
N
S
L
A
D
A
Site 35
S370
S
Q
S
S
S
V
N
S
L
A
D
A
S
D
N
Site 36
S375
V
N
S
L
A
D
A
S
D
N
E
E
E
E
E
Site 37
T408
M
M
Q
E
G
E
H
T
V
T
S
H
S
S
I
Site 38
T410
Q
E
G
E
H
T
V
T
S
H
S
S
I
I
H
Site 39
S411
E
G
E
H
T
V
T
S
H
S
S
I
I
H
R
Site 40
S414
H
T
V
T
S
H
S
S
I
I
H
R
L
P
G
Site 41
S422
I
I
H
R
L
P
G
S
D
N
L
Y
D
D
P
Site 42
Y426
L
P
G
S
D
N
L
Y
D
D
P
Y
Q
P
E
Site 43
Y430
D
N
L
Y
D
D
P
Y
Q
P
E
I
T
P
S
Site 44
T435
D
P
Y
Q
P
E
I
T
P
S
P
L
Q
P
P
Site 45
S437
Y
Q
P
E
I
T
P
S
P
L
Q
P
P
A
A
Site 46
T448
P
P
A
A
P
A
P
T
S
T
T
S
S
A
R
Site 47
S449
P
A
A
P
A
P
T
S
T
T
S
S
A
R
R
Site 48
S452
P
A
P
T
S
T
T
S
S
A
R
R
R
A
Y
Site 49
S453
A
P
T
S
T
T
S
S
A
R
R
R
A
Y
C
Site 50
Y459
S
S
A
R
R
R
A
Y
C
R
N
R
D
H
F
Site 51
T468
R
N
R
D
H
F
A
T
I
R
T
A
S
L
V
Site 52
T471
D
H
F
A
T
I
R
T
A
S
L
V
S
R
Q
Site 53
S473
F
A
T
I
R
T
A
S
L
V
S
R
Q
I
Q
Site 54
S486
I
Q
E
H
E
Q
D
S
A
L
R
E
Q
L
S
Site 55
S493
S
A
L
R
E
Q
L
S
G
Y
K
R
M
R
R
Site 56
Y495
L
R
E
Q
L
S
G
Y
K
R
M
R
R
Q
H
Site 57
S511
K
Q
L
L
A
L
E
S
R
L
R
G
E
R
E
Site 58
S521
R
G
E
R
E
E
H
S
A
R
L
Q
R
E
L
Site 59
Y587
L
E
A
Q
K
R
T
Y
K
L
R
K
E
Q
L
Site 60
S603
E
E
L
Q
E
N
P
S
T
P
K
R
E
K
A
Site 61
T604
E
L
Q
E
N
P
S
T
P
K
R
E
K
A
E
Site 62
Y638
L
L
R
R
Q
R
Q
Y
F
E
L
Q
C
R
Q
Site 63
Y646
F
E
L
Q
C
R
Q
Y
K
R
K
M
L
L
A
Site 64
S656
K
M
L
L
A
R
H
S
L
D
Q
D
L
L
R
Site 65
T671
E
D
L
N
K
K
Q
T
Q
K
D
L
E
C
A
Site 66
T687
L
L
R
Q
H
E
A
T
R
E
L
E
L
R
Q
Site 67
T712
L
T
R
L
Q
H
Q
T
E
L
G
N
Q
L
E
Site 68
Y720
E
L
G
N
Q
L
E
Y
N
K
R
R
E
Q
E
Site 69
S742
Q
V
R
Q
Q
P
K
S
L
K
V
R
A
G
Q
Site 70
T767
G
A
L
G
P
P
N
T
G
T
P
I
E
Q
Q
Site 71
T769
L
G
P
P
N
T
G
T
P
I
E
Q
Q
P
C
Site 72
S777
P
I
E
Q
Q
P
C
S
P
G
Q
E
A
V
L
Site 73
T808
I
L
G
K
E
G
A
T
L
E
P
K
Q
Q
R
Site 74
S821
Q
R
I
L
G
E
E
S
G
A
P
S
P
S
P
Site 75
S825
G
E
E
S
G
A
P
S
P
S
P
Q
K
H
G
Site 76
S827
E
S
G
A
P
S
P
S
P
Q
K
H
G
S
L
Site 77
S833
P
S
P
Q
K
H
G
S
L
V
D
E
E
V
W
Site 78
S853
I
E
E
L
R
V
P
S
L
V
P
Q
E
R
S
Site 79
T869
V
G
Q
E
E
A
G
T
W
S
L
W
G
K
E
Site 80
S879
L
W
G
K
E
D
E
S
L
L
D
E
E
F
E
Site 81
T896
W
V
Q
G
P
A
L
T
P
V
P
E
E
E
E
Site 82
T913
E
E
G
A
P
I
G
T
P
R
D
P
G
D
G
Site 83
S923
D
P
G
D
G
C
P
S
P
D
I
P
P
E
P
Site 84
T933
I
P
P
E
P
P
P
T
H
L
R
P
C
P
A
Site 85
S941
H
L
R
P
C
P
A
S
Q
L
P
G
L
L
S
Site 86
S1082
P
R
V
R
R
G
I
S
R
L
W
L
R
V
L
Site 87
Y1115
D
R
G
L
F
A
L
Y
P
K
T
N
K
D
G
Site 88
T1118
L
F
A
L
Y
P
K
T
N
K
D
G
F
R
S
Site 89
S1125
T
N
K
D
G
F
R
S
R
L
P
V
P
G
P
Site 90
T1139
P
R
R
R
N
P
R
T
T
Q
H
P
L
A
L
Site 91
T1140
R
R
R
N
P
R
T
T
Q
H
P
L
A
L
L
Site 92
S1165
N
W
R
L
A
R
A
S
Q
G
L
A
S
H
L
Site 93
S1170
R
A
S
Q
G
L
A
S
H
L
P
P
W
A
I
Site 94
T1192
L
L
R
G
E
R
P
T
R
I
P
R
L
L
P
Site 95
S1201
I
P
R
L
L
P
R
S
Q
R
Q
L
G
P
P
Site 96
S1210
R
Q
L
G
P
P
A
S
R
Q
P
L
P
G
T
Site 97
T1217
S
R
Q
P
L
P
G
T
L
A
G
R
R
S
R
Site 98
S1223
G
T
L
A
G
R
R
S
R
T
R
Q
S
R
A
Site 99
T1225
L
A
G
R
R
S
R
T
R
Q
S
R
A
L
P
Site 100
S1228
R
R
S
R
T
R
Q
S
R
A
L
P
P
W
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation