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Updated November 2019
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Protein Info
Short Name:
MYT1L
Full Name:
Myelin transcription factor 1-like protein
Alias:
Type:
Mass (Da):
133081
Number AA:
1186
UniProt ID:
Q9UL68
International Prot ID:
IPI00007843
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0007399
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
T
E
E
K
R
H
R
T
R
S
K
G
V
R
V
Site 2
S14
E
K
R
H
R
T
R
S
K
G
V
R
V
P
V
Site 3
T33
Q
E
L
F
S
C
P
T
P
G
C
D
G
S
G
Site 4
S39
P
T
P
G
C
D
G
S
G
H
V
S
G
K
Y
Site 5
S43
C
D
G
S
G
H
V
S
G
K
Y
A
R
H
R
Site 6
Y46
S
G
H
V
S
G
K
Y
A
R
H
R
S
V
Y
Site 7
S51
G
K
Y
A
R
H
R
S
V
Y
G
C
P
L
A
Site 8
Y53
Y
A
R
H
R
S
V
Y
G
C
P
L
A
K
K
Site 9
T63
P
L
A
K
K
R
K
T
Q
D
K
Q
P
Q
E
Site 10
S84
P
F
A
V
K
A
D
S
S
S
V
D
E
C
D
Site 11
S85
F
A
V
K
A
D
S
S
S
V
D
E
C
D
D
Site 12
S86
A
V
K
A
D
S
S
S
V
D
E
C
D
D
S
Site 13
S93
S
V
D
E
C
D
D
S
D
G
T
E
D
M
D
Site 14
Y110
E
E
D
E
G
E
E
Y
S
E
D
N
D
E
P
Site 15
T184
N
T
R
I
M
Q
D
T
E
K
D
D
N
N
S
Site 16
S191
T
E
K
D
D
N
N
S
D
E
Y
D
N
Y
D
Site 17
Y194
D
D
N
N
S
D
E
Y
D
N
Y
D
E
L
V
Site 18
Y197
N
S
D
E
Y
D
N
Y
D
E
L
V
A
K
S
Site 19
S204
Y
D
E
L
V
A
K
S
L
L
N
L
G
K
I
Site 20
Y217
K
I
A
E
D
A
A
Y
R
A
R
T
E
S
E
Site 21
T221
D
A
A
Y
R
A
R
T
E
S
E
M
N
S
N
Site 22
S223
A
Y
R
A
R
T
E
S
E
M
N
S
N
T
S
Site 23
S227
R
T
E
S
E
M
N
S
N
T
S
N
S
L
E
Site 24
S230
S
E
M
N
S
N
T
S
N
S
L
E
D
D
S
Site 25
S232
M
N
S
N
T
S
N
S
L
E
D
D
S
D
K
Site 26
S237
S
N
S
L
E
D
D
S
D
K
N
E
N
L
G
Site 27
S247
N
E
N
L
G
R
K
S
E
L
S
L
D
L
D
Site 28
S250
L
G
R
K
S
E
L
S
L
D
L
D
S
D
V
Site 29
S255
E
L
S
L
D
L
D
S
D
V
V
R
E
T
V
Site 30
T261
D
S
D
V
V
R
E
T
V
D
S
L
K
L
L
Site 31
S277
Q
G
H
G
V
V
L
S
E
N
M
N
D
R
N
Site 32
Y285
E
N
M
N
D
R
N
Y
A
D
S
M
S
Q
Q
Site 33
S288
N
D
R
N
Y
A
D
S
M
S
Q
Q
D
S
R
Site 34
S290
R
N
Y
A
D
S
M
S
Q
Q
D
S
R
N
M
Site 35
Y299
Q
D
S
R
N
M
N
Y
V
M
L
G
K
P
M
Site 36
S325
S
D
E
E
V
C
L
S
S
L
E
C
L
R
N
Site 37
S342
F
D
L
A
R
K
L
S
E
T
N
P
Q
E
R
Site 38
T344
L
A
R
K
L
S
E
T
N
P
Q
E
R
N
P
Site 39
T371
E
E
D
F
P
G
R
T
P
D
R
N
Y
S
D
Site 40
Y376
G
R
T
P
D
R
N
Y
S
D
M
L
N
L
M
Site 41
S377
R
T
P
D
R
N
Y
S
D
M
L
N
L
M
R
Site 42
S390
M
R
L
E
E
Q
L
S
P
R
S
R
V
F
A
Site 43
S393
E
E
Q
L
S
P
R
S
R
V
F
A
S
C
A
Site 44
T412
C
H
E
R
D
D
D
T
T
S
V
N
S
D
R
Site 45
T413
H
E
R
D
D
D
T
T
S
V
N
S
D
R
S
Site 46
S414
E
R
D
D
D
T
T
S
V
N
S
D
R
S
E
Site 47
S417
D
D
T
T
S
V
N
S
D
R
S
E
E
V
F
Site 48
S420
T
S
V
N
S
D
R
S
E
E
V
F
D
M
T
Site 49
T427
S
E
E
V
F
D
M
T
K
G
N
L
T
L
L
Site 50
S464
G
R
R
D
N
M
R
S
Y
E
D
Q
S
P
R
Site 51
Y465
R
R
D
N
M
R
S
Y
E
D
Q
S
P
R
Q
Site 52
S469
M
R
S
Y
E
D
Q
S
P
R
Q
L
P
G
E
Site 53
S482
G
E
D
R
K
P
K
S
S
D
S
H
V
K
K
Site 54
S483
E
D
R
K
P
K
S
S
D
S
H
V
K
K
P
Site 55
S485
R
K
P
K
S
S
D
S
H
V
K
K
P
Y
Y
Site 56
Y491
D
S
H
V
K
K
P
Y
Y
G
K
D
P
S
R
Site 57
Y492
S
H
V
K
K
P
Y
Y
G
K
D
P
S
R
T
Site 58
S497
P
Y
Y
G
K
D
P
S
R
T
E
K
K
E
S
Site 59
S504
S
R
T
E
K
K
E
S
K
C
P
T
P
G
C
Site 60
T508
K
K
E
S
K
C
P
T
P
G
C
D
G
T
G
Site 61
T514
P
T
P
G
C
D
G
T
G
H
V
T
G
L
Y
Site 62
Y521
T
G
H
V
T
G
L
Y
P
H
H
R
S
L
S
Site 63
S526
G
L
Y
P
H
H
R
S
L
S
G
C
P
H
K
Site 64
S528
Y
P
H
H
R
S
L
S
G
C
P
H
K
D
R
Site 65
T552
E
S
V
L
K
C
P
T
P
G
C
T
G
R
G
Site 66
S563
T
G
R
G
H
V
N
S
N
R
N
S
H
R
S
Site 67
S567
H
V
N
S
N
R
N
S
H
R
S
L
S
G
C
Site 68
S570
S
N
R
N
S
H
R
S
L
S
G
C
P
I
A
Site 69
S572
R
N
S
H
R
S
L
S
G
C
P
I
A
A
A
Site 70
S591
K
A
Q
E
K
H
Q
S
C
D
V
S
K
S
S
Site 71
S595
K
H
Q
S
C
D
V
S
K
S
S
Q
A
S
D
Site 72
S597
Q
S
C
D
V
S
K
S
S
Q
A
S
D
R
V
Site 73
S598
S
C
D
V
S
K
S
S
Q
A
S
D
R
V
L
Site 74
S601
V
S
K
S
S
Q
A
S
D
R
V
L
R
P
M
Site 75
Y619
K
Q
L
E
I
P
Q
Y
G
Y
R
N
N
V
P
Site 76
T627
G
Y
R
N
N
V
P
T
T
T
P
R
S
N
L
Site 77
T628
Y
R
N
N
V
P
T
T
T
P
R
S
N
L
A
Site 78
T629
R
N
N
V
P
T
T
T
P
R
S
N
L
A
K
Site 79
S632
V
P
T
T
T
P
R
S
N
L
A
K
E
L
E
Site 80
Y641
L
A
K
E
L
E
K
Y
S
K
T
S
F
E
Y
Site 81
S642
A
K
E
L
E
K
Y
S
K
T
S
F
E
Y
N
Site 82
T644
E
L
E
K
Y
S
K
T
S
F
E
Y
N
S
Y
Site 83
S645
L
E
K
Y
S
K
T
S
F
E
Y
N
S
Y
D
Site 84
Y648
Y
S
K
T
S
F
E
Y
N
S
Y
D
N
H
T
Site 85
Y651
T
S
F
E
Y
N
S
Y
D
N
H
T
Y
G
K
Site 86
Y656
N
S
Y
D
N
H
T
Y
G
K
R
A
I
A
P
Site 87
S671
K
V
Q
T
R
D
I
S
P
K
G
Y
D
D
A
Site 88
Y675
R
D
I
S
P
K
G
Y
D
D
A
K
R
Y
C
Site 89
Y681
G
Y
D
D
A
K
R
Y
C
K
D
P
S
P
S
Site 90
S686
K
R
Y
C
K
D
P
S
P
S
S
S
S
T
S
Site 91
S688
Y
C
K
D
P
S
P
S
S
S
S
T
S
S
Y
Site 92
S689
C
K
D
P
S
P
S
S
S
S
T
S
S
Y
A
Site 93
S690
K
D
P
S
P
S
S
S
S
T
S
S
Y
A
P
Site 94
S691
D
P
S
P
S
S
S
S
T
S
S
Y
A
P
S
Site 95
T692
P
S
P
S
S
S
S
T
S
S
Y
A
P
S
S
Site 96
S693
S
P
S
S
S
S
T
S
S
Y
A
P
S
S
S
Site 97
S694
P
S
S
S
S
T
S
S
Y
A
P
S
S
S
S
Site 98
Y695
S
S
S
S
T
S
S
Y
A
P
S
S
S
S
N
Site 99
S698
S
T
S
S
Y
A
P
S
S
S
S
N
L
S
C
Site 100
S699
T
S
S
Y
A
P
S
S
S
S
N
L
S
C
G
Site 101
S700
S
S
Y
A
P
S
S
S
S
N
L
S
C
G
G
Site 102
S701
S
Y
A
P
S
S
S
S
N
L
S
C
G
G
G
Site 103
S704
P
S
S
S
S
N
L
S
C
G
G
G
S
S
A
Site 104
S709
N
L
S
C
G
G
G
S
S
A
S
S
T
C
S
Site 105
S710
L
S
C
G
G
G
S
S
A
S
S
T
C
S
K
Site 106
S712
C
G
G
G
S
S
A
S
S
T
C
S
K
S
S
Site 107
S713
G
G
G
S
S
A
S
S
T
C
S
K
S
S
F
Site 108
T714
G
G
S
S
A
S
S
T
C
S
K
S
S
F
D
Site 109
S716
S
S
A
S
S
T
C
S
K
S
S
F
D
Y
T
Site 110
S718
A
S
S
T
C
S
K
S
S
F
D
Y
T
H
D
Site 111
S719
S
S
T
C
S
K
S
S
F
D
Y
T
H
D
M
Site 112
Y722
C
S
K
S
S
F
D
Y
T
H
D
M
E
A
A
Site 113
T723
S
K
S
S
F
D
Y
T
H
D
M
E
A
A
H
Site 114
S740
A
T
A
I
L
N
L
S
T
R
C
R
E
M
P
Site 115
S751
R
E
M
P
Q
N
L
S
T
K
P
Q
D
L
C
Site 116
S776
E
N
G
T
L
D
L
S
M
N
K
Q
R
P
R
Site 117
S785
N
K
Q
R
P
R
D
S
C
C
P
I
L
T
P
Site 118
S797
L
T
P
L
E
P
M
S
P
Q
Q
Q
A
V
M
Site 119
Y823
C
W
D
L
P
V
D
Y
T
K
M
K
P
R
R
Site 120
S836
R
R
I
D
E
D
E
S
K
D
I
T
P
E
D
Site 121
T840
E
D
E
S
K
D
I
T
P
E
D
L
D
P
F
Site 122
Y856
E
A
L
E
E
R
R
Y
P
G
E
V
T
I
P
Site 123
S864
P
G
E
V
T
I
P
S
P
K
P
K
Y
P
Q
Site 124
Y869
I
P
S
P
K
P
K
Y
P
Q
C
K
E
S
K
Site 125
S875
K
Y
P
Q
C
K
E
S
K
K
D
L
I
T
L
Site 126
T881
E
S
K
K
D
L
I
T
L
S
G
C
P
L
A
Site 127
S883
K
K
D
L
I
T
L
S
G
C
P
L
A
D
K
Site 128
T898
S
I
R
S
M
L
A
T
S
S
Q
E
L
K
C
Site 129
S900
R
S
M
L
A
T
S
S
Q
E
L
K
C
P
T
Site 130
T907
S
Q
E
L
K
C
P
T
P
G
C
D
G
S
G
Site 131
S913
P
T
P
G
C
D
G
S
G
H
I
T
G
N
Y
Site 132
T917
C
D
G
S
G
H
I
T
G
N
Y
A
S
H
R
Site 133
Y920
S
G
H
I
T
G
N
Y
A
S
H
R
S
L
S
Site 134
S922
H
I
T
G
N
Y
A
S
H
R
S
L
S
G
C
Site 135
S925
G
N
Y
A
S
H
R
S
L
S
G
C
P
R
A
Site 136
S927
Y
A
S
H
R
S
L
S
G
C
P
R
A
K
K
Site 137
S942
R
G
I
R
I
A
Q
S
K
E
D
K
E
D
Q
Site 138
Y969
Q
G
H
I
T
G
K
Y
A
S
H
R
S
A
S
Site 139
S971
H
I
T
G
K
Y
A
S
H
R
S
A
S
G
C
Site 140
S974
G
K
Y
A
S
H
R
S
A
S
G
C
P
L
A
Site 141
S976
Y
A
S
H
R
S
A
S
G
C
P
L
A
A
K
Site 142
Y989
A
K
R
Q
K
E
G
Y
L
N
G
S
Q
F
S
Site 143
S993
K
E
G
Y
L
N
G
S
Q
F
S
W
K
S
V
Site 144
S999
G
S
Q
F
S
W
K
S
V
K
T
E
G
M
S
Site 145
T1002
F
S
W
K
S
V
K
T
E
G
M
S
C
P
T
Site 146
S1006
S
V
K
T
E
G
M
S
C
P
T
P
G
C
D
Site 147
T1009
T
E
G
M
S
C
P
T
P
G
C
D
G
S
G
Site 148
S1015
P
T
P
G
C
D
G
S
G
H
V
S
G
S
F
Site 149
S1019
C
D
G
S
G
H
V
S
G
S
F
L
T
H
R
Site 150
S1021
G
S
G
H
V
S
G
S
F
L
T
H
R
S
L
Site 151
T1024
H
V
S
G
S
F
L
T
H
R
S
L
S
G
C
Site 152
S1027
G
S
F
L
T
H
R
S
L
S
G
C
P
R
A
Site 153
S1029
F
L
T
H
R
S
L
S
G
C
P
R
A
T
S
Site 154
T1035
L
S
G
C
P
R
A
T
S
A
M
K
K
A
K
Site 155
S1036
S
G
C
P
R
A
T
S
A
M
K
K
A
K
L
Site 156
T1050
L
S
G
E
Q
M
L
T
I
K
Q
R
A
S
N
Site 157
S1056
L
T
I
K
Q
R
A
S
N
G
I
E
N
D
E
Site 158
S1078
E
I
K
E
L
N
E
S
N
S
Q
M
E
A
D
Site 159
S1080
K
E
L
N
E
S
N
S
Q
M
E
A
D
M
I
Site 160
T1095
K
L
R
T
Q
I
T
T
M
E
S
N
L
K
T
Site 161
T1102
T
M
E
S
N
L
K
T
I
E
E
E
N
K
V
Site 162
S1116
V
I
E
Q
Q
N
E
S
L
L
H
E
L
A
N
Site 163
Y1151
N
E
Q
N
F
D
A
Y
V
T
T
L
T
E
M
Site 164
Y1165
M
Y
T
N
Q
D
R
Y
Q
S
P
E
N
K
A
Site 165
S1167
T
N
Q
D
R
Y
Q
S
P
E
N
K
A
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation