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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZDHHC8
Full Name:
Probable palmitoyltransferase ZDHHC8
Alias:
KIAA1292; ZDHC8; Zinc finger DHHC domain containing 8; Zinc finger DHHC domain-containing protein 8; Zinc finger protein 378; Zinc finger, DHHC-type containing 8; ZNF378
Type:
EC 2.3.1.-; Transferase
Mass (Da):
81443
Number AA:
765
UniProt ID:
Q9ULC8
International Prot ID:
IPI00182118
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031410
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0008415
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
T
R
L
K
P
A
K
Y
I
P
V
A
T
A
A
Site 2
Y91
D
D
F
R
A
P
L
Y
K
N
V
D
V
R
G
Site 3
Y146
N
C
I
G
R
R
N
Y
R
Y
F
F
L
F
L
Site 4
T216
V
L
V
T
R
G
R
T
T
N
E
Q
V
T
G
Site 5
T217
L
V
T
R
G
R
T
T
N
E
Q
V
T
G
K
Site 6
Y252
C
S
P
L
A
P
R
Y
V
V
E
P
P
R
L
Site 7
S286
A
P
L
K
V
K
L
S
D
N
G
L
K
A
G
Site 8
S297
L
K
A
G
L
G
R
S
K
S
K
G
S
L
D
Site 9
S299
A
G
L
G
R
S
K
S
K
G
S
L
D
R
L
Site 10
S302
G
R
S
K
S
K
G
S
L
D
R
L
D
E
K
Site 11
T325
P
P
K
I
E
A
G
T
F
S
S
D
L
Q
T
Site 12
S328
I
E
A
G
T
F
S
S
D
L
Q
T
P
R
P
Site 13
T332
T
F
S
S
D
L
Q
T
P
R
P
G
S
A
E
Site 14
S337
L
Q
T
P
R
P
G
S
A
E
S
A
L
S
V
Site 15
S343
G
S
A
E
S
A
L
S
V
Q
R
T
S
P
P
Site 16
T347
S
A
L
S
V
Q
R
T
S
P
P
T
P
A
M
Site 17
S348
A
L
S
V
Q
R
T
S
P
P
T
P
A
M
Y
Site 18
T351
V
Q
R
T
S
P
P
T
P
A
M
Y
K
F
R
Site 19
T363
K
F
R
P
A
F
P
T
G
P
K
V
P
F
C
Site 20
S381
E
Q
V
P
G
P
D
S
L
T
L
G
D
D
S
Site 21
T383
V
P
G
P
D
S
L
T
L
G
D
D
S
I
R
Site 22
S391
L
G
D
D
S
I
R
S
L
D
F
V
S
E
P
Site 23
S396
I
R
S
L
D
F
V
S
E
P
S
L
D
L
P
Site 24
S399
L
D
F
V
S
E
P
S
L
D
L
P
D
Y
G
Site 25
Y405
P
S
L
D
L
P
D
Y
G
P
G
G
L
H
A
Site 26
Y414
P
G
G
L
H
A
A
Y
P
P
S
P
P
L
S
Site 27
S417
L
H
A
A
Y
P
P
S
P
P
L
S
A
S
D
Site 28
S421
Y
P
P
S
P
P
L
S
A
S
D
A
F
S
G
Site 29
S434
S
G
A
L
R
S
L
S
L
K
A
S
S
R
R
Site 30
S438
R
S
L
S
L
K
A
S
S
R
R
G
G
D
H
Site 31
S439
S
L
S
L
K
A
S
S
R
R
G
G
D
H
V
Site 32
S453
V
A
L
Q
P
L
R
S
E
G
G
P
P
T
P
Site 33
T459
R
S
E
G
G
P
P
T
P
H
R
S
I
F
A
Site 34
S463
G
P
P
T
P
H
R
S
I
F
A
P
H
A
L
Site 35
S476
A
L
P
N
R
N
G
S
L
S
Y
D
S
L
L
Site 36
S478
P
N
R
N
G
S
L
S
Y
D
S
L
L
N
P
Site 37
Y479
N
R
N
G
S
L
S
Y
D
S
L
L
N
P
G
Site 38
S481
N
G
S
L
S
Y
D
S
L
L
N
P
G
S
P
Site 39
S487
D
S
L
L
N
P
G
S
P
G
G
H
A
C
P
Site 40
Y504
P
A
V
G
V
A
G
Y
H
S
P
Y
L
H
P
Site 41
Y508
V
A
G
Y
H
S
P
Y
L
H
P
G
A
T
G
Site 42
S524
P
P
R
P
L
P
R
S
F
S
P
V
L
G
P
Site 43
S526
R
P
L
P
R
S
F
S
P
V
L
G
P
R
P
Site 44
S537
G
P
R
P
R
E
P
S
P
V
R
Y
D
N
L
Site 45
Y541
R
E
P
S
P
V
R
Y
D
N
L
S
R
T
I
Site 46
S545
P
V
R
Y
D
N
L
S
R
T
I
M
A
S
I
Site 47
T547
R
Y
D
N
L
S
R
T
I
M
A
S
I
Q
E
Site 48
S551
L
S
R
T
I
M
A
S
I
Q
E
R
K
D
R
Site 49
S567
E
R
E
R
L
L
R
S
Q
A
D
S
L
F
G
Site 50
S571
L
L
R
S
Q
A
D
S
L
F
G
D
S
G
V
Site 51
Y579
L
F
G
D
S
G
V
Y
D
A
P
S
S
Y
S
Site 52
S583
S
G
V
Y
D
A
P
S
S
Y
S
L
Q
Q
A
Site 53
S584
G
V
Y
D
A
P
S
S
Y
S
L
Q
Q
A
S
Site 54
S586
Y
D
A
P
S
S
Y
S
L
Q
Q
A
S
V
L
Site 55
S591
S
Y
S
L
Q
Q
A
S
V
L
S
E
G
P
R
Site 56
S594
L
Q
Q
A
S
V
L
S
E
G
P
R
G
P
A
Site 57
Y604
P
R
G
P
A
L
R
Y
G
S
R
D
D
L
V
Site 58
S606
G
P
A
L
R
Y
G
S
R
D
D
L
V
A
G
Site 59
T626
A
R
N
P
A
L
Q
T
S
L
S
S
L
S
S
Site 60
S627
R
N
P
A
L
Q
T
S
L
S
S
L
S
S
S
Site 61
S629
P
A
L
Q
T
S
L
S
S
L
S
S
S
V
S
Site 62
S630
A
L
Q
T
S
L
S
S
L
S
S
S
V
S
R
Site 63
S632
Q
T
S
L
S
S
L
S
S
S
V
S
R
A
P
Site 64
S633
T
S
L
S
S
L
S
S
S
V
S
R
A
P
R
Site 65
S634
S
L
S
S
L
S
S
S
V
S
R
A
P
R
T
Site 66
S636
S
S
L
S
S
S
V
S
R
A
P
R
T
S
S
Site 67
T641
S
V
S
R
A
P
R
T
S
S
S
S
L
Q
A
Site 68
S642
V
S
R
A
P
R
T
S
S
S
S
L
Q
A
D
Site 69
S643
S
R
A
P
R
T
S
S
S
S
L
Q
A
D
Q
Site 70
S645
A
P
R
T
S
S
S
S
L
Q
A
D
Q
A
S
Site 71
S652
S
L
Q
A
D
Q
A
S
S
N
A
P
G
P
R
Site 72
S653
L
Q
A
D
Q
A
S
S
N
A
P
G
P
R
P
Site 73
S661
N
A
P
G
P
R
P
S
S
G
S
H
R
S
P
Site 74
S662
H
T
L
V
K
K
V
S
G
V
G
G
T
T
Y
Site 75
S664
G
P
R
P
S
S
G
S
H
R
S
P
A
R
Q
Site 76
S667
P
S
S
G
S
H
R
S
P
A
R
Q
G
L
P
Site 77
S675
P
A
R
Q
G
L
P
S
P
P
G
T
P
H
S
Site 78
T679
G
L
P
S
P
P
G
T
P
H
S
P
S
Y
A
Site 79
S682
S
P
P
G
T
P
H
S
P
S
Y
A
G
P
K
Site 80
S684
P
G
T
P
H
S
P
S
Y
A
G
P
K
A
V
Site 81
Y685
G
T
P
H
S
P
S
Y
A
G
P
K
A
V
A
Site 82
T696
K
A
V
A
F
I
H
T
D
L
P
E
P
P
P
Site 83
S704
D
L
P
E
P
P
P
S
L
T
V
Q
R
D
H
Site 84
T706
P
E
P
P
P
S
L
T
V
Q
R
D
H
P
Q
Site 85
T716
R
D
H
P
Q
L
K
T
P
P
S
K
L
N
G
Site 86
S719
P
Q
L
K
T
P
P
S
K
L
N
G
Q
S
P
Site 87
S725
P
S
K
L
N
G
Q
S
P
G
L
A
R
L
G
Site 88
T735
L
A
R
L
G
P
A
T
G
P
P
G
P
S
A
Site 89
S741
A
T
G
P
P
G
P
S
A
S
P
T
R
H
T
Site 90
S743
G
P
P
G
P
S
A
S
P
T
R
H
T
L
V
Site 91
T745
P
G
P
S
A
S
P
T
R
H
T
L
V
K
K
Site 92
T748
S
A
S
P
T
R
H
T
L
V
K
K
V
S
G
Site 93
S754
H
T
L
V
K
K
V
S
G
V
G
G
T
T
Y
Site 94
T759
K
V
S
G
V
G
G
T
T
Y
E
I
S
V
_
Site 95
Y761
S
G
V
G
G
T
T
Y
E
I
S
V
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation