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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCNH3
Full Name:
Alias:
Type:
Mass (Da):
117129
Number AA:
1083
UniProt ID:
Q9ULD8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
P
Q
N
T
F
L
D
T
I
A
T
R
F
D
G
Site 2
T53
S
D
G
F
C
D
L
T
G
F
S
R
A
E
V
Site 3
T75
S
F
L
Y
G
P
D
T
S
E
L
V
R
Q
Q
Site 4
S134
L
V
S
H
K
D
I
S
E
T
K
N
R
G
G
Site 5
T136
S
H
K
D
I
S
E
T
K
N
R
G
G
P
D
Site 6
Y155
T
G
G
G
R
R
R
Y
G
R
A
R
S
K
G
Site 7
S160
R
R
Y
G
R
A
R
S
K
G
F
N
A
N
R
Site 8
S170
F
N
A
N
R
R
R
S
R
A
V
L
Y
H
L
Site 9
Y175
R
R
S
R
A
V
L
Y
H
L
S
G
H
L
Q
Site 10
S178
R
A
V
L
Y
H
L
S
G
H
L
Q
K
Q
P
Site 11
Y205
E
K
P
N
L
P
E
Y
K
V
A
A
I
R
K
Site 12
S255
V
S
T
A
R
E
P
S
A
A
R
G
P
P
S
Site 13
Y352
L
L
P
R
L
D
R
Y
S
Q
Y
S
A
V
V
Site 14
S353
L
P
R
L
D
R
Y
S
Q
Y
S
A
V
V
L
Site 15
Y355
R
L
D
R
Y
S
Q
Y
S
A
V
V
L
T
L
Site 16
S389
G
Q
R
E
I
E
S
S
E
S
E
L
P
E
I
Site 17
S391
R
E
I
E
S
S
E
S
E
L
P
E
I
G
W
Site 18
T408
E
L
A
R
R
L
E
T
P
Y
Y
L
V
G
R
Site 19
Y410
A
R
R
L
E
T
P
Y
Y
L
V
G
R
R
P
Site 20
Y411
R
R
L
E
T
P
Y
Y
L
V
G
R
R
P
A
Site 21
S422
R
R
P
A
G
G
N
S
S
G
Q
S
D
N
C
Site 22
S423
R
P
A
G
G
N
S
S
G
Q
S
D
N
C
S
Site 23
S426
G
G
N
S
S
G
Q
S
D
N
C
S
S
S
S
Site 24
S430
S
G
Q
S
D
N
C
S
S
S
S
E
A
N
G
Site 25
S432
Q
S
D
N
C
S
S
S
S
E
A
N
G
T
G
Site 26
S433
S
D
N
C
S
S
S
S
E
A
N
G
T
G
L
Site 27
T438
S
S
S
E
A
N
G
T
G
L
E
L
L
G
G
Site 28
T477
N
V
S
A
N
T
D
T
E
K
I
F
S
I
C
Site 29
Y508
T
A
I
I
Q
R
M
Y
A
R
R
F
L
Y
H
Site 30
Y514
M
Y
A
R
R
F
L
Y
H
S
R
T
R
D
L
Site 31
S516
A
R
R
F
L
Y
H
S
R
T
R
D
L
R
D
Site 32
Y524
R
T
R
D
L
R
D
Y
I
R
I
H
R
I
P
Site 33
Y541
L
K
Q
R
M
L
E
Y
F
Q
A
T
W
A
V
Site 34
T555
V
N
N
G
I
D
T
T
E
L
L
Q
S
L
P
Site 35
S560
D
T
T
E
L
L
Q
S
L
P
D
E
L
R
A
Site 36
Y608
A
F
C
T
P
G
E
Y
L
I
H
Q
G
D
A
Site 37
Y685
L
H
D
S
L
A
L
Y
P
E
F
A
P
R
F
Site 38
S693
P
E
F
A
P
R
F
S
R
G
L
R
G
E
L
Site 39
S701
R
G
L
R
G
E
L
S
Y
N
L
G
A
G
G
Site 40
Y702
G
L
R
G
E
L
S
Y
N
L
G
A
G
G
G
Site 41
T715
G
G
S
A
E
V
D
T
S
S
L
S
G
D
N
Site 42
S716
G
S
A
E
V
D
T
S
S
L
S
G
D
N
T
Site 43
S717
S
A
E
V
D
T
S
S
L
S
G
D
N
T
L
Site 44
S719
E
V
D
T
S
S
L
S
G
D
N
T
L
M
S
Site 45
T723
S
S
L
S
G
D
N
T
L
M
S
T
L
E
E
Site 46
S726
S
G
D
N
T
L
M
S
T
L
E
E
K
E
T
Site 47
T733
S
T
L
E
E
K
E
T
D
G
E
Q
G
P
T
Site 48
T740
T
D
G
E
Q
G
P
T
V
S
P
A
P
A
D
Site 49
S742
G
E
Q
G
P
T
V
S
P
A
P
A
D
E
P
Site 50
S750
P
A
P
A
D
E
P
S
S
P
L
L
S
P
G
Site 51
S751
A
P
A
D
E
P
S
S
P
L
L
S
P
G
C
Site 52
S755
E
P
S
S
P
L
L
S
P
G
C
T
S
S
S
Site 53
T759
P
L
L
S
P
G
C
T
S
S
S
S
A
A
K
Site 54
S762
S
P
G
C
T
S
S
S
S
A
A
K
L
L
S
Site 55
S763
P
G
C
T
S
S
S
S
A
A
K
L
L
S
P
Site 56
S769
S
S
A
A
K
L
L
S
P
R
R
T
A
P
R
Site 57
T773
K
L
L
S
P
R
R
T
A
P
R
P
R
L
G
Site 58
S798
L
K
A
E
A
G
P
S
A
P
P
R
A
L
E
Site 59
S821
W
N
V
P
P
D
L
S
P
R
V
V
D
G
I
Site 60
S834
G
I
E
D
G
C
G
S
D
Q
P
K
F
S
F
Site 61
S840
G
S
D
Q
P
K
F
S
F
R
V
G
Q
S
G
Site 62
S846
F
S
F
R
V
G
Q
S
G
P
E
C
S
S
S
Site 63
S851
G
Q
S
G
P
E
C
S
S
S
P
S
P
G
P
Site 64
S852
Q
S
G
P
E
C
S
S
S
P
S
P
G
P
E
Site 65
S853
S
G
P
E
C
S
S
S
P
S
P
G
P
E
S
Site 66
S855
P
E
C
S
S
S
P
S
P
G
P
E
S
G
L
Site 67
S860
S
P
S
P
G
P
E
S
G
L
L
T
V
P
H
Site 68
T864
G
P
E
S
G
L
L
T
V
P
H
G
P
S
E
Site 69
T875
G
P
S
E
A
R
N
T
D
T
L
D
K
L
R
Site 70
T877
S
E
A
R
N
T
D
T
L
D
K
L
R
Q
A
Site 71
S889
R
Q
A
V
T
E
L
S
E
Q
V
L
Q
M
R
Site 72
S901
Q
M
R
E
G
L
Q
S
L
R
Q
A
V
Q
L
Site 73
S922
E
G
P
C
P
R
A
S
G
E
G
P
C
P
A
Site 74
S930
G
E
G
P
C
P
A
S
T
S
G
L
L
Q
P
Site 75
S958
P
P
A
G
S
V
L
S
G
T
W
P
H
P
R
Site 76
T960
A
G
S
V
L
S
G
T
W
P
H
P
R
P
G
Site 77
S982
W
P
W
G
P
P
A
S
Q
S
S
P
W
P
R
Site 78
S984
W
G
P
P
A
S
Q
S
S
P
W
P
R
A
T
Site 79
S985
G
P
P
A
S
Q
S
S
P
W
P
R
A
T
A
Site 80
T991
S
S
P
W
P
R
A
T
A
F
W
T
S
T
S
Site 81
S996
R
A
T
A
F
W
T
S
T
S
D
S
E
P
P
Site 82
S998
T
A
F
W
T
S
T
S
D
S
E
P
P
A
S
Site 83
S1000
F
W
T
S
T
S
D
S
E
P
P
A
S
G
D
Site 84
S1005
S
D
S
E
P
P
A
S
G
D
L
C
S
E
P
Site 85
S1010
P
A
S
G
D
L
C
S
E
P
S
T
P
A
S
Site 86
S1013
G
D
L
C
S
E
P
S
T
P
A
S
P
P
P
Site 87
T1014
D
L
C
S
E
P
S
T
P
A
S
P
P
P
S
Site 88
S1017
S
E
P
S
T
P
A
S
P
P
P
S
E
E
G
Site 89
S1021
T
P
A
S
P
P
P
S
E
E
G
A
R
T
G
Site 90
T1027
P
S
E
E
G
A
R
T
G
P
A
E
P
V
S
Site 91
S1034
T
G
P
A
E
P
V
S
Q
A
E
A
T
S
T
Site 92
T1041
S
Q
A
E
A
T
S
T
G
E
P
P
P
G
S
Site 93
S1048
T
G
E
P
P
P
G
S
G
G
L
A
L
P
W
Site 94
T1072
I
G
C
H
G
S
G
T
V
Q
W
T
Q
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation