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Updated November 2019
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Protein Info
Short Name:
ZNF608
Full Name:
ISOFORM 1 OF ZINC FINGER PROTEIN 608.
Alias:
DKFZp434M098; KIAA1281; NY-REN-36; Zinc finger protein 608; ZN608
Type:
Intracellular, Cytoplasm, Nucleus protein
Mass (Da):
162221
Number AA:
1512
UniProt ID:
Q9ULD9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
G
K
G
V
D
P
N
T
V
D
T
Y
D
S
G
Site 2
Y20
D
P
N
T
V
D
T
Y
D
S
G
D
D
W
E
Site 3
S22
N
T
V
D
T
Y
D
S
G
D
D
W
E
I
G
Site 4
S53
Q
K
F
E
M
N
N
S
T
T
T
T
S
S
S
Site 5
T54
K
F
E
M
N
N
S
T
T
T
T
S
S
S
N
Site 6
T55
F
E
M
N
N
S
T
T
T
T
S
S
S
N
S
Site 7
T56
E
M
N
N
S
T
T
T
T
S
S
S
N
S
K
Site 8
T57
M
N
N
S
T
T
T
T
S
S
S
N
S
K
D
Site 9
S58
N
N
S
T
T
T
T
S
S
S
N
S
K
D
C
Site 10
S59
N
S
T
T
T
T
S
S
S
N
S
K
D
C
G
Site 11
S60
S
T
T
T
T
S
S
S
N
S
K
D
C
G
G
Site 12
S62
T
T
T
S
S
S
N
S
K
D
C
G
G
P
A
Site 13
S70
K
D
C
G
G
P
A
S
S
G
A
G
A
T
A
Site 14
S71
D
C
G
G
P
A
S
S
G
A
G
A
T
A
A
Site 15
S87
A
D
G
L
K
F
A
S
V
Q
A
S
A
P
Q
Site 16
S91
K
F
A
S
V
Q
A
S
A
P
Q
G
N
S
H
Site 17
T101
Q
G
N
S
H
K
E
T
S
K
S
K
V
K
R
Site 18
S104
S
H
K
E
T
S
K
S
K
V
K
R
S
K
T
Site 19
S109
S
K
S
K
V
K
R
S
K
T
S
K
D
A
N
Site 20
T111
S
K
V
K
R
S
K
T
S
K
D
A
N
K
S
Site 21
S118
T
S
K
D
A
N
K
S
L
P
S
A
A
L
Y
Site 22
T133
G
I
P
E
I
S
S
T
G
K
R
Q
E
V
Q
Site 23
T147
Q
G
R
P
G
E
A
T
G
M
N
S
A
L
G
Site 24
S156
M
N
S
A
L
G
Q
S
V
S
S
G
G
S
G
Site 25
S158
S
A
L
G
Q
S
V
S
S
G
G
S
G
N
P
Site 26
S162
Q
S
V
S
S
G
G
S
G
N
P
N
S
N
S
Site 27
S167
G
G
S
G
N
P
N
S
N
S
T
S
T
S
T
Site 28
S169
S
G
N
P
N
S
N
S
T
S
T
S
T
S
A
Site 29
S171
N
P
N
S
N
S
T
S
T
S
T
S
A
A
T
Site 30
S173
N
S
N
S
T
S
T
S
T
S
A
A
T
A
G
Site 31
S175
N
S
T
S
T
S
T
S
A
A
T
A
G
A
G
Site 32
S183
A
A
T
A
G
A
G
S
C
G
K
S
K
E
E
Site 33
S187
G
A
G
S
C
G
K
S
K
E
E
K
P
G
K
Site 34
S195
K
E
E
K
P
G
K
S
Q
S
S
R
G
A
K
Site 35
S197
E
K
P
G
K
S
Q
S
S
R
G
A
K
R
D
Site 36
S225
L
Q
G
H
Q
N
G
S
G
S
Q
A
P
S
G
Site 37
S227
G
H
Q
N
G
S
G
S
Q
A
P
S
G
G
H
Site 38
S231
G
S
G
S
Q
A
P
S
G
G
H
L
Y
G
F
Site 39
Y236
A
P
S
G
G
H
L
Y
G
F
G
A
K
S
N
Site 40
S242
L
Y
G
F
G
A
K
S
N
G
G
G
A
S
P
Site 41
S248
K
S
N
G
G
G
A
S
P
F
H
C
G
G
T
Site 42
S269
A
A
G
E
V
S
K
S
A
P
D
S
G
L
M
Site 43
S273
V
S
K
S
A
P
D
S
G
L
M
G
N
S
M
Site 44
S279
D
S
G
L
M
G
N
S
M
L
V
K
K
E
E
Site 45
S291
K
E
E
E
E
E
E
S
H
R
R
I
K
K
L
Site 46
T300
R
R
I
K
K
L
K
T
E
K
V
D
P
L
F
Site 47
T308
E
K
V
D
P
L
F
T
V
P
A
P
P
P
P
Site 48
S317
P
A
P
P
P
P
I
S
S
S
L
T
P
Q
I
Site 49
S319
P
P
P
P
I
S
S
S
L
T
P
Q
I
L
P
Site 50
T321
P
P
I
S
S
S
L
T
P
Q
I
L
P
S
Y
Site 51
S327
L
T
P
Q
I
L
P
S
Y
F
S
P
S
S
S
Site 52
Y328
T
P
Q
I
L
P
S
Y
F
S
P
S
S
S
N
Site 53
S330
Q
I
L
P
S
Y
F
S
P
S
S
S
N
I
A
Site 54
S332
L
P
S
Y
F
S
P
S
S
S
N
I
A
A
P
Site 55
S333
P
S
Y
F
S
P
S
S
S
N
I
A
A
P
V
Site 56
S334
S
Y
F
S
P
S
S
S
N
I
A
A
P
V
E
Site 57
S349
Q
L
L
V
R
T
R
S
V
G
V
N
T
C
E
Site 58
T400
N
V
T
W
R
N
K
T
Y
V
G
T
L
L
D
Site 59
Y401
V
T
W
R
N
K
T
Y
V
G
T
L
L
D
C
Site 60
S421
A
P
P
R
F
C
E
S
P
T
S
D
L
E
M
Site 61
S424
R
F
C
E
S
P
T
S
D
L
E
M
R
G
G
Site 62
S440
G
R
G
K
R
A
R
S
A
A
A
A
P
G
S
Site 63
S447
S
A
A
A
A
P
G
S
E
A
S
F
T
E
S
Site 64
S450
A
A
P
G
S
E
A
S
F
T
E
S
R
G
L
Site 65
T452
P
G
S
E
A
S
F
T
E
S
R
G
L
Q
N
Site 66
S454
S
E
A
S
F
T
E
S
R
G
L
Q
N
K
N
Site 67
S473
N
G
K
G
R
R
G
S
L
N
A
S
G
R
R
Site 68
S477
R
R
G
S
L
N
A
S
G
R
R
T
P
P
N
Site 69
T481
L
N
A
S
G
R
R
T
P
P
N
C
A
A
E
Site 70
S493
A
A
E
D
I
K
A
S
P
S
S
T
N
K
R
Site 71
S495
E
D
I
K
A
S
P
S
S
T
N
K
R
K
N
Site 72
S496
D
I
K
A
S
P
S
S
T
N
K
R
K
N
K
Site 73
T497
I
K
A
S
P
S
S
T
N
K
R
K
N
K
P
Site 74
S512
P
M
E
L
D
L
N
S
S
S
E
D
N
K
P
Site 75
S513
M
E
L
D
L
N
S
S
S
E
D
N
K
P
G
Site 76
S514
E
L
D
L
N
S
S
S
E
D
N
K
P
G
K
Site 77
T525
K
P
G
K
R
V
R
T
N
S
R
S
T
P
T
Site 78
S527
G
K
R
V
R
T
N
S
R
S
T
P
T
T
P
Site 79
S529
R
V
R
T
N
S
R
S
T
P
T
T
P
Q
G
Site 80
T530
V
R
T
N
S
R
S
T
P
T
T
P
Q
G
K
Site 81
T533
N
S
R
S
T
P
T
T
P
Q
G
K
P
E
T
Site 82
T541
P
Q
G
K
P
E
T
T
F
L
D
Q
G
C
S
Site 83
S549
F
L
D
Q
G
C
S
S
P
V
L
I
D
C
P
Site 84
Y564
H
P
N
C
N
K
K
Y
K
H
I
N
G
L
R
Site 85
Y572
K
H
I
N
G
L
R
Y
H
Q
A
H
A
H
L
Site 86
S591
K
L
E
F
E
P
D
S
E
D
K
I
S
D
C
Site 87
S596
P
D
S
E
D
K
I
S
D
C
E
E
G
L
S
Site 88
S603
S
D
C
E
E
G
L
S
N
V
A
L
E
C
S
Site 89
S610
S
N
V
A
L
E
C
S
E
P
S
T
S
V
S
Site 90
S613
A
L
E
C
S
E
P
S
T
S
V
S
A
Y
D
Site 91
T614
L
E
C
S
E
P
S
T
S
V
S
A
Y
D
Q
Site 92
S615
E
C
S
E
P
S
T
S
V
S
A
Y
D
Q
L
Site 93
S617
S
E
P
S
T
S
V
S
A
Y
D
Q
L
K
A
Site 94
S627
D
Q
L
K
A
P
A
S
P
G
A
G
N
P
P
Site 95
T636
G
A
G
N
P
P
G
T
P
K
G
K
R
E
L
Site 96
S645
K
G
K
R
E
L
M
S
N
G
P
G
S
I
I
Site 97
S685
N
M
T
A
A
L
D
S
C
S
A
A
D
G
S
Site 98
S692
S
C
S
A
A
D
G
S
L
A
A
E
M
P
K
Site 99
T725
K
K
A
N
N
C
K
T
D
K
N
L
S
K
L
Site 100
S730
C
K
T
D
K
N
L
S
K
L
K
S
A
R
P
Site 101
S734
K
N
L
S
K
L
K
S
A
R
P
I
A
P
A
Site 102
T779
T
T
T
V
V
Q
A
T
P
K
S
P
P
L
K
Site 103
S782
V
V
Q
A
T
P
K
S
P
P
L
K
P
I
Q
Site 104
S807
T
V
N
P
A
L
V
S
L
K
D
K
K
K
K
Site 105
T827
K
D
K
E
G
K
E
T
G
S
P
K
M
D
A
Site 106
S829
K
E
G
K
E
T
G
S
P
K
M
D
A
K
L
Site 107
S842
K
L
G
K
L
E
D
S
K
G
A
S
K
D
L
Site 108
S846
L
E
D
S
K
G
A
S
K
D
L
P
G
H
F
Site 109
S869
E
G
L
A
N
G
L
S
E
S
Q
E
S
R
M
Site 110
S871
L
A
N
G
L
S
E
S
Q
E
S
R
M
A
S
Site 111
S874
G
L
S
E
S
Q
E
S
R
M
A
S
I
K
A
Site 112
S878
S
Q
E
S
R
M
A
S
I
K
A
E
A
D
K
Site 113
Y887
K
A
E
A
D
K
V
Y
T
F
T
D
N
A
P
Site 114
T888
A
E
A
D
K
V
Y
T
F
T
D
N
A
P
S
Site 115
S895
T
F
T
D
N
A
P
S
P
S
I
G
S
A
S
Site 116
S897
T
D
N
A
P
S
P
S
I
G
S
A
S
R
L
Site 117
S900
A
P
S
P
S
I
G
S
A
S
R
L
E
C
S
Site 118
S902
S
P
S
I
G
S
A
S
R
L
E
C
S
T
L
Site 119
T908
A
S
R
L
E
C
S
T
L
V
N
G
Q
A
P
Site 120
T923
M
A
P
L
H
V
L
T
Q
N
G
A
E
S
S
Site 121
S930
T
Q
N
G
A
E
S
S
A
A
K
T
S
S
P
Site 122
T934
A
E
S
S
A
A
K
T
S
S
P
A
Y
S
D
Site 123
S936
S
S
A
A
K
T
S
S
P
A
Y
S
D
I
S
Site 124
Y939
A
K
T
S
S
P
A
Y
S
D
I
S
D
A
A
Site 125
S940
K
T
S
S
P
A
Y
S
D
I
S
D
A
A
D
Site 126
S943
S
P
A
Y
S
D
I
S
D
A
A
D
D
G
G
Site 127
S951
D
A
A
D
D
G
G
S
D
S
R
S
E
G
M
Site 128
S953
A
D
D
G
G
S
D
S
R
S
E
G
M
R
S
Site 129
S955
D
G
G
S
D
S
R
S
E
G
M
R
S
K
A
Site 130
S960
S
R
S
E
G
M
R
S
K
A
S
S
P
S
D
Site 131
S963
E
G
M
R
S
K
A
S
S
P
S
D
I
I
S
Site 132
S964
G
M
R
S
K
A
S
S
P
S
D
I
I
S
S
Site 133
S966
R
S
K
A
S
S
P
S
D
I
I
S
S
K
D
Site 134
S970
S
S
P
S
D
I
I
S
S
K
D
S
V
V
K
Site 135
S971
S
P
S
D
I
I
S
S
K
D
S
V
V
K
G
Site 136
S974
D
I
I
S
S
K
D
S
V
V
K
G
H
S
S
Site 137
S981
S
V
V
K
G
H
S
S
T
T
A
Q
S
S
Q
Site 138
T982
V
V
K
G
H
S
S
T
T
A
Q
S
S
Q
L
Site 139
S987
S
S
T
T
A
Q
S
S
Q
L
K
E
S
H
S
Site 140
S992
Q
S
S
Q
L
K
E
S
H
S
P
Y
Y
H
S
Site 141
S994
S
Q
L
K
E
S
H
S
P
Y
Y
H
S
Y
D
Site 142
Y996
L
K
E
S
H
S
P
Y
Y
H
S
Y
D
P
Y
Site 143
Y997
K
E
S
H
S
P
Y
Y
H
S
Y
D
P
Y
Y
Site 144
Y1000
H
S
P
Y
Y
H
S
Y
D
P
Y
Y
S
P
S
Site 145
Y1003
Y
Y
H
S
Y
D
P
Y
Y
S
P
S
Y
M
H
Site 146
Y1004
Y
H
S
Y
D
P
Y
Y
S
P
S
Y
M
H
P
Site 147
S1005
H
S
Y
D
P
Y
Y
S
P
S
Y
M
H
P
G
Site 148
Y1008
D
P
Y
Y
S
P
S
Y
M
H
P
G
Q
V
G
Site 149
S1022
G
A
P
A
A
G
N
S
G
S
T
Q
G
M
K
Site 150
S1024
P
A
A
G
N
S
G
S
T
Q
G
M
K
I
K
Site 151
S1049
D
K
A
E
Q
L
D
S
K
K
V
D
H
N
S
Site 152
S1056
S
K
K
V
D
H
N
S
A
S
L
Q
P
Q
H
Site 153
S1058
K
V
D
H
N
S
A
S
L
Q
P
Q
H
Q
S
Site 154
Y1079
P
A
L
A
Q
S
L
Y
Y
G
Q
Y
A
Y
G
Site 155
Y1083
Q
S
L
Y
Y
G
Q
Y
A
Y
G
L
Y
M
D
Site 156
Y1088
G
Q
Y
A
Y
G
L
Y
M
D
Q
K
S
L
M
Site 157
S1093
G
L
Y
M
D
Q
K
S
L
M
A
T
S
P
A
Site 158
S1098
Q
K
S
L
M
A
T
S
P
A
Y
R
Q
Q
Y
Site 159
Y1105
S
P
A
Y
R
Q
Q
Y
E
K
Y
Y
E
D
Q
Site 160
Y1108
Y
R
Q
Q
Y
E
K
Y
Y
E
D
Q
R
L
A
Site 161
Y1109
R
Q
Q
Y
E
K
Y
Y
E
D
Q
R
L
A
E
Site 162
S1131
R
G
D
C
E
R
K
S
E
L
P
L
K
E
L
Site 163
T1143
K
E
L
G
K
E
E
T
K
Q
K
N
M
P
S
Site 164
S1150
T
K
Q
K
N
M
P
S
A
T
I
S
K
A
P
Site 165
T1152
Q
K
N
M
P
S
A
T
I
S
K
A
P
S
T
Site 166
S1154
N
M
P
S
A
T
I
S
K
A
P
S
T
P
E
Site 167
S1158
A
T
I
S
K
A
P
S
T
P
E
P
N
K
N
Site 168
T1159
T
I
S
K
A
P
S
T
P
E
P
N
K
N
H
Site 169
S1172
N
H
S
K
L
G
P
S
V
P
N
K
T
E
E
Site 170
T1177
G
P
S
V
P
N
K
T
E
E
T
G
K
S
Q
Site 171
S1183
K
T
E
E
T
G
K
S
Q
L
L
S
N
H
Q
Site 172
S1187
T
G
K
S
Q
L
L
S
N
H
Q
Q
Q
L
Q
Site 173
S1197
Q
Q
Q
L
Q
A
D
S
F
K
A
K
Q
M
E
Site 174
S1217
K
E
A
V
E
M
K
S
V
M
D
S
M
K
Q
Site 175
S1221
E
M
K
S
V
M
D
S
M
K
Q
T
G
V
D
Site 176
T1225
V
M
D
S
M
K
Q
T
G
V
D
P
T
S
R
Site 177
T1230
K
Q
T
G
V
D
P
T
S
R
F
K
Q
D
P
Site 178
S1231
Q
T
G
V
D
P
T
S
R
F
K
Q
D
P
D
Site 179
S1239
R
F
K
Q
D
P
D
S
R
T
W
H
H
Y
V
Site 180
Y1245
D
S
R
T
W
H
H
Y
V
Y
Q
P
K
Y
L
Site 181
Y1251
H
Y
V
Y
Q
P
K
Y
L
D
Q
Q
K
S
E
Site 182
S1257
K
Y
L
D
Q
Q
K
S
E
E
L
D
R
E
K
Site 183
S1270
E
K
K
L
K
E
D
S
P
R
K
T
P
N
K
Site 184
T1274
K
E
D
S
P
R
K
T
P
N
K
E
S
G
V
Site 185
S1279
R
K
T
P
N
K
E
S
G
V
P
S
L
P
V
Site 186
S1283
N
K
E
S
G
V
P
S
L
P
V
S
L
T
S
Site 187
S1287
G
V
P
S
L
P
V
S
L
T
S
I
K
E
E
Site 188
T1289
P
S
L
P
V
S
L
T
S
I
K
E
E
P
K
Site 189
S1290
S
L
P
V
S
L
T
S
I
K
E
E
P
K
E
Site 190
S1303
K
E
A
K
H
P
D
S
Q
S
M
E
E
S
K
Site 191
S1305
A
K
H
P
D
S
Q
S
M
E
E
S
K
L
K
Site 192
S1309
D
S
Q
S
M
E
E
S
K
L
K
N
D
D
R
Site 193
T1318
L
K
N
D
D
R
K
T
P
V
N
W
K
D
S
Site 194
T1328
N
W
K
D
S
R
G
T
R
V
A
V
S
S
P
Site 195
S1333
R
G
T
R
V
A
V
S
S
P
M
S
Q
H
Q
Site 196
S1334
G
T
R
V
A
V
S
S
P
M
S
Q
H
Q
S
Site 197
S1337
V
A
V
S
S
P
M
S
Q
H
Q
S
Y
I
Q
Site 198
Y1342
P
M
S
Q
H
Q
S
Y
I
Q
Y
L
H
A
Y
Site 199
Y1345
Q
H
Q
S
Y
I
Q
Y
L
H
A
Y
P
Y
P
Site 200
Y1351
Q
Y
L
H
A
Y
P
Y
P
Q
M
Y
D
P
S
Site 201
Y1355
A
Y
P
Y
P
Q
M
Y
D
P
S
H
P
A
Y
Site 202
Y1362
Y
D
P
S
H
P
A
Y
R
A
V
S
P
V
L
Site 203
S1366
H
P
A
Y
R
A
V
S
P
V
L
M
H
S
Y
Site 204
Y1373
S
P
V
L
M
H
S
Y
P
G
A
Y
L
S
P
Site 205
Y1377
M
H
S
Y
P
G
A
Y
L
S
P
G
F
H
Y
Site 206
S1379
S
Y
P
G
A
Y
L
S
P
G
F
H
Y
P
V
Site 207
Y1384
Y
L
S
P
G
F
H
Y
P
V
Y
G
K
M
S
Site 208
Y1387
P
G
F
H
Y
P
V
Y
G
K
M
S
G
R
E
Site 209
S1391
Y
P
V
Y
G
K
M
S
G
R
E
E
T
E
K
Site 210
T1396
K
M
S
G
R
E
E
T
E
K
V
N
T
S
P
Site 211
T1401
E
E
T
E
K
V
N
T
S
P
S
V
N
T
K
Site 212
S1402
E
T
E
K
V
N
T
S
P
S
V
N
T
K
T
Site 213
S1404
E
K
V
N
T
S
P
S
V
N
T
K
T
T
T
Site 214
T1407
N
T
S
P
S
V
N
T
K
T
T
T
E
S
K
Site 215
T1409
S
P
S
V
N
T
K
T
T
T
E
S
K
A
L
Site 216
T1411
S
V
N
T
K
T
T
T
E
S
K
A
L
D
L
Site 217
Y1426
L
Q
Q
H
A
N
Q
Y
R
S
K
S
P
A
P
Site 218
S1430
A
N
Q
Y
R
S
K
S
P
A
P
V
E
K
A
Site 219
S1453
E
R
E
R
D
R
H
S
P
F
G
Q
R
H
L
Site 220
Y1472
H
T
H
V
G
M
G
Y
P
L
I
P
G
Q
Y
Site 221
Y1479
Y
P
L
I
P
G
Q
Y
D
P
F
Q
G
L
T
Site 222
S1501
Q
Q
V
A
A
Q
A
S
A
S
G
M
F
P
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation