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Updated November 2019
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Protein Info
Short Name:
WWC3
Full Name:
Protein WWC3
Alias:
WWC family member 3
Type:
Phosphoprotein
Mass (Da):
122676
Number AA:
1092
UniProt ID:
Q9ULE0
International Prot ID:
IPI00395925
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y28
Q
E
R
M
L
K
E
Y
L
I
V
A
Q
E
A
Site 2
Y57
F
E
L
A
Q
E
E
Y
Q
Q
L
H
K
M
C
Site 3
S68
H
K
M
C
E
D
D
S
R
S
Y
A
S
S
F
Site 4
S70
M
C
E
D
D
S
R
S
Y
A
S
S
F
S
G
Site 5
Y71
C
E
D
D
S
R
S
Y
A
S
S
F
S
G
Y
Site 6
S74
D
S
R
S
Y
A
S
S
F
S
G
Y
S
T
N
Site 7
S76
R
S
Y
A
S
S
F
S
G
Y
S
T
N
T
K
Site 8
T80
S
S
F
S
G
Y
S
T
N
T
K
Y
D
P
H
Site 9
Y84
G
Y
S
T
N
T
K
Y
D
P
H
Q
I
K
A
Site 10
S95
Q
I
K
A
E
I
A
S
R
R
D
R
L
S
R
Site 11
S101
A
S
R
R
D
R
L
S
R
L
K
R
E
L
T
Site 12
T108
S
R
L
K
R
E
L
T
Q
M
K
Q
E
L
Q
Site 13
S132
Q
E
I
D
R
K
M
S
S
T
H
T
S
Y
K
Site 14
S133
E
I
D
R
K
M
S
S
T
H
T
S
Y
K
L
Site 15
T134
I
D
R
K
M
S
S
T
H
T
S
Y
K
L
D
Site 16
T136
R
K
M
S
S
T
H
T
S
Y
K
L
D
E
A
Site 17
S137
K
M
S
S
T
H
T
S
Y
K
L
D
E
A
Q
Site 18
S170
E
R
R
D
L
M
H
S
L
A
K
L
T
D
S
Site 19
T175
M
H
S
L
A
K
L
T
D
S
F
K
N
S
C
Site 20
S177
S
L
A
K
L
T
D
S
F
K
N
S
C
S
V
Site 21
S181
L
T
D
S
F
K
N
S
C
S
V
T
D
S
L
Site 22
S183
D
S
F
K
N
S
C
S
V
T
D
S
L
V
D
Site 23
T185
F
K
N
S
C
S
V
T
D
S
L
V
D
F
P
Site 24
S187
N
S
C
S
V
T
D
S
L
V
D
F
P
H
H
Site 25
S212
Q
Q
F
C
D
A
G
S
Q
T
D
I
I
G
E
Site 26
T226
E
F
V
F
D
D
K
T
R
L
V
D
R
V
R
Site 27
Y238
R
V
R
L
N
W
Q
Y
E
E
A
R
K
R
V
Site 28
S259
L
A
R
L
D
N
E
S
W
P
S
T
A
E
A
Site 29
S262
L
D
N
E
S
W
P
S
T
A
E
A
D
R
D
Site 30
T263
D
N
E
S
W
P
S
T
A
E
A
D
R
D
R
Site 31
S293
L
I
I
A
Q
R
R
S
A
G
D
V
A
R
L
Site 32
T317
E
L
R
R
A
R
A
T
S
A
Q
G
A
T
E
Site 33
S318
L
R
R
A
R
A
T
S
A
Q
G
A
T
E
R
Site 34
T346
L
E
E
A
T
R
L
T
S
Y
L
Q
S
Q
L
Site 35
S347
E
E
A
T
R
L
T
S
Y
L
Q
S
Q
L
K
Site 36
Y348
E
A
T
R
L
T
S
Y
L
Q
S
Q
L
K
S
Site 37
S351
R
L
T
S
Y
L
Q
S
Q
L
K
S
L
C
A
Site 38
T362
S
L
C
A
S
T
L
T
V
S
S
G
S
S
R
Site 39
S364
C
A
S
T
L
T
V
S
S
G
S
S
R
G
S
Site 40
S365
A
S
T
L
T
V
S
S
G
S
S
R
G
S
L
Site 41
S367
T
L
T
V
S
S
G
S
S
R
G
S
L
A
S
Site 42
S368
L
T
V
S
S
G
S
S
R
G
S
L
A
S
S
Site 43
S371
S
S
G
S
S
R
G
S
L
A
S
S
R
G
S
Site 44
S374
S
S
R
G
S
L
A
S
S
R
G
S
L
A
S
Site 45
S375
S
R
G
S
L
A
S
S
R
G
S
L
A
S
S
Site 46
S378
S
L
A
S
S
R
G
S
L
A
S
S
R
G
S
Site 47
S381
S
S
R
G
S
L
A
S
S
R
G
S
L
S
S
Site 48
S382
S
R
G
S
L
A
S
S
R
G
S
L
S
S
V
Site 49
S385
S
L
A
S
S
R
G
S
L
S
S
V
S
F
T
Site 50
S387
A
S
S
R
G
S
L
S
S
V
S
F
T
D
I
Site 51
S388
S
S
R
G
S
L
S
S
V
S
F
T
D
I
Y
Site 52
Y395
S
V
S
F
T
D
I
Y
G
L
P
Q
Y
E
K
Site 53
Y400
D
I
Y
G
L
P
Q
Y
E
K
P
D
A
E
G
Site 54
S408
E
K
P
D
A
E
G
S
Q
L
L
R
F
D
L
Site 55
S420
F
D
L
I
P
F
D
S
L
G
R
D
A
P
F
Site 56
S428
L
G
R
D
A
P
F
S
E
P
P
G
P
S
G
Site 57
S442
G
F
H
K
Q
R
R
S
L
D
T
P
Q
S
L
Site 58
T445
K
Q
R
R
S
L
D
T
P
Q
S
L
A
S
L
Site 59
S448
R
S
L
D
T
P
Q
S
L
A
S
L
S
S
R
Site 60
S451
D
T
P
Q
S
L
A
S
L
S
S
R
S
S
L
Site 61
S453
P
Q
S
L
A
S
L
S
S
R
S
S
L
S
S
Site 62
S454
Q
S
L
A
S
L
S
S
R
S
S
L
S
S
L
Site 63
S456
L
A
S
L
S
S
R
S
S
L
S
S
L
S
P
Site 64
S457
A
S
L
S
S
R
S
S
L
S
S
L
S
P
P
Site 65
S459
L
S
S
R
S
S
L
S
S
L
S
P
P
S
S
Site 66
S460
S
S
R
S
S
L
S
S
L
S
P
P
S
S
P
Site 67
S462
R
S
S
L
S
S
L
S
P
P
S
S
P
L
D
Site 68
S465
L
S
S
L
S
P
P
S
S
P
L
D
T
P
F
Site 69
S466
S
S
L
S
P
P
S
S
P
L
D
T
P
F
L
Site 70
T470
P
P
S
S
P
L
D
T
P
F
L
P
A
S
R
Site 71
S476
D
T
P
F
L
P
A
S
R
D
S
P
L
A
Q
Site 72
S479
F
L
P
A
S
R
D
S
P
L
A
Q
L
A
D
Site 73
S504
D
R
L
R
A
H
A
S
A
M
G
D
E
D
L
Site 74
S538
E
R
G
P
P
P
A
S
A
P
V
G
G
T
V
Site 75
T546
A
P
V
G
G
T
V
T
L
R
E
D
S
A
K
Site 76
S551
T
V
T
L
R
E
D
S
A
K
R
L
E
R
R
Site 77
S563
E
R
R
A
R
R
I
S
A
C
L
S
D
Y
S
Site 78
S567
R
R
I
S
A
C
L
S
D
Y
S
L
A
S
D
Site 79
S573
L
S
D
Y
S
L
A
S
D
S
G
V
F
E
P
Site 80
S575
D
Y
S
L
A
S
D
S
G
V
F
E
P
L
T
Site 81
T582
S
G
V
F
E
P
L
T
K
R
N
E
D
A
E
Site 82
Y593
E
D
A
E
E
P
A
Y
G
D
T
A
S
N
G
Site 83
S598
P
A
Y
G
D
T
A
S
N
G
D
P
Q
I
H
Site 84
Y643
C
K
V
H
I
R
V
Y
L
P
P
L
D
S
G
Site 85
S649
V
Y
L
P
P
L
D
S
G
T
P
N
T
Y
C
Site 86
T651
L
P
P
L
D
S
G
T
P
N
T
Y
C
S
K
Site 87
T654
L
D
S
G
T
P
N
T
Y
C
S
K
A
L
E
Site 88
Y655
D
S
G
T
P
N
T
Y
C
S
K
A
L
E
F
Site 89
T694
Q
L
Y
V
C
S
V
T
P
Q
L
Q
E
E
L
Site 90
Y712
A
Q
I
N
L
A
D
Y
D
S
L
S
E
M
Q
Site 91
S714
I
N
L
A
D
Y
D
S
L
S
E
M
Q
L
R
Site 92
S716
L
A
D
Y
D
S
L
S
E
M
Q
L
R
W
H
Site 93
S724
E
M
Q
L
R
W
H
S
V
Q
V
F
T
S
S
Site 94
S730
H
S
V
Q
V
F
T
S
S
E
P
S
R
T
R
Site 95
S731
S
V
Q
V
F
T
S
S
E
P
S
R
T
R
E
Site 96
S734
V
F
T
S
S
E
P
S
R
T
R
E
A
G
C
Site 97
T736
T
S
S
E
P
S
R
T
R
E
A
G
C
A
G
Site 98
S746
A
G
C
A
G
E
S
S
A
R
D
P
A
H
T
Site 99
T753
S
A
R
D
P
A
H
T
I
S
I
S
G
K
T
Site 100
S755
R
D
P
A
H
T
I
S
I
S
G
K
T
D
A
Site 101
S757
P
A
H
T
I
S
I
S
G
K
T
D
A
V
T
Site 102
Y790
E
E
R
A
K
L
E
Y
T
E
E
E
V
L
E
Site 103
S809
E
E
Q
A
E
A
I
S
E
R
S
W
Q
A
D
Site 104
S817
E
R
S
W
Q
A
D
S
V
D
S
G
C
S
N
Site 105
S823
D
S
V
D
S
G
C
S
N
C
T
Q
T
S
P
Site 106
T826
D
S
G
C
S
N
C
T
Q
T
S
P
P
Y
P
Site 107
T828
G
C
S
N
C
T
Q
T
S
P
P
Y
P
E
P
Site 108
S829
C
S
N
C
T
Q
T
S
P
P
Y
P
E
P
C
Site 109
Y832
C
T
Q
T
S
P
P
Y
P
E
P
C
C
M
G
Site 110
S856
A
A
Q
A
G
P
Y
S
P
E
K
F
Q
P
S
Site 111
S863
S
P
E
K
F
Q
P
S
P
L
K
V
D
K
E
Site 112
S883
L
F
L
E
E
A
A
S
L
V
K
E
R
P
S
Site 113
S890
S
L
V
K
E
R
P
S
R
R
A
R
G
S
P
Site 114
S896
P
S
R
R
A
R
G
S
P
F
V
R
S
G
T
Site 115
T903
S
P
F
V
R
S
G
T
I
V
R
S
Q
T
F
Site 116
S907
R
S
G
T
I
V
R
S
Q
T
F
S
P
G
A
Site 117
T909
G
T
I
V
R
S
Q
T
F
S
P
G
A
R
S
Site 118
S911
I
V
R
S
Q
T
F
S
P
G
A
R
S
Q
Y
Site 119
S916
T
F
S
P
G
A
R
S
Q
Y
V
C
R
L
Y
Site 120
Y918
S
P
G
A
R
S
Q
Y
V
C
R
L
Y
R
S
Site 121
Y923
S
Q
Y
V
C
R
L
Y
R
S
D
S
D
S
S
Site 122
S925
Y
V
C
R
L
Y
R
S
D
S
D
S
S
T
L
Site 123
S927
C
R
L
Y
R
S
D
S
D
S
S
T
L
P
R
Site 124
S929
L
Y
R
S
D
S
D
S
S
T
L
P
R
K
S
Site 125
S930
Y
R
S
D
S
D
S
S
T
L
P
R
K
S
P
Site 126
T931
R
S
D
S
D
S
S
T
L
P
R
K
S
P
F
Site 127
S936
S
S
T
L
P
R
K
S
P
F
V
R
N
T
L
Site 128
T942
K
S
P
F
V
R
N
T
L
E
R
R
T
L
R
Site 129
T947
R
N
T
L
E
R
R
T
L
R
Y
K
Q
S
C
Site 130
Y950
L
E
R
R
T
L
R
Y
K
Q
S
C
R
S
S
Site 131
S953
R
T
L
R
Y
K
Q
S
C
R
S
S
L
A
E
Site 132
S957
Y
K
Q
S
C
R
S
S
L
A
E
L
M
A
R
Site 133
S976
L
E
L
D
L
Q
A
S
R
T
R
Q
R
Q
L
Site 134
T978
L
D
L
Q
A
S
R
T
R
Q
R
Q
L
N
E
Site 135
T1006
D
A
Q
L
R
G
Q
T
D
L
P
P
W
V
L
Site 136
T1029
L
R
E
A
E
R
Q
T
R
Q
T
K
L
D
Y
Site 137
T1032
A
E
R
Q
T
R
Q
T
K
L
D
Y
R
H
E
Site 138
Y1036
T
R
Q
T
K
L
D
Y
R
H
E
Q
A
A
E
Site 139
Y1054
K
K
A
S
K
E
I
Y
Q
L
R
G
Q
S
H
Site 140
S1060
I
Y
Q
L
R
G
Q
S
H
K
E
P
I
Q
V
Site 141
T1069
K
E
P
I
Q
V
Q
T
F
R
E
K
I
A
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation