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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DENND2A
Full Name:
DENN domain-containing protein 2A
Alias:
DEN2A; DENN/MADD domain containing 2A; FAM31D; KIAA1277
Type:
Unknown function
Mass (Da):
113893
Number AA:
1009
UniProt ID:
Q9ULE3
International Prot ID:
IPI00472075
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
G
V
Q
N
P
C
P
S
A
R
A
R
P
R
H
Site 2
S43
R
A
R
P
R
H
K
S
L
N
I
K
D
K
I
Site 3
S51
L
N
I
K
D
K
I
S
E
W
E
G
K
K
E
Site 4
T61
E
G
K
K
E
V
P
T
P
A
P
S
R
R
A
Site 5
S65
E
V
P
T
P
A
P
S
R
R
A
D
G
Q
E
Site 6
Y74
R
A
D
G
Q
E
D
Y
L
P
S
S
T
V
E
Site 7
S78
Q
E
D
Y
L
P
S
S
T
V
E
R
R
S
S
Site 8
T79
E
D
Y
L
P
S
S
T
V
E
R
R
S
S
D
Site 9
S84
S
S
T
V
E
R
R
S
S
D
G
V
R
T
Q
Site 10
S85
S
T
V
E
R
R
S
S
D
G
V
R
T
Q
V
Site 11
T93
D
G
V
R
T
Q
V
T
E
A
K
N
G
M
R
Site 12
T103
K
N
G
M
R
P
G
T
E
S
T
E
K
E
R
Site 13
S105
G
M
R
P
G
T
E
S
T
E
K
E
R
N
K
Site 14
S129
P
E
P
G
Q
D
L
S
Q
P
E
R
E
V
D
Site 15
S138
P
E
R
E
V
D
P
S
W
G
R
G
R
E
P
Site 16
S158
R
F
Q
N
D
H
L
S
V
L
K
Q
V
K
K
Site 17
T184
L
D
P
Q
L
P
G
T
C
Y
S
P
H
C
P
Site 18
Y186
P
Q
L
P
G
T
C
Y
S
P
H
C
P
P
D
Site 19
S187
Q
L
P
G
T
C
Y
S
P
H
C
P
P
D
K
Site 20
S199
P
D
K
A
E
A
G
S
T
L
P
E
N
L
G
Site 21
T200
D
K
A
E
A
G
S
T
L
P
E
N
L
G
G
Site 22
S211
N
L
G
G
G
S
G
S
E
V
S
Q
R
V
H
Site 23
S214
G
G
S
G
S
E
V
S
Q
R
V
H
P
S
D
Site 24
S220
V
S
Q
R
V
H
P
S
D
L
E
G
R
E
P
Site 25
T228
D
L
E
G
R
E
P
T
P
E
L
V
E
D
R
Site 26
S238
L
V
E
D
R
K
G
S
C
R
R
P
W
D
R
Site 27
S246
C
R
R
P
W
D
R
S
L
E
N
V
Y
R
G
Site 28
Y251
D
R
S
L
E
N
V
Y
R
G
S
E
G
S
P
Site 29
S254
L
E
N
V
Y
R
G
S
E
G
S
P
T
K
P
Site 30
S257
V
Y
R
G
S
E
G
S
P
T
K
P
F
I
N
Site 31
T259
R
G
S
E
G
S
P
T
K
P
F
I
N
P
L
Site 32
T272
P
L
P
K
P
R
R
T
F
K
H
A
G
E
G
Site 33
S301
R
N
L
P
P
L
P
S
L
P
P
P
P
L
P
Site 34
S309
L
P
P
P
P
L
P
S
S
P
P
P
S
S
V
Site 35
S310
P
P
P
P
L
P
S
S
P
P
P
S
S
V
N
Site 36
S314
L
P
S
S
P
P
P
S
S
V
N
R
R
L
W
Site 37
S315
P
S
S
P
P
P
S
S
V
N
R
R
L
W
T
Site 38
T322
S
V
N
R
R
L
W
T
G
R
Q
K
S
S
A
Site 39
S327
L
W
T
G
R
Q
K
S
S
A
D
H
R
K
S
Site 40
S328
W
T
G
R
Q
K
S
S
A
D
H
R
K
S
Y
Site 41
S334
S
S
A
D
H
R
K
S
Y
E
F
E
D
L
L
Site 42
Y335
S
A
D
H
R
K
S
Y
E
F
E
D
L
L
Q
Site 43
S343
E
F
E
D
L
L
Q
S
S
S
E
S
S
R
V
Site 44
S344
F
E
D
L
L
Q
S
S
S
E
S
S
R
V
D
Site 45
S345
E
D
L
L
Q
S
S
S
E
S
S
R
V
D
W
Site 46
S347
L
L
Q
S
S
S
E
S
S
R
V
D
W
Y
A
Site 47
S348
L
Q
S
S
S
E
S
S
R
V
D
W
Y
A
Q
Site 48
Y353
E
S
S
R
V
D
W
Y
A
Q
T
K
L
G
L
Site 49
T361
A
Q
T
K
L
G
L
T
R
T
L
S
E
E
N
Site 50
T363
T
K
L
G
L
T
R
T
L
S
E
E
N
V
Y
Site 51
S365
L
G
L
T
R
T
L
S
E
E
N
V
Y
E
D
Site 52
Y370
T
L
S
E
E
N
V
Y
E
D
I
L
D
P
P
Site 53
Y383
E
S
S
R
V
D
W
Y
A
Q
T
K
L
G
L
Site 54
S404
C
V
L
N
F
P
A
S
P
T
S
S
I
P
D
Site 55
T406
L
N
F
P
A
S
P
T
S
S
I
P
D
T
L
Site 56
S407
N
F
P
A
S
P
T
S
S
I
P
D
T
L
T
Site 57
S408
F
P
A
S
P
T
S
S
I
P
D
T
L
T
K
Site 58
T412
P
T
S
S
I
P
D
T
L
T
K
Q
S
L
S
Site 59
T414
S
S
I
P
D
T
L
T
K
Q
S
L
S
K
P
Site 60
S417
P
D
T
L
T
K
Q
S
L
S
K
P
A
F
F
Site 61
S419
T
L
T
K
Q
S
L
S
K
P
A
F
F
R
Q
Site 62
S428
P
A
F
F
R
Q
N
S
E
R
R
N
F
K
L
Site 63
T438
R
N
F
K
L
L
D
T
R
K
L
S
R
D
G
Site 64
S442
L
L
D
T
R
K
L
S
R
D
G
T
G
S
P
Site 65
T446
R
K
L
S
R
D
G
T
G
S
P
S
K
I
S
Site 66
S448
L
S
R
D
G
T
G
S
P
S
K
I
S
P
P
Site 67
S450
R
D
G
T
G
S
P
S
K
I
S
P
P
S
T
Site 68
S453
T
G
S
P
S
K
I
S
P
P
S
T
P
S
S
Site 69
S456
P
S
K
I
S
P
P
S
T
P
S
S
P
D
D
Site 70
T457
S
K
I
S
P
P
S
T
P
S
S
P
D
D
I
Site 71
S459
I
S
P
P
S
T
P
S
S
P
D
D
I
F
F
Site 72
S460
S
P
P
S
T
P
S
S
P
D
D
I
F
F
N
Site 73
Y491
V
L
R
I
N
A
I
Y
E
V
R
R
G
K
K
Site 74
S504
K
K
R
V
K
R
L
S
Q
S
M
E
S
N
S
Site 75
S506
R
V
K
R
L
S
Q
S
M
E
S
N
S
G
K
Site 76
S509
R
L
S
Q
S
M
E
S
N
S
G
K
V
T
D
Site 77
T515
E
S
N
S
G
K
V
T
D
E
N
S
E
S
D
Site 78
S519
G
K
V
T
D
E
N
S
E
S
D
S
D
T
E
Site 79
S521
V
T
D
E
N
S
E
S
D
S
D
T
E
E
K
Site 80
S523
D
E
N
S
E
S
D
S
D
T
E
E
K
L
K
Site 81
T525
N
S
E
S
D
S
D
T
E
E
K
L
K
A
H
Site 82
S533
E
E
K
L
K
A
H
S
Q
R
L
V
N
V
K
Site 83
S541
Q
R
L
V
N
V
K
S
R
L
K
Q
A
P
R
Site 84
Y549
R
L
K
Q
A
P
R
Y
P
S
L
A
R
E
L
Site 85
S551
K
Q
A
P
R
Y
P
S
L
A
R
E
L
I
E
Site 86
Y559
L
A
R
E
L
I
E
Y
Q
E
R
Q
L
F
E
Site 87
Y582
K
K
Q
A
G
A
A
Y
V
P
E
L
T
Q
Q
Site 88
S597
F
P
L
K
L
E
R
S
F
K
F
M
R
E
A
Site 89
S634
Q
F
T
S
E
T
F
S
F
V
L
T
G
E
D
Site 90
T638
E
T
F
S
F
V
L
T
G
E
D
G
S
R
R
Site 91
S643
V
L
T
G
E
D
G
S
R
R
F
G
Y
C
R
Site 92
Y648
D
G
S
R
R
F
G
Y
C
R
R
L
L
P
G
Site 93
S691
V
E
K
R
R
G
I
S
P
A
L
V
Q
P
L
Site 94
S736
E
L
C
R
P
L
D
S
R
L
E
H
V
D
F
Site 95
S855
R
Q
M
D
D
E
D
S
I
L
P
R
K
L
Q
Site 96
S892
D
G
R
H
G
P
E
S
S
P
L
N
E
V
V
Site 97
S893
G
R
H
G
P
E
S
S
P
L
N
E
V
V
S
Site 98
T919
G
H
Y
S
L
F
L
T
S
G
E
R
E
E
R
Site 99
S920
H
Y
S
L
F
L
T
S
G
E
R
E
E
R
T
Site 100
T927
S
G
E
R
E
E
R
T
L
Q
R
E
A
F
R
Site 101
S938
E
A
F
R
K
A
V
S
S
K
S
L
R
H
F
Site 102
S939
A
F
R
K
A
V
S
S
K
S
L
R
H
F
L
Site 103
S941
R
K
A
V
S
S
K
S
L
R
H
F
L
E
V
Site 104
Y980
F
E
V
R
A
Q
E
Y
L
E
T
L
P
S
G
Site 105
T983
R
A
Q
E
Y
L
E
T
L
P
S
G
E
H
S
Site 106
S986
E
Y
L
E
T
L
P
S
G
E
H
S
G
V
N
Site 107
S990
T
L
P
S
G
E
H
S
G
V
N
K
F
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation