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Updated November 2019
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Protein Info
Short Name:
KIDINS220
Full Name:
Ankyrin repeat-rich membrane spanning protein
Alias:
Ankyrin repeat-rich membrane-spanning protein; ARMS; KIAA1250; Kinase D-interacting substrate of 220 kDa; Kinase D-interacting substrate of 220 kDa: Ankyrin repeat-rich membrane spanning protein: Kinase D-interacting substrate of 220 kDa: Ankyrin repeat-rich membrane spanning protein: Kinase D-interacting substrate of 220 kDa: Ankyrin repeat-rich membrane spanning protein: Kinase D-interacting substrate of 220 kDa: Ankyrin repeat-rich membrane spanning protein; Kinase D-interacting substrate, 220kDa
Type:
Protein kinase, regulatory subunit
Mass (Da):
196542
Number AA:
1771
UniProt ID:
Q9ULH0
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
I
S
Q
S
V
I
N
Y
V
E
E
E
N
I
P
Site 2
T40
E
R
N
E
C
G
Q
T
P
L
M
I
A
A
E
Site 3
T73
L
E
D
L
D
N
W
T
A
L
I
S
A
S
K
Site 4
S77
D
N
W
T
A
L
I
S
A
S
K
E
G
H
V
Site 5
S166
N
G
A
K
V
N
C
S
D
K
Y
G
T
T
P
Site 6
Y169
K
V
N
C
S
D
K
Y
G
T
T
P
L
V
W
Site 7
T172
C
S
D
K
Y
G
T
T
P
L
V
W
A
A
R
Site 8
Y215
I
V
A
V
K
G
G
Y
T
Q
S
V
K
E
I
Site 9
S218
V
K
G
G
Y
T
Q
S
V
K
E
I
L
K
R
Site 10
S244
N
T
A
L
M
I
A
S
K
E
G
H
T
E
I
Site 11
T260
Q
D
L
L
D
A
G
T
Y
V
N
I
P
D
R
Site 12
Y261
D
L
L
D
A
G
T
Y
V
N
I
P
D
R
S
Site 13
T304
I
R
G
Q
D
N
K
T
A
L
Y
W
A
V
E
Site 14
Y307
Q
D
N
K
T
A
L
Y
W
A
V
E
K
G
N
Site 15
T337
I
C
T
K
D
G
E
T
P
L
I
K
A
T
K
Site 16
S362
L
D
K
G
A
K
V
S
A
V
D
K
K
G
D
Site 17
T370
A
V
D
K
K
G
D
T
P
L
H
I
A
I
R
Site 18
S380
H
I
A
I
R
G
R
S
R
K
L
A
E
L
L
Site 19
Y398
P
K
D
G
R
L
L
Y
R
P
N
K
A
G
E
Site 20
T406
R
P
N
K
A
G
E
T
P
Y
N
I
D
C
S
Site 21
Y408
N
K
A
G
E
T
P
Y
N
I
D
C
S
H
Q
Site 22
S429
I
F
G
A
R
H
L
S
P
T
E
T
D
G
D
Site 23
T431
G
A
R
H
L
S
P
T
E
T
D
G
D
M
L
Site 24
T433
R
H
L
S
P
T
E
T
D
G
D
M
L
G
Y
Site 25
Y440
T
D
G
D
M
L
G
Y
D
L
Y
S
S
A
L
Site 26
S452
S
A
L
A
D
I
L
S
E
P
T
M
Q
P
P
Site 27
S470
G
L
Y
A
Q
W
G
S
G
K
S
F
L
L
K
Site 28
S473
A
Q
W
G
S
G
K
S
F
L
L
K
K
L
E
Site 29
T485
K
L
E
D
E
M
K
T
F
A
G
Q
Q
I
E
Site 30
T600
L
P
V
R
F
L
F
T
D
Y
N
R
L
S
S
Site 31
Y602
V
R
F
L
F
T
D
Y
N
R
L
S
S
V
G
Site 32
S606
F
T
D
Y
N
R
L
S
S
V
G
G
E
T
S
Site 33
S607
T
D
Y
N
R
L
S
S
V
G
G
E
T
S
L
Site 34
S622
A
E
M
I
A
T
L
S
D
A
C
E
R
E
F
Site 35
T642
R
L
F
R
V
F
K
T
E
D
T
Q
G
K
K
Site 36
T645
R
V
F
K
T
E
D
T
Q
G
K
K
K
W
K
Site 37
T654
G
K
K
K
W
K
K
T
C
C
L
P
S
F
V
Site 38
S717
T
W
W
Q
V
L
D
S
L
L
N
S
Q
R
K
Site 39
S721
V
L
D
S
L
L
N
S
Q
R
K
R
L
H
N
Site 40
S731
K
R
L
H
N
A
A
S
K
L
H
K
L
K
S
Site 41
S738
S
K
L
H
K
L
K
S
E
G
F
M
K
V
L
Site 42
S761
R
M
A
K
T
I
D
S
F
T
Q
N
Q
T
R
Site 43
T763
A
K
T
I
D
S
F
T
Q
N
Q
T
R
L
V
Site 44
S821
A
I
N
Q
N
L
N
S
V
L
R
D
S
N
I
Site 45
S826
L
N
S
V
L
R
D
S
N
I
N
G
H
D
Y
Site 46
Y833
S
N
I
N
G
H
D
Y
M
R
N
I
V
H
L
Site 47
S850
F
L
N
S
R
G
L
S
N
A
R
K
F
L
V
Site 48
T858
N
A
R
K
F
L
V
T
S
A
T
N
G
D
V
Site 49
S868
T
N
G
D
V
P
C
S
D
T
T
G
I
Q
E
Site 50
S882
E
D
A
D
R
R
V
S
Q
N
S
L
G
E
M
Site 51
S885
D
R
R
V
S
Q
N
S
L
G
E
M
T
K
L
Site 52
T903
T
A
L
N
R
R
D
T
Y
R
R
R
Q
M
Q
Site 53
Y904
A
L
N
R
R
D
T
Y
R
R
R
Q
M
Q
R
Site 54
T912
R
R
R
Q
M
Q
R
T
I
T
R
Q
M
S
F
Site 55
T914
R
Q
M
Q
R
T
I
T
R
Q
M
S
F
D
L
Site 56
S918
R
T
I
T
R
Q
M
S
F
D
L
T
K
L
L
Site 57
T922
R
Q
M
S
F
D
L
T
K
L
L
V
T
E
D
Site 58
S932
L
V
T
E
D
W
F
S
D
I
S
P
Q
T
M
Site 59
S935
E
D
W
F
S
D
I
S
P
Q
T
M
R
R
L
Site 60
T938
F
S
D
I
S
P
Q
T
M
R
R
L
L
N
I
Site 61
S959
L
L
R
A
N
Q
I
S
F
N
W
D
R
L
A
Site 62
Y977
N
L
T
E
Q
W
P
Y
R
T
S
W
L
I
L
Site 63
Y985
R
T
S
W
L
I
L
Y
L
E
E
T
E
G
I
Site 64
T997
E
G
I
P
D
Q
M
T
L
K
T
I
Y
E
R
Site 65
T1000
P
D
Q
M
T
L
K
T
I
Y
E
R
I
S
K
Site 66
Y1002
Q
M
T
L
K
T
I
Y
E
R
I
S
K
N
I
Site 67
S1006
K
T
I
Y
E
R
I
S
K
N
I
P
T
T
K
Site 68
T1012
I
S
K
N
I
P
T
T
K
D
V
E
P
L
L
Site 69
Y1079
I
S
I
G
G
L
A
Y
P
P
L
P
L
H
E
Site 70
S1093
E
G
P
P
R
A
P
S
G
Y
S
Q
P
P
S
Site 71
Y1095
P
P
R
A
P
S
G
Y
S
Q
P
P
S
V
C
Site 72
S1096
P
R
A
P
S
G
Y
S
Q
P
P
S
V
C
S
Site 73
S1100
S
G
Y
S
Q
P
P
S
V
C
S
S
T
S
F
Site 74
S1103
S
Q
P
P
S
V
C
S
S
T
S
F
N
G
P
Site 75
S1104
Q
P
P
S
V
C
S
S
T
S
F
N
G
P
F
Site 76
S1106
P
S
V
C
S
S
T
S
F
N
G
P
F
A
G
Site 77
S1117
P
F
A
G
G
V
V
S
P
Q
P
H
S
S
Y
Site 78
S1122
V
V
S
P
Q
P
H
S
S
Y
Y
S
G
M
T
Site 79
S1123
V
S
P
Q
P
H
S
S
Y
Y
S
G
M
T
G
Site 80
Y1124
S
P
Q
P
H
S
S
Y
Y
S
G
M
T
G
P
Site 81
Y1125
P
Q
P
H
S
S
Y
Y
S
G
M
T
G
P
Q
Site 82
S1126
Q
P
H
S
S
Y
Y
S
G
M
T
G
P
Q
H
Site 83
Y1136
T
G
P
Q
H
P
F
Y
N
R
P
F
F
A
P
Site 84
Y1144
N
R
P
F
F
A
P
Y
L
Y
T
P
R
Y
Y
Site 85
Y1146
P
F
F
A
P
Y
L
Y
T
P
R
Y
Y
P
G
Site 86
T1147
F
F
A
P
Y
L
Y
T
P
R
Y
Y
P
G
G
Site 87
Y1150
P
Y
L
Y
T
P
R
Y
Y
P
G
G
S
Q
H
Site 88
Y1151
Y
L
Y
T
P
R
Y
Y
P
G
G
S
Q
H
L
Site 89
S1155
P
R
Y
Y
P
G
G
S
Q
H
L
I
S
R
P
Site 90
S1160
G
G
S
Q
H
L
I
S
R
P
S
V
K
T
S
Site 91
S1163
Q
H
L
I
S
R
P
S
V
K
T
S
L
P
R
Site 92
T1166
I
S
R
P
S
V
K
T
S
L
P
R
D
Q
N
Site 93
S1167
S
R
P
S
V
K
T
S
L
P
R
D
Q
N
N
Site 94
S1188
E
D
A
A
E
G
L
S
S
P
T
D
S
S
R
Site 95
S1189
D
A
A
E
G
L
S
S
P
T
D
S
S
R
G
Site 96
T1191
A
E
G
L
S
S
P
T
D
S
S
R
G
S
G
Site 97
S1193
G
L
S
S
P
T
D
S
S
R
G
S
G
P
A
Site 98
S1194
L
S
S
P
T
D
S
S
R
G
S
G
P
A
P
Site 99
S1197
P
T
D
S
S
R
G
S
G
P
A
P
G
P
V
Site 100
Y1233
D
Q
S
M
L
P
Q
Y
C
T
T
I
K
K
A
Site 101
T1235
S
M
L
P
Q
Y
C
T
T
I
K
K
A
N
I
Site 102
T1272
D
W
H
L
F
R
S
T
V
L
E
M
R
N
A
Site 103
S1292
P
E
D
P
R
F
L
S
E
S
S
S
G
P
A
Site 104
S1294
D
P
R
F
L
S
E
S
S
S
G
P
A
P
H
Site 105
S1295
P
R
F
L
S
E
S
S
S
G
P
A
P
H
G
Site 106
S1296
R
F
L
S
E
S
S
S
G
P
A
P
H
G
E
Site 107
S1309
G
E
P
A
R
R
A
S
H
N
E
L
P
H
T
Site 108
T1316
S
H
N
E
L
P
H
T
E
L
S
S
Q
T
P
Site 109
S1319
E
L
P
H
T
E
L
S
S
Q
T
P
Y
T
L
Site 110
S1320
L
P
H
T
E
L
S
S
Q
T
P
Y
T
L
N
Site 111
T1322
H
T
E
L
S
S
Q
T
P
Y
T
L
N
F
S
Site 112
Y1324
E
L
S
S
Q
T
P
Y
T
L
N
F
S
F
E
Site 113
T1325
L
S
S
Q
T
P
Y
T
L
N
F
S
F
E
E
Site 114
S1329
T
P
Y
T
L
N
F
S
F
E
E
L
N
T
L
Site 115
T1335
F
S
F
E
E
L
N
T
L
G
L
D
E
G
A
Site 116
S1346
D
E
G
A
P
R
H
S
N
L
S
W
Q
S
Q
Site 117
S1349
A
P
R
H
S
N
L
S
W
Q
S
Q
T
R
R
Site 118
S1352
H
S
N
L
S
W
Q
S
Q
T
R
R
T
P
S
Site 119
T1357
W
Q
S
Q
T
R
R
T
P
S
L
S
S
L
N
Site 120
S1359
S
Q
T
R
R
T
P
S
L
S
S
L
N
S
Q
Site 121
S1361
T
R
R
T
P
S
L
S
S
L
N
S
Q
D
S
Site 122
S1362
R
R
T
P
S
L
S
S
L
N
S
Q
D
S
S
Site 123
S1365
S
Q
T
R
R
T
P
S
L
S
S
L
N
S
Q
Site 124
S1368
R
R
T
P
S
L
S
S
L
N
S
Q
D
S
S
Site 125
S1369
S
L
N
S
Q
D
S
S
I
E
I
S
K
L
T
Site 126
S1373
Q
D
S
S
I
E
I
S
K
L
T
D
K
V
Q
Site 127
Y1383
T
D
K
V
Q
A
E
Y
R
D
A
Y
R
E
Y
Site 128
Y1387
Q
A
E
Y
R
D
A
Y
R
E
Y
I
A
Q
M
Site 129
Y1390
Y
R
D
A
Y
R
E
Y
I
A
Q
M
S
Q
L
Site 130
S1395
R
E
Y
I
A
Q
M
S
Q
L
E
G
G
P
G
Site 131
S1403
Q
L
E
G
G
P
G
S
T
T
I
S
G
R
S
Site 132
T1405
E
G
G
P
G
S
T
T
I
S
G
R
S
S
P
Site 133
S1407
G
P
G
S
T
T
I
S
G
R
S
S
P
H
S
Site 134
S1410
S
T
T
I
S
G
R
S
S
P
H
S
T
Y
Y
Site 135
S1411
T
T
I
S
G
R
S
S
P
H
S
T
Y
Y
M
Site 136
S1414
S
G
R
S
S
P
H
S
T
Y
Y
M
G
Q
S
Site 137
T1415
G
R
S
S
P
H
S
T
Y
Y
M
G
Q
S
S
Site 138
Y1416
R
S
S
P
H
S
T
Y
Y
M
G
Q
S
S
S
Site 139
Y1417
S
S
P
H
S
T
Y
Y
M
G
Q
S
S
S
G
Site 140
S1421
S
T
Y
Y
M
G
Q
S
S
S
G
G
S
I
H
Site 141
S1422
T
Y
Y
M
G
Q
S
S
S
G
G
S
I
H
S
Site 142
S1423
Y
Y
M
G
Q
S
S
S
G
G
S
I
H
S
N
Site 143
S1426
G
Q
S
S
S
G
G
S
I
H
S
N
L
E
Q
Site 144
S1429
S
S
G
G
S
I
H
S
N
L
E
Q
E
K
G
Site 145
S1449
K
P
D
D
G
R
K
S
F
L
M
K
R
G
D
Site 146
Y1460
K
R
G
D
V
I
D
Y
S
S
S
G
V
S
T
Site 147
S1461
R
G
D
V
I
D
Y
S
S
S
G
V
S
T
N
Site 148
S1462
G
D
V
I
D
Y
S
S
S
G
V
S
T
N
D
Site 149
S1463
D
V
I
D
Y
S
S
S
G
V
S
T
N
D
A
Site 150
S1466
D
Y
S
S
S
G
V
S
T
N
D
A
S
P
L
Site 151
T1467
Y
S
S
S
G
V
S
T
N
D
A
S
P
L
D
Site 152
S1471
G
V
S
T
N
D
A
S
P
L
D
P
I
T
E
Site 153
T1477
A
S
P
L
D
P
I
T
E
E
D
E
K
S
D
Site 154
S1483
I
T
E
E
D
E
K
S
D
Q
S
G
S
K
L
Site 155
S1486
E
D
E
K
S
D
Q
S
G
S
K
L
L
P
G
Site 156
S1488
E
K
S
D
Q
S
G
S
K
L
L
P
G
K
K
Site 157
S1496
K
L
L
P
G
K
K
S
S
E
R
S
S
L
F
Site 158
S1497
L
L
P
G
K
K
S
S
E
R
S
S
L
F
Q
Site 159
S1500
G
K
K
S
S
E
R
S
S
L
F
Q
T
D
L
Site 160
S1501
K
K
S
S
E
R
S
S
L
F
Q
T
D
L
K
Site 161
T1505
E
R
S
S
L
F
Q
T
D
L
K
L
K
G
S
Site 162
S1512
T
D
L
K
L
K
G
S
G
L
R
Y
Q
K
L
Site 163
Y1516
L
K
G
S
G
L
R
Y
Q
K
L
P
S
D
E
Site 164
S1521
L
R
Y
Q
K
L
P
S
D
E
D
E
S
G
T
Site 165
S1526
L
P
S
D
E
D
E
S
G
T
E
E
S
D
N
Site 166
T1528
S
D
E
D
E
S
G
T
E
E
S
D
N
T
P
Site 167
S1531
D
E
S
G
T
E
E
S
D
N
T
P
L
L
K
Site 168
T1534
G
T
E
E
S
D
N
T
P
L
L
K
D
D
K
Site 169
S1555
K
V
E
R
V
P
K
S
P
E
H
S
A
E
P
Site 170
S1559
V
P
K
S
P
E
H
S
A
E
P
I
R
T
F
Site 171
T1565
H
S
A
E
P
I
R
T
F
I
K
A
K
E
Y
Site 172
Y1572
T
F
I
K
A
K
E
Y
L
S
D
A
L
L
D
Site 173
S1583
A
L
L
D
K
K
D
S
S
D
S
G
V
R
S
Site 174
S1584
L
L
D
K
K
D
S
S
D
S
G
V
R
S
S
Site 175
S1586
D
K
K
D
S
S
D
S
G
V
R
S
S
E
S
Site 176
S1590
S
S
D
S
G
V
R
S
S
E
S
S
P
N
H
Site 177
S1591
S
D
S
G
V
R
S
S
E
S
S
P
N
H
S
Site 178
S1593
S
G
V
R
S
S
E
S
S
P
N
H
S
L
H
Site 179
S1594
G
V
R
S
S
E
S
S
P
N
H
S
L
H
N
Site 180
S1598
S
E
S
S
P
N
H
S
L
H
N
E
V
A
D
Site 181
S1607
H
N
E
V
A
D
D
S
Q
L
E
K
A
N
L
Site 182
S1621
L
I
E
L
E
D
D
S
H
S
G
K
R
G
I
Site 183
S1623
E
L
E
D
D
S
H
S
G
K
R
G
I
P
H
Site 184
S1631
G
K
R
G
I
P
H
S
L
S
G
L
Q
D
P
Site 185
S1633
R
G
I
P
H
S
L
S
G
L
Q
D
P
I
I
Site 186
S1644
D
P
I
I
A
R
M
S
I
C
S
E
D
K
K
Site 187
S1647
I
A
R
M
S
I
C
S
E
D
K
K
S
P
S
Site 188
S1652
I
C
S
E
D
K
K
S
P
S
E
C
S
L
I
Site 189
S1654
S
E
D
K
K
S
P
S
E
C
S
L
I
A
S
Site 190
S1657
K
K
S
P
S
E
C
S
L
I
A
S
S
P
E
Site 191
S1661
S
E
C
S
L
I
A
S
S
P
E
E
N
W
P
Site 192
S1662
E
C
S
L
I
A
S
S
P
E
E
N
W
P
A
Site 193
Y1674
W
P
A
C
Q
K
A
Y
N
L
N
R
T
P
S
Site 194
T1679
K
A
Y
N
L
N
R
T
P
S
T
V
T
L
N
Site 195
S1681
Y
N
L
N
R
T
P
S
T
V
T
L
N
N
N
Site 196
T1682
N
L
N
R
T
P
S
T
V
T
L
N
N
N
S
Site 197
T1684
N
R
T
P
S
T
V
T
L
N
N
N
S
A
P
Site 198
T1708
E
M
E
G
I
R
E
T
S
Q
V
I
L
R
P
Site 199
S1709
M
E
G
I
R
E
T
S
Q
V
I
L
R
P
S
Site 200
S1716
S
Q
V
I
L
R
P
S
S
S
P
N
P
T
T
Site 201
S1717
Q
V
I
L
R
P
S
S
S
P
N
P
T
T
I
Site 202
S1718
V
I
L
R
P
S
S
S
P
N
P
T
T
I
Q
Site 203
T1722
P
S
S
S
P
N
P
T
T
I
Q
N
E
N
L
Site 204
T1723
S
S
S
P
N
P
T
T
I
Q
N
E
N
L
K
Site 205
S1731
I
Q
N
E
N
L
K
S
M
T
H
K
R
S
Q
Site 206
T1733
N
E
N
L
K
S
M
T
H
K
R
S
Q
R
S
Site 207
S1737
K
S
M
T
H
K
R
S
Q
R
S
S
Y
T
R
Site 208
S1741
H
K
R
S
Q
R
S
S
Y
T
R
L
S
K
D
Site 209
Y1742
K
R
S
Q
R
S
S
Y
T
R
L
S
K
D
P
Site 210
S1746
R
S
S
Y
T
R
L
S
K
D
P
P
E
L
H
Site 211
S1757
P
E
L
H
A
A
A
S
S
E
S
T
G
F
G
Site 212
S1758
E
L
H
A
A
A
S
S
E
S
T
G
F
G
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation