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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MKL2
Full Name:
MKL/myocardin-like protein 2
Alias:
FLJ31823; Megakaryoblastic leukemia 2; MKL/myocardin-like 2; MRTFB; MRTF-B; Myocardin-related transcription factor B; NPD001
Type:
Transcription protein, coactivator/corepressor
Mass (Da):
118127
Number AA:
1088
UniProt ID:
Q9ULH7
International Prot ID:
IPI00329152
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0042802
GO:0003676
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0045844
GO:0045944
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
E
K
E
C
L
E
G
S
N
Q
K
S
L
K
E
Site 2
S37
L
E
G
S
N
Q
K
S
L
K
E
V
L
Q
L
Site 3
T51
L
R
L
Q
Q
R
R
T
R
E
Q
L
V
D
Q
Site 4
S66
G
I
M
P
P
L
K
S
P
A
A
F
H
E
Q
Site 5
S76
A
F
H
E
Q
I
K
S
L
E
R
A
R
T
E
Site 6
T82
K
S
L
E
R
A
R
T
E
N
F
L
K
H
K
Site 7
S97
I
R
S
R
P
D
R
S
E
L
V
R
M
H
I
Site 8
T108
R
M
H
I
L
E
E
T
F
A
E
P
S
L
Q
Site 9
S113
E
E
T
F
A
E
P
S
L
Q
A
T
Q
M
K
Site 10
T117
A
E
P
S
L
Q
A
T
Q
M
K
L
K
R
A
Site 11
Y167
I
G
V
G
K
E
D
Y
P
H
T
Q
G
D
F
Site 12
T170
G
K
E
D
Y
P
H
T
Q
G
D
F
S
F
D
Site 13
S175
P
H
T
Q
G
D
F
S
F
D
E
D
S
S
D
Site 14
S180
D
F
S
F
D
E
D
S
S
D
A
L
S
P
D
Site 15
S181
F
S
F
D
E
D
S
S
D
A
L
S
P
D
Q
Site 16
S185
E
D
S
S
D
A
L
S
P
D
Q
P
A
S
Q
Site 17
S191
L
S
P
D
Q
P
A
S
Q
E
S
Q
G
S
A
Site 18
S197
A
S
Q
E
S
Q
G
S
A
A
S
P
S
E
P
Site 19
S200
E
S
Q
G
S
A
A
S
P
S
E
P
K
V
S
Site 20
S202
Q
G
S
A
A
S
P
S
E
P
K
V
S
E
S
Site 21
S207
S
P
S
E
P
K
V
S
E
S
P
S
P
V
T
Site 22
S209
S
E
P
K
V
S
E
S
P
S
P
V
T
T
N
Site 23
S211
P
K
V
S
E
S
P
S
P
V
T
T
N
T
P
Site 24
T214
S
E
S
P
S
P
V
T
T
N
T
P
A
Q
F
Site 25
T215
E
S
P
S
P
V
T
T
N
T
P
A
Q
F
A
Site 26
T217
P
S
P
V
T
T
N
T
P
A
Q
F
A
S
V
Site 27
S223
N
T
P
A
Q
F
A
S
V
S
P
T
V
P
E
Site 28
T234
T
V
P
E
F
L
K
T
P
P
T
A
D
Q
P
Site 29
T237
E
F
L
K
T
P
P
T
A
D
Q
P
P
P
R
Site 30
T254
A
P
V
L
P
T
N
T
V
S
S
A
K
P
G
Site 31
S257
L
P
T
N
T
V
S
S
A
K
P
G
P
A
L
Site 32
S268
G
P
A
L
V
K
Q
S
H
P
K
N
P
N
D
Site 33
Y294
P
R
V
K
K
L
K
Y
H
Q
Y
I
P
P
D
Site 34
Y297
P
R
V
K
K
L
K
Y
H
Q
Y
I
P
P
D
Site 35
Y315
E
P
Q
M
D
S
N
Y
A
R
L
L
Q
Q
Q
Site 36
Y340
Q
Q
K
Q
H
Y
N
Y
Q
T
I
L
P
A
P
Site 37
T342
K
Q
H
Y
N
Y
Q
T
I
L
P
A
P
F
K
Site 38
S356
K
P
L
N
D
K
N
S
N
S
G
N
S
A
L
Site 39
S358
L
N
D
K
N
S
N
S
G
N
S
A
L
N
N
Site 40
T367
N
S
A
L
N
N
A
T
P
N
T
P
R
Q
N
Site 41
T370
L
N
N
A
T
P
N
T
P
R
Q
N
T
S
T
Site 42
T375
P
N
T
P
R
Q
N
T
S
T
P
V
R
K
P
Site 43
S376
N
T
P
R
Q
N
T
S
T
P
V
R
K
P
G
Site 44
T377
T
P
R
Q
N
T
S
T
P
V
R
K
P
G
P
Site 45
S387
R
K
P
G
P
L
P
S
S
L
D
D
L
K
V
Site 46
S388
K
P
G
P
L
P
S
S
L
D
D
L
K
V
S
Site 47
S395
S
L
D
D
L
K
V
S
E
L
K
T
E
L
K
Site 48
T399
L
K
V
S
E
L
K
T
E
L
K
L
R
G
L
Site 49
S409
K
L
R
G
L
P
V
S
G
T
K
P
D
L
I
Site 50
T411
R
G
L
P
V
S
G
T
K
P
D
L
I
E
R
Site 51
Y422
L
I
E
R
L
K
P
Y
Q
E
V
N
S
S
G
Site 52
S428
P
Y
Q
E
V
N
S
S
G
L
A
A
G
G
I
Site 53
T462
P
V
T
T
L
H
N
T
V
T
S
S
V
S
T
Site 54
T464
T
T
L
H
N
T
V
T
S
S
V
S
T
L
K
Site 55
S466
L
H
N
T
V
T
S
S
V
S
T
L
K
A
E
Site 56
T469
T
V
T
S
S
V
S
T
L
K
A
E
L
P
P
Site 57
T477
L
K
A
E
L
P
P
T
G
T
S
N
A
T
R
Site 58
S490
T
R
V
E
N
V
H
S
P
L
P
I
S
P
S
Site 59
S495
V
H
S
P
L
P
I
S
P
S
P
S
E
Q
S
Site 60
S497
S
P
L
P
I
S
P
S
P
S
E
Q
S
S
L
Site 61
S499
L
P
I
S
P
S
P
S
E
Q
S
S
L
S
T
Site 62
S503
P
S
P
S
E
Q
S
S
L
S
T
D
D
T
N
Site 63
S505
P
S
E
Q
S
S
L
S
T
D
D
T
N
M
A
Site 64
T506
S
E
Q
S
S
L
S
T
D
D
T
N
M
A
D
Site 65
T509
S
S
L
S
T
D
D
T
N
M
A
D
T
F
T
Site 66
S523
T
E
I
M
T
M
M
S
P
S
Q
F
L
S
S
Site 67
S529
M
S
P
S
Q
F
L
S
S
S
P
L
R
M
T
Site 68
S530
S
P
S
Q
F
L
S
S
S
P
L
R
M
T
N
Site 69
S531
P
S
Q
F
L
S
S
S
P
L
R
M
T
N
N
Site 70
T536
S
S
S
P
L
R
M
T
N
N
E
D
S
L
S
Site 71
S541
R
M
T
N
N
E
D
S
L
S
P
T
S
S
T
Site 72
S543
T
N
N
E
D
S
L
S
P
T
S
S
T
L
S
Site 73
T545
N
E
D
S
L
S
P
T
S
S
T
L
S
N
L
Site 74
S546
E
D
S
L
S
P
T
S
S
T
L
S
N
L
E
Site 75
S547
D
S
L
S
P
T
S
S
T
L
S
N
L
E
L
Site 76
T548
S
L
S
P
T
S
S
T
L
S
N
L
E
L
D
Site 77
S550
S
P
T
S
S
T
L
S
N
L
E
L
D
A
A
Site 78
S608
R
P
L
E
A
Q
P
S
A
P
G
H
S
V
K
Site 79
S616
A
P
G
H
S
V
K
S
D
Q
K
H
G
S
L
Site 80
S622
K
S
D
Q
K
H
G
S
L
G
S
S
I
K
D
Site 81
S626
K
H
G
S
L
G
S
S
I
K
D
E
A
S
L
Site 82
S632
S
S
I
K
D
E
A
S
L
P
D
C
S
S
S
Site 83
S637
E
A
S
L
P
D
C
S
S
S
R
Q
P
I
P
Site 84
S638
A
S
L
P
D
C
S
S
S
R
Q
P
I
P
V
Site 85
S639
S
L
P
D
C
S
S
S
R
Q
P
I
P
V
A
Site 86
S647
R
Q
P
I
P
V
A
S
H
A
V
G
Q
P
V
Site 87
S682
V
G
Q
A
E
Q
Q
S
V
V
S
Q
F
Y
V
Site 88
S685
A
E
Q
Q
S
V
V
S
Q
F
Y
V
S
S
Q
Site 89
Y688
Q
S
V
V
S
Q
F
Y
V
S
S
Q
G
Q
P
Site 90
S691
V
S
Q
F
Y
V
S
S
Q
G
Q
P
P
P
A
Site 91
S734
S
V
Q
L
P
V
G
S
L
K
L
Q
T
S
P
Site 92
S740
G
S
L
K
L
Q
T
S
P
Q
A
G
M
Q
T
Site 93
T773
L
A
P
T
V
P
Q
T
Q
D
T
F
P
Q
H
Site 94
T776
T
V
P
Q
T
Q
D
T
F
P
Q
H
V
L
S
Site 95
S783
T
F
P
Q
H
V
L
S
Q
P
Q
Q
V
R
K
Site 96
T793
Q
Q
V
R
K
V
F
T
N
S
A
S
S
N
T
Site 97
S795
V
R
K
V
F
T
N
S
A
S
S
N
T
V
L
Site 98
S797
K
V
F
T
N
S
A
S
S
N
T
V
L
P
Y
Site 99
S798
V
F
T
N
S
A
S
S
N
T
V
L
P
Y
Q
Site 100
T800
T
N
S
A
S
S
N
T
V
L
P
Y
Q
R
H
Site 101
Y804
S
S
N
T
V
L
P
Y
Q
R
H
P
A
P
A
Site 102
S821
Q
P
F
I
N
K
A
S
N
S
V
L
Q
S
R
Site 103
S823
F
I
N
K
A
S
N
S
V
L
Q
S
R
N
A
Site 104
S827
A
S
N
S
V
L
Q
S
R
N
A
P
L
P
S
Site 105
S834
S
R
N
A
P
L
P
S
L
Q
N
G
P
N
T
Site 106
T841
S
L
Q
N
G
P
N
T
P
N
K
P
S
S
P
Site 107
S846
P
N
T
P
N
K
P
S
S
P
P
P
P
Q
Q
Site 108
S847
N
T
P
N
K
P
S
S
P
P
P
P
Q
Q
F
Site 109
S863
V
Q
H
S
L
F
G
S
P
V
A
K
T
K
D
Site 110
Y874
K
T
K
D
P
P
R
Y
E
E
A
I
K
Q
T
Site 111
T884
A
I
K
Q
T
R
S
T
Q
A
P
L
P
E
I
Site 112
S892
Q
A
P
L
P
E
I
S
N
A
H
S
Q
Q
M
Site 113
S896
P
E
I
S
N
A
H
S
Q
Q
M
D
D
L
F
Site 114
S913
L
I
K
S
G
E
I
S
L
P
I
K
E
E
P
Site 115
S921
L
P
I
K
E
E
P
S
P
I
S
K
M
R
P
Site 116
S924
K
E
E
P
S
P
I
S
K
M
R
P
V
T
A
Site 117
S932
K
M
R
P
V
T
A
S
I
T
T
M
P
V
N
Site 118
S962
V
S
L
E
P
M
G
S
L
S
A
S
L
E
N
Site 119
S964
L
E
P
M
G
S
L
S
A
S
L
E
N
Q
L
Site 120
S966
P
M
G
S
L
S
A
S
L
E
N
Q
L
E
A
Site 121
S991
E
I
P
P
L
Q
S
S
S
E
D
R
E
P
F
Site 122
S992
I
P
P
L
Q
S
S
S
E
D
R
E
P
F
S
Site 123
S999
S
E
D
R
E
P
F
S
L
I
E
D
L
Q
N
Site 124
S1010
D
L
Q
N
D
L
L
S
H
S
G
M
L
D
H
Site 125
S1012
Q
N
D
L
L
S
H
S
G
M
L
D
H
S
H
Site 126
S1018
H
S
G
M
L
D
H
S
H
S
P
M
E
T
S
Site 127
S1020
G
M
L
D
H
S
H
S
P
M
E
T
S
E
T
Site 128
S1025
S
H
S
P
M
E
T
S
E
T
Q
F
A
A
G
Site 129
T1027
S
P
M
E
T
S
E
T
Q
F
A
A
G
T
P
Site 130
S1037
A
A
G
T
P
C
L
S
L
D
L
S
D
S
N
Site 131
S1041
P
C
L
S
L
D
L
S
D
S
N
L
D
N
M
Site 132
S1043
L
S
L
D
L
S
D
S
N
L
D
N
M
E
W
Site 133
T1054
N
M
E
W
L
D
I
T
M
P
N
S
S
S
G
Site 134
S1060
I
T
M
P
N
S
S
S
G
L
T
P
L
S
T
Site 135
T1063
P
N
S
S
S
G
L
T
P
L
S
T
T
A
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation