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Updated November 2019
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Protein Info
Short Name:
ATAD2B
Full Name:
ATPase family AAA domain-containing protein 2B
Alias:
ATD2B; ATPase family AAA domain-containing 2B; ATPase family, AAA domain containing 2B; KIAA1240
Type:
Unknown function
Mass (Da):
164942
Number AA:
1458
UniProt ID:
Q9ULI0
International Prot ID:
IPI00739581
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003824
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
V
N
T
R
K
S
S
L
R
L
L
G
S
Site 2
S8
M
V
N
T
R
K
S
S
L
R
L
L
G
S
K
Site 3
S14
S
S
L
R
L
L
G
S
K
S
P
G
P
G
P
Site 4
S16
L
R
L
L
G
S
K
S
P
G
P
G
P
G
P
Site 5
T32
A
G
A
E
P
G
A
T
G
G
S
S
H
F
I
Site 6
S36
P
G
A
T
G
G
S
S
H
F
I
S
S
R
T
Site 7
S40
G
G
S
S
H
F
I
S
S
R
T
R
S
S
K
Site 8
S41
G
S
S
H
F
I
S
S
R
T
R
S
S
K
T
Site 9
S45
F
I
S
S
R
T
R
S
S
K
T
R
A
A
S
Site 10
S46
I
S
S
R
T
R
S
S
K
T
R
A
A
S
C
Site 11
T48
S
R
T
R
S
S
K
T
R
A
A
S
C
P
A
Site 12
S52
S
S
K
T
R
A
A
S
C
P
A
A
K
A
G
Site 13
S61
P
A
A
K
A
G
G
S
G
G
A
G
V
T
L
Site 14
S79
R
K
V
E
V
D
G
S
L
S
D
S
H
V
S
Site 15
S81
V
E
V
D
G
S
L
S
D
S
H
V
S
P
P
Site 16
S83
V
D
G
S
L
S
D
S
H
V
S
P
P
A
K
Site 17
S86
S
L
S
D
S
H
V
S
P
P
A
K
R
T
L
Site 18
S98
R
T
L
K
Q
P
D
S
V
C
K
D
K
S
K
Site 19
S104
D
S
V
C
K
D
K
S
K
S
R
S
T
G
Q
Site 20
S106
V
C
K
D
K
S
K
S
R
S
T
G
Q
R
E
Site 21
S108
K
D
K
S
K
S
R
S
T
G
Q
R
E
E
W
Site 22
T109
D
K
S
K
S
R
S
T
G
Q
R
E
E
W
N
Site 23
S118
Q
R
E
E
W
N
L
S
T
G
Q
A
R
L
T
Site 24
T125
S
T
G
Q
A
R
L
T
S
Q
P
G
A
T
L
Site 25
S126
T
G
Q
A
R
L
T
S
Q
P
G
A
T
L
P
Site 26
S137
A
T
L
P
N
G
H
S
G
L
S
L
R
S
H
Site 27
S140
P
N
G
H
S
G
L
S
L
R
S
H
P
L
R
Site 28
S157
K
K
G
D
G
D
L
S
C
I
N
G
D
M
E
Site 29
S168
G
D
M
E
V
R
K
S
C
R
S
R
K
N
R
Site 30
S171
E
V
R
K
S
C
R
S
R
K
N
R
F
E
S
Site 31
S178
S
R
K
N
R
F
E
S
V
N
Q
S
L
L
F
Site 32
S182
R
F
E
S
V
N
Q
S
L
L
F
D
Q
L
V
Site 33
S211
N
I
R
R
N
R
R
S
G
E
V
E
R
L
R
Site 34
T221
V
E
R
L
R
M
W
T
D
T
E
F
E
N
M
Site 35
T223
R
L
R
M
W
T
D
T
E
F
E
N
M
D
M
Site 36
Y231
E
F
E
N
M
D
M
Y
S
R
V
K
R
R
R
Site 37
S240
R
V
K
R
R
R
K
S
L
R
R
N
S
Y
G
Site 38
S245
R
K
S
L
R
R
N
S
Y
G
I
Q
N
H
H
Site 39
Y246
K
S
L
R
R
N
S
Y
G
I
Q
N
H
H
E
Site 40
S263
T
E
G
E
E
E
E
S
Q
E
E
D
G
D
I
Site 41
Y284
G
E
E
N
D
R
P
Y
N
L
R
Q
R
K
T
Site 42
T291
Y
N
L
R
Q
R
K
T
V
D
R
Y
Q
A
P
Site 43
Y295
Q
R
K
T
V
D
R
Y
Q
A
P
P
I
V
P
Site 44
T311
H
Q
K
K
R
E
N
T
L
F
D
I
H
R
S
Site 45
S318
T
L
F
D
I
H
R
S
P
A
R
R
S
H
I
Site 46
S323
H
R
S
P
A
R
R
S
H
I
R
R
K
K
H
Site 47
S334
R
K
K
H
A
I
H
S
S
D
T
T
S
S
D
Site 48
S335
K
K
H
A
I
H
S
S
D
T
T
S
S
D
E
Site 49
T338
A
I
H
S
S
D
T
T
S
S
D
E
E
R
F
Site 50
S339
I
H
S
S
D
T
T
S
S
D
E
E
R
F
E
Site 51
S340
H
S
S
D
T
T
S
S
D
E
E
R
F
E
R
Site 52
S350
E
R
F
E
R
R
K
S
K
S
M
A
R
A
R
Site 53
S352
F
E
R
R
K
S
K
S
M
A
R
A
R
N
R
Site 54
S372
F
R
A
E
D
L
A
S
G
I
L
R
E
R
V
Site 55
S384
E
R
V
K
V
G
A
S
L
A
D
V
D
P
M
Site 56
S396
D
P
M
N
I
D
K
S
V
R
F
D
S
I
G
Site 57
S401
D
K
S
V
R
F
D
S
I
G
G
L
S
H
H
Site 58
Y440
P
P
R
G
C
L
F
Y
G
P
P
G
T
G
K
Site 59
S459
R
A
L
A
N
E
C
S
Q
G
D
K
K
V
A
Site 60
S477
R
K
G
A
D
C
L
S
K
W
V
G
E
S
E
Site 61
S483
L
S
K
W
V
G
E
S
E
R
Q
L
R
L
L
Site 62
S515
D
G
L
A
P
V
R
S
S
R
Q
D
Q
I
H
Site 63
S516
G
L
A
P
V
R
S
S
R
Q
D
Q
I
H
S
Site 64
S523
S
R
Q
D
Q
I
H
S
S
I
V
S
T
L
L
Site 65
S524
R
Q
D
Q
I
H
S
S
I
V
S
T
L
L
A
Site 66
S553
G
A
T
N
R
L
D
S
I
D
P
A
L
R
R
Site 67
S594
R
D
W
N
P
K
L
S
D
A
F
L
G
E
L
Site 68
Y629
L
I
A
L
R
R
R
Y
P
Q
I
Y
A
S
S
Site 69
Y633
R
R
R
Y
P
Q
I
Y
A
S
S
H
K
L
Q
Site 70
S635
R
Y
P
Q
I
Y
A
S
S
H
K
L
Q
L
D
Site 71
S664
M
Q
N
I
V
P
A
S
Q
R
A
V
M
S
S
Site 72
S670
A
S
Q
R
A
V
M
S
S
G
H
A
L
S
P
Site 73
S671
S
Q
R
A
V
M
S
S
G
H
A
L
S
P
I
Site 74
S704
V
F
P
H
A
E
I
S
Q
S
D
K
K
E
D
Site 75
S706
P
H
A
E
I
S
Q
S
D
K
K
E
D
I
E
Site 76
T714
D
K
K
E
D
I
E
T
L
I
L
E
D
S
E
Site 77
S720
E
T
L
I
L
E
D
S
E
D
E
N
A
L
S
Site 78
S727
S
E
D
E
N
A
L
S
I
F
E
T
N
C
H
Site 79
T731
N
A
L
S
I
F
E
T
N
C
H
S
G
S
P
Site 80
S735
I
F
E
T
N
C
H
S
G
S
P
K
K
Q
S
Site 81
S737
E
T
N
C
H
S
G
S
P
K
K
Q
S
S
S
Site 82
S742
S
G
S
P
K
K
Q
S
S
S
A
A
I
H
K
Site 83
S743
G
S
P
K
K
Q
S
S
S
A
A
I
H
K
P
Site 84
S744
S
P
K
K
Q
S
S
S
A
A
I
H
K
P
Y
Site 85
Y751
S
A
A
I
H
K
P
Y
L
H
F
T
M
S
P
Site 86
S757
P
Y
L
H
F
T
M
S
P
Y
H
Q
P
T
S
Site 87
Y759
L
H
F
T
M
S
P
Y
H
Q
P
T
S
Y
R
Site 88
S764
S
P
Y
H
Q
P
T
S
Y
R
P
R
L
L
L
Site 89
Y765
P
Y
H
Q
P
T
S
Y
R
P
R
L
L
L
S
Site 90
S772
Y
R
P
R
L
L
L
S
G
E
R
G
S
G
Q
Site 91
S777
L
L
S
G
E
R
G
S
G
Q
T
S
H
L
A
Site 92
S781
E
R
G
S
G
Q
T
S
H
L
A
P
A
L
L
Site 93
S795
L
H
T
L
E
R
F
S
V
H
R
L
D
L
P
Site 94
Y805
R
L
D
L
P
A
L
Y
S
V
S
A
K
T
P
Site 95
S806
L
D
L
P
A
L
Y
S
V
S
A
K
T
P
E
Site 96
T811
L
Y
S
V
S
A
K
T
P
E
E
S
C
A
Q
Site 97
S829
E
A
R
R
T
V
P
S
I
V
Y
M
P
H
I
Site 98
Y832
R
T
V
P
S
I
V
Y
M
P
H
I
G
D
W
Site 99
T872
F
L
L
S
T
S
E
T
M
Y
S
E
L
P
E
Site 100
Y874
L
S
T
S
E
T
M
Y
S
E
L
P
E
E
V
Site 101
S875
S
T
S
E
T
M
Y
S
E
L
P
E
E
V
K
Site 102
Y894
I
Q
Y
E
E
V
L
Y
I
Q
R
P
I
E
E
Site 103
S916
E
L
I
L
N
Q
A
S
M
A
P
P
R
R
K
Site 104
S939
V
L
P
L
A
L
P
S
P
P
R
Q
L
S
E
Site 105
S945
P
S
P
P
R
Q
L
S
E
S
E
K
S
R
M
Site 106
S947
P
P
R
Q
L
S
E
S
E
K
S
R
M
E
D
Site 107
S950
Q
L
S
E
S
E
K
S
R
M
E
D
Q
E
E
Site 108
T959
M
E
D
Q
E
E
N
T
L
R
E
L
R
L
F
Site 109
T971
R
L
F
L
R
D
V
T
K
R
L
A
T
D
K
Site 110
T976
D
V
T
K
R
L
A
T
D
K
R
F
N
I
F
Site 111
S984
D
K
R
F
N
I
F
S
K
P
V
D
I
E
E
Site 112
S993
P
V
D
I
E
E
V
S
D
Y
L
E
V
I
K
Site 113
Y995
D
I
E
E
V
S
D
Y
L
E
V
I
K
E
P
Site 114
S1006
I
K
E
P
M
D
L
S
T
V
I
T
K
I
D
Site 115
T1007
K
E
P
M
D
L
S
T
V
I
T
K
I
D
K
Site 116
T1010
M
D
L
S
T
V
I
T
K
I
D
K
H
N
Y
Site 117
Y1017
T
K
I
D
K
H
N
Y
L
T
A
K
D
F
L
Site 118
T1019
I
D
K
H
N
Y
L
T
A
K
D
F
L
K
D
Site 119
T1054
I
I
R
H
R
A
C
T
L
K
D
T
A
H
A
Site 120
S1088
A
R
I
K
R
G
L
S
V
T
S
E
Q
I
N
Site 121
T1090
I
K
R
G
L
S
V
T
S
E
Q
I
N
P
H
Site 122
S1091
K
R
G
L
S
V
T
S
E
Q
I
N
P
H
S
Site 123
S1098
S
E
Q
I
N
P
H
S
T
G
A
R
K
T
E
Site 124
T1104
H
S
T
G
A
R
K
T
E
T
R
V
E
E
A
Site 125
S1138
A
F
R
V
R
R
K
S
R
R
R
S
Q
W
G
Site 126
S1142
R
R
K
S
R
R
R
S
Q
W
G
K
G
I
I
Site 127
Y1169
E
D
T
K
F
A
D
Y
E
N
H
T
E
D
R
Site 128
S1187
E
N
G
E
F
E
V
S
T
D
C
H
E
E
N
Site 129
T1188
N
G
E
F
E
V
S
T
D
C
H
E
E
N
G
Site 130
S1202
G
E
E
T
G
D
L
S
M
T
N
D
E
S
S
Site 131
T1204
E
T
G
D
L
S
M
T
N
D
E
S
S
C
D
Site 132
S1208
L
S
M
T
N
D
E
S
S
C
D
I
M
D
L
Site 133
S1209
S
M
T
N
D
E
S
S
C
D
I
M
D
L
D
Site 134
S1233
G
T
K
E
N
F
A
S
T
E
E
E
S
S
N
Site 135
T1234
T
K
E
N
F
A
S
T
E
E
E
S
S
N
E
Site 136
S1238
F
A
S
T
E
E
E
S
S
N
E
S
L
L
V
Site 137
S1239
A
S
T
E
E
E
S
S
N
E
S
L
L
V
N
Site 138
S1242
E
E
E
S
S
N
E
S
L
L
V
N
S
S
S
Site 139
S1248
E
S
L
L
V
N
S
S
S
S
L
N
P
E
Q
Site 140
S1249
S
L
L
V
N
S
S
S
S
L
N
P
E
Q
T
Site 141
S1250
L
L
V
N
S
S
S
S
L
N
P
E
Q
T
S
Site 142
T1256
S
S
L
N
P
E
Q
T
S
R
K
E
T
F
L
Site 143
T1261
E
Q
T
S
R
K
E
T
F
L
K
G
N
C
L
Site 144
S1273
N
C
L
N
G
E
A
S
T
D
S
F
E
G
I
Site 145
S1276
N
G
E
A
S
T
D
S
F
E
G
I
P
V
L
Site 146
S1294
N
G
K
L
E
V
V
S
F
C
D
S
G
D
K
Site 147
S1298
E
V
V
S
F
C
D
S
G
D
K
C
S
S
E
Site 148
S1303
C
D
S
G
D
K
C
S
S
E
Q
K
I
L
L
Site 149
S1304
D
S
G
D
K
C
S
S
E
Q
K
I
L
L
E
Site 150
S1314
K
I
L
L
E
D
Q
S
K
E
K
P
E
T
S
Site 151
T1320
Q
S
K
E
K
P
E
T
S
T
E
N
H
G
D
Site 152
S1338
K
L
E
A
L
E
C
S
N
N
E
K
L
E
P
Site 153
S1347
N
E
K
L
E
P
G
S
D
V
E
V
K
D
A
Site 154
T1377
L
I
L
E
Q
A
K
T
T
S
L
E
L
V
P
Site 155
S1379
L
E
Q
A
K
T
T
S
L
E
L
V
P
E
E
Site 156
S1388
E
L
V
P
E
E
P
S
E
P
V
P
P
L
I
Site 157
S1412
L
D
L
L
V
D
K
S
N
N
L
A
V
D
Q
Site 158
S1425
D
Q
L
E
R
L
Y
S
L
L
S
Q
C
I
Y
Site 159
S1428
E
R
L
Y
S
L
L
S
Q
C
I
Y
R
H
R
Site 160
Y1432
S
L
L
S
Q
C
I
Y
R
H
R
K
D
Y
D
Site 161
Y1438
I
Y
R
H
R
K
D
Y
D
K
S
Q
L
V
E
Site 162
S1441
H
R
K
D
Y
D
K
S
Q
L
V
E
E
M
E
Site 163
T1450
L
V
E
E
M
E
R
T
V
H
M
F
E
T
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation