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Updated November 2019
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Protein Info
Short Name:
ANKRD50
Full Name:
Ankyrin repeat domain-containing protein 50
Alias:
Ankyrin repeat domain 50; Ankyrin repeat domain-containing 50; ANR50; KIAA1223
Type:
Unknown function
Mass (Da):
149589
Number AA:
1375
UniProt ID:
Q9ULJ7
International Prot ID:
IPI00221285
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S46
E
K
S
N
C
C
N
S
A
V
N
A
P
S
L
Site 2
S52
N
S
A
V
N
A
P
S
L
V
M
N
S
G
N
Site 3
T88
S
G
K
T
A
L
C
T
E
L
L
W
P
S
S
Site 4
S94
C
T
E
L
L
W
P
S
S
P
A
S
L
Q
R
Site 5
S95
T
E
L
L
W
P
S
S
P
A
S
L
Q
R
G
Site 6
S98
L
W
P
S
S
P
A
S
L
Q
R
G
L
H
R
Site 7
S154
L
R
D
P
A
V
Q
S
L
L
Q
P
G
E
C
Site 8
S186
G
M
K
P
P
Q
Q
S
L
Y
L
L
V
D
S
Site 9
Y188
K
P
P
Q
Q
S
L
Y
L
L
V
D
S
V
D
Site 10
T206
N
I
T
E
G
E
Q
T
S
T
S
L
S
G
T
Site 11
S207
I
T
E
G
E
Q
T
S
T
S
L
S
G
T
V
Site 12
T208
T
E
G
E
Q
T
S
T
S
L
S
G
T
V
A
Site 13
S209
E
G
E
Q
T
S
T
S
L
S
G
T
V
A
A
Site 14
S234
P
W
L
L
L
L
C
S
A
R
K
Q
S
K
A
Site 15
S239
L
C
S
A
R
K
Q
S
K
A
V
T
K
M
F
Site 16
T243
R
K
Q
S
K
A
V
T
K
M
F
T
G
F
R
Site 17
S253
F
T
G
F
R
K
I
S
L
D
D
L
R
K
A
Site 18
Y261
L
D
D
L
R
K
A
Y
I
V
K
D
V
Q
Q
Site 19
S300
N
Q
L
H
I
K
S
S
G
C
F
L
Y
L
E
Site 20
Y305
K
S
S
G
C
F
L
Y
L
E
R
V
L
D
G
Site 21
T329
E
I
R
D
I
P
G
T
L
N
G
L
Y
L
W
Site 22
Y370
P
L
T
I
T
E
L
Y
H
A
V
W
T
K
N
Site 23
T375
E
L
Y
H
A
V
W
T
K
N
M
S
L
T
L
Site 24
T381
W
T
K
N
M
S
L
T
L
E
D
F
Q
R
K
Site 25
Y425
V
K
H
C
T
Q
K
Y
L
C
N
A
A
E
G
Site 26
T441
R
M
L
A
M
S
Y
T
C
Q
A
K
N
L
T
Site 27
T448
T
C
Q
A
K
N
L
T
P
L
E
A
Q
E
F
Site 28
T480
L
W
M
I
W
N
G
T
P
V
R
D
S
L
S
Site 29
S485
N
G
T
P
V
R
D
S
L
S
T
L
I
P
K
Site 30
S487
T
P
V
R
D
S
L
S
T
L
I
P
K
E
Q
Site 31
T488
P
V
R
D
S
L
S
T
L
I
P
K
E
Q
E
Site 32
T514
V
N
S
E
D
D
R
T
S
C
I
V
R
Q
A
Site 33
S515
N
S
E
D
D
R
T
S
C
I
V
R
Q
A
L
Site 34
S527
Q
A
L
E
R
E
D
S
I
R
T
L
L
D
N
Site 35
S543
A
S
V
N
Q
C
D
S
N
G
R
T
L
L
A
Site 36
T547
Q
C
D
S
N
G
R
T
L
L
A
N
A
A
Y
Site 37
T580
I
E
D
A
H
G
H
T
P
L
T
L
A
A
R
Site 38
T583
A
H
G
H
T
P
L
T
L
A
A
R
Q
G
H
Site 39
S644
V
D
C
A
D
A
D
S
R
T
A
L
R
A
A
Site 40
T777
G
G
A
D
V
D
H
T
D
N
N
G
R
T
P
Site 41
T783
H
T
D
N
N
G
R
T
P
L
L
A
A
A
S
Site 42
S819
S
E
G
R
T
V
L
S
I
A
S
A
Q
G
N
Site 43
T832
G
N
V
E
V
V
R
T
L
L
D
R
G
L
D
Site 44
S904
Q
I
L
L
E
N
K
S
N
I
D
Q
R
G
Y
Site 45
Y911
S
N
I
D
Q
R
G
Y
D
G
R
N
A
L
R
Site 46
T949
K
D
A
D
G
R
P
T
L
Y
I
L
A
L
E
Site 47
Y951
A
D
G
R
P
T
L
Y
I
L
A
L
E
N
Q
Site 48
Y964
N
Q
L
T
M
A
E
Y
F
L
E
N
G
A
N
Site 49
S975
N
G
A
N
V
E
A
S
D
A
E
G
R
T
A
Site 50
S1014
A
A
D
N
E
K
R
S
A
L
Q
S
A
A
W
Site 51
S1018
E
K
R
S
A
L
Q
S
A
A
W
Q
G
H
V
Site 52
T1041
H
G
A
V
V
D
H
T
C
N
Q
G
A
T
A
Site 53
S1091
V
A
A
K
N
G
H
S
Q
I
I
K
L
L
E
Site 54
S1104
L
E
K
Y
G
A
S
S
L
N
G
C
S
P
S
Site 55
S1109
G
P
T
H
A
F
S
S
P
S
E
S
P
D
S
Site 56
S1111
S
L
N
G
C
S
P
S
P
V
H
T
M
E
Q
Site 57
T1115
C
S
P
S
P
V
H
T
M
E
Q
K
P
L
Q
Site 58
S1123
M
E
Q
K
P
L
Q
S
L
S
S
K
V
Q
S
Site 59
S1125
Q
K
P
L
Q
S
L
S
S
K
V
Q
S
L
T
Site 60
S1126
K
P
L
Q
S
L
S
S
K
V
Q
S
L
T
I
Site 61
S1130
S
L
S
S
K
V
Q
S
L
T
I
K
S
N
S
Site 62
T1132
S
S
K
V
Q
S
L
T
I
K
S
N
S
S
G
Site 63
S1135
V
Q
S
L
T
I
K
S
N
S
S
G
S
T
G
Site 64
S1137
S
L
T
I
K
S
N
S
S
G
S
T
G
G
G
Site 65
S1138
L
T
I
K
S
N
S
S
G
S
T
G
G
G
D
Site 66
S1149
G
G
G
D
M
Q
P
S
L
R
G
L
P
N
G
Site 67
T1158
R
G
L
P
N
G
P
T
H
A
F
S
S
P
S
Site 68
S1162
N
G
P
T
H
A
F
S
S
P
S
E
S
P
D
Site 69
S1163
G
P
T
H
A
F
S
S
P
S
E
S
P
D
S
Site 70
S1165
T
H
A
F
S
S
P
S
E
S
P
D
S
T
V
Site 71
S1167
A
F
S
S
P
S
E
S
P
D
S
T
V
D
R
Site 72
S1170
S
P
S
E
S
P
D
S
T
V
D
R
Q
K
S
Site 73
T1171
P
S
E
S
P
D
S
T
V
D
R
Q
K
S
S
Site 74
S1177
S
T
V
D
R
Q
K
S
S
L
S
N
N
S
L
Site 75
S1178
T
V
D
R
Q
K
S
S
L
S
N
N
S
L
K
Site 76
S1180
D
R
Q
K
S
S
L
S
N
N
S
L
K
S
S
Site 77
S1183
K
S
S
L
S
N
N
S
L
K
S
S
K
N
S
Site 78
S1186
L
S
N
N
S
L
K
S
S
K
N
S
S
L
R
Site 79
S1187
S
N
N
S
L
K
S
S
K
N
S
S
L
R
T
Site 80
S1190
S
L
K
S
S
K
N
S
S
L
R
T
T
S
S
Site 81
S1191
L
K
S
S
K
N
S
S
L
R
T
T
S
S
T
Site 82
T1194
S
K
N
S
S
L
R
T
T
S
S
T
A
T
A
Site 83
T1195
K
N
S
S
L
R
T
T
S
S
T
A
T
A
Q
Site 84
S1196
N
S
S
L
R
T
T
S
S
T
A
T
A
Q
T
Site 85
S1197
S
S
L
R
T
T
S
S
T
A
T
A
Q
T
V
Site 86
T1198
S
L
R
T
T
S
S
T
A
T
A
Q
T
V
P
Site 87
T1200
R
T
T
S
S
T
A
T
A
Q
T
V
P
I
D
Site 88
T1203
S
S
T
A
T
A
Q
T
V
P
I
D
S
F
H
Site 89
S1208
A
Q
T
V
P
I
D
S
F
H
N
L
S
F
T
Site 90
S1213
I
D
S
F
H
N
L
S
F
T
E
Q
I
Q
Q
Site 91
T1215
S
F
H
N
L
S
F
T
E
Q
I
Q
Q
H
S
Site 92
S1222
T
E
Q
I
Q
Q
H
S
L
P
R
S
R
S
R
Site 93
S1226
Q
Q
H
S
L
P
R
S
R
S
R
Q
S
I
V
Site 94
S1228
H
S
L
P
R
S
R
S
R
Q
S
I
V
S
P
Site 95
S1231
P
R
S
R
S
R
Q
S
I
V
S
P
S
S
T
Site 96
S1234
R
S
R
Q
S
I
V
S
P
S
S
T
T
Q
S
Site 97
S1236
R
Q
S
I
V
S
P
S
S
T
T
Q
S
L
G
Site 98
S1237
Q
S
I
V
S
P
S
S
T
T
Q
S
L
G
Q
Site 99
T1238
S
I
V
S
P
S
S
T
T
Q
S
L
G
Q
S
Site 100
S1241
S
P
S
S
T
T
Q
S
L
G
Q
S
H
N
S
Site 101
S1245
T
T
Q
S
L
G
Q
S
H
N
S
P
S
S
E
Site 102
S1248
S
L
G
Q
S
H
N
S
P
S
S
E
F
E
W
Site 103
S1250
G
Q
S
H
N
S
P
S
S
E
F
E
W
S
Q
Site 104
S1251
Q
S
H
N
S
P
S
S
E
F
E
W
S
Q
V
Site 105
S1256
P
S
S
E
F
E
W
S
Q
V
K
P
S
L
K
Site 106
S1261
E
W
S
Q
V
K
P
S
L
K
S
T
K
A
S
Site 107
S1264
Q
V
K
P
S
L
K
S
T
K
A
S
K
G
G
Site 108
T1265
V
K
P
S
L
K
S
T
K
A
S
K
G
G
K
Site 109
S1268
S
L
K
S
T
K
A
S
K
G
G
K
S
E
N
Site 110
S1273
K
A
S
K
G
G
K
S
E
N
S
A
K
S
G
Site 111
S1276
K
G
G
K
S
E
N
S
A
K
S
G
S
A
G
Site 112
S1279
K
S
E
N
S
A
K
S
G
S
A
G
K
K
A
Site 113
S1281
E
N
S
A
K
S
G
S
A
G
K
K
A
K
Q
Site 114
S1289
A
G
K
K
A
K
Q
S
N
S
S
Q
P
K
V
Site 115
S1291
K
K
A
K
Q
S
N
S
S
Q
P
K
V
L
E
Site 116
S1292
K
A
K
Q
S
N
S
S
Q
P
K
V
L
E
Y
Site 117
Y1299
S
Q
P
K
V
L
E
Y
E
M
T
Q
F
D
R
Site 118
T1302
K
V
L
E
Y
E
M
T
Q
F
D
R
R
G
P
Site 119
S1313
R
R
G
P
I
A
K
S
G
T
A
A
P
P
K
Site 120
S1342
A
Q
Q
E
I
G
R
S
Q
Q
Q
F
L
I
H
Site 121
S1352
Q
F
L
I
H
Q
Q
S
G
E
Q
K
K
R
N
Site 122
Y1367
G
I
M
T
N
P
N
Y
H
L
Q
S
N
Q
V
Site 123
S1380
Q
V
F
L
G
R
V
S
V
P
R
T
M
Q
D
Site 124
T1384
G
R
V
S
V
P
R
T
M
Q
D
R
G
H
Q
Site 125
Y1397
H
Q
E
V
L
E
G
Y
P
S
S
E
T
E
L
Site 126
S1399
E
V
L
E
G
Y
P
S
S
E
T
E
L
S
L
Site 127
S1400
V
L
E
G
Y
P
S
S
E
T
E
L
S
L
K
Site 128
T1402
E
G
Y
P
S
S
E
T
E
L
S
L
K
Q
A
Site 129
S1405
P
S
S
E
T
E
L
S
L
K
Q
A
L
K
L
Site 130
S1417
L
K
L
Q
I
E
G
S
D
P
S
F
N
Y
K
Site 131
S1420
Q
I
E
G
S
D
P
S
F
N
Y
K
K
E
T
Site 132
Y1423
G
S
D
P
S
F
N
Y
K
K
E
T
P
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation