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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CRSP3
Full Name:
Mediator of RNA polymerase II transcription subunit 23
Alias:
130 kDa transcriptional co-activator; CRSP130; DRIP130; MED23; Mediator complex subunit 23; Sur2
Type:
Mass (Da):
156474
Number AA:
1368
UniProt ID:
Q9ULK4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005667
Uniprot
OncoNet
Molecular Function:
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0006357
GO:0006367
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T29
F
P
G
M
F
M
D
T
P
E
D
E
K
T
K
Site 2
T35
D
T
P
E
D
E
K
T
K
L
I
S
C
L
G
Site 3
S52
R
Q
F
W
G
G
L
S
Q
E
S
H
E
Q
C
Site 4
S72
K
F
I
H
G
Q
H
S
P
K
R
I
S
F
L
Site 5
S77
Q
H
S
P
K
R
I
S
F
L
Y
D
C
L
A
Site 6
S100
P
P
R
L
V
C
E
S
L
I
N
S
D
T
L
Site 7
S104
V
C
E
S
L
I
N
S
D
T
L
E
W
E
R
Site 8
T106
E
S
L
I
N
S
D
T
L
E
W
E
R
T
Q
Site 9
T112
D
T
L
E
W
E
R
T
Q
L
W
A
L
T
F
Site 10
Y191
V
T
E
I
R
K
L
Y
P
E
G
K
L
P
H
Site 11
S220
R
P
T
A
R
I
N
S
I
C
G
R
C
S
L
Site 12
T247
S
W
K
L
D
P
A
T
L
R
F
P
L
K
G
Site 13
Y272
P
Q
T
A
L
L
R
Y
V
L
E
Q
P
Y
S
Site 14
Y278
R
Y
V
L
E
Q
P
Y
S
R
D
M
V
C
N
Site 15
T317
Y
A
M
E
R
S
E
T
E
E
K
F
D
D
G
Site 16
S327
K
F
D
D
G
G
T
S
Q
L
L
W
Q
H
L
Site 17
Y403
M
K
L
F
D
L
L
Y
P
E
K
E
Y
I
P
Site 18
S419
P
D
I
N
K
P
Q
S
T
H
A
F
A
M
T
Site 19
S441
R
K
A
Q
N
D
N
S
K
L
Q
I
P
I
P
Site 20
S450
L
Q
I
P
I
P
H
S
L
R
L
H
H
E
F
Site 21
S461
H
H
E
F
L
Q
Q
S
L
R
N
K
S
L
Q
Site 22
S466
Q
Q
S
L
R
N
K
S
L
Q
M
N
D
Y
K
Site 23
Y472
K
S
L
Q
M
N
D
Y
K
I
A
L
L
C
N
Site 24
T512
M
R
I
P
L
P
G
T
N
C
M
A
S
G
S
Site 25
T532
M
N
L
L
D
S
L
T
V
H
A
K
M
S
L
Site 26
S555
I
K
L
A
H
A
K
S
S
V
A
L
A
P
A
Site 27
Y610
T
L
L
E
M
F
S
Y
R
M
H
H
I
Q
P
Site 28
Y619
M
H
H
I
Q
P
H
Y
R
V
Q
L
L
S
H
Site 29
S670
P
Q
F
T
R
F
L
S
D
P
K
T
V
L
S
Site 30
T674
R
F
L
S
D
P
K
T
V
L
S
A
E
S
E
Site 31
S677
S
D
P
K
T
V
L
S
A
E
S
E
E
L
N
Site 32
T698
L
A
R
A
T
H
V
T
D
F
F
T
G
S
D
Site 33
T702
T
H
V
T
D
F
F
T
G
S
D
S
I
Q
G
Site 34
S704
V
T
D
F
F
T
G
S
D
S
I
Q
G
T
W
Site 35
T710
G
S
D
S
I
Q
G
T
W
C
K
D
I
L
Q
Site 36
T731
P
H
N
W
A
S
H
T
L
S
C
F
P
G
P
Site 37
T778
S
N
E
N
D
I
I
T
H
F
S
M
Q
G
S
Site 38
S781
N
D
I
I
T
H
F
S
M
Q
G
S
P
P
L
Site 39
S835
D
F
L
V
Y
E
F
S
T
S
A
G
G
Q
Q
Site 40
Y857
L
N
D
M
V
W
K
Y
N
I
V
T
L
D
R
Site 41
S901
N
D
F
R
N
R
V
S
D
F
V
K
E
N
S
Site 42
S908
S
D
F
V
K
E
N
S
P
E
H
W
L
Q
N
Site 43
Y928
H
M
N
Y
H
K
K
Y
P
E
K
L
Y
F
E
Site 44
Y933
K
K
Y
P
E
K
L
Y
F
E
G
L
A
E
Q
Site 45
S949
D
P
P
V
Q
I
Q
S
P
Y
L
P
I
Y
F
Site 46
Y951
P
V
Q
I
Q
S
P
Y
L
P
I
Y
F
G
N
Site 47
S983
E
L
L
P
V
S
K
S
L
E
T
L
L
D
H
Site 48
T1003
K
F
H
D
R
P
V
T
Y
L
Y
N
T
L
H
Site 49
Y1004
F
H
D
R
P
V
T
Y
L
Y
N
T
L
H
Y
Site 50
Y1006
D
R
P
V
T
Y
L
Y
N
T
L
H
Y
Y
E
Site 51
Y1011
Y
L
Y
N
T
L
H
Y
Y
E
M
H
L
R
D
Site 52
Y1012
L
Y
N
T
L
H
Y
Y
E
M
H
L
R
D
R
Site 53
S1033
L
V
H
A
I
I
G
S
L
K
D
N
R
P
Q
Site 54
Y1067
P
W
V
P
D
D
T
Y
Y
C
R
L
I
G
R
Site 55
Y1068
W
V
P
D
D
T
Y
Y
C
R
L
I
G
R
L
Site 56
S1083
V
D
T
M
A
G
K
S
P
G
P
F
P
N
C
Site 57
S1173
D
R
I
V
S
V
I
S
S
P
S
L
T
S
E
Site 58
S1176
V
S
V
I
S
S
P
S
L
T
S
E
T
E
W
Site 59
T1178
V
I
S
S
P
S
L
T
S
E
T
E
W
V
G
Site 60
Y1186
S
E
T
E
W
V
G
Y
P
F
R
L
F
D
F
Site 61
Y1200
F
T
A
C
H
Q
S
Y
S
E
M
S
C
S
Y
Site 62
S1204
H
Q
S
Y
S
E
M
S
C
S
Y
T
L
A
L
Site 63
S1206
S
Y
S
E
M
S
C
S
Y
T
L
A
L
A
H
Site 64
Y1303
D
F
L
Y
H
M
K
Y
M
F
T
G
D
S
V
Site 65
S1309
K
Y
M
F
T
G
D
S
V
K
E
Q
V
E
K
Site 66
T1333
K
L
R
L
R
F
I
T
H
I
S
K
M
E
P
Site 67
S1350
V
P
P
Q
A
M
N
S
G
S
P
A
P
Q
S
Site 68
S1352
P
Q
A
M
N
S
G
S
P
A
P
Q
S
N
Q
Site 69
S1357
S
G
S
P
A
P
Q
S
N
Q
V
P
V
S
L
Site 70
S1363
Q
S
N
Q
V
P
V
S
L
P
V
T
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation