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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TPCN1
Full Name:
Two pore calcium channel protein 1
Alias:
FLJ20612; KIAA1169; TPC1; Two pore segment channel 1; Two-pore channel 1; Two-pore segment channel 1; Voltage-dependent calcium channel protein TPC1
Type:
Membrane protein, integral; Channel, calcium
Mass (Da):
94147
Number AA:
816
UniProt ID:
Q9ULQ1
International Prot ID:
IPI00385917
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005262
GO:0005509
GO:0005244
PhosphoSite+
KinaseNET
Biological Process:
GO:0006816
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
L
T
L
D
E
G
G
S
A
P
L
A
P
S
N
Site 2
S36
L
G
Q
E
E
L
P
S
K
N
G
G
S
Y
A
Site 3
S41
L
P
S
K
N
G
G
S
Y
A
I
H
D
S
Q
Site 4
S47
G
S
Y
A
I
H
D
S
Q
A
P
S
L
S
S
Site 5
S51
I
H
D
S
Q
A
P
S
L
S
S
G
G
E
S
Site 6
S53
D
S
Q
A
P
S
L
S
S
G
G
E
S
S
P
Site 7
S54
S
Q
A
P
S
L
S
S
G
G
E
S
S
P
S
Site 8
S58
S
L
S
S
G
G
E
S
S
P
S
S
P
A
H
Site 9
S59
L
S
S
G
G
E
S
S
P
S
S
P
A
H
N
Site 10
S61
S
G
G
E
S
S
P
S
S
P
A
H
N
W
E
Site 11
S62
G
G
E
S
S
P
S
S
P
A
H
N
W
E
M
Site 12
Y71
A
H
N
W
E
M
N
Y
Q
E
A
A
I
Y
L
Site 13
Y77
N
Y
Q
E
A
A
I
Y
L
Q
E
G
E
N
N
Site 14
T166
L
R
W
L
G
L
H
T
F
I
R
H
K
R
T
Site 15
T173
T
F
I
R
H
K
R
T
M
V
K
T
S
V
L
Site 16
S255
I
L
G
F
Y
L
F
S
P
N
P
S
D
P
Y
Site 17
S259
Y
L
F
S
P
N
P
S
D
P
Y
F
S
T
L
Site 18
Y262
S
P
N
P
S
D
P
Y
F
S
T
L
E
N
S
Site 19
S264
N
P
S
D
P
Y
F
S
T
L
E
N
S
I
V
Site 20
T265
P
S
D
P
Y
F
S
T
L
E
N
S
I
V
S
Site 21
Y309
V
Y
L
S
I
E
L
Y
F
I
M
N
L
L
L
Site 22
S333
I
E
K
R
K
F
K
S
L
L
L
H
K
R
T
Site 23
S351
H
A
Y
R
L
L
I
S
Q
R
R
P
A
G
I
Site 24
S359
Q
R
R
P
A
G
I
S
Y
R
Q
F
E
G
L
Site 25
Y360
R
R
P
A
G
I
S
Y
R
Q
F
E
G
L
M
Site 26
Y370
F
E
G
L
M
R
F
Y
K
P
R
M
S
A
R
Site 27
S375
R
F
Y
K
P
R
M
S
A
R
E
R
Y
L
T
Site 28
Y380
R
M
S
A
R
E
R
Y
L
T
F
K
A
L
N
Site 29
T382
S
A
R
E
R
Y
L
T
F
K
A
L
N
Q
N
Site 30
T391
K
A
L
N
Q
N
N
T
P
L
L
S
L
K
D
Site 31
S395
Q
N
N
T
P
L
L
S
L
K
D
F
Y
D
I
Site 32
T426
W
F
D
E
L
P
R
T
A
L
L
I
F
K
G
Site 33
S505
G
P
V
E
Y
L
S
S
G
W
N
L
F
D
F
Site 34
T559
R
Y
R
N
V
L
D
T
M
F
E
L
L
P
R
Site 35
Y607
T
S
T
V
A
D
A
Y
R
W
R
N
H
T
V
Site 36
T613
A
Y
R
W
R
N
H
T
V
G
N
R
T
V
V
Site 37
T618
N
H
T
V
G
N
R
T
V
V
E
E
G
Y
Y
Site 38
Y624
R
T
V
V
E
E
G
Y
Y
Y
L
N
N
F
D
Site 39
Y625
T
V
V
E
E
G
Y
Y
Y
L
N
N
F
D
N
Site 40
Y626
V
V
E
E
G
Y
Y
Y
L
N
N
F
D
N
I
Site 41
S658
I
I
M
E
G
V
T
S
Q
T
S
H
W
S
R
Site 42
S661
E
G
V
T
S
Q
T
S
H
W
S
R
L
Y
F
Site 43
Y696
A
F
V
F
R
M
N
Y
S
R
K
N
Q
D
S
Site 44
S703
Y
S
R
K
N
Q
D
S
E
V
D
G
G
I
T
Site 45
T710
S
E
V
D
G
G
I
T
L
E
K
E
I
S
K
Site 46
S734
Y
R
E
A
R
G
A
S
S
D
V
T
R
L
L
Site 47
S735
R
E
A
R
G
A
S
S
D
V
T
R
L
L
E
Site 48
T738
R
G
A
S
S
D
V
T
R
L
L
E
T
L
S
Site 49
S745
T
R
L
L
E
T
L
S
Q
M
E
R
Y
Q
Q
Site 50
Y750
T
L
S
Q
M
E
R
Y
Q
Q
H
S
M
V
F
Site 51
S762
M
V
F
L
G
R
R
S
R
T
K
S
D
L
S
Site 52
T764
F
L
G
R
R
S
R
T
K
S
D
L
S
L
K
Site 53
S766
G
R
R
S
R
T
K
S
D
L
S
L
K
M
Y
Site 54
S769
S
R
T
K
S
D
L
S
L
K
M
Y
Q
E
E
Site 55
Y773
S
D
L
S
L
K
M
Y
Q
E
E
I
Q
E
W
Site 56
S795
Q
E
Q
Q
R
Q
L
S
S
S
A
A
P
A
A
Site 57
S797
Q
Q
R
Q
L
S
S
S
A
A
P
A
A
Q
Q
Site 58
S808
A
A
Q
Q
P
P
G
S
R
Q
R
S
Q
T
V
Site 59
S812
P
P
G
S
R
Q
R
S
Q
T
V
T
_
_
_
Site 60
T814
G
S
R
Q
R
S
Q
T
V
T
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation