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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPM1H
Full Name:
Protein phosphatase 1H (PP2C domain containing)
Alias:
Ras homologue gene family, member C like 1; ARHCL1; EC 3.1.3.16; FLJ13253; KIAA1157; NERPP-2C; Neurite extension-related protein phosphatase related to PP2C; Ras homolog gene family, member C like 1
Type:
Protein-serine phosphatase
Mass (Da):
56448
Number AA:
514
UniProt ID:
Q9ULR3
International Prot ID:
IPI00736251
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0004721
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
M
G
G
I
M
A
G
S
S
G
S
E
H
G
G
Site 2
S21
G
G
I
M
A
G
S
S
G
S
E
H
G
G
G
Site 3
S23
I
M
A
G
S
S
G
S
E
H
G
G
G
S
C
Site 4
S29
G
S
E
H
G
G
G
S
C
G
G
S
D
L
P
Site 5
S33
G
G
G
S
C
G
G
S
D
L
P
L
R
F
P
Site 6
Y41
D
L
P
L
R
F
P
Y
G
R
P
E
F
L
G
Site 7
S50
R
P
E
F
L
G
L
S
Q
D
E
V
E
C
S
Site 8
S57
S
Q
D
E
V
E
C
S
A
D
H
I
A
R
P
Site 9
T71
P
I
L
I
L
K
E
T
R
R
L
P
W
A
T
Site 10
T78
T
R
R
L
P
W
A
T
G
Y
A
E
V
I
N
Site 11
S89
E
V
I
N
A
G
K
S
T
H
N
E
D
Q
A
Site 12
S97
T
H
N
E
D
Q
A
S
C
E
V
L
T
V
K
Site 13
T102
Q
A
S
C
E
V
L
T
V
K
K
K
A
G
A
Site 14
T111
K
K
K
A
G
A
V
T
S
T
P
N
R
N
S
Site 15
S112
K
K
A
G
A
V
T
S
T
P
N
R
N
S
S
Site 16
T113
K
A
G
A
V
T
S
T
P
N
R
N
S
S
K
Site 17
S118
T
S
T
P
N
R
N
S
S
K
R
R
S
S
L
Site 18
S119
S
T
P
N
R
N
S
S
K
R
R
S
S
L
P
Site 19
S123
R
N
S
S
K
R
R
S
S
L
P
N
G
E
G
Site 20
S124
N
S
S
K
R
R
S
S
L
P
N
G
E
G
L
Site 21
S139
Q
L
K
E
N
S
E
S
E
G
V
S
C
H
Y
Site 22
Y146
S
E
G
V
S
C
H
Y
W
S
L
F
D
G
H
Site 23
T199
L
G
E
E
P
E
N
T
P
A
N
S
R
T
L
Site 24
T205
N
T
P
A
N
S
R
T
L
T
R
A
A
S
L
Site 25
T207
P
A
N
S
R
T
L
T
R
A
A
S
L
R
G
Site 26
S211
R
T
L
T
R
A
A
S
L
R
G
G
V
G
A
Site 27
S221
G
G
V
G
A
P
G
S
P
S
T
P
P
T
R
Site 28
S223
V
G
A
P
G
S
P
S
T
P
P
T
R
F
F
Site 29
T224
G
A
P
G
S
P
S
T
P
P
T
R
F
F
T
Site 30
T227
G
S
P
S
T
P
P
T
R
F
F
T
E
K
K
Site 31
T231
T
P
P
T
R
F
F
T
E
K
K
I
P
H
E
Site 32
S261
L
Q
I
E
R
E
R
S
S
Y
N
I
S
G
G
Site 33
S262
Q
I
E
R
E
R
S
S
Y
N
I
S
G
G
C
Site 34
Y263
I
E
R
E
R
S
S
Y
N
I
S
G
G
C
T
Site 35
S266
E
R
S
S
Y
N
I
S
G
G
C
T
A
L
I
Site 36
S289
Y
V
A
N
A
G
D
S
R
A
I
I
I
R
N
Site 37
S303
N
G
E
I
I
P
M
S
S
E
F
T
P
E
T
Site 38
T307
I
P
M
S
S
E
F
T
P
E
T
E
R
Q
R
Site 39
T310
S
S
E
F
T
P
E
T
E
R
Q
R
L
Q
Y
Site 40
Y317
T
E
R
Q
R
L
Q
Y
L
A
F
M
Q
P
H
Site 41
T331
H
L
L
G
N
E
F
T
H
L
E
F
P
R
R
Site 42
Y350
E
L
G
K
K
M
L
Y
R
D
F
N
M
T
G
Site 43
Y405
K
V
H
D
S
N
I
Y
I
K
P
F
L
S
S
Site 44
Y419
S
A
P
E
V
R
I
Y
D
L
S
K
Y
D
H
Site 45
S422
E
V
R
I
Y
D
L
S
K
Y
D
H
G
S
D
Site 46
Y424
R
I
Y
D
L
S
K
Y
D
H
G
S
D
D
V
Site 47
S428
L
S
K
Y
D
H
G
S
D
D
V
L
I
L
A
Site 48
S444
D
G
L
W
D
V
L
S
N
E
E
V
A
E
A
Site 49
Y467
D
P
D
D
P
H
R
Y
T
L
A
A
Q
D
L
Site 50
T468
P
D
D
P
H
R
Y
T
L
A
A
Q
D
L
V
Site 51
S490
K
D
R
G
W
R
I
S
N
D
R
L
G
S
G
Site 52
S496
I
S
N
D
R
L
G
S
G
D
D
I
S
V
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation