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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FZR1
Full Name:
Fizzy-related protein homologue
Alias:
CDC20-like 1b; CDH1; Cdh1/Hct1 homologue; Fizzy-related; FYR; Fzr; FZR; FZR2; HCDH
Type:
Anaphase-promoting complex, Cytoplasm, Nucleus protein
Mass (Da):
55179
Number AA:
496
UniProt ID:
Q9UM11
International Prot ID:
IPI00383919
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005680
GO:0005829
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0008047
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
GO:0051436
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y5
_
_
_
M
D
Q
D
Y
E
R
R
L
L
R
Q
Site 2
T25
E
N
T
M
P
R
V
T
E
M
R
R
T
L
T
Site 3
T30
R
V
T
E
M
R
R
T
L
T
P
A
S
S
P
Site 4
T32
T
E
M
R
R
T
L
T
P
A
S
S
P
V
S
Site 5
S35
R
R
T
L
T
P
A
S
S
P
V
S
S
P
S
Site 6
S36
R
T
L
T
P
A
S
S
P
V
S
S
P
S
K
Site 7
S39
T
P
A
S
S
P
V
S
S
P
S
K
H
G
D
Site 8
S40
P
A
S
S
P
V
S
S
P
S
K
H
G
D
R
Site 9
S42
S
S
P
V
S
S
P
S
K
H
G
D
R
F
I
Site 10
S51
H
G
D
R
F
I
P
S
R
A
G
A
N
W
S
Site 11
S70
R
I
N
E
N
E
K
S
P
S
Q
N
R
K
A
Site 12
S72
N
E
N
E
K
S
P
S
Q
N
R
K
A
K
D
Site 13
S82
R
K
A
K
D
A
T
S
D
N
G
K
D
G
L
Site 14
Y91
N
G
K
D
G
L
A
Y
S
A
L
L
K
N
E
Site 15
S92
G
K
D
G
L
A
Y
S
A
L
L
K
N
E
L
Site 16
T112
E
K
V
Q
D
P
Q
T
E
D
R
R
L
Q
P
Site 17
S120
E
D
R
R
L
Q
P
S
T
P
E
K
K
G
L
Site 18
T121
D
R
R
L
Q
P
S
T
P
E
K
K
G
L
F
Site 19
T129
P
E
K
K
G
L
F
T
Y
S
L
S
T
K
R
Site 20
S131
K
K
G
L
F
T
Y
S
L
S
T
K
R
S
S
Site 21
S133
G
L
F
T
Y
S
L
S
T
K
R
S
S
P
D
Site 22
T134
L
F
T
Y
S
L
S
T
K
R
S
S
P
D
D
Site 23
S137
Y
S
L
S
T
K
R
S
S
P
D
D
G
N
D
Site 24
S138
S
L
S
T
K
R
S
S
P
D
D
G
N
D
V
Site 25
S146
P
D
D
G
N
D
V
S
P
Y
S
L
S
P
V
Site 26
Y148
D
G
N
D
V
S
P
Y
S
L
S
P
V
S
N
Site 27
S149
G
N
D
V
S
P
Y
S
L
S
P
V
S
N
K
Site 28
S151
D
V
S
P
Y
S
L
S
P
V
S
N
K
S
Q
Site 29
S154
P
Y
S
L
S
P
V
S
N
K
S
Q
K
L
L
Site 30
S157
L
S
P
V
S
N
K
S
Q
K
L
L
R
S
P
Site 31
S163
K
S
Q
K
L
L
R
S
P
R
K
P
T
R
K
Site 32
T168
L
R
S
P
R
K
P
T
R
K
I
S
K
I
P
Site 33
S172
R
K
P
T
R
K
I
S
K
I
P
F
K
V
L
Site 34
Y189
P
E
L
Q
D
D
F
Y
L
N
L
V
D
W
S
Site 35
S231
D
L
S
V
E
G
D
S
V
T
S
V
G
W
S
Site 36
T233
S
V
E
G
D
S
V
T
S
V
G
W
S
E
R
Site 37
S238
S
V
T
S
V
G
W
S
E
R
G
N
L
V
A
Site 38
S285
A
W
N
A
E
Q
L
S
S
G
S
R
D
R
M
Site 39
S286
W
N
A
E
Q
L
S
S
G
S
R
D
R
M
I
Site 40
T300
I
L
Q
R
D
I
R
T
P
P
L
Q
S
E
R
Site 41
S305
I
R
T
P
P
L
Q
S
E
R
R
L
Q
G
H
Site 42
S343
K
L
L
V
W
N
H
S
S
L
S
P
V
Q
Q
Site 43
S344
L
L
V
W
N
H
S
S
L
S
P
V
Q
Q
Y
Site 44
S346
V
W
N
H
S
S
L
S
P
V
Q
Q
Y
T
E
Site 45
T398
Q
P
L
Q
C
I
D
T
G
S
Q
V
C
N
L
Site 46
T417
H
A
N
E
L
V
S
T
H
G
Y
S
Q
N
Q
Site 47
Y420
E
L
V
S
T
H
G
Y
S
Q
N
Q
I
L
V
Site 48
T434
V
W
K
Y
P
S
L
T
Q
V
A
K
L
T
G
Site 49
Y448
G
H
S
Y
R
V
L
Y
L
A
M
S
P
D
G
Site 50
T460
P
D
G
E
A
I
V
T
G
A
G
D
E
T
L
Site 51
S474
L
R
F
W
N
V
F
S
K
T
R
S
T
K
V
Site 52
S478
N
V
F
S
K
T
R
S
T
K
V
K
W
E
S
Site 53
T479
V
F
S
K
T
R
S
T
K
V
K
W
E
S
V
Site 54
S487
K
V
K
W
E
S
V
S
V
L
N
L
F
T
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation