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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HHLA2
Full Name:
Alias:
Human endogenous retrovirus-H long terminal repeat-associating protein 2
Type:
Mass (Da):
46850
Number AA:
414
UniProt ID:
Q9UM44
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S51
D
E
D
I
I
L
P
S
S
F
E
R
G
S
E
Site 2
S52
E
D
I
I
L
P
S
S
F
E
R
G
S
E
V
Site 3
S57
P
S
S
F
E
R
G
S
E
V
V
I
H
W
K
Site 4
Y65
E
V
V
I
H
W
K
Y
Q
D
S
Y
K
V
H
Site 5
Y69
H
W
K
Y
Q
D
S
Y
K
V
H
S
Y
Y
K
Site 6
S73
Q
D
S
Y
K
V
H
S
Y
Y
K
G
S
D
H
Site 7
Y74
D
S
Y
K
V
H
S
Y
Y
K
G
S
D
H
L
Site 8
S78
V
H
S
Y
Y
K
G
S
D
H
L
E
S
Q
D
Site 9
S83
K
G
S
D
H
L
E
S
Q
D
P
R
Y
A
N
Site 10
Y88
L
E
S
Q
D
P
R
Y
A
N
R
T
S
L
F
Site 11
T92
D
P
R
Y
A
N
R
T
S
L
F
Y
N
E
I
Site 12
S93
P
R
Y
A
N
R
T
S
L
F
Y
N
E
I
Q
Site 13
Y96
A
N
R
T
S
L
F
Y
N
E
I
Q
N
G
N
Site 14
S105
E
I
Q
N
G
N
A
S
L
F
F
R
R
V
S
Site 15
Y148
F
L
T
P
V
M
K
Y
E
K
R
N
T
N
S
Site 16
S155
Y
E
K
R
N
T
N
S
F
L
I
C
S
V
L
Site 17
S180
K
M
D
N
T
P
I
S
E
N
N
M
E
E
T
Site 18
S189
N
N
M
E
E
T
G
S
L
D
S
F
S
I
N
Site 19
S192
E
E
T
G
S
L
D
S
F
S
I
N
S
P
L
Site 20
S194
T
G
S
L
D
S
F
S
I
N
S
P
L
N
I
Site 21
S197
L
D
S
F
S
I
N
S
P
L
N
I
T
G
S
Site 22
T202
I
N
S
P
L
N
I
T
G
S
N
S
S
Y
E
Site 23
S204
S
P
L
N
I
T
G
S
N
S
S
Y
E
C
T
Site 24
S206
L
N
I
T
G
S
N
S
S
Y
E
C
T
I
E
Site 25
Y208
I
T
G
S
N
S
S
Y
E
C
T
I
E
N
S
Site 26
T211
S
N
S
S
Y
E
C
T
I
E
N
S
L
L
K
Site 27
T222
S
L
L
K
Q
T
W
T
G
R
W
T
M
K
D
Site 28
S236
D
G
L
H
K
M
Q
S
E
H
V
S
L
S
C
Site 29
S240
K
M
Q
S
E
H
V
S
L
S
C
Q
P
V
N
Site 30
S242
Q
S
E
H
V
S
L
S
C
Q
P
V
N
D
Y
Site 31
Y249
S
C
Q
P
V
N
D
Y
F
S
P
N
Q
D
F
Site 32
S251
Q
P
V
N
D
Y
F
S
P
N
Q
D
F
K
V
Site 33
T267
W
S
R
M
K
S
G
T
F
S
V
L
A
Y
Y
Site 34
Y273
G
T
F
S
V
L
A
Y
Y
L
S
S
S
Q
N
Site 35
Y274
T
F
S
V
L
A
Y
Y
L
S
S
S
Q
N
T
Site 36
S278
L
A
Y
Y
L
S
S
S
Q
N
T
I
I
N
E
Site 37
T281
Y
L
S
S
S
Q
N
T
I
I
N
E
S
R
F
Site 38
S310
N
L
M
D
L
N
L
S
D
S
G
E
Y
L
C
Site 39
S312
M
D
L
N
L
S
D
S
G
E
Y
L
C
N
I
Site 40
Y315
N
L
S
D
S
G
E
Y
L
C
N
I
S
S
D
Site 41
S320
G
E
Y
L
C
N
I
S
S
D
E
Y
T
L
L
Site 42
S321
E
Y
L
C
N
I
S
S
D
E
Y
T
L
L
T
Site 43
Y324
C
N
I
S
S
D
E
Y
T
L
L
T
I
H
T
Site 44
T325
N
I
S
S
D
E
Y
T
L
L
T
I
H
T
V
Site 45
T331
Y
T
L
L
T
I
H
T
V
H
V
E
P
S
Q
Site 46
S337
H
T
V
H
V
E
P
S
Q
E
T
A
S
H
N
Site 47
S377
A
Q
L
E
A
R
R
S
R
H
P
A
D
G
A
Site 48
S399
P
P
G
E
R
C
P
S
A
P
D
N
G
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation