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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NOTCH3
Full Name:
Neurogenic locus notch homologue protein 3
Alias:
Cadasil; Casil; Notc3; Notch 3; Notch homologue 3; Notch homologue 3 (drosophila); Notch3
Type:
Plasma membrane, Nucleus, Integral membrane protein
Mass (Da):
243659
Number AA:
2321
UniProt ID:
Q9UM47
International Prot ID:
IPI00029819
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005634
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0007219
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
R
R
R
R
R
P
M
S
P
P
P
P
P
P
P
Site 2
T211
S
P
C
R
N
G
G
T
C
R
Q
S
G
D
L
Site 3
Y529
C
V
D
Q
P
D
G
Y
E
C
R
C
A
E
G
Site 4
Y1197
R
C
T
C
P
P
G
Y
T
G
L
R
C
E
A
Site 5
S1672
A
R
R
K
R
E
H
S
T
L
W
F
P
E
G
Site 6
T1673
R
R
K
R
E
H
S
T
L
W
F
P
E
G
F
Site 7
S1688
S
L
H
K
D
V
A
S
G
H
K
G
R
R
E
Site 8
T1724
V
A
T
D
W
M
D
T
E
C
P
E
A
K
R
Site 9
T1769
V
A
P
A
M
A
L
T
P
P
Q
G
D
A
D
Site 10
T1808
G
A
L
E
P
M
P
T
E
E
D
E
A
D
D
Site 11
T1816
E
E
D
E
A
D
D
T
S
A
S
I
I
S
D
Site 12
S1817
E
D
E
A
D
D
T
S
A
S
I
I
S
D
L
Site 13
T1838
L
G
A
R
T
D
R
T
G
E
T
A
L
H
L
Site 14
Y1849
A
L
H
L
A
A
R
Y
A
R
A
D
A
A
K
Site 15
T1865
L
L
D
A
G
A
D
T
N
A
Q
D
H
S
G
Site 16
S1871
D
T
N
A
Q
D
H
S
G
R
T
P
L
H
T
Site 17
T1874
A
Q
D
H
S
G
R
T
P
L
H
T
A
V
T
Site 18
T1878
S
G
R
T
P
L
H
T
A
V
T
A
D
A
Q
Site 19
S1896
Q
I
L
I
R
N
R
S
T
D
L
D
A
R
M
Site 20
T1897
I
L
I
R
N
R
S
T
D
L
D
A
R
M
A
Site 21
S1970
A
N
K
D
M
Q
D
S
K
E
E
T
P
L
F
Site 22
T1974
M
Q
D
S
K
E
E
T
P
L
F
L
A
A
R
Site 23
T2001
H
F
A
N
R
E
I
T
D
H
L
D
R
L
P
Site 24
S2028
V
R
L
L
D
Q
P
S
G
P
R
S
P
P
G
Site 25
S2032
D
Q
P
S
G
P
R
S
P
P
G
P
H
G
L
Site 26
S2058
P
G
L
K
A
A
Q
S
G
S
K
K
S
R
R
Site 27
S2063
A
Q
S
G
S
K
K
S
R
R
P
P
G
K
A
Site 28
T2085
R
G
R
G
K
K
L
T
L
A
C
P
G
P
L
Site 29
S2096
P
G
P
L
A
D
S
S
V
T
L
S
P
V
D
Site 30
S2100
A
D
S
S
V
T
L
S
P
V
D
S
L
D
S
Site 31
S2104
V
T
L
S
P
V
D
S
L
D
S
P
R
P
F
Site 32
S2107
S
P
V
D
S
L
D
S
P
R
P
F
G
G
P
Site 33
S2117
P
F
G
G
P
P
A
S
P
G
G
F
P
L
E
Site 34
T2200
P
Q
L
L
N
P
G
T
P
V
S
P
Q
E
R
Site 35
S2203
L
N
P
G
T
P
V
S
P
Q
E
R
P
P
P
Site 36
Y2211
P
Q
E
R
P
P
P
Y
L
A
V
P
G
H
G
Site 37
Y2221
V
P
G
H
G
E
E
Y
P
V
A
G
A
H
S
Site 38
S2229
P
V
A
G
A
H
S
S
P
P
K
A
R
F
L
Site 39
S2240
A
R
F
L
R
V
P
S
E
H
P
Y
L
T
P
Site 40
Y2244
R
V
P
S
E
H
P
Y
L
T
P
S
P
E
S
Site 41
T2246
P
S
E
H
P
Y
L
T
P
S
P
E
S
P
E
Site 42
S2248
E
H
P
Y
L
T
P
S
P
E
S
P
E
H
W
Site 43
S2251
Y
L
T
P
S
P
E
S
P
E
H
W
A
S
P
Site 44
S2257
E
S
P
E
H
W
A
S
P
S
P
P
S
L
S
Site 45
S2259
P
E
H
W
A
S
P
S
P
P
S
L
S
D
W
Site 46
S2262
W
A
S
P
S
P
P
S
L
S
D
W
S
E
S
Site 47
S2264
S
P
S
P
P
S
L
S
D
W
S
E
S
T
P
Site 48
S2267
P
P
S
L
S
D
W
S
E
S
T
P
S
P
A
Site 49
S2269
S
L
S
D
W
S
E
S
T
P
S
P
A
T
A
Site 50
T2270
L
S
D
W
S
E
S
T
P
S
P
A
T
A
T
Site 51
S2272
D
W
S
E
S
T
P
S
P
A
T
A
T
G
A
Site 52
S2299
L
P
L
S
V
P
S
S
L
A
Q
A
Q
T
Q
Site 53
T2314
L
G
P
Q
P
E
V
T
P
K
R
Q
V
L
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation