KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
MYO6
Full Name:
Myosin-VI
Alias:
DFNA22; DFNB37; KIAA0389; Myosin 6; Myosin VI; SV
Type:
Motor protein
Mass (Da):
149691
Number AA:
1294
UniProt ID:
Q9UM54
International Prot ID:
IPI00069126
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016591
GO:0005794
GO:0005938
Uniprot
OncoNet
Molecular Function:
GO:0043531
GO:0005524
GO:0051015
PhosphoSite+
KinaseNET
Biological Process:
GO:0030330
GO:0030048
GO:0006897
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T30
D
I
G
P
D
S
L
T
I
E
P
L
N
Q
K
Site 2
T40
P
L
N
Q
K
G
K
T
F
L
A
L
I
N
Q
Site 3
S55
V
F
P
A
E
E
D
S
K
K
D
V
E
D
N
Site 4
S64
K
D
V
E
D
N
C
S
L
M
Y
L
N
E
A
Site 5
Y87
R
Y
S
K
D
R
I
Y
T
Y
V
A
N
I
L
Site 6
T88
Y
S
K
D
R
I
Y
T
Y
V
A
N
I
L
I
Site 7
S108
F
D
I
P
K
I
Y
S
S
E
A
I
K
S
Y
Site 8
S109
D
I
P
K
I
Y
S
S
E
A
I
K
S
Y
Q
Site 9
S114
Y
S
S
E
A
I
K
S
Y
Q
G
K
S
L
G
Site 10
Y115
S
S
E
A
I
K
S
Y
Q
G
K
S
L
G
T
Site 11
S119
I
K
S
Y
Q
G
K
S
L
G
T
R
P
P
H
Site 12
S150
M
S
Q
S
I
I
V
S
G
E
S
G
A
G
K
Site 13
S153
S
I
I
V
S
G
E
S
G
A
G
K
T
E
N
Site 14
Y167
N
T
K
F
V
L
R
Y
L
T
E
S
Y
G
T
Site 15
T169
K
F
V
L
R
Y
L
T
E
S
Y
G
T
G
Q
Site 16
S171
V
L
R
Y
L
T
E
S
Y
G
T
G
Q
D
I
Site 17
T197
E
A
F
G
N
A
K
T
V
R
N
N
N
S
S
Site 18
S203
K
T
V
R
N
N
N
S
S
R
F
G
K
F
V
Site 19
S204
T
V
R
N
N
N
S
S
R
F
G
K
F
V
E
Site 20
S233
S
H
Y
L
L
E
K
S
R
I
C
V
Q
G
K
Site 21
Y245
Q
G
K
E
E
R
N
Y
H
I
F
Y
R
L
C
Site 22
S256
Y
R
L
C
A
G
A
S
E
D
I
R
E
K
L
Site 23
S266
I
R
E
K
L
H
L
S
S
P
D
N
F
R
Y
Site 24
S267
R
E
K
L
H
L
S
S
P
D
N
F
R
Y
L
Site 25
Y273
S
S
P
D
N
F
R
Y
L
N
R
G
C
T
R
Site 26
Y281
L
N
R
G
C
T
R
Y
F
A
N
K
E
T
D
Site 27
S297
Q
I
L
Q
N
R
K
S
P
E
Y
L
K
A
G
Site 28
Y300
Q
N
R
K
S
P
E
Y
L
K
A
G
S
M
K
Site 29
S357
I
D
F
E
E
A
G
S
T
S
G
G
C
N
L
Site 30
S368
G
C
N
L
K
N
K
S
A
Q
S
L
E
Y
C
Site 31
S389
D
Q
D
D
L
R
V
S
L
T
T
R
V
M
L
Site 32
T397
L
T
T
R
V
M
L
T
T
A
G
G
T
K
G
Site 33
T398
T
T
R
V
M
L
T
T
A
G
G
T
K
G
T
Site 34
T405
T
A
G
G
T
K
G
T
V
I
K
V
P
L
K
Site 35
T426
A
R
D
A
L
A
K
T
V
Y
S
H
L
F
D
Site 36
Y462
L
D
I
A
G
F
E
Y
F
E
H
N
S
F
E
Site 37
Y496
L
K
E
E
Q
E
L
Y
Q
K
E
G
L
G
V
Site 38
Y508
L
G
V
N
E
V
H
Y
V
D
N
Q
D
C
I
Site 39
S539
E
N
R
L
P
Q
P
S
D
Q
H
F
T
S
A
Site 40
T558
H
K
D
H
F
R
L
T
I
P
R
K
S
K
L
Site 41
S563
R
L
T
I
P
R
K
S
K
L
A
V
H
R
N
Site 42
S604
N
N
D
A
L
H
M
S
L
E
S
L
I
C
E
Site 43
S607
A
L
H
M
S
L
E
S
L
I
C
E
S
R
D
Site 44
S623
F
I
R
E
L
F
E
S
S
T
N
N
N
K
D
Site 45
S639
K
Q
K
A
G
K
L
S
F
I
S
V
G
N
K
Site 46
S642
A
G
K
L
S
F
I
S
V
G
N
K
F
K
T
Site 47
T649
S
V
G
N
K
F
K
T
Q
L
N
L
L
L
D
Site 48
S660
L
L
L
D
K
L
R
S
T
G
A
S
F
I
R
Site 49
T661
L
L
D
K
L
R
S
T
G
A
S
F
I
R
C
Site 50
S664
K
L
R
S
T
G
A
S
F
I
R
C
I
K
P
Site 51
Y705
L
D
L
M
Q
G
G
Y
P
S
R
A
S
F
H
Site 52
S707
L
M
Q
G
G
Y
P
S
R
A
S
F
H
E
L
Site 53
S710
G
G
Y
P
S
R
A
S
F
H
E
L
Y
N
M
Site 54
Y715
R
A
S
F
H
E
L
Y
N
M
Y
K
K
Y
M
Site 55
Y721
L
Y
N
M
Y
K
K
Y
M
P
D
K
L
A
R
Site 56
Y749
L
G
L
N
E
N
D
Y
K
F
G
L
T
K
V
Site 57
S772
E
F
D
Q
I
M
K
S
D
P
D
H
L
A
E
Site 58
S802
K
V
Q
W
C
S
L
S
V
I
K
L
K
N
K
Site 59
T845
D
G
L
V
K
V
G
T
L
K
K
R
L
D
K
Site 60
T891
K
I
K
S
T
M
M
T
Q
E
Q
I
Q
K
E
Site 61
S905
E
Y
D
A
L
V
K
S
S
E
E
L
L
S
A
Site 62
S911
K
S
S
E
E
L
L
S
A
L
Q
K
K
K
Q
Site 63
S1025
Q
S
E
A
E
L
I
S
D
E
A
Q
A
D
L
Site 64
S1037
A
D
L
A
L
R
R
S
L
D
S
Y
P
V
S
Site 65
S1040
A
L
R
R
S
L
D
S
Y
P
V
S
K
N
D
Site 66
Y1041
L
R
R
S
L
D
S
Y
P
V
S
K
N
D
G
Site 67
S1044
S
L
D
S
Y
P
V
S
K
N
D
G
T
R
P
Site 68
T1049
P
V
S
K
N
D
G
T
R
P
K
M
T
P
E
Site 69
T1054
D
G
T
R
P
K
M
T
P
E
Q
M
A
K
E
Site 70
S1067
K
E
M
S
E
F
L
S
R
G
P
A
V
L
A
Site 71
Y1084
A
A
A
G
T
K
K
Y
D
L
S
K
W
K
Y
Site 72
S1087
G
T
K
K
Y
D
L
S
K
W
K
Y
A
E
L
Site 73
Y1091
Y
D
L
S
K
W
K
Y
A
E
L
R
D
T
I
Site 74
T1097
K
Y
A
E
L
R
D
T
I
N
T
S
C
D
I
Site 75
T1100
E
L
R
D
T
I
N
T
S
C
D
I
E
L
L
Site 76
Y1121
F
H
R
R
L
K
V
Y
H
A
W
K
S
K
N
Site 77
T1133
S
K
N
K
K
R
N
T
E
T
E
Q
R
A
P
Site 78
S1142
T
E
Q
R
A
P
K
S
V
T
D
Y
D
F
A
Site 79
Y1146
A
P
K
S
V
T
D
Y
D
F
A
P
F
L
N
Site 80
S1155
F
A
P
F
L
N
N
S
P
Q
Q
N
P
A
A
Site 81
Y1191
F
I
R
P
A
D
Q
Y
K
D
P
Q
S
K
K
Site 82
S1196
D
Q
Y
K
D
P
Q
S
K
K
K
G
W
W
Y
Site 83
T1246
N
L
E
E
T
G
L
T
R
K
R
G
A
E
I
Site 84
Y1270
E
R
C
G
G
I
Q
Y
L
Q
N
A
I
E
S
Site 85
T1283
E
S
R
Q
A
R
P
T
Y
A
T
A
M
L
Q
Site 86
Y1284
S
R
Q
A
R
P
T
Y
A
T
A
M
L
Q
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation