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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CAPN11
Full Name:
Calpain-11
Alias:
Calcium-activated neutral proteinase 11; Calpain 11; Calpain11; CAN11; CANP 11; EC 3.4.22.-
Type:
Intracellular, Acrosome protein
Mass (Da):
84423
Number AA:
739
UniProt ID:
Q9UMQ6
International Prot ID:
IPI00218934
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0001669
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004198
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
L
Y
S
P
G
P
S
L
P
E
S
A
E
S
Site 2
S12
P
G
P
S
L
P
E
S
A
E
S
L
D
G
S
Site 3
S15
S
L
P
E
S
A
E
S
L
D
G
S
Q
E
D
Site 4
S19
S
A
E
S
L
D
G
S
Q
E
D
K
P
R
G
Site 5
S27
Q
E
D
K
P
R
G
S
C
A
E
P
T
F
T
Site 6
T32
R
G
S
C
A
E
P
T
F
T
D
T
G
M
V
Site 7
T34
S
C
A
E
P
T
F
T
D
T
G
M
V
A
H
Site 8
T36
A
E
P
T
F
T
D
T
G
M
V
A
H
I
N
Site 9
S65
A
Q
N
F
G
N
Q
S
F
E
E
L
R
A
A
Site 10
S101
F
K
D
L
G
P
N
S
K
N
V
Q
N
I
S
Site 11
S108
S
K
N
V
Q
N
I
S
W
Q
R
P
K
D
I
Site 12
Y156
T
T
C
P
K
L
L
Y
R
V
V
P
R
G
Q
Site 13
S164
R
V
V
P
R
G
Q
S
F
K
K
N
Y
A
G
Site 14
Y169
G
Q
S
F
K
K
N
Y
A
G
I
F
H
F
Q
Site 15
T194
V
V
D
D
R
L
P
T
K
N
D
K
L
V
F
Site 16
S204
D
K
L
V
F
V
H
S
T
E
R
S
E
F
W
Site 17
T205
K
L
V
F
V
H
S
T
E
R
S
E
F
W
S
Site 18
S208
F
V
H
S
T
E
R
S
E
F
W
S
A
L
L
Site 19
S212
T
E
R
S
E
F
W
S
A
L
L
E
K
A
Y
Site 20
Y219
S
A
L
L
E
K
A
Y
A
K
L
S
G
S
Y
Site 21
S223
E
K
A
Y
A
K
L
S
G
S
Y
E
A
L
S
Site 22
S225
A
Y
A
K
L
S
G
S
Y
E
A
L
S
G
G
Site 23
S230
S
G
S
Y
E
A
L
S
G
G
S
T
M
E
G
Site 24
T234
E
A
L
S
G
G
S
T
M
E
G
L
E
D
F
Site 25
T242
M
E
G
L
E
D
F
T
G
G
V
A
Q
S
F
Site 26
S248
F
T
G
G
V
A
Q
S
F
Q
L
Q
R
P
P
Site 27
S270
R
K
A
V
E
R
S
S
L
M
G
C
S
I
E
Site 28
S275
R
S
S
L
M
G
C
S
I
E
V
T
S
D
S
Site 29
T279
M
G
C
S
I
E
V
T
S
D
S
E
L
E
S
Site 30
S280
G
C
S
I
E
V
T
S
D
S
E
L
E
S
M
Site 31
S282
S
I
E
V
T
S
D
S
E
L
E
S
M
T
D
Site 32
S286
T
S
D
S
E
L
E
S
M
T
D
K
M
L
V
Site 33
T301
R
G
H
A
Y
S
V
T
G
L
Q
D
V
H
Y
Site 34
Y308
T
G
L
Q
D
V
H
Y
R
G
K
M
E
T
L
Site 35
T314
H
Y
R
G
K
M
E
T
L
I
R
V
R
N
P
Site 36
S343
R
E
W
E
E
V
A
S
D
I
Q
M
Q
L
L
Site 37
T381
I
C
N
L
T
P
D
T
L
S
G
D
Y
K
S
Site 38
S383
N
L
T
P
D
T
L
S
G
D
Y
K
S
Y
W
Site 39
Y386
P
D
T
L
S
G
D
Y
K
S
Y
W
H
T
T
Site 40
S398
H
T
T
F
Y
E
G
S
W
R
R
G
S
S
A
Site 41
S403
E
G
S
W
R
R
G
S
S
A
G
G
C
R
N
Site 42
S404
G
S
W
R
R
G
S
S
A
G
G
C
R
N
H
Site 43
Y493
K
K
E
F
F
T
K
Y
Q
D
H
G
F
S
E
Site 44
T503
H
G
F
S
E
I
F
T
N
S
R
E
V
S
S
Site 45
S505
F
S
E
I
F
T
N
S
R
E
V
S
S
Q
L
Site 46
S509
F
T
N
S
R
E
V
S
S
Q
L
R
L
P
P
Site 47
S510
T
N
S
R
E
V
S
S
Q
L
R
L
P
P
G
Site 48
S524
G
E
Y
I
I
I
P
S
T
F
E
P
H
R
D
Site 49
T525
E
Y
I
I
I
P
S
T
F
E
P
H
R
D
A
Site 50
T540
D
F
L
L
R
V
F
T
E
K
H
S
E
S
W
Site 51
S564
Q
L
Q
E
E
K
V
S
E
D
D
M
D
Q
D
Site 52
Y589
E
G
K
E
I
G
V
Y
E
L
Q
R
L
L
N
Site 53
S604
R
M
A
I
K
F
K
S
F
K
T
K
G
F
G
Site 54
S657
R
E
C
D
Q
D
H
S
G
T
L
N
S
Y
E
Site 55
S662
D
H
S
G
T
L
N
S
Y
E
M
R
L
V
I
Site 56
Y663
H
S
G
T
L
N
S
Y
E
M
R
L
V
I
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation