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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRPF19
Full Name:
Pre-mRNA-processing factor 19
Alias:
NMP200; Nuclear matrix protein 200; Nuclear matrix protein NMP200 related to splicing factor PRP19; PRP19; PRP19/PSO4; PRP19/PSO4 homologue; PRP19/PSO4 pre-mRNA processing factor 19; PSO4; Senescence evasion factor; SNEV; UBOX4
Type:
Mass (Da):
55181
Number AA:
504
UniProt ID:
Q9UMS4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
GO:0005681
GO:0000151
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0008380
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
S
L
I
C
S
I
S
N
E
V
P
E
H
P
Site 2
S18
V
P
E
H
P
C
V
S
P
V
S
N
H
V
Y
Site 3
S21
H
P
C
V
S
P
V
S
N
H
V
Y
E
R
R
Site 4
Y25
S
P
V
S
N
H
V
Y
E
R
R
L
I
E
K
Site 5
Y33
E
R
R
L
I
E
K
Y
I
A
E
N
G
T
D
Site 6
S48
P
I
N
N
Q
P
L
S
E
E
Q
L
I
D
I
Site 7
S67
P
I
R
P
K
P
P
S
A
T
S
I
P
A
I
Site 8
S70
P
K
P
P
S
A
T
S
I
P
A
I
L
K
A
Site 9
T98
T
L
R
Q
Q
L
Q
T
T
R
Q
E
L
S
H
Site 10
S104
Q
T
T
R
Q
E
L
S
H
A
L
Y
Q
H
D
Site 11
Y108
Q
E
L
S
H
A
L
Y
Q
H
D
A
A
C
R
Site 12
S149
V
P
Q
A
V
P
S
S
Q
P
S
V
V
G
A
Site 13
S152
A
V
P
S
S
Q
P
S
V
V
G
A
G
E
P
Site 14
T181
Q
K
L
Q
D
K
A
T
V
L
T
T
E
R
K
Site 15
T193
E
R
K
K
R
G
K
T
V
P
E
E
L
V
K
Site 16
S205
L
V
K
P
E
E
L
S
K
Y
R
Q
V
A
S
Site 17
Y207
K
P
E
E
L
S
K
Y
R
Q
V
A
S
H
V
Site 18
S212
S
K
Y
R
Q
V
A
S
H
V
G
L
H
S
A
Site 19
T234
L
D
L
C
P
S
D
T
N
K
I
L
T
G
G
Site 20
T259
S
S
E
Q
I
L
A
T
L
K
G
H
T
K
K
Site 21
T268
K
G
H
T
K
K
V
T
S
V
V
F
H
P
S
Site 22
S269
G
H
T
K
K
V
T
S
V
V
F
H
P
S
Q
Site 23
S281
P
S
Q
D
L
V
F
S
A
S
P
D
A
T
I
Site 24
S307
Q
V
V
R
A
H
E
S
A
V
T
G
L
S
L
Site 25
T310
R
A
H
E
S
A
V
T
G
L
S
L
H
A
T
Site 26
S313
E
S
A
V
T
G
L
S
L
H
A
T
G
D
Y
Site 27
Y320
S
L
H
A
T
G
D
Y
L
L
S
S
S
D
D
Site 28
S323
A
T
G
D
Y
L
L
S
S
S
D
D
Q
Y
W
Site 29
S324
T
G
D
Y
L
L
S
S
S
D
D
Q
Y
W
A
Site 30
S325
G
D
Y
L
L
S
S
S
D
D
Q
Y
W
A
F
Site 31
Y329
L
S
S
S
D
D
Q
Y
W
A
F
S
D
I
Q
Site 32
T342
I
Q
T
G
R
V
L
T
K
V
T
D
E
T
S
Site 33
T345
G
R
V
L
T
K
V
T
D
E
T
S
G
C
S
Site 34
T348
L
T
K
V
T
D
E
T
S
G
C
S
L
T
C
Site 35
S349
T
K
V
T
D
E
T
S
G
C
S
L
T
C
A
Site 36
T354
E
T
S
G
C
S
L
T
C
A
Q
F
H
P
D
Site 37
T396
P
G
H
S
G
P
I
T
S
I
A
F
S
E
N
Site 38
S397
G
H
S
G
P
I
T
S
I
A
F
S
E
N
G
Site 39
Y406
A
F
S
E
N
G
Y
Y
L
A
T
A
A
D
D
Site 40
S415
A
T
A
A
D
D
S
S
V
K
L
W
D
L
R
Site 41
T429
R
K
L
K
N
F
K
T
L
Q
L
D
N
N
F
Site 42
S440
D
N
N
F
E
V
K
S
L
I
F
D
Q
S
G
Site 43
Y460
G
G
T
D
V
Q
I
Y
I
C
K
Q
W
T
E
Site 44
T479
T
E
H
S
G
L
T
T
G
V
A
F
G
H
H
Site 45
S498
A
S
T
G
M
D
R
S
L
K
F
Y
S
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation