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Updated November 2019
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Protein Info
Short Name:
SYNPO2
Full Name:
Synaptopodin-2
Alias:
Genethonin 2; Genethonin-2; Myopodin; Myopodin;Genethonin-2; Striated muscle specific; Synaptopodin 2; SYNP2
Type:
Cytoskeletal protein
Mass (Da):
117514
Number AA:
1093
UniProt ID:
Q9UMS6
International Prot ID:
IPI00735855
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S40
V
A
K
I
R
N
Q
S
K
A
S
G
S
G
L
Site 2
S43
I
R
N
Q
S
K
A
S
G
S
G
L
C
E
G
Site 3
S88
Q
M
L
I
K
R
P
S
S
G
I
S
E
A
L
Site 4
S92
K
R
P
S
S
G
I
S
E
A
L
I
S
E
N
Site 5
S97
G
I
S
E
A
L
I
S
E
N
E
N
K
N
L
Site 6
Y112
E
H
L
T
H
G
G
Y
V
E
S
T
T
L
Q
Site 7
T124
T
L
Q
I
R
P
A
T
K
T
Q
C
T
E
F
Site 8
T126
Q
I
R
P
A
T
K
T
Q
C
T
E
F
F
L
Site 9
S148
P
L
A
E
N
Q
R
S
G
P
D
C
A
G
S
Site 10
S155
S
G
P
D
C
A
G
S
L
K
E
E
T
G
P
Site 11
S163
L
K
E
E
T
G
P
S
Y
Q
R
A
P
Q
M
Site 12
Y164
K
E
E
T
G
P
S
Y
Q
R
A
P
Q
M
P
Site 13
S173
R
A
P
Q
M
P
D
S
Q
R
G
R
V
A
E
Site 14
S202
P
V
V
E
L
Q
L
S
L
S
Q
E
R
H
K
Site 15
S204
V
E
L
Q
L
S
L
S
Q
E
R
H
K
G
A
Site 16
S212
Q
E
R
H
K
G
A
S
G
P
L
V
A
L
P
Site 17
S224
A
L
P
G
A
E
K
S
K
S
P
D
P
D
P
Site 18
S226
P
G
A
E
K
S
K
S
P
D
P
D
P
N
L
Site 19
S234
P
D
P
D
P
N
L
S
H
D
R
I
V
H
I
Site 20
S257
A
D
P
F
L
R
S
S
K
I
I
Q
I
S
S
Site 21
S263
S
S
K
I
I
Q
I
S
S
G
R
E
L
R
V
Site 22
S274
E
L
R
V
I
Q
E
S
E
A
G
D
A
G
L
Site 23
S291
V
E
V
I
L
D
C
S
D
R
Q
K
T
E
G
Site 24
T296
D
C
S
D
R
Q
K
T
E
G
C
R
L
Q
A
Site 25
S310
A
G
K
E
C
V
D
S
P
V
E
G
G
Q
S
Site 26
S317
S
P
V
E
G
G
Q
S
E
A
P
P
S
L
V
Site 27
S329
S
L
V
S
F
A
V
S
S
E
G
T
E
Q
G
Site 28
S341
E
Q
G
E
D
P
R
S
E
K
D
H
S
R
P
Site 29
S346
P
R
S
E
K
D
H
S
R
P
H
K
H
R
A
Site 30
S361
R
H
A
R
L
R
R
S
E
S
L
S
E
K
Q
Site 31
S363
A
R
L
R
R
S
E
S
L
S
E
K
Q
V
K
Site 32
S365
L
R
R
S
E
S
L
S
E
K
Q
V
K
E
A
Site 33
S374
K
Q
V
K
E
A
K
S
K
C
K
S
I
A
L
Site 34
S378
E
A
K
S
K
C
K
S
I
A
L
L
L
T
D
Site 35
T384
K
S
I
A
L
L
L
T
D
A
P
N
P
N
S
Site 36
S391
T
D
A
P
N
P
N
S
K
G
V
L
M
F
K
Site 37
Y407
R
R
R
R
A
R
K
Y
T
L
V
S
Y
G
T
Site 38
T408
R
R
R
A
R
K
Y
T
L
V
S
Y
G
T
G
Site 39
Y412
R
K
Y
T
L
V
S
Y
G
T
G
E
L
E
R
Site 40
T432
E
E
G
D
K
E
D
T
C
E
V
A
F
L
G
Site 41
S451
E
V
D
E
E
L
L
S
D
V
D
D
N
T
Q
Site 42
S466
V
V
N
F
D
W
D
S
G
L
V
D
I
E
K
Site 43
T487
K
M
E
M
L
P
D
T
T
G
K
G
A
L
M
Site 44
T506
R
E
R
M
D
Q
I
T
A
Q
K
E
E
D
K
Site 45
T517
E
E
D
K
V
G
G
T
P
S
R
E
Q
D
A
Site 46
T533
Q
T
D
G
L
R
T
T
T
S
Y
Q
R
K
E
Site 47
T534
T
D
G
L
R
T
T
T
S
Y
Q
R
K
E
E
Site 48
S535
D
G
L
R
T
T
T
S
Y
Q
R
K
E
E
E
Site 49
Y536
G
L
R
T
T
T
S
Y
Q
R
K
E
E
E
S
Site 50
S543
Y
Q
R
K
E
E
E
S
V
R
T
Q
S
S
V
Site 51
T546
K
E
E
E
S
V
R
T
Q
S
S
V
S
K
S
Site 52
S548
E
E
S
V
R
T
Q
S
S
V
S
K
S
Y
I
Site 53
S549
E
S
V
R
T
Q
S
S
V
S
K
S
Y
I
E
Site 54
S553
T
Q
S
S
V
S
K
S
Y
I
E
V
S
H
G
Site 55
Y554
Q
S
S
V
S
K
S
Y
I
E
V
S
H
G
L
Site 56
S558
S
K
S
Y
I
E
V
S
H
G
L
G
H
V
P
Site 57
T588
R
M
V
P
M
N
R
T
A
K
P
F
P
G
S
Site 58
S595
T
A
K
P
F
P
G
S
V
N
Q
P
A
T
P
Site 59
T601
G
S
V
N
Q
P
A
T
P
F
S
P
T
R
N
Site 60
S604
N
Q
P
A
T
P
F
S
P
T
R
N
M
T
S
Site 61
T610
F
S
P
T
R
N
M
T
S
P
I
A
D
F
P
Site 62
S611
S
P
T
R
N
M
T
S
P
I
A
D
F
P
A
Site 63
Y622
D
F
P
A
P
P
P
Y
S
A
V
T
P
P
P
Site 64
S623
F
P
A
P
P
P
Y
S
A
V
T
P
P
P
D
Site 65
T626
P
P
P
Y
S
A
V
T
P
P
P
D
A
F
S
Site 66
S633
T
P
P
P
D
A
F
S
R
G
V
S
S
P
I
Site 67
S637
D
A
F
S
R
G
V
S
S
P
I
A
G
P
A
Site 68
S638
A
F
S
R
G
V
S
S
P
I
A
G
P
A
Q
Site 69
Y661
P
W
S
Q
P
A
F
Y
D
S
S
E
R
I
A
Site 70
S663
S
Q
P
A
F
Y
D
S
S
E
R
I
A
S
R
Site 71
S664
Q
P
A
F
Y
D
S
S
E
R
I
A
S
R
D
Site 72
S669
D
S
S
E
R
I
A
S
R
D
E
R
I
S
V
Site 73
S675
A
S
R
D
E
R
I
S
V
P
A
K
R
T
G
Site 74
S691
L
Q
E
A
K
R
R
S
T
T
K
P
M
F
T
Site 75
T692
Q
E
A
K
R
R
S
T
T
K
P
M
F
T
F
Site 76
T693
E
A
K
R
R
S
T
T
K
P
M
F
T
F
K
Site 77
T698
S
T
T
K
P
M
F
T
F
K
E
P
K
V
S
Site 78
S705
T
F
K
E
P
K
V
S
P
N
P
E
L
L
S
Site 79
S712
S
P
N
P
E
L
L
S
L
L
Q
N
S
E
G
Site 80
S717
L
L
S
L
L
Q
N
S
E
G
K
R
G
T
G
Site 81
T723
N
S
E
G
K
R
G
T
G
A
G
G
D
S
G
Site 82
S729
G
T
G
A
G
G
D
S
G
P
E
E
D
Y
L
Site 83
Y735
D
S
G
P
E
E
D
Y
L
S
L
G
A
E
A
Site 84
S737
G
P
E
E
D
Y
L
S
L
G
A
E
A
C
N
Site 85
S750
C
N
F
M
Q
S
S
S
A
K
Q
K
T
P
P
Site 86
T755
S
S
S
A
K
Q
K
T
P
P
P
V
A
P
K
Site 87
S767
A
P
K
P
A
V
K
S
S
S
S
Q
P
V
T
Site 88
S768
P
K
P
A
V
K
S
S
S
S
Q
P
V
T
P
Site 89
S769
K
P
A
V
K
S
S
S
S
Q
P
V
T
P
V
Site 90
S770
P
A
V
K
S
S
S
S
Q
P
V
T
P
V
S
Site 91
T774
S
S
S
S
Q
P
V
T
P
V
S
P
V
W
S
Site 92
S777
S
Q
P
V
T
P
V
S
P
V
W
S
P
G
V
Site 93
S781
T
P
V
S
P
V
W
S
P
G
V
A
P
T
Q
Site 94
T794
T
Q
P
P
A
F
P
T
S
N
P
S
K
G
T
Site 95
S795
Q
P
P
A
F
P
T
S
N
P
S
K
G
T
V
Site 96
T801
T
S
N
P
S
K
G
T
V
V
S
S
I
K
I
Site 97
S805
S
K
G
T
V
V
S
S
I
K
I
A
Q
P
S
Site 98
S812
S
I
K
I
A
Q
P
S
Y
P
P
A
R
P
A
Site 99
Y813
I
K
I
A
Q
P
S
Y
P
P
A
R
P
A
S
Site 100
S820
Y
P
P
A
R
P
A
S
T
L
N
V
A
G
P
Site 101
S837
G
P
Q
A
A
V
A
S
Q
N
Y
T
P
K
P
Site 102
T841
A
V
A
S
Q
N
Y
T
P
K
P
T
V
S
T
Site 103
S847
Y
T
P
K
P
T
V
S
T
P
T
V
N
A
V
Site 104
T848
T
P
K
P
T
V
S
T
P
T
V
N
A
V
Q
Site 105
S869
S
N
E
L
P
G
M
S
G
R
G
A
Q
L
F
Site 106
S881
Q
L
F
A
K
R
Q
S
R
M
E
K
Y
V
V
Site 107
Y886
R
Q
S
R
M
E
K
Y
V
V
D
S
D
T
V
Site 108
S890
M
E
K
Y
V
V
D
S
D
T
V
Q
A
H
A
Site 109
T892
K
Y
V
V
D
S
D
T
V
Q
A
H
A
A
R
Site 110
S902
A
H
A
A
R
A
Q
S
P
T
P
S
L
P
A
Site 111
T904
A
A
R
A
Q
S
P
T
P
S
L
P
A
S
W
Site 112
S906
R
A
Q
S
P
T
P
S
L
P
A
S
W
K
Y
Site 113
S910
P
T
P
S
L
P
A
S
W
K
Y
S
S
N
V
Site 114
S914
L
P
A
S
W
K
Y
S
S
N
V
R
A
P
P
Site 115
S915
P
A
S
W
K
Y
S
S
N
V
R
A
P
P
P
Site 116
Y925
R
A
P
P
P
V
A
Y
N
P
I
H
S
P
S
Site 117
S932
Y
N
P
I
H
S
P
S
Y
P
L
A
A
L
K
Site 118
Y933
N
P
I
H
S
P
S
Y
P
L
A
A
L
K
S
Site 119
S940
Y
P
L
A
A
L
K
S
Q
P
S
A
A
Q
P
Site 120
S943
A
A
L
K
S
Q
P
S
A
A
Q
P
S
K
M
Site 121
Y970
D
V
M
K
H
Q
P
Y
Q
L
N
A
S
L
F
Site 122
S975
Q
P
Y
Q
L
N
A
S
L
F
T
F
Q
P
P
Site 123
S992
K
D
G
L
P
Q
K
S
S
V
K
V
N
S
A
Site 124
S993
D
G
L
P
Q
K
S
S
V
K
V
N
S
A
L
Site 125
S1015
P
R
P
V
N
A
A
S
P
T
N
V
Q
A
S
Site 126
S1022
S
P
T
N
V
Q
A
S
S
V
Y
S
V
P
A
Site 127
S1023
P
T
N
V
Q
A
S
S
V
Y
S
V
P
A
Y
Site 128
Y1025
N
V
Q
A
S
S
V
Y
S
V
P
A
Y
T
S
Site 129
S1026
V
Q
A
S
S
V
Y
S
V
P
A
Y
T
S
P
Site 130
S1032
Y
S
V
P
A
Y
T
S
P
P
S
F
F
A
E
Site 131
S1035
P
A
Y
T
S
P
P
S
F
F
A
E
A
S
S
Site 132
S1041
P
S
F
F
A
E
A
S
S
P
V
S
A
S
P
Site 133
S1056
V
P
V
G
I
P
T
S
P
K
Q
E
S
A
S
Site 134
S1061
P
T
S
P
K
Q
E
S
A
S
S
S
Y
F
V
Site 135
S1063
S
P
K
Q
E
S
A
S
S
S
Y
F
V
A
P
Site 136
S1065
K
Q
E
S
A
S
S
S
Y
F
V
A
P
R
P
Site 137
S1075
V
A
P
R
P
K
F
S
A
K
K
S
G
V
T
Site 138
S1079
P
K
F
S
A
K
K
S
G
V
T
I
Q
V
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation