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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP18
Full Name:
Alias:
43 kDa ISG15-specific protease;ISG15-specific-processing protease;Ubl thiolesterase 18
Type:
Mass (Da):
43011
Number AA:
372
UniProt ID:
Q9UMW8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
Q
S
I
L
A
E
S
S
Q
S
P
A
D
L
E
Site 2
S22
I
L
A
E
S
S
Q
S
P
A
D
L
E
E
K
Site 3
S34
E
E
K
K
E
E
D
S
N
M
K
R
E
Q
P
Site 4
Y50
E
R
P
R
A
W
D
Y
P
H
G
L
V
G
L
Site 5
T87
T
R
I
L
K
R
I
T
V
P
R
G
A
D
E
Site 6
S98
G
A
D
E
Q
R
R
S
V
P
F
Q
M
L
L
Site 7
Y144
Q
H
D
A
A
Q
L
Y
L
K
L
W
N
L
I
Site 8
T156
N
L
I
K
D
Q
I
T
D
V
H
L
V
E
R
Site 9
Y168
V
E
R
L
Q
A
L
Y
T
I
R
V
K
D
S
Site 10
T169
E
R
L
Q
A
L
Y
T
I
R
V
K
D
S
L
Site 11
S185
C
V
D
C
A
M
E
S
S
R
N
S
S
M
L
Site 12
S189
A
M
E
S
S
R
N
S
S
M
L
T
L
P
L
Site 13
S190
M
E
S
S
R
N
S
S
M
L
T
L
P
L
S
Site 14
T193
S
R
N
S
S
M
L
T
L
P
L
S
L
F
D
Site 15
S203
L
S
L
F
D
V
D
S
K
P
L
K
T
L
E
Site 16
T208
V
D
S
K
P
L
K
T
L
E
D
A
L
H
C
Site 17
S223
F
F
Q
P
R
E
L
S
S
K
S
K
C
F
C
Site 18
S224
F
Q
P
R
E
L
S
S
K
S
K
C
F
C
E
Site 19
S226
P
R
E
L
S
S
K
S
K
C
F
C
E
N
C
Site 20
T246
G
K
Q
V
L
K
L
T
H
L
P
Q
T
L
T
Site 21
T251
K
L
T
H
L
P
Q
T
L
T
I
H
L
M
R
Site 22
S260
T
I
H
L
M
R
F
S
I
R
N
S
Q
T
R
Site 23
S272
Q
T
R
K
I
C
H
S
L
Y
F
P
Q
S
L
Site 24
Y274
R
K
I
C
H
S
L
Y
F
P
Q
S
L
D
F
Site 25
S278
H
S
L
Y
F
P
Q
S
L
D
F
S
Q
I
L
Site 26
S282
F
P
Q
S
L
D
F
S
Q
I
L
P
M
K
R
Site 27
S291
I
L
P
M
K
R
E
S
C
D
A
E
E
Q
S
Site 28
Y302
E
E
Q
S
G
G
Q
Y
E
L
F
A
V
I
A
Site 29
Y322
D
S
G
H
Y
C
V
Y
I
R
N
A
V
D
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation