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Updated November 2019
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Protein Info
Short Name:
SYNRG
Full Name:
Synergin gamma
Alias:
Adaptor-related protein complex 1 gamma subunit-binding protein 1; AP1 gamma subunit binding protein 1; AP1 subunit gamma-binding protein 1; AP1GBP1; Gamma-synergin; MGC104959; Synergin, gamma; SYNG
Type:
Adaptor/scaffold
Mass (Da):
140654
Number AA:
1314
UniProt ID:
Q9UMZ2
International Prot ID:
IPI00297931
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030121
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0006897
GO:0006886
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
L
R
P
G
A
G
S
G
G
G
G
A
A
G
Site 2
Y68
Q
G
I
M
G
M
N
Y
S
S
Q
M
S
Q
G
Site 3
S69
G
I
M
G
M
N
Y
S
S
Q
M
S
Q
G
P
Site 4
S73
M
N
Y
S
S
Q
M
S
Q
G
P
I
A
M
Q
Site 5
Y111
M
R
P
P
G
P
Q
Y
T
P
D
M
Q
K
Q
Site 6
T112
R
P
P
G
P
Q
Y
T
P
D
M
Q
K
Q
F
Site 7
S154
K
Q
K
L
R
L
L
S
S
V
K
P
K
T
G
Site 8
S155
Q
K
L
R
L
L
S
S
V
K
P
K
T
G
E
Site 9
T160
L
S
S
V
K
P
K
T
G
E
K
S
R
D
D
Site 10
S180
K
G
N
L
D
G
F
S
R
D
A
K
M
H
P
Site 11
T188
R
D
A
K
M
H
P
T
P
A
S
H
P
K
K
Site 12
S191
K
M
H
P
T
P
A
S
H
P
K
K
P
G
P
Site 13
S234
H
K
A
L
G
P
G
S
S
K
K
Y
P
S
L
Site 14
S235
K
A
L
G
P
G
S
S
K
K
Y
P
S
L
M
Site 15
Y238
G
P
G
S
S
K
K
Y
P
S
L
M
A
S
N
Site 16
S240
G
S
S
K
K
Y
P
S
L
M
A
S
N
G
V
Site 17
S244
K
Y
P
S
L
M
A
S
N
G
V
A
V
D
G
Site 18
T258
G
C
V
S
G
T
T
T
A
E
A
E
N
T
S
Site 19
T264
T
T
A
E
A
E
N
T
S
D
Q
N
L
S
I
Site 20
S270
N
T
S
D
Q
N
L
S
I
E
E
S
G
V
G
Site 21
S274
Q
N
L
S
I
E
E
S
G
V
G
V
F
P
S
Site 22
S281
S
G
V
G
V
F
P
S
Q
D
P
A
Q
P
R
Site 23
Y294
P
R
M
P
P
W
I
Y
N
E
S
L
V
P
D
Site 24
Y303
E
S
L
V
P
D
A
Y
K
K
I
L
E
T
T
Site 25
T312
K
I
L
E
T
T
M
T
P
T
G
I
D
T
A
Site 26
T334
S
S
G
L
P
R
E
T
L
G
Q
I
W
A
L
Site 27
T346
W
A
L
A
N
R
T
T
P
G
K
L
T
K
E
Site 28
S373
Q
R
G
V
P
A
M
S
P
D
A
L
N
Q
F
Site 29
T403
P
T
P
V
S
Q
P
T
V
I
P
S
G
P
A
Site 30
S407
S
Q
P
T
V
I
P
S
G
P
A
G
S
M
P
Site 31
Y445
S
S
G
F
I
P
T
Y
P
A
N
Q
V
V
K
Site 32
S465
F
Q
D
F
Q
D
A
S
K
S
G
S
L
D
D
Site 33
S467
D
F
Q
D
A
S
K
S
G
S
L
D
D
S
F
Site 34
S469
Q
D
A
S
K
S
G
S
L
D
D
S
F
S
D
Site 35
S473
K
S
G
S
L
D
D
S
F
S
D
F
Q
E
L
Site 36
S475
G
S
L
D
D
S
F
S
D
F
Q
E
L
P
A
Site 37
S483
D
F
Q
E
L
P
A
S
S
K
T
S
N
S
Q
Site 38
S487
L
P
A
S
S
K
T
S
N
S
Q
H
G
N
S
Site 39
S489
A
S
S
K
T
S
N
S
Q
H
G
N
S
A
P
Site 40
S494
S
N
S
Q
H
G
N
S
A
P
S
L
L
M
P
Site 41
S497
Q
H
G
N
S
A
P
S
L
L
M
P
L
P
G
Site 42
Y514
A
L
P
S
M
D
K
Y
A
V
F
K
G
I
A
Site 43
S525
K
G
I
A
A
D
K
S
S
E
N
T
V
P
P
Site 44
S526
G
I
A
A
D
K
S
S
E
N
T
V
P
P
G
Site 45
T529
A
D
K
S
S
E
N
T
V
P
P
G
D
P
G
Site 46
Y539
P
G
D
P
G
D
K
Y
S
A
F
R
E
L
E
Site 47
S540
G
D
P
G
D
K
Y
S
A
F
R
E
L
E
Q
Site 48
T548
A
F
R
E
L
E
Q
T
A
E
N
K
P
L
G
Site 49
S557
E
N
K
P
L
G
E
S
F
A
E
F
R
S
A
Site 50
T571
A
G
T
D
D
G
F
T
D
F
K
T
A
D
S
Site 51
T575
D
G
F
T
D
F
K
T
A
D
S
V
S
P
L
Site 52
S578
T
D
F
K
T
A
D
S
V
S
P
L
E
P
P
Site 53
S580
F
K
T
A
D
S
V
S
P
L
E
P
P
T
K
Site 54
T590
E
P
P
T
K
D
K
T
F
P
P
S
F
P
S
Site 55
S594
K
D
K
T
F
P
P
S
F
P
S
G
T
I
Q
Site 56
S621
L
A
D
L
D
M
F
S
S
V
N
C
S
S
E
Site 57
S622
A
D
L
D
M
F
S
S
V
N
C
S
S
E
K
Site 58
S626
M
F
S
S
V
N
C
S
S
E
K
P
L
S
F
Site 59
S627
F
S
S
V
N
C
S
S
E
K
P
L
S
F
S
Site 60
S632
C
S
S
E
K
P
L
S
F
S
A
V
F
S
T
Site 61
S634
S
E
K
P
L
S
F
S
A
V
F
S
T
S
K
Site 62
S640
F
S
A
V
F
S
T
S
K
S
V
S
T
P
Q
Site 63
S642
A
V
F
S
T
S
K
S
V
S
T
P
Q
S
T
Site 64
S644
F
S
T
S
K
S
V
S
T
P
Q
S
T
G
S
Site 65
T645
S
T
S
K
S
V
S
T
P
Q
S
T
G
S
A
Site 66
S648
K
S
V
S
T
P
Q
S
T
G
S
A
A
T
M
Site 67
S651
S
T
P
Q
S
T
G
S
A
A
T
M
T
A
L
Site 68
S665
L
A
A
T
K
T
S
S
L
A
D
D
F
G
E
Site 69
S674
A
D
D
F
G
E
F
S
L
F
G
E
Y
S
G
Site 70
S698
F
A
D
F
M
A
F
S
N
S
S
I
S
S
E
Site 71
S700
D
F
M
A
F
S
N
S
S
I
S
S
E
Q
K
Site 72
S701
F
M
A
F
S
N
S
S
I
S
S
E
Q
K
P
Site 73
S703
A
F
S
N
S
S
I
S
S
E
Q
K
P
D
D
Site 74
S704
F
S
N
S
S
I
S
S
E
Q
K
P
D
D
K
Site 75
Y712
E
Q
K
P
D
D
K
Y
D
A
L
K
E
E
A
Site 76
S720
D
A
L
K
E
E
A
S
P
V
P
L
T
S
N
Site 77
S730
P
L
T
S
N
V
G
S
T
V
K
G
G
Q
N
Site 78
S738
T
V
K
G
G
Q
N
S
T
A
A
S
T
K
Y
Site 79
S742
G
Q
N
S
T
A
A
S
T
K
Y
D
V
F
R
Site 80
T743
Q
N
S
T
A
A
S
T
K
Y
D
V
F
R
Q
Site 81
Y745
S
T
A
A
S
T
K
Y
D
V
F
R
Q
L
S
Site 82
S752
Y
D
V
F
R
Q
L
S
L
E
G
S
G
L
G
Site 83
S756
R
Q
L
S
L
E
G
S
G
L
G
V
E
D
L
Site 84
T767
V
E
D
L
K
D
N
T
P
S
G
K
S
D
D
Site 85
S772
D
N
T
P
S
G
K
S
D
D
D
F
A
D
F
Site 86
S781
D
D
F
A
D
F
H
S
S
K
F
S
S
I
N
Site 87
S782
D
F
A
D
F
H
S
S
K
F
S
S
I
N
S
Site 88
S785
D
F
H
S
S
K
F
S
S
I
N
S
D
K
S
Site 89
S786
F
H
S
S
K
F
S
S
I
N
S
D
K
S
L
Site 90
S789
S
K
F
S
S
I
N
S
D
K
S
L
G
E
K
Site 91
S792
S
S
I
N
S
D
K
S
L
G
E
K
A
V
A
Site 92
T803
K
A
V
A
F
R
H
T
K
E
D
S
A
S
V
Site 93
S807
F
R
H
T
K
E
D
S
A
S
V
K
S
L
D
Site 94
S809
H
T
K
E
D
S
A
S
V
K
S
L
D
L
P
Site 95
S812
E
D
S
A
S
V
K
S
L
D
L
P
S
I
G
Site 96
S821
D
L
P
S
I
G
G
S
S
V
G
K
E
D
S
Site 97
S822
L
P
S
I
G
G
S
S
V
G
K
E
D
S
E
Site 98
S828
S
S
V
G
K
E
D
S
E
D
A
L
S
V
Q
Site 99
S833
E
D
S
E
D
A
L
S
V
Q
F
D
M
K
L
Site 100
S852
G
D
L
K
H
V
M
S
D
S
S
L
D
L
P
Site 101
S854
L
K
H
V
M
S
D
S
S
L
D
L
P
T
V
Site 102
S855
K
H
V
M
S
D
S
S
L
D
L
P
T
V
S
Site 103
T860
D
S
S
L
D
L
P
T
V
S
G
Q
H
P
P
Site 104
S862
S
L
D
L
P
T
V
S
G
Q
H
P
P
A
A
Site 105
Y876
A
D
I
E
D
L
K
Y
A
A
F
G
S
Y
S
Site 106
S889
Y
S
S
N
F
A
V
S
T
L
T
S
Y
D
W
Site 107
T890
S
S
N
F
A
V
S
T
L
T
S
Y
D
W
S
Site 108
S893
F
A
V
S
T
L
T
S
Y
D
W
S
D
R
D
Site 109
S897
T
L
T
S
Y
D
W
S
D
R
D
D
A
T
Q
Site 110
T903
W
S
D
R
D
D
A
T
Q
G
R
K
L
S
P
Site 111
S909
A
T
Q
G
R
K
L
S
P
F
V
L
S
A
G
Site 112
S914
K
L
S
P
F
V
L
S
A
G
S
G
S
P
S
Site 113
S919
V
L
S
A
G
S
G
S
P
S
A
T
S
I
L
Site 114
S921
S
A
G
S
G
S
P
S
A
T
S
I
L
Q
K
Site 115
T923
G
S
G
S
P
S
A
T
S
I
L
Q
K
K
E
Site 116
S924
S
G
S
P
S
A
T
S
I
L
Q
K
K
E
T
Site 117
T931
S
I
L
Q
K
K
E
T
S
F
G
S
S
E
N
Site 118
S932
I
L
Q
K
K
E
T
S
F
G
S
S
E
N
I
Site 119
S935
K
K
E
T
S
F
G
S
S
E
N
I
T
M
T
Site 120
S936
K
E
T
S
F
G
S
S
E
N
I
T
M
T
S
Site 121
T940
F
G
S
S
E
N
I
T
M
T
S
L
S
K
V
Site 122
S943
S
E
N
I
T
M
T
S
L
S
K
V
T
T
F
Site 123
T959
S
E
D
A
L
P
E
T
T
F
P
A
L
A
S
Site 124
S966
T
T
F
P
A
L
A
S
F
K
D
T
I
P
Q
Site 125
T970
A
L
A
S
F
K
D
T
I
P
Q
T
S
E
Q
Site 126
Y980
Q
T
S
E
Q
K
E
Y
E
N
R
D
Y
K
D
Site 127
Y985
K
E
Y
E
N
R
D
Y
K
D
F
T
K
Q
D
Site 128
T989
N
R
D
Y
K
D
F
T
K
Q
D
L
P
T
A
Site 129
T995
F
T
K
Q
D
L
P
T
A
E
R
S
Q
E
A
Site 130
S999
D
L
P
T
A
E
R
S
Q
E
A
T
C
P
S
Site 131
T1003
A
E
R
S
Q
E
A
T
C
P
S
P
A
S
S
Site 132
S1006
S
Q
E
A
T
C
P
S
P
A
S
S
G
A
S
Site 133
S1009
A
T
C
P
S
P
A
S
S
G
A
S
Q
E
T
Site 134
S1010
T
C
P
S
P
A
S
S
G
A
S
Q
E
T
P
Site 135
S1013
S
P
A
S
S
G
A
S
Q
E
T
P
N
E
C
Site 136
T1016
S
S
G
A
S
Q
E
T
P
N
E
C
S
D
D
Site 137
S1029
D
D
F
G
E
F
Q
S
E
K
P
K
I
S
K
Site 138
S1035
Q
S
E
K
P
K
I
S
K
F
D
F
L
V
A
Site 139
S1044
F
D
F
L
V
A
T
S
Q
S
K
M
K
S
S
Site 140
S1046
F
L
V
A
T
S
Q
S
K
M
K
S
S
E
E
Site 141
S1050
T
S
Q
S
K
M
K
S
S
E
E
M
I
K
S
Site 142
S1051
S
Q
S
K
M
K
S
S
E
E
M
I
K
S
E
Site 143
S1057
S
S
E
E
M
I
K
S
E
L
A
T
F
D
L
Site 144
S1065
E
L
A
T
F
D
L
S
V
Q
G
S
H
K
R
Site 145
S1069
F
D
L
S
V
Q
G
S
H
K
R
S
L
S
L
Site 146
S1073
V
Q
G
S
H
K
R
S
L
S
L
G
D
K
E
Site 147
S1075
G
S
H
K
R
S
L
S
L
G
D
K
E
I
S
Site 148
S1082
S
L
G
D
K
E
I
S
R
S
S
P
S
P
A
Site 149
S1084
G
D
K
E
I
S
R
S
S
P
S
P
A
L
E
Site 150
S1085
D
K
E
I
S
R
S
S
P
S
P
A
L
E
Q
Site 151
S1087
E
I
S
R
S
S
P
S
P
A
L
E
Q
P
F
Site 152
S1098
E
Q
P
F
R
D
R
S
N
T
L
N
E
K
P
Site 153
T1100
P
F
R
D
R
S
N
T
L
N
E
K
P
A
L
Site 154
Y1114
L
P
V
I
R
D
K
Y
K
D
L
T
G
E
V
Site 155
T1118
R
D
K
Y
K
D
L
T
G
E
V
E
E
N
E
Site 156
Y1127
E
V
E
E
N
E
R
Y
A
Y
E
W
Q
R
C
Site 157
Y1129
E
E
N
E
R
Y
A
Y
E
W
Q
R
C
L
G
Site 158
T1148
V
I
K
K
A
N
D
T
L
N
G
I
S
S
S
Site 159
S1154
D
T
L
N
G
I
S
S
S
S
V
C
T
E
V
Site 160
T1222
F
M
S
L
A
T
L
T
P
D
E
N
S
L
D
Site 161
S1227
T
L
T
P
D
E
N
S
L
D
F
S
S
C
M
Site 162
S1231
D
E
N
S
L
D
F
S
S
C
M
L
R
P
G
Site 163
S1232
E
N
S
L
D
F
S
S
C
M
L
R
P
G
I
Site 164
S1256
V
C
L
L
N
V
D
S
R
S
R
K
E
E
K
Site 165
S1275
H
P
K
K
A
F
N
S
E
T
D
S
F
K
L
Site 166
T1277
K
K
A
F
N
S
E
T
D
S
F
K
L
A
Y
Site 167
S1279
A
F
N
S
E
T
D
S
F
K
L
A
Y
G
G
Site 168
Y1289
L
A
Y
G
G
H
Q
Y
H
A
S
C
A
N
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation