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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
G3BP2
Full Name:
Ras GTPase-activating protein-binding protein 2
Alias:
G3B2; GAP SH3-domain binding protein 2; GTPase activating protein (SH3 domain) binding protein 2; KIAA0660; Ras-GTPase activating protein SH3 domain-binding protein 2; Ras-GTPase-activating protein binding protein 2
Type:
RNA binding protein, adaptor/scaffold
Mass (Da):
54121
Number AA:
482
UniProt ID:
Q9UN86
International Prot ID:
IPI00009057
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0000166
GO:0030159
PhosphoSite+
KinaseNET
Biological Process:
GO:0007265
GO:0007253
GO:0051028
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
V
M
E
K
P
S
P
L
L
V
G
R
E
Site 2
Y19
G
R
E
F
V
R
Q
Y
Y
T
L
L
N
K
A
Site 3
Y20
R
E
F
V
R
Q
Y
Y
T
L
L
N
K
A
P
Site 4
Y29
L
L
N
K
A
P
E
Y
L
H
R
F
Y
G
R
Site 5
Y34
P
E
Y
L
H
R
F
Y
G
R
N
S
S
Y
V
Site 6
S39
R
F
Y
G
R
N
S
S
Y
V
H
G
G
V
D
Site 7
Y40
F
Y
G
R
N
S
S
Y
V
H
G
G
V
D
A
Site 8
S48
V
H
G
G
V
D
A
S
G
K
P
Q
E
A
V
Site 9
Y56
G
K
P
Q
E
A
V
Y
G
Q
N
D
I
H
H
Site 10
S71
K
V
L
S
L
N
F
S
E
C
H
T
K
I
R
Site 11
S99
V
Q
V
M
G
L
L
S
N
S
G
Q
P
E
R
Site 12
S101
V
M
G
L
L
S
N
S
G
Q
P
E
R
K
F
Site 13
T111
P
E
R
K
F
M
Q
T
F
V
L
A
P
E
G
Site 14
Y125
G
S
V
P
N
K
F
Y
V
H
N
D
M
F
R
Site 15
Y133
V
H
N
D
M
F
R
Y
E
D
E
V
F
G
D
Site 16
S141
E
D
E
V
F
G
D
S
E
P
E
L
D
E
E
Site 17
S149
E
P
E
L
D
E
E
S
E
D
E
V
E
E
E
Site 18
S163
E
Q
E
E
R
Q
P
S
P
E
P
V
Q
E
N
Site 19
S173
P
V
Q
E
N
A
N
S
G
Y
Y
E
A
H
P
Site 20
Y175
Q
E
N
A
N
S
G
Y
Y
E
A
H
P
V
T
Site 21
Y176
E
N
A
N
S
G
Y
Y
E
A
H
P
V
T
N
Site 22
S193
E
E
P
L
E
E
S
S
H
E
P
E
P
E
P
Site 23
S202
E
P
E
P
E
P
E
S
E
T
K
T
E
E
L
Site 24
T206
E
P
E
S
E
T
K
T
E
E
L
K
P
Q
V
Site 25
S225
L
E
E
L
E
E
K
S
T
T
P
P
P
A
E
Site 26
T226
E
E
L
E
E
K
S
T
T
P
P
P
A
E
P
Site 27
T227
E
L
E
E
K
S
T
T
P
P
P
A
E
P
V
Site 28
S235
P
P
P
A
E
P
V
S
L
P
Q
E
P
P
K
Site 29
S245
Q
E
P
P
K
A
F
S
W
A
S
V
T
S
K
Site 30
S248
P
K
A
F
S
W
A
S
V
T
S
K
N
L
P
Site 31
S251
F
S
W
A
S
V
T
S
K
N
L
P
P
S
G
Site 32
S257
T
S
K
N
L
P
P
S
G
T
V
S
S
S
G
Site 33
T259
K
N
L
P
P
S
G
T
V
S
S
S
G
I
P
Site 34
S261
L
P
P
S
G
T
V
S
S
S
G
I
P
P
H
Site 35
S262
P
P
S
G
T
V
S
S
S
G
I
P
P
H
V
Site 36
S263
P
S
G
T
V
S
S
S
G
I
P
P
H
V
K
Site 37
S274
P
H
V
K
A
P
V
S
Q
P
R
V
E
A
K
Site 38
S286
E
A
K
P
E
V
Q
S
Q
P
P
R
V
R
E
Site 39
S319
G
D
M
E
Q
N
D
S
D
N
R
R
I
I
R
Site 40
Y327
D
N
R
R
I
I
R
Y
P
D
S
H
Q
L
F
Site 41
S353
E
L
K
E
F
F
M
S
F
G
N
V
V
E
L
Site 42
T364
V
V
E
L
R
I
N
T
K
G
V
G
G
K
L
Site 43
T409
L
N
V
E
E
K
K
T
R
A
A
R
E
R
E
Site 44
T417
R
A
A
R
E
R
E
T
R
G
G
G
D
D
R
Site 45
S466
G
M
A
Q
K
L
G
S
G
R
G
T
G
Q
M
Site 46
T470
K
L
G
S
G
R
G
T
G
Q
M
E
G
R
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation