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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAMTS5
Full Name:
Alias:
A disintegrin and metalloproteinase with thrombospondin motifs 11;ADMP-2;Aggrecanase-2
Type:
Mass (Da):
101716
Number AA:
930
UniProt ID:
Q9UNA0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
A
A
V
G
P
A
A
T
P
A
Q
D
K
A
G
Site 2
S70
P
L
A
Q
R
R
R
S
K
G
L
V
Q
N
I
Site 3
Y81
V
Q
N
I
D
Q
L
Y
S
G
G
G
K
V
G
Site 4
S82
Q
N
I
D
Q
L
Y
S
G
G
G
K
V
G
Y
Site 5
Y89
S
G
G
G
K
V
G
Y
L
V
Y
A
G
G
R
Site 6
Y92
G
K
V
G
Y
L
V
Y
A
G
G
R
R
F
L
Site 7
Y132
R
H
R
S
H
C
F
Y
R
G
T
V
D
A
S
Site 8
T135
S
H
C
F
Y
R
G
T
V
D
A
S
P
R
S
Site 9
S139
Y
R
G
T
V
D
A
S
P
R
S
L
A
V
F
Site 10
T164
A
V
K
H
A
R
Y
T
L
K
P
L
L
R
G
Site 11
Y182
E
E
E
K
G
R
V
Y
G
D
G
S
A
R
I
Site 12
S186
G
R
V
Y
G
D
G
S
A
R
I
L
H
V
Y
Site 13
Y193
S
A
R
I
L
H
V
Y
T
R
E
G
F
S
F
Site 14
S199
V
Y
T
R
E
G
F
S
F
E
A
L
P
P
R
Site 15
S208
E
A
L
P
P
R
A
S
C
E
T
P
A
S
T
Site 16
T211
P
P
R
A
S
C
E
T
P
A
S
T
P
E
A
Site 17
S214
A
S
C
E
T
P
A
S
T
P
E
A
H
E
H
Site 18
T215
S
C
E
T
P
A
S
T
P
E
A
H
E
H
A
Site 19
S229
A
P
A
H
S
N
P
S
G
R
A
A
L
A
S
Site 20
S236
S
G
R
A
A
L
A
S
Q
L
L
D
Q
S
A
Site 21
S242
A
S
Q
L
L
D
Q
S
A
L
S
P
A
G
G
Site 22
S245
L
L
D
Q
S
A
L
S
P
A
G
G
S
G
P
Site 23
T254
A
G
G
S
G
P
Q
T
W
W
R
R
R
R
R
Site 24
S262
W
W
R
R
R
R
R
S
I
S
R
A
R
Q
V
Site 25
S264
R
R
R
R
R
S
I
S
R
A
R
Q
V
E
L
Site 26
Y283
D
A
S
M
A
R
L
Y
G
R
G
L
Q
H
Y
Site 27
Y302
A
S
I
A
N
R
L
Y
S
H
A
S
I
E
N
Site 28
S303
S
I
A
N
R
L
Y
S
H
A
S
I
E
N
H
Site 29
S306
N
R
L
Y
S
H
A
S
I
E
N
H
I
R
L
Site 30
S327
V
L
G
D
K
D
K
S
L
E
V
S
K
N
A
Site 31
S331
K
D
K
S
L
E
V
S
K
N
A
A
T
T
L
Site 32
Y359
G
D
D
H
E
E
H
Y
D
A
A
I
L
F
T
Site 33
S393
T
I
C
S
P
E
R
S
C
A
V
I
E
D
D
Site 34
S419
I
G
H
L
L
G
L
S
H
D
D
S
K
F
C
Site 35
S423
L
G
L
S
H
D
D
S
K
F
C
E
E
T
F
Site 36
T429
D
S
K
F
C
E
E
T
F
G
S
T
E
D
K
Site 37
S432
F
C
E
E
T
F
G
S
T
E
D
K
R
L
M
Site 38
S440
T
E
D
K
R
L
M
S
S
I
L
T
S
I
D
Site 39
S441
E
D
K
R
L
M
S
S
I
L
T
S
I
D
A
Site 40
T444
R
L
M
S
S
I
L
T
S
I
D
A
S
K
P
Site 41
S449
I
L
T
S
I
D
A
S
K
P
W
S
K
C
T
Site 42
S453
I
D
A
S
K
P
W
S
K
C
T
S
A
T
I
Site 43
S457
K
P
W
S
K
C
T
S
A
T
I
T
E
F
L
Site 44
T461
K
C
T
S
A
T
I
T
E
F
L
D
D
G
H
Site 45
Y491
E
E
L
P
G
Q
T
Y
D
A
T
Q
Q
C
N
Site 46
T500
A
T
Q
Q
C
N
L
T
F
G
P
E
Y
S
V
Site 47
Y505
N
L
T
F
G
P
E
Y
S
V
C
P
G
M
D
Site 48
T540
K
L
P
A
V
E
G
T
P
C
G
K
G
R
I
Site 49
T557
Q
G
K
C
V
D
K
T
K
K
K
Y
Y
S
T
Site 50
Y561
V
D
K
T
K
K
K
Y
Y
S
T
S
S
H
G
Site 51
Y562
D
K
T
K
K
K
Y
Y
S
T
S
S
H
G
N
Site 52
S563
K
T
K
K
K
Y
Y
S
T
S
S
H
G
N
W
Site 53
S565
K
K
K
Y
Y
S
T
S
S
H
G
N
W
G
S
Site 54
Y591
G
G
G
V
Q
F
A
Y
R
H
C
N
N
P
A
Site 55
Y605
A
P
R
N
N
G
R
Y
C
T
G
K
R
A
I
Site 56
T607
R
N
N
G
R
Y
C
T
G
K
R
A
I
Y
R
Site 57
Y613
C
T
G
K
R
A
I
Y
R
S
C
S
L
M
P
Site 58
S615
G
K
R
A
I
Y
R
S
C
S
L
M
P
C
P
Site 59
S617
R
A
I
Y
R
S
C
S
L
M
P
C
P
P
N
Site 60
S641
E
A
K
N
G
Y
Q
S
D
A
K
G
V
K
T
Site 61
T648
S
D
A
K
G
V
K
T
F
V
E
W
V
P
K
Site 62
T668
P
A
D
V
C
K
L
T
C
R
A
K
G
T
G
Site 63
Y676
C
R
A
K
G
T
G
Y
Y
V
V
F
S
P
K
Site 64
Y677
R
A
K
G
T
G
Y
Y
V
V
F
S
P
K
V
Site 65
S681
T
G
Y
Y
V
V
F
S
P
K
V
T
D
G
T
Site 66
T688
S
P
K
V
T
D
G
T
E
C
R
P
Y
S
N
Site 67
Y693
D
G
T
E
C
R
P
Y
S
N
S
V
C
V
R
Site 68
S694
G
T
E
C
R
P
Y
S
N
S
V
C
V
R
G
Site 69
T732
G
G
D
N
S
S
C
T
K
I
V
G
T
F
N
Site 70
T737
S
C
T
K
I
V
G
T
F
N
K
K
S
K
G
Site 71
S742
V
G
T
F
N
K
K
S
K
G
Y
T
D
V
V
Site 72
T746
N
K
K
S
K
G
Y
T
D
V
V
R
I
P
E
Site 73
T772
A
K
D
Q
T
R
F
T
A
Y
L
A
L
K
K
Site 74
Y784
L
K
K
K
N
G
E
Y
L
I
N
G
K
Y
M
Site 75
Y790
E
Y
L
I
N
G
K
Y
M
I
S
T
S
E
T
Site 76
S793
I
N
G
K
Y
M
I
S
T
S
E
T
I
I
D
Site 77
S795
G
K
Y
M
I
S
T
S
E
T
I
I
D
I
N
Site 78
Y808
I
N
G
T
V
M
N
Y
S
G
W
S
H
R
D
Site 79
Y823
D
F
L
H
G
M
G
Y
S
A
T
K
E
I
L
Site 80
Y847
T
K
P
L
D
V
R
Y
S
F
F
V
P
K
K
Site 81
S848
K
P
L
D
V
R
Y
S
F
F
V
P
K
K
S
Site 82
S855
S
F
F
V
P
K
K
S
T
P
K
V
N
S
V
Site 83
T856
F
F
V
P
K
K
S
T
P
K
V
N
S
V
T
Site 84
S861
K
S
T
P
K
V
N
S
V
T
S
H
G
S
N
Site 85
S867
N
S
V
T
S
H
G
S
N
K
V
G
S
H
T
Site 86
S872
H
G
S
N
K
V
G
S
H
T
S
Q
P
Q
W
Site 87
S875
N
K
V
G
S
H
T
S
Q
P
Q
W
V
T
G
Site 88
T899
D
T
G
W
H
T
R
T
V
Q
C
Q
D
G
N
Site 89
S916
L
A
K
G
C
P
L
S
Q
R
P
S
A
F
K
Site 90
S920
C
P
L
S
Q
R
P
S
A
F
K
Q
C
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation