PhosphoNET

           
Protein Info 
   
Short Name:  POLI
Full Name:  DNA polymerase iota
Alias:  EC 2.7.7.7; Eta2; Polymerase (DNA directed) iota; RAD30 homolog B; RAD30B; RAD3OB
Type:  Transferase; DNA repair; EC 2.7.7.7
Mass (Da):  80346
Number AA:  715
UniProt ID:  Q9UNA4
International Prot ID:  IPI00296840
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005654     Uniprot OncoNet
Molecular Function:  GO:0003887  GO:0003684  GO:0000287 PhosphoSite+ KinaseNET
Biological Process:  GO:0006281  GO:0006260   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T22VHDQVLPTPNASSRV
Site 2T100LVNGEDLTRYREMSY
Site 3Y102NGEDLTRYREMSYKV
Site 4S106LTRYREMSYKVTELL
Site 5T110REMSYKVTELLEEFS
Site 6S117TELLEEFSPVVERLG
Site 7T133DENFVDLTEMVEKRL
Site 8S145KRLQQLQSDELSAVT
Site 9S149QLQSDELSAVTVSGH
Site 10T152SDELSAVTVSGHVYN
Site 11Y158VTVSGHVYNNQSINL
Site 12Y188AEMREAMYNQLGLTG
Site 13S225QTVLLPESCQHLIHS
Site 14T263NSVRDLQTFSPKILE
Site 15S265VRDLQTFSPKILEKE
Site 16S276LEKELGISVAQRIQK
Site 17S285AQRIQKLSFGEDNSP
Site 18S291LSFGEDNSPVILSGP
Site 19S296DNSPVILSGPPQSFS
Site 20S301ILSGPPQSFSEEDSF
Site 21S303SGPPQSFSEEDSFKK
Site 22S307QSFSEEDSFKKCSSE
Site 23T341QDGRKPHTVRLIIRR
Site 24Y349VRLIIRRYSSEKHYG
Site 25S350RLIIRRYSSEKHYGR
Site 26S351LIIRRYSSEKHYGRE
Site 27Y355RYSSEKHYGRESRQC
Site 28S359EKHYGRESRQCPIPS
Site 29T374HVIQKLGTGNYDVMT
Site 30Y377QKLGTGNYDVMTPMV
Site 31Y426AKKGLIDYYLMPSLS
Site 32Y427KKGLIDYYLMPSLST
Site 33S431IDYYLMPSLSTTSRS
Site 34S433YYLMPSLSTTSRSGK
Site 35T434YLMPSLSTTSRSGKH
Site 36T435LMPSLSTTSRSGKHS
Site 37S436MPSLSTTSRSGKHSF
Site 38S438SLSTTSRSGKHSFKM
Site 39S442TSRSGKHSFKMKDTH
Site 40T459DFPKDKETNRDFLPS
Site 41S466TNRDFLPSGRIESTR
Site 42S471LPSGRIESTRTRESP
Site 43T472PSGRIESTRTRESPL
Site 44T474GRIESTRTRESPLDT
Site 45S477ESTRTRESPLDTTNF
Site 46T481TRESPLDTTNFSKEK
Site 47T482RESPLDTTNFSKEKD
Site 48S520DIQEEILSGKSREKF
Site 49S523EEILSGKSREKFQGK
Site 50S532EKFQGKGSVSCPLHA
Site 51S534FQGKGSVSCPLHASR
Site 52S545HASRGVLSFFSKKQM
Site 53S564INPRDHLSSSKQVSS
Site 54S565NPRDHLSSSKQVSSV
Site 55S566PRDHLSSSKQVSSVS
Site 56S570LSSSKQVSSVSPCEP
Site 57S571SSSKQVSSVSPCEPG
Site 58S573SKQVSSVSPCEPGTS
Site 59T579VSPCEPGTSGFNSSS
Site 60S580SPCEPGTSGFNSSSS
Site 61S584PGTSGFNSSSSSYMS
Site 62S585GTSGFNSSSSSYMSS
Site 63S586TSGFNSSSSSYMSSQ
Site 64S587SGFNSSSSSYMSSQK
Site 65S588GFNSSSSSYMSSQKD
Site 66Y589FNSSSSSYMSSQKDY
Site 67S591SSSSSYMSSQKDYSY
Site 68S592SSSSYMSSQKDYSYY
Site 69Y596YMSSQKDYSYYLDNR
Site 70S597MSSQKDYSYYLDNRL
Site 71Y598SSQKDYSYYLDNRLK
Site 72Y599SQKDYSYYLDNRLKD
Site 73S610RLKDERISQGPKEPQ
Site 74S624QGFHFTNSNPAVSAF
Site 75S629TNSNPAVSAFHSFPN
Site 76S633PAVSAFHSFPNLQSE
Site 77S639HSFPNLQSEQLFSRN
Site 78T648QLFSRNHTTDSHKQT
Site 79S651SRNHTTDSHKQTVAT
Site 80T655TTDSHKQTVATDSHE
Site 81S660KQTVATDSHEGLTEN
Site 82T665TDSHEGLTENREPDS
Site 83S672TENREPDSVDEKITF
Site 84S681DEKITFPSDIDPQVF
Site 85Y689DIDPQVFYELPEAVQ
Site 86T706LLAEWKRTGSDFHIG
Site 87S708AEWKRTGSDFHIGHK
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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