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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLI
Full Name:
DNA polymerase iota
Alias:
EC 2.7.7.7; Eta2; Polymerase (DNA directed) iota; RAD30 homolog B; RAD30B; RAD3OB
Type:
Transferase; DNA repair; EC 2.7.7.7
Mass (Da):
80346
Number AA:
715
UniProt ID:
Q9UNA4
International Prot ID:
IPI00296840
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003887
GO:0003684
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0006260
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
V
H
D
Q
V
L
P
T
P
N
A
S
S
R
V
Site 2
T100
L
V
N
G
E
D
L
T
R
Y
R
E
M
S
Y
Site 3
Y102
N
G
E
D
L
T
R
Y
R
E
M
S
Y
K
V
Site 4
S106
L
T
R
Y
R
E
M
S
Y
K
V
T
E
L
L
Site 5
T110
R
E
M
S
Y
K
V
T
E
L
L
E
E
F
S
Site 6
S117
T
E
L
L
E
E
F
S
P
V
V
E
R
L
G
Site 7
T133
D
E
N
F
V
D
L
T
E
M
V
E
K
R
L
Site 8
S145
K
R
L
Q
Q
L
Q
S
D
E
L
S
A
V
T
Site 9
S149
Q
L
Q
S
D
E
L
S
A
V
T
V
S
G
H
Site 10
T152
S
D
E
L
S
A
V
T
V
S
G
H
V
Y
N
Site 11
Y158
V
T
V
S
G
H
V
Y
N
N
Q
S
I
N
L
Site 12
Y188
A
E
M
R
E
A
M
Y
N
Q
L
G
L
T
G
Site 13
S225
Q
T
V
L
L
P
E
S
C
Q
H
L
I
H
S
Site 14
T263
N
S
V
R
D
L
Q
T
F
S
P
K
I
L
E
Site 15
S265
V
R
D
L
Q
T
F
S
P
K
I
L
E
K
E
Site 16
S276
L
E
K
E
L
G
I
S
V
A
Q
R
I
Q
K
Site 17
S285
A
Q
R
I
Q
K
L
S
F
G
E
D
N
S
P
Site 18
S291
L
S
F
G
E
D
N
S
P
V
I
L
S
G
P
Site 19
S296
D
N
S
P
V
I
L
S
G
P
P
Q
S
F
S
Site 20
S301
I
L
S
G
P
P
Q
S
F
S
E
E
D
S
F
Site 21
S303
S
G
P
P
Q
S
F
S
E
E
D
S
F
K
K
Site 22
S307
Q
S
F
S
E
E
D
S
F
K
K
C
S
S
E
Site 23
T341
Q
D
G
R
K
P
H
T
V
R
L
I
I
R
R
Site 24
Y349
V
R
L
I
I
R
R
Y
S
S
E
K
H
Y
G
Site 25
S350
R
L
I
I
R
R
Y
S
S
E
K
H
Y
G
R
Site 26
S351
L
I
I
R
R
Y
S
S
E
K
H
Y
G
R
E
Site 27
Y355
R
Y
S
S
E
K
H
Y
G
R
E
S
R
Q
C
Site 28
S359
E
K
H
Y
G
R
E
S
R
Q
C
P
I
P
S
Site 29
T374
H
V
I
Q
K
L
G
T
G
N
Y
D
V
M
T
Site 30
Y377
Q
K
L
G
T
G
N
Y
D
V
M
T
P
M
V
Site 31
Y426
A
K
K
G
L
I
D
Y
Y
L
M
P
S
L
S
Site 32
Y427
K
K
G
L
I
D
Y
Y
L
M
P
S
L
S
T
Site 33
S431
I
D
Y
Y
L
M
P
S
L
S
T
T
S
R
S
Site 34
S433
Y
Y
L
M
P
S
L
S
T
T
S
R
S
G
K
Site 35
T434
Y
L
M
P
S
L
S
T
T
S
R
S
G
K
H
Site 36
T435
L
M
P
S
L
S
T
T
S
R
S
G
K
H
S
Site 37
S436
M
P
S
L
S
T
T
S
R
S
G
K
H
S
F
Site 38
S438
S
L
S
T
T
S
R
S
G
K
H
S
F
K
M
Site 39
S442
T
S
R
S
G
K
H
S
F
K
M
K
D
T
H
Site 40
T459
D
F
P
K
D
K
E
T
N
R
D
F
L
P
S
Site 41
S466
T
N
R
D
F
L
P
S
G
R
I
E
S
T
R
Site 42
S471
L
P
S
G
R
I
E
S
T
R
T
R
E
S
P
Site 43
T472
P
S
G
R
I
E
S
T
R
T
R
E
S
P
L
Site 44
T474
G
R
I
E
S
T
R
T
R
E
S
P
L
D
T
Site 45
S477
E
S
T
R
T
R
E
S
P
L
D
T
T
N
F
Site 46
T481
T
R
E
S
P
L
D
T
T
N
F
S
K
E
K
Site 47
T482
R
E
S
P
L
D
T
T
N
F
S
K
E
K
D
Site 48
S520
D
I
Q
E
E
I
L
S
G
K
S
R
E
K
F
Site 49
S523
E
E
I
L
S
G
K
S
R
E
K
F
Q
G
K
Site 50
S532
E
K
F
Q
G
K
G
S
V
S
C
P
L
H
A
Site 51
S534
F
Q
G
K
G
S
V
S
C
P
L
H
A
S
R
Site 52
S545
H
A
S
R
G
V
L
S
F
F
S
K
K
Q
M
Site 53
S564
I
N
P
R
D
H
L
S
S
S
K
Q
V
S
S
Site 54
S565
N
P
R
D
H
L
S
S
S
K
Q
V
S
S
V
Site 55
S566
P
R
D
H
L
S
S
S
K
Q
V
S
S
V
S
Site 56
S570
L
S
S
S
K
Q
V
S
S
V
S
P
C
E
P
Site 57
S571
S
S
S
K
Q
V
S
S
V
S
P
C
E
P
G
Site 58
S573
S
K
Q
V
S
S
V
S
P
C
E
P
G
T
S
Site 59
T579
V
S
P
C
E
P
G
T
S
G
F
N
S
S
S
Site 60
S580
S
P
C
E
P
G
T
S
G
F
N
S
S
S
S
Site 61
S584
P
G
T
S
G
F
N
S
S
S
S
S
Y
M
S
Site 62
S585
G
T
S
G
F
N
S
S
S
S
S
Y
M
S
S
Site 63
S586
T
S
G
F
N
S
S
S
S
S
Y
M
S
S
Q
Site 64
S587
S
G
F
N
S
S
S
S
S
Y
M
S
S
Q
K
Site 65
S588
G
F
N
S
S
S
S
S
Y
M
S
S
Q
K
D
Site 66
Y589
F
N
S
S
S
S
S
Y
M
S
S
Q
K
D
Y
Site 67
S591
S
S
S
S
S
Y
M
S
S
Q
K
D
Y
S
Y
Site 68
S592
S
S
S
S
Y
M
S
S
Q
K
D
Y
S
Y
Y
Site 69
Y596
Y
M
S
S
Q
K
D
Y
S
Y
Y
L
D
N
R
Site 70
S597
M
S
S
Q
K
D
Y
S
Y
Y
L
D
N
R
L
Site 71
Y598
S
S
Q
K
D
Y
S
Y
Y
L
D
N
R
L
K
Site 72
Y599
S
Q
K
D
Y
S
Y
Y
L
D
N
R
L
K
D
Site 73
S610
R
L
K
D
E
R
I
S
Q
G
P
K
E
P
Q
Site 74
S624
Q
G
F
H
F
T
N
S
N
P
A
V
S
A
F
Site 75
S629
T
N
S
N
P
A
V
S
A
F
H
S
F
P
N
Site 76
S633
P
A
V
S
A
F
H
S
F
P
N
L
Q
S
E
Site 77
S639
H
S
F
P
N
L
Q
S
E
Q
L
F
S
R
N
Site 78
T648
Q
L
F
S
R
N
H
T
T
D
S
H
K
Q
T
Site 79
S651
S
R
N
H
T
T
D
S
H
K
Q
T
V
A
T
Site 80
T655
T
T
D
S
H
K
Q
T
V
A
T
D
S
H
E
Site 81
S660
K
Q
T
V
A
T
D
S
H
E
G
L
T
E
N
Site 82
T665
T
D
S
H
E
G
L
T
E
N
R
E
P
D
S
Site 83
S672
T
E
N
R
E
P
D
S
V
D
E
K
I
T
F
Site 84
S681
D
E
K
I
T
F
P
S
D
I
D
P
Q
V
F
Site 85
Y689
D
I
D
P
Q
V
F
Y
E
L
P
E
A
V
Q
Site 86
T706
L
L
A
E
W
K
R
T
G
S
D
F
H
I
G
Site 87
S708
A
E
W
K
R
T
G
S
D
F
H
I
G
H
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation